14 results on '"Gal Michael"'
Search Results
2. The effect of disopyramide on uterine contractions during pregnancy
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Tadmor, Ofer P., Keren, Andre, Rosenak, Dani, Gal, Michael, Shaia, Michael, Hornstein, Eliezer, Yaffe, Haim, Graff, Eran, Stern, Shlomo, and Diamant, Yoram Z.
- Subjects
Uterus -- Contraction ,Arrhythmia -- Drug therapy ,Labor, Induced (Obstetrics) -- Health aspects ,Disopyramide -- Adverse and side effects ,Obstetrical pharmacology -- Evaluation ,Health - Abstract
Disopyramide is a drug given to patients with abnormal heart rhythms. The physiological effect of disopyramide during pregnancy has been questioned. To see if disopyramide can cause contractions of the uterus significant enough to induce labor, 10 women were given disopyramide or a placebo, 48 hours before planned labor induction for other medical reasons. In the group receiving disopyramide, 10 patients had contractions and eight patients delivered within 48 hours. There were no contractions noted in any of the ten patients receiving the placebo and no deliveries. The time it took for the onset of regular uterine contractions was 4.15 hours, compared with 56.13 hours in the nontreated group. The levels of disopyramide during labor contractions were significantly lower than the levels required to prevent abnormal heart rhythms. There were no significant side effects of disopyramide in the mother or fetus. It is unlikely that disopyramide would be a candidate for a labor-inducing drug, since it did not initiate labor in two women. In addition, the duration of labor was prolonged when compared with other agents. Disopyramide should not be used to prevent abnormal heart rhythms in pregnant cardiac patients. (Consumer Summary produced by Reliance Medical Information, Inc.) more...
- Published
- 1990
Catalog
3. Delivering elsewhere between the first and second delivery is a risk marker for obstetric complications in the second delivery
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Reichman, Orna, Nezer, Meirav, Gal, Michael, Shen, Ori, Calderon-Margalit, Ronit, Farkash, Rivka, and Samueloff, Arnon
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- 2016
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4. Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues
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Anuka, Eli, Gal, Michael, Stocco, Douglas M., and Orly, Joseph
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STEROIDOGENIC acute regulatory protein , *STEROID hormone synthesis , *ADRENAL cortex , *GONADS , *MITOCHONDRIAL membranes , *CENTRAL nervous system , *PEROXISOME proliferator-activated receptors - Abstract
Abstract: The activity of the steroidogenic acute regulatory (StAR) protein is indispensable and rate limiting for high output synthesis of steroid hormones in the adrenal cortex and the gonads, known as the ‘classical’ steroidogenic organs (StAR is not expressed in the human placenta). In addition, studies of recent years have shown that StAR is also expressed in many tissues that produce steroid hormones for local use, potentially conferring some functional advantage by acting via intracrine, autocrine or paracrine fashion. Others hypothesized that StAR might also function in non-steroidogenic roles in specific tissues. This review highlights the evidence for the presence of StAR in 17 extra-adrenal and extra-gonadal organs, cell types and malignancies. Provided is the physiological context and the rationale for searching for the presence of StAR in such cells. Since in many of the tissues the overall level of StAR is relatively low, we also reviewed the methods used for StAR detection. The gathered information suggests that a comprehensive understanding of StAR activity in ‘non-classical’ tissues will require the use of experimental approaches that are able to analyze StAR presence at single-cell resolution. [Copyright &y& Elsevier] more...
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- 2013
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5. ▪ A prospective evaluation of uterine abnormalities by saline infusion sonohysterography in 1,009 women with infertility or abnormal uterine bleeding
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Tur-Kaspa, Ilan, Gal, Michael, Hartman, Michael, Hartman, Jason, and Hartman, Alex
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HUMAN fertility , *GENITAL diseases , *INFERTILITY , *PATIENTS , *UTERUS abnormalities , *COMPARATIVE studies , *DIAGNOSTIC imaging , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *SALT , *ULTRASONIC imaging , *UTERINE hemorrhage , *UTERUS , *VAGINAL medication , *EVALUATION research , *PARENTERAL infusions , *DISEASE complications ,RESEARCH evaluation - Abstract
Objective: To evaluate the role of saline infusion sonohysterography (SIS) in the investigation of uterine abnormalities and malformations in patients referred for infertility work-up compared with women with abnormal uterine bleeding (AUB).Design: Prospective cohort study.Setting: Academically oriented private practice.Patient(s): One thousand nine consecutive women examined by SIS for infertility work-up (n = 600, infertility group) or AUB investigation (n = 409, AUB group).Intervention(s): SIS.Main Outcome Measure(s): Intracavitary abnormalities and uterine anomalies.Result(s): Among the women in the infertility group, 16.2% (n = 97) were found to have intracavitary abnormalities, including polyps (13.0%), submucous fibroids (2.8%), and adhesions (0.3%). Significantly, more patients in the AUB group (39.6%, n = 162) revealed intracavitary abnormalities, including polyps (29.8%), submucous fibroids (9.0%), and adhesions (0.7%). In contrast, significantly more uterine anomalies were found in the infertility group (20%, n = 120) compared with the AUB group (9.5%, n = 39). Arcuate uterus was the most common finding (15% vs. 6.4% of patients, respectively).Conclusion(s): An SIS procedure for infertility work-up revealed a substantial percentage of infertile patients with intracavitary abnormalities and uterine anomalies. Because the technique is safe, well tolerated, and feasible in an outpatient setting, SIS should be considered routinely in the early stage of infertility and AUB investigation. [ABSTRACT FROM AUTHOR] more...- Published
- 2006
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6. 493: A practical classification for detecting parturients at risk for postpartum hemorrhage.
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Reichman, Orna, Khayyat, Izzat, Emanuel, Michael, Gal, Michael, and Samueloff, Arnon
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HEMORRHAGE risk factors ,PUERPERAL disorders ,PARTURITION ,PARITY (Obstetrics) ,DELIVERY (Obstetrics) ,GYNECOLOGY - Published
- 2016
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7. 'Luckily, I don't believe in statistics': survey of women's understanding of chance of success with futile fertility treatments.
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Miron-Shatz, Talya, Holzer, Hananel, Revel, Ariel, Weissman, Ariel, Tarashandegan, Danit, Hurwitz, Arye, Gal, Michael, Ben-chetrit, Avraham, Weintraub, Amir, Ravhon, Amir, and Tsafrir, Avi
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REPRODUCTIVE technology , *MATERNAL age , *FERTILITY clinics , *OVUM donation , *FERTILIZATION in vitro , *PROGNOSIS - Abstract
Why are women who face poor prognoses for success in assisted reproductive technology (ART) treatment choosing to pursue procedures using their own eggs, despite receiving information that their chances of success are very low. Cross-sectional study based on an anonymous questionnaire distributed to women aged between 43 and 45 years, undergoing ART using their own oocytes, at six public outpatient fertility clinics and three public in-hospital IVF units in Israel between 2015 and 2016. The main outcome measure was personal estimation of chance to achieve a live birth after the current ART treatment cycle and the cumulative estimated rate after all the treatment cycles the patient intended to undergo. Response rate was 70.0%, with 91 participants of mean age 43.8 ± 0.7 years. Participants estimated their delivery rates after the next ART treatment cycle at 49.0 ± 31.8% (response rate 93.4%) and their cumulative delivery rates after all the ART treatments they would undergo at 57.7 ± 36.3% (response rate 90.1%). This is significantly higher than the predicted success rates of 5% and 15%, respectively (both P < 0.001), which are based on national register data. Nearly one-half of patients rated themselves as having a better than average chance of conception (47.3%). Women do not pursue futile treatments because they lack information. Despite being informed of the low success rates of conception using ART treatments, many patients of advanced maternal age have unrealistically high expectations from ART, essentially ignoring their estimated prognosis when deciding on treatment continuation. Future work should examine the psychological reasons behind continuing futile fertility treatments. [ABSTRACT FROM AUTHOR] more...
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- 2021
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8. Cancer in IVF patients treated at age 40 years and older: long term follow-up.
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Tsafrir, Avi, Lerner-Geva, Liat, Zaslavsky-Paltiel, Inna, Laufer, Neri, Simon, Alex, Einav, Sharon, Eldar-Geva, Talia, Holzer, Hananel, Gal, Michael, and Hirsh-Yechezkel, Galit
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CANCER patients , *OLDER women , *INDUCED ovulation , *CONFIDENCE intervals , *BREAST cancer ,FALLOPIAN tube diseases - Abstract
Current knowledge of cancer risk among women who undergo IVF is based mainly on studies of women treated in their thirties, frequently with short follow-up periods. Therefore, information about cancer risk among infertile menopausal women is limited. We aimed to evaluate the risk of cancer among IVF patients treated at age 40 years and older, followed up for an extended period. Historical cohort study of all IVF patients treated at the age of 40 years or older at two university-affiliated IVF units in Jerusalem, Israel, between 1994 and 2002. Data were cross-linked with the Israel National Cancer Registry to 2016. Standardized incidence ratios (SIR) and 95% confidence intervals were computed by comparing the observed number of cancer cases with the expected cancer rate in the general Israeli population adjusted for age and year of birth. In addition, Kaplan–Meier analysis was conducted to account for the length of follow-up. A total of 501 patients were included in the analysis, with mean follow-up of 16.7 ± 3.7 years (range 2–22 years). Mean age at first IVF cycle was 42.3 years (±2.1). Mean number of IVF cycles was 3.2 ± 2.6 (range 1–15). Thirty-six women (7.2%) developed invasive cancer, compared with 47.2 expected cases; SIR 0.76 (95% CI 0.53 to 1.06); 22 women were diagnosed with invasive breast cancer, compared with 19.84 expected; SIR 1.11 (95% CI 0.69 to 1.68). Older women undergoing IVF treatment were not significantly associated with an excess risk of cancer at long-term follow up. Further studies, however, are needed to confirm these findings. [ABSTRACT FROM AUTHOR] more...
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- 2020
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9. Placenta increta originating from placental remnants of a first trimester vanished twin.
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Sapir, Alon, Reichman, Orna, Gal, Michael, and Samueloff, Arnon
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- 2014
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10. Cryopreserved embryo transfer: adjacent or non-adjacent to failed fresh long GnRH-agonist protocol IVF cycle.
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Volodarsky-Perel, Alexander, Eldar-Geva, Talia, Holzer, Hananel E.G., Schonberger, Oshrat, Reichman, Orna, and Gal, Michael
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EMBRYO transfer , *CRYOPRESERVATION of organs, tissues, etc. , *LUTEINIZING hormone releasing hormone antagonists , *HEALTH outcome assessment , *MENSTRUAL cycle - Abstract
The optimal time to perform cryopreserved embryo transfer (CET) after a failed oocyte retrieval-embryo transfer (OR-ET) cycle is unknown. Similar clinical pregnancy rates were recently reported in immediate and delayed CET, performed after failed fresh OR-ET, in cycles with the gonadotrophin-releasing hormone (GnRH) antagonist protocol. This study compared outcomes of CET performed adjacently (<50 days, n = 67) and non-adjacently (≥50 to 120 days, n = 62) to the last OR-day of cycles with the GnRH agonist down-regulation protocol. Additional inclusion criteria were patients' age 20–38 years, the transfer of only 1–2 cryopreserved embryos, one treatment cycle per patient and artificial preparation for CET. Significantly higher implantation, clinical pregnancy and live birth rates were found in the non-adjacent group than in the adjacent group: 30.5% versus 11.3% ( P = 0.001), 41.9% versus 17.9% ( P = 0.003) and 32.3% versus 13.4% ( P = 0.01), respectively. These results support the postponement of CET after a failed OR-ET for at least one menstrual cycle, when a preceding long GnRH-agonist protocol is used. [ABSTRACT FROM AUTHOR] more...
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- 2017
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11. The dynamics of serum anti-Mullerian-hormone levels during controlled ovarian hyperstimulation with GnRH-antagonist short protocol in polycystic ovary syndrome and low responders.
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Weintraub, Amir, Margalioth, Ehud J., Chetrit, Avraham Ben, Gal, Michael, Goldberg, Doron, Alerhand, Sara, and Eldar-Geva, Talia
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ANTI-Mullerian hormone , *BLOOD serum analysis , *OVARIAN hyperstimulation syndrome , *GONADOTROPIN releasing hormone , *POLYCYSTIC ovary syndrome , *HUMAN in vitro fertilization , *HYPERANDROGENISM - Abstract
Abstract: Objective: To determine whether the decrease in AMH levels during ovarian hyperstimulation for IVF occurs in patients with polycystic ovary syndrome (PCOS) and patients with low ovarian reserve (LOR), as in normal cycling women. Study design: A cohort of 22 infertile patients treated in a single tertiary center with a GnRH-antagonist short protocol for IVF were prospectively included and divided into three groups: PCOS with hyperandrogenism (n =7), LOR (n =8) and control (n =7). Serum AMH levels were measured before and during FSH treatment, on the day of HCG administration, at the mid-luteal phase, and 14 days after embryo transfer. The three groups were compared using an ANOVA model in the case of continuous data and with Fisher's exact test when the data were discrete. Results: In the PCOS group, AMH levels increased at the beginning of the stimulation, but later decreased, until the mid-luteal stage. In the other two groups, AMH levels decreased throughout ovarian stimulation until the mid-luteal stage. In all groups, AMH levels returned to baseline levels two weeks after HCG administration, regardless of treatment outcome (pregnancy or not). Conclusions: AMH levels decline during controlled ovarian hyperstimulation with a GnRH-antagonist short protocol in women with low and normal ovarian reserves. In contrast, in women with PCOS, an increase in AMH levels precedes this decline. These findings may support the hypothesis that androgens may play a role in AMH regulation in women. [Copyright &y& Elsevier] more...
- Published
- 2014
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12. Ovarian hemorrhage after transvaginal ultrasonographically guided oocyte aspiration: a potentially catastrophic and not so rare complication among lean patients with polycystic ovary syndrome
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Liberty, Gad, Hyman, Jordana Hadassah, Eldar-Geva, Talia, Latinsky, Boris, Gal, Michael, and Margalioth, Ehud J.
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HEMORRHAGE complications , *POLYCYSTIC ovary syndrome treatment , *TRANSVAGINAL ultrasonography , *OVUM , *RETROSPECTIVE studies , *HEALTH outcome assessment , *ELECTROCOAGULATION (Medicine) , *DISEASES in women , *HUMAN in vitro fertilization - Abstract
Objective: To report the first case series of ovarian hemorrhage after transvaginal ultrasonographically guided oocyte aspiration (TVOA).Design: Retrospective analysis. old>Setting: In vitro fertilization unit of a tertiary university hospital.Patient(s): Patients who underwent TVOA during a 6-year period.Intervention(s): Surgical intervention due to active bleeding from the ovary.Main Outcome Measure(s): Prevalence and risk factors.Result(s): Among 3,241 patients undergoing TVOA, 7 were diagnosed as having ovarian hemorrhage afterward. All patients were thin, with a body mass index of 19-21 kg/m(2), and 4 had polycystic ovary syndrome (PCOS). The prevalence of ovarian bleeding among lean patients with PCOS was 4.5%. The odds ratio for bleeding in lean patients with PCOS vs. all other patients was 50 (95% confidence interval 11-250). The interval between the TVOA and surgical intervention ranged from 5 to 18 hours (mean +/- SD, 11.4 +/- 5 hours). The Delta decrease in hemoglobin levels was 3.2-9 g/dL (mean 6.1 +/- 1.8). In 6 of the 7 patients, laparoscopically guided electrocoagulation was sufficient to achieve hemorrhagic control.Conclusion(s): Although acute hemorrhage is a rare event after TVOA, lean patients with PCOS specifically are at much higher risk for this complication. [ABSTRACT FROM AUTHOR] more...- Published
- 2010
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13. Si–C linked oligo(ethylene glycol) layers in silicon-based photonic crystals: Optimization for implantable optical materials
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Kilian, Kristopher A., Böcking, Till, Gaus, Katharina, Gal, Michael, and Gooding, J. Justin
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ETHYLENE glycol , *SILICON crystals , *SERUM albumin , *POROUS materials - Abstract
Abstract: Porous silicon has shown potential for various applications in biology and medicine, which require that the material (1) remain stable for the length of the intended application and (2) resist non-specific adsorption of proteins. Here we explore the efficacy of short oligo(ethylene glycol) moieties incorporated into organic layers via two separate strategies in achieving these aims. In the first strategy the porous silicon structure was modified in a single step via hydrosilylation of α-oligo(ethylene glycol)-ω-alkenes containing three or six ethylene glycol units. The second strategy employs two steps: (1) hydrosilylation of succinimidyl-10-undecenoate and (2) coupling of an amino hexa(ethylene glycol) species. The porous silicon photonic crystals modified by the two-step strategy displayed greater stability relative to the single step procedure when exposed to conditions of physiological temperature and pH. Both strategies produced layers that resist non-specific adsorption of proteins as determined with fluorescently labelled bovine serum albumin. The antifouling behaviour and greater stability to physiological conditions provided by this chemistry enhances the suitability of porous silicon for biomaterials applications. [Copyright &y& Elsevier] more...
- Published
- 2007
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14. Successful pregnancy and delivery after calcium ionophore oocyte activation in a normozoospermic patient with previous repeated failed fertilization after intracytoplasmic sperm injection.
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Eldar-Geva, Talia, Brooks, Baruch, Margalioth, Ehud J, Zylber-Haran, Edit, Gal, Michael, and Silber, Sherman J
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CONCEPTION , *FERTILIZATION in vitro , *HETEROCYCLIC compounds , *OVUM , *PROTEINS - Abstract
To describe a successful pregnancy and delivery after calcium ionophore oocyte activation in a normozoospermic patient with previous repeated failed fertilization after intracytoplasmic sperm injection (ICSI).Case report. In vitro fertilization unit in a university affiliated medical center.A couple with 5 years of unexplained primary infertility who had repeated failed fertilization after ICSI. Controlled ovarian hyperstimulation, oocyte pick-up, ICSI, assisted oocyte activation with calcium ionophore, embryo culture, and ET. Fertilization rate, implantation, pregnancy, and delivery. Assisted oocyte activation with calcium ionophore A23187 after ICSI resulted in reasonable fertilization rates in three cycles (4/6, 5/16 and 7/20 oocytes). Two pregnancies were achieved; the first ended with second trimester miscarriage due to fetal anomaly and the second with a delivery of three healthy babies.Calcium ionophore oocyte activation seems to be a useful method in cases of repeated failed fertilization after ICSI. [ABSTRACT FROM AUTHOR] more...
- Published
- 2003
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