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The purpose of this paper is to propose a novel hybrid framework for evaluating and benchmarking trustworthy artificial intelligence (AI) applications in healthcare by using multi-criteria decision-making (MCDM) techniques under a new fuzzy environment. To develop such a framework, a new decision matrix has been built, and then integrated with q-ROF2TL-FWZIC (q‐Rung Orthopair Fuzzy 2‐Tuple Linguistic Fuzzy-Weighted Zero-Inconsistency) and q-ROF2TL-CODAS (q‐Rung Orthopair Fuzzy 2‐Tuple Linguistic Combinative Distance-Based Assessment). In this integration, q-ROF2TL-FWZIC is utilized for assigning the weights of evaluation attributes of trustworthy AI, while q-ROF2TL-CODAS is employed for benchmarking trustworthy AI applications. Findings show that the q-ROF2TL-FWZIC method effectively weights the evaluation attributes. The transparency attribute receives the highest importance weight (0.173566825), whereas the human agency and oversight criterion has the lowest weight (0.105741901). The remaining attributes are distributed in between. Moreover, alternative_4 receives the highest rank order (score of 7.370410417), while alternative_13 receives the lowest rank order (score of −4.759794397). To evaluate the validity of the proposed framework, systematic ranking and sensitivity analysis assessments were employed. [ABSTRACT FROM AUTHOR]