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Melia L. is a small genus of only 2–3 species, which is native to Indo-Malesia, India, Pakistan and southern parts of tropical Africa. Fossil records of Melia are known from the early Miocene to the Pleistocene. Here we describe some mummified fossil endocarps of Melia from the upper part of the Yongning Formation (late Oligocene) in Nanning Basin, South China. These well-preserved stony endocarps are 8–14 mm long and 5–9 mm wide, and have 5 locules with a single spindle seed per locule. We interpret these endocarps as the internal remains of a Melia drupe, and assign them as a new species: M. santangensis sp. nov. This is the only fossil record of anatomically preserved Melia found in China, and also the oldest fossil record of Melia so far reported globally. The fossil record confirms the presence of Melia in Asia at the late Oligocene, and provides evidence supporting the distribution and dispersal hypothesis of the Meliaceae. [ABSTRACT FROM AUTHOR]

The thermal stable Eu(HCOO) 3 red-emitting crystals were synthesized by a facile hydrothermal route. Both excitation and emission spectra revealed that the prepared crystals can be efficiently pumped by the near-ultraviolet (NUV) light and it can emit brightness red light with admirable color purity of 90.4%. With the help of Judd-Ofelt theory, the optical transition intensity parameters of Eu3+ ions were evaluated so as to explore its local symmetry performance in the Eu(HCOO) 3 host lattices. The thermal quenching behaviors of the studied samples were investigated through the temperature-dependent emission spectra. Ultimately, a white light-emitting diode (WLED) lamp with good color rendering index (78.2) and correlated color temperature (6386 K) was packaged through coating the tricolor phosphors (BaMgAl 10 O 7 :Eu2+ blue-emitting phosphor, (Ba,Sr) 2 SiO 4 :Eu2+ green-emitting phosphor and resultant red-emitting crystals) onto the surface of a NUV chip. These results disclosed the high brightness Eu(HCOO) 3 red-emitting crystals were suitable for NUV chip triggered WLED applications. • The resultant crystals emitted glaring red emission with high color purity of 90.4%. • The local symmetry properties of Eu3+ ions were studied by Judd-Ofelt theory. • The crystals exhibited splendid thermal stability with activation energy of 0.16 eV. • The LED device can emit bight white light with proper CCT and CRI values. [ABSTRACT FROM AUTHOR]

Platelets, the often-overlooked component of the immune system, have been shown to promote tumor growth. Non-alcoholic fatty liver disease (NAFLD) is a common disease in the Western world and rising risk for hepatocellular carcinoma (HCC). Unexpectedly, we observed that platelets can inhibit the growth of established HCC in NAFLD mice. Through pharmacological inhibition and genetic depletion of P2Y12 as well as in vivo transfusion of wild-type (WT) or CD40L−/− platelets, we demonstrate that the anti-tumor function of platelets is mediated through P2Y12-dependent CD40L release, which leads to CD8+ T cell activation by the CD40 receptor. Unlike P2Y12 inhibition, blocking platelets with aspirin does not prevent platelet CD40L release nor accelerate HCC in NAFLD mice. Similar findings were observed in liver metastasis models. All together, our study reveals a complex role of platelets in tumor regulation. Anti-platelet treatment without inhibiting CD40L release could be considered for liver cancer patients with NAFLD. [Display omitted] • Platelets enhance anti-tumor immune response in NAFLD through CD40L • CD8+ T cells mediate the anti-tumor immune response • P2Y12/leukotrienes control CD40L release from platelets in NAFLD • Macrophages release IL-12 to promote CD40L production by megakaryocytes Anti-platelet therapy is associated with reduced liver cancer. NAFLD, a rising risk for liver cancer, is known to activate platelets. Unexpectedly, Ma et al. found that platelets have a complex role in tumor regulation and can enhance CD8+ T cell-dependent anti-tumor immunity through P2Y12-dependent CD40L release from platelets. [ABSTRACT FROM AUTHOR]

About 60 hydrologic changes in response to the Chi-Chi earthquake with Ms7.6 on September 21, 1999, occurred in 52 wells, including groundwater level, temperature, discharge rate, well pressure and radon, etc., in the subsurface fluid monitoring network. These response changes were mainly co-seismic, but some pre- and post-earthquake changes occurred mainly within 5 days before and after the Chi-Chi earthquake. The response changes of different wells clustering in different tectonic areas showed different features. These changes are distributed in five areas named as A, B, C, D and E. The response changes in A area with short hypo-central distance (less than 550 km) were mainly pre-earthquake changes occurring more than 5 days before the event. Those in area B (in Huanan tectonic block) and C (in Huabei tectonic block) were mainly co-seismic changes. The hypo-central distance is about 1100–1280 and 800–1160 km, respectively. These changes were high-frequency water-level oscillations induced by seismic waves and accompanied by prominent and permanent water-level jumps and drops. There are also some post-seismic changes including discharge rate and water radon and well pressure changes in area C. Those in area D in the Yanshan tectonic block were mainly co-seismic and post-seismic changes including water level, water temperature, and water radon concentration, etc., showing prominent and permanent water-level jumps and drops and rising concentrations of water radon. The hypo-central distance is about 1750–2060 km. Those in Area E were mainly co-seismic changes showing prominent and permanent water-level jump. The hypo-central distance is about 1810–2120 km. Three moderate earthquakes occurred in area D and one strong earthquake occurred in area E 4 months after the Chi-Chi earthquake. The different features of the response changes might be caused by the changes of local hydrologic conditions (like permeability) induced by seismic waves. On the other hand, these response changes might indicate the near-critical conditions in the area where the response changes clustered. Such changes might be understood by the crustal buckling hypothesis. It is thought that the response changes might be a kind of precursor that implies elevated earthquake risk in the region. [Copyright &y& Elsevier]

Nonalcoholic steatohepatitis causes loss of hepatic CD4+ T cells and promotes tumor growth. The liver is the most common site of distant metastases from a variety of malignancies, many of which respond to immunotherapy. We investigated the effects of steatohepatitis on the efficacy of immunotherapeutic agents against liver tumors in mice. Steatohepatitis was induced by feeding C57BL/6NCrl or BALB/c AnNCr mice a methionine and choline–deficient diet or a choline-deficient l -amino acid–defined diet. Mice were given intrahepatic or subcutaneous injections of B16 melanoma and CT26 colon cancer cells, followed by intravenous injections of M30-RNA vaccine (M30) or intraperitoneal injections of an antibody against OX40 (aOX40) on days 3, 7, and 10 after injection of the tumor cells. We measured tumor growth and analyzed immune cells in tumor tissues by flow cytometry. Mice were given N-acetylcysteine to prevent loss of CD4+ T cells from liver. Administration of M30 and aOX40 inhibited growth of tumors from intrahepatic injections of B16 or CT26 cells in mice on regular diet. However, M30 and/or aOX40 did not slow growth of liver tumors from B16 or CT26 cells in mice with diet-induced steatohepatitis (methionine and choline–deficient diet or choline–deficient l -amino acid-defined diet). Steatohepatitis did not affect the ability of M30 to slow growth of subcutaneous B16 tumors. In mice with steatohepatitis given N-acetylcysteine, which prevents loss of CD4+ T cells, M30 and aOX40 were able slow growth of hepatic tumors. Flow cytometry analysis of liver tumors revealed reduced CD4+ T cells and effector memory cells in mice with vs without steatohepatitis. Steatohepatitis reduces the abilities of immunotherapeutic agents, such as M30 and aOX40, to inhibit tumor liver growth by reducing tumor infiltration by CD4+ T cells and effector memory cells. N-acetylcysteine restores T-cell numbers in tumors and increases the ability of M30 and aOX40 to slow tumor growth in mice. [ABSTRACT FROM AUTHOR]

• Most high school students with ADHD improve functioning with training intervention. • Improvement most likely for adolescents with better pre-treatment functioning. • Multiple malleable factors (e.g., dosage) increase likelihood of improved functioning. • Some students may require additional school-based services with training intervention. Adolescents with attention-deficit/hyperactivity disorder (ADHD) experience significant academic, behavioral, and social skill difficulties including underachievement, risk for school dropout, poor peer relations, and emotion dysregulation. Although stimulant medication reduces ADHD symptoms, psychosocial and educational interventions are necessary to address functional impairments. We examined the nature and predictors of academic, behavioral, and social skills trajectories in response to multicomponent organizational and interpersonal skills training in 92 high school students with ADHD. Latent trajectory class analyses revealed positive treatment response ranging from 61.5% (report card grades) to 100% (inattention symptoms, organizational skills, social skills). Organizational skill and academic grade treatment response trajectories were predicted by assigned sex, pretreatment anxiety, and treatment dosage, while improvement in behavioral and social functioning was associated with better emotion regulation and family relations prior to treatment along with stronger working alliance with treatment coach at midtreatment. Multicomponent organizational and interpersonal skills training appears effective for most high school students with ADHD and the degree treatment-induced change is associated with multiple malleable factors can be leveraged to enhance intervention response. [ABSTRACT FROM AUTHOR]

Poverty continues be most prevalent among young children under three years of age, when development, particularly in communication and language skills, is rapid and vulnerable to socioeconomic impacts. Home visiting was intentionally formulated to support parents in promoting children's development and health, offsetting poverty's threats. Little Talks, a parent-mediated intervention to promote children's communication and language growth, was designed for implementation in home visiting programs. Developed through community-partnership research methods, Little Talks is a modular intervention that is tailored to parents' styles and preferences for interacting with their children. A randomized control trial of Little Talks' effectiveness in attaining outcomes aligned with the two-generational processes inherent in home visiting was undertaken. Situated in an Early Head Start program, home visitors and the families they served were randomly assigned to receive EHS with Little Talks and typical EHS services. Assessed across four time points during a 10-month period, Little Talks was demonstrated to significantly enhance the quality of home visits and parents' involvement in their children's early learning experiences. In addition, parents' depressive symptoms did not increase as noted for the comparison condition. Communication and language growth improved for EHS Little Talks children, although statistical significance was not attained. Moreover, parenting outcomes were greatest for families who were less acculturated to US either by immigration status and/or language preferences. Implications advancing Little Talks as a feasible and effective addition to home visiting programs are offered. [ABSTRACT FROM AUTHOR]

Multi-component training interventions such as the Challenging Horizons Program (CHP) improve organization skills and academic functioning of middle school students with attention-deficit/hyperactivity disorder (ADHD); however, few studies have investigated treatment for high school students. We explored the extent to which CHP adapted for high school would improve proximal (e.g., organization skills, homework performance) and distal (e.g., report card grades) academic outcomes through 6-month follow-up relative to a community care (CC) condition. Participants included 186 adolescents who were randomly assigned to CHP (n = 92; 80% male; M age = 15.0; SD = 0.8) or CC (n = 94; 78% male; M age = 15.1; SD = 0.9) with CHP delivered over one school year. Parent, teacher, and self-report ratings of organization skills and academic performance, report card grades, and achievement tests were collected across multiple occasions. Intent-to-treat analyses using hierarchical linear modeling revealed significant improvements of small to medium magnitude (d range = 0.32 to 0.58) for parent-rated organization skills, homework performance, and academic functioning at 6-month follow-up. CHP effect on grades was small, but associated with a less steep decline than that found for CC. No statistically significant effects on teacher or self-report ratings were obtained. CHP appears efficacious for ameliorating organization skills and homework performance deficits exhibited by high school students with ADHD and can protect against decline in report card grades experienced by these students. CHP may require supplementation with academic skills instruction for some students and may need implementation beyond one school year to produce durable effects. [ABSTRACT FROM AUTHOR]

tRNA fragments (tRFs) are a recently identified class of small noncoding RNAs. To date, the regulation of tRF abundance and its functional mechanisms have been largely unclear in plants. We investigated how the Arabidopsis thaliana receptor kinase FERONIA (FER) regulates the abundance of tRFs to inhibit global mRNA translation. We demonstrate that FER regulates tRF abundance by directly phosphorylating the tRNA-binding protein YUELAO (YL) to modulate its function. Downregulation of FER and YL prevented the modification of tRNA via cytosine-5-methylation and 2′-O-methylation, thereby increasing tRF abundance. Furthermore, we show that YL acts as an important genetic downstream target of FER signaling, and knockdown of a specific tRF partially rescues the root hair growth defects of fer and yl mutants. Our findings shed light on the abundance and regulatory mechanisms of tRF and their role in inhibiting translation in plants. [Display omitted] • FER mediates the abundance of certain 5′ tRFs that inhibit translation • FER physically associates with and phosphorylates the tRNA-binding protein YL • FER-YL regulates tRNA methylation levels • FER-YL signaling plays a key role in plant reproduction and development Zhu et al. report that FERONIA functions together with YUELAO to modulate the abundance of tRNA fragments, which, in turn, inhibit translation in Arabidopsis. [ABSTRACT FROM AUTHOR]

Abstract: Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase (NOS) inhibitor, has been implicated in vascular inflammation through induction of reactive oxygen species (ROS) and proinflammatory genes in endothelial cells. However, relatively few attentions have been paid to the effect of ADMA on monocytes, one of the important cells throughout all stages of atherosclerosis. In the present study, we found that reinioside C, the main component extracted from Polygala fallax Hemsl., dose-dependently inhibited tumor necrosis factor-α (TNF-α) production induced by ADMA in monocytes, Furthermore, reinioside C attenuated ADMA-induced generation of reactive oxygen species and activation of nuclear factor-κB (NF–κB) activity in monocytes in a dose-dependent manner, this effect was inhibited by l-arginine (NOS substrate) and PDTC (inhibitor of NF–κB). These data suggest that reinioside C could attenuate the increase of TNF-α induced by exogenous ADMA through inhibition ROS/NF–κB pathway in monocytes. [Copyright &y& Elsevier]

Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE), with unclear etiopathogenesis. We evaluated the role of macrophage migration inhibitory factor (MIF), which has been implicated in idiopathic pulmonary hypertension (PH), in SLE-associated PAH. Circulating MIF was measured in SLE patients, SLE-PAH patients, and healthy donors. In situ pulmonary artery MIF protein expression was determined in spontaneous SLE mice (MRL/ lpr) and hypoxia-induced C57BL/6J mice. Daily MIF098 was administered to C57BL/6J mice, and these mice were maintained in a hypoxic chamber for 4 weeks. The right ventricular systolic pressure (RVSP) and pathological characteristics of the pulmonary artery (PA), such as hyperproliferation, muscularization, and fibrosis were then measured in each group of mice. Data were also obtained in vitro using pulmonary smooth muscle cells (PASMC) challenged with platelet-derived growth factor (PDGF)-BB or 1% O 2 hypoxia. As a result, circulating MIF was elevated in SLE-PAH patients compared with SLE patients or healthy donors. Higher RVSP SLE mice produced more MIF protein than lower RVSP SLE mice in the pulmonary artery. MIF098 decreased RVSP and inhibited distal pulmonary artery hyperproliferation, muscularization, and collagen deposition in hypoxia challenged mice. In addition, MIF098 inhibited PASMC proliferation and migration by regulating mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 (MAPK/ERK1/2) signal- and cell-cycle-related proteins. MIF098 also reduced collagen synthesis by inhibiting the TGFβ1/Smad2/Smad3 pathway in cell-based experiments. In conclusion, MIF may serve as a biomarker and a therapeutic target of SLE-associated PAH. Pharmacologic MIF antagonism may be an effective means to ameliorate SLE-PAH. • Circulating MIF was elevated in SLE-PAH patients compared with SLE patients or healthy donors. • The protein level of MIF was increased in the pulmonary arteries of SLE-PAH mice. • MIF antagonist MIF098 ameliorated the pathological progression of PAH associated with murine SLE. • MIF098 inhibited pulmonary smooth muscle cells proliferation, migration and fibrosis in vitro. [ABSTRACT FROM AUTHOR]