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Your search keyword '"Fukushima, Takeshi"' showing total 90 results
Start Over Author "Fukushima, Takeshi" Publisher elsevier b.v.
90 results on '"Fukushima, Takeshi"'

39. Possible role of d-serine in the pathophysiology of Alzheimer's disease

Author

Hashimoto, Kenji, Fukushima, Takeshi, Shimizu, Eiji, Okada, Shin-ichi, Komatsu, Naoya, Okamura, Naoe, Koike, Kaori, Koizumi, Hiroki, Kumakiri, Chikara, Imai, Kazuhiro, and Iyo, Masaomi

Subjects
*GLYCINE, *PATHOLOGICAL physiology, *ALZHEIMER'S disease, *SERUM
Abstract

Several lines of evidence suggest that d-serine may function as an endogenous agonist of the glycine site on the N-methyl-d-aspartate (NMDA) receptor that has been implicated in the pathophysiology of Alzheimer''s disease (AD). The purpose of the study was to determine whether serum levels of d- and l-serine in patients with AD are altered as compared with normal controls. Serum levels of d- and l-serine in patients of AD and age- and gender-matched normal controls were determined using a high-performance liquid chromatography (HPLC). Serum levels of d-serine in the patients with AD were slightly (z=−1.77, p=0.078) lower than those of normal controls. In contrast, serum levels of l-serine in the patients were slightly (z=−1.73, p=0.083) higher than those of controls. In addition, the percentage (%) of d-serine in the total (l+d) serine in the patients was significantly (z=−2.36, p=0.018) lower than that of controls. The present study suggests that the reduced activity of serine racemase, an enzyme catalyzing the formation of d-serine from l-serine may play a role in the pathophysiology of AD. [Copyright &y& Elsevier]

Published
2004
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40. Recent progress in derivatization methods for LC and CE analysis

Author

Fukushima, Takeshi, Usui, Noriko, Santa, Tomofumi, and Imai, Kazuhiro

Subjects
*HIGH performance liquid chromatography, *FLUORESCENCE, *CHEMILUMINESCENCE
Abstract

The derivatization procedure with a suitable fluorescence or chemiluminescence reagent is performed for the purpose of increasing the detection sensitivity and selectivity, in high-performance liquid chromatography (HPLC) and/or capillary electrophoresis (CE). In this article, recent derivatization methods and their applications to biosamples are described. In HPLC, femto mol order of mass detection limits are obtained by derivatization. Regarding the fluorescence reagents, the use of water-soluble reagents has been effective to avoid an undesired adsorption in the process of determination of peptides. In CE, the advantages of having extremely low mass detection limits (ranging from atto to yocto mol level) and requiring only a very short analysis time (less than a few minutes) are made possible by using laser-induced fluorescence or near infra-red detections. [Copyright &y& Elsevier]

Published
2003
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41. Corrosion behaviour of HVOF sprayed SUS316L stainless steel in seawater

Author

Kawakita, Jin, Fukushima, Takeshi, Kuroda, Seiji, and Kodama, Toshiaki

Subjects
*STAINLESS steel, *MICROSCOPY, *POROSITY
Abstract

SUS316L stainless steel was coated onto the SUS316L plate by the high velocity oxy-fuel (HVOF) spray technique. Its corrosion behaviour in seawater was investigated by the electrochemical method and the microscopy. The coating had corrosion resistance inferior to the bulk plate. The corrosion of the HVOF sprayed SUS316L coating was related to both its porosity and its oxygen content. Depending on them, the corrosion took place at the small pore and the boundary between the spray particles on the surface. [ABSTRACT FROM AUTHOR]

Published
2002
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