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121 results on '"García, Héctor"'

4. Self-expanding and balloon-expandable valves in low risk TAVR patients

Author

Bhogal, Sukhdeep, Waksman, Ron, Shea, Corey, Zhang, Cheng, Gordon, Paul, Ehsan, Afshin, Wilson, Sean R., Levitt, Robert, Parikh, Puja, Bilfinger, Thomas, Hanna, Nicholas, Buchbinder, Maurice, Asch, Federico M., Weissman, Gaby, Ben-Dor, Itsik, Shults, Christian C., Ali, Syed, Garcia-Garcia, Hector M., Satler, Lowell F., and Rogers, Toby

Published
2024
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17. In vivo serial invasive imaging of the second-generation drug-eluting absorbable metal scaffold (Magmaris — DREAMS 2G) in de novo coronary lesions: Insights from the BIOSOLVE-II First-In-Man Trial

Author

Garcia-Garcia, Hector M., Haude, Michael, Kuku, Kayode, Hideo-Kajita, Alexandre, Ince, Hüseyin, Abizaid, Alexandre, Tölg, Ralph, Lemos, Pedro Alves, von Birgelen, Clemens, Christiansen, Evald Høj, Wijns, William, Escaned, Javier, Dijkstra, Jouke, and Waksman, Ron

Published
2018
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19. Effect of High-Intensity Statin Therapy on Atherosclerosis (IBIS-4): Manual Versus Automated Methods of IVUS Analysis.

Author

Bass, Ronald D., García-García, Héctor M., Ueki, Yasushi, Holmvang, Lene, Pedrazzini, Giovanni, Roffi, Marco, Koskinas, Konstantinos C., Shibutani, Hiroki, Losdat, Sylvain, Ziemer, Paulo G.P., Blanco, Pablo J., Levine, Molly B., Bourantas, Christos V., and Räber, Lorenz

Subjects
*MACHINE learning, *STATINS (Cardiovascular agents), *INTRAVASCULAR ultrasonography, *CORONARY arteries, *ATHEROSCLEROSIS
Abstract

Standard manual analysis of IVUS to study the impact of anti-atherosclerotic therapies on the coronary vessel wall is done by a core laboratory (CL), the ground truth (GT). Automatic segmentation of IVUS with a machine learning (ML) algorithm has the potential to replace manual readings with an unbiased and reproducible method. The aim is to determine if results from a CL can be replicated with ML methods. This is a post-hoc, comparative analysis of the IBIS-4 (Integrated Biomarkers and Imaging Study-4) study (NCT00962416). The GT baseline and 13-month follow-up measurements of lumen and vessel area and percent atheroma volume (PAV) after statin induction were repeated by the ML algorithm. The primary endpoint was change in PAV. PAV as measured by GT was 43.95 % at baseline and 43.02 % at follow-up with a change of −0.90 % (p = 0.007) while the ML algorithm measured 43.69 % and 42.41 % for baseline and follow-up, respectively, with a change of −1.28 % (p < 0.001). Along the most diseased 10 mm segments, GT-PAV was 52.31 % at baseline and 49.42 % at follow-up, with a change of −2.94 % (p < 0.001). The same segments measured by the ML algorithm resulted in PAV of 51.55 % at baseline and 47.81 % at follow-up with a change of −3.74 % (p < 0.001). PAV, the most used endpoint in clinical trials, analyzed by the CL is closely replicated by the ML algorithm. ML automatic segmentation of lumen, vessel and plaque effectively reproduces GT and may be used in future clinical trials as the standard. • Automated intravascular ultrasound segmentation can reproduce manual readings. • A validated machine learning algorithm replicates results from a core laboratory. • Use of automated methods are warranted in the catheterization laboratory. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Tackling NCD in LMIC: Achievements and Lessons Learned From the NHLBI–UnitedHealth Global Health Centers of Excellence Program

Author

Rubinstein, Adolfo, He, Jiang, Alam, Dewan S., Peters, David H., Wu, Yangfeng, Yan, Lijing L., Merson, Michael, Ramirez, Manuel, Caballero, Benjamin, Xavier, Denis, Yusuf, Salim, Prabhakaran, Dorairaj, Narayan, K.M. Venkat, Kimaiyo, Sylvester, Velazquez, Eric, Denman, Catalina A., Cornejo, Elsa, de Zapien, Jill, Rosales, Cecilia, Miranda, J. Jaime, Gilman, Robert H., Levitt, Naomi, Gaziano, Thomas A., Ghannem, Hassen, Laatikainen, Tiina, Rabadan-Diehl, Cristina, Engelgau, Michael M., Belis, Deshiree, Sampson, Uchechukwu, Smith, Richard, Dianis, Nancy L., Wolbach, Tracy L., Matta, Gabriela, Gutierrez, Laura, Elorriaga, Natalia, Poggio, Rosana, Irazola, Vilma, Bazzano, Lydia, Bhuiya, Abbas, Wazed, Abdul, Khan, Alfazal, Siddiquee, Ali T., Islam, Anwar, Khan, Jahangir A.M., Uddin, Jasim, Hasan, Khaled, Khanam, Masuma A., Yunus, Mohammad, Chowdhury, Muhammad A.H., Monalisa, Nazratun N., Alam, Nurul, Streatfield, Peter K., Ahmed, Shyfuddin, Parvin, Sonia, Ali, Taslim, Niessen, Louis W., Hossain, Mohammad D., Koehlmoos, Tracey L.P., Standing, Hilary, Lucas, Henry, Bleich, Sara N., Anderson, Gerard F., Trujillo, Antonio J., Mirelman, Andrew J., Hao, Jesse, Zhang, Jing, Tian, Maoyi, Huang, Polly, Luo, Rong, Fang, Weigang, Li, Xian, Feng, Xiangxian, Li, Zhifang, Deal, Kelly, Peterson, Eric, DeLong, Elizabeth, Zhou, Bo, Shi, Jingpu, Neal, Bruce, Jan, Stephen, Li, Nicole, McMahon, Stephen, Zhang, Jianxin, Sun, Jixin, Elliot, Paul, Zhao, Yi, Zhang, Yuhong, Yao, Chen, Sun, Ningling Huang, Han, Qide, Shen, Ruqun, Niu, Wenyi, Wang, Yanfang, Ke, Yang, Huang, Yining, Leeder, Stephen, Lopez, Alan, Zhang, Ruijuan, Yu, Yan, Roman, Ana V., Mendoza, Carlos, Roche, Dina, Mejicano, Gabriela, Cordova, Maria A., Kroker, Maria F., Fort, Meredith, Letona, Paola, Kanter, Rebecca, Garcia, Regina, Murillo, Sandra, Chacon, Violeta, Montero, Rafael, Lopez, Erika J., Peña, Liz, Castro, Maricruz, Dengo, Ana L., Ulate, Emilce, Alvarado, Nadia, Sibrian, Josefina, Alegria, Astarte, Gutierrez, Ana M., Fontes, Flavia, Sigamani, Alben, Kamath, Deepak, Xavier, Freeda, Deepthi, K.B., Anupama, M., Mathu, Nandini, George, Nisha, Rahul, Pranjali, Pais, Prem, Girish, Preeti, Thomas, Seena, Usha, T., Thomas, Tinku, Joshi, Rajnish, Chidambaram, N., Gupta, Rajeev, Chow, Clara, Pogue, Janice, O'Donnell, Martin, Devereaux, P.J., Misquith, Dominic, Agrawal, Twinkle, Fathima, Farah N., Reddy, Kolli Srinath, Shivashankar, Roopa, Ajay, Vamadevan S., Khan, Hassan M., Kadir, M. Masood, Masood, Muhammad Q., Fatmi, Zafar, Krishnan, Anand, Singh, Kavita, Tandon, Nikhil, Khadgawat, Rajesh, Menon, V. Usha, Sethi, Bipin Kumar, Unnikrishnan, A.G., Hutcheson, Mark L., Ali, Mohammed K., Cunningham, Solveig A., Patel, Shivani A., Gujral, Unjali, Desai, Ankush, Mohan, Deepa, Pradeepa, R. Guha, Mohan, V., Viswanathan, Vijay, Sahay, Rakesh, Shah, Seema, Bantwal, Ganapathi, Varthakavi, Premlata K., Nair, Manisha, Akwanalo, Constantine, Lagat, David, Barasa, Felix, Koech, Myra, Sugut, Wilson, Korir, Belinda, Mosol, Priscah, Ali, Shamim, Sherman, Charles B., Carter, Jane, Bloomfield, Gerald, Binanay, Cynthia, Vedanthan, Rajesh, Bernabé-Ortiz, A., León-Velarde, F., Smith, George D., Málaga, Germán, García, Héctor H., Casas, Juan P., Sacksteder, Katherine, Smeeth, Liam, Huicho, Luis, Rivera, María, Gamboa, Raúl, Ebrahim, Shah, Montori, Víctor M., Wise, Robert A., Checkley, William, Diette, Gregory B., Nojilana, Beatrice, Majikela-Dlangamandla, Buyelwa, Sylvester, Carmelita, Malan, Johanna, Murphy, Katherine, Steyn, Krisela, van Niekerk, Lindi, Mash, Robert, Puoane, Thandi, Kim, Grace, Pandya, Ankur, Abrahams-Gessel, Shafika, Rhode, Hilary, Pather, Michael, Andrade, Alvaro R., Garcia, Beatriz, Velasco, Carlos, Medina, David, Bravo, Delia, Munguia, Diana, Bateman, Eric, Castro, Francisco, Schneider, Helen, Ibarra, Ilse, Zulu, Jabulisiwe, Felix, Joel, Tribe, Karla, Bobrow, Kirsten, Fairall, Lara, Folb, Naomi, Murillo, Norma, Pacheco, Norma, Rodriguez, Paloma, Navarro, Paola, Flores, Reyna, Van Zyl Smit, Richard, Meddoza, Rosario, Surka, Sameer, Van Haght, Serena, Hernandez, Yanira, Tsolekile, Lungiswa, Jeridi, Gouider, Harrabi, Imed, Maatoug, Jihen, Boughammoura, Lamia, Chaieb, Larbi, Mrizek, Nejib, Gaha, Rafika, Limam, Khalifa, Amimi, Souad, Gaha, Karima, Gamra, Habib, Al'Absi, Mustafa, Vartiainen, Erkki, Moore, Cornelius, Spillan, Debi, Cooper, Kristiane, Mitchell, Megan, Kirby, Ruth, Gao, Yunling, Aluko, Emmanuel, Sampson, Uchechukwu K., Miranda, Jaime, and Bloomfield, Gerald S.

Published
2016
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24. The Relationship Between Socioeconomic Status and CV Risk Factors: The CRONICAS Cohort Study of Peruvian Adults

Author

Bernabé-Ortiz, Antonio, Casas, Juan P., Smith, George Davey, Ebrahim, Shah, García, Héctor H., Gilman, Robert H., Huicho, Luis, Málaga, Germán, Miranda, J. Jaime, Montori, Víctor M., Smeeth, Liam, Checkley, William, Diette, Gregory B., León-Velarde, Fabiola, Rivera, María, Wise, Robert A., Sacksteder, Katherine, Quispe, Renato, Benziger, Catherine P., Bazo-Alvarez, Juan Carlos, and Howe, Laura D.

Published
2016
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25. Characteristics Associated With Antihypertensive Treatment and Blood Pressure Control: A Population-Based Follow-Up Study in Peru

Author

Bernabé-Ortiz, Antonio, Casas, Juan P., Smith, George Davey, Ebrahim, Shah, García, Héctor H., Gilman, Robert H., Huicho, Luis, Málaga, Germán, Miranda, J. Jaime, Montori, Víctor M., Smeeth, Liam, Checkley, William, Diette, Gregory B., León-Velarde, Fabiola, Rivera, María, Wise, Robert A., Sacksteder, Katherine, Zavala-Loayza, J. Alfredo, Benziger, Catherine Pastorius, Cárdenas, María Kathia, and Carrillo-Larco, Rodrigo M.

Published
2016
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27. Building a Platform for Translational Research in Chronic Noncommunicable Diseases to Address Population Health: Lessons From NHLBI Supported CRONICAS in Peru

Author

Miranda, J. Jaime, Bernabé-Ortiz, Antonio, Diez-Canseco, Francisco, Málaga, Germán, Cardenas, María K., Carrillo-Larco, Rodrigo M., Pesantes, M. Amalia, Araya, Ricardo, Boggio, Oscar, Checkley, William, García, Patricia J., León-Velarde, Fabiola, Lescano, Andrés G., Montori, Victor, Pan, William, Rivera-Chira, Maria, Sacksteder, Katherine, Smeeth, Liam, García, Héctor H., and Gilman, Robert H.

Published
2015
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35. Risk factors for COVID-19 hospitalization after COVID-19 vaccination: a population-based cohort study in Canada.

Author

Velásquez García, Héctor A., Adu, Prince A., Harrigan, Sean, Wilton, James, Rasali, Drona, Binka, Mawuena, Sbihi, Hind, Smolina, Kate, and Janjua, Naveed Z.

Subjects
*COVID-19 vaccines, *VACCINATION status, *HOSPITAL care, *COHORT analysis, *COVID-19
Abstract

• The risk factors for COVID-19-related hospitalization differ by vaccination status. • The overall risk is more reduced among vaccinated individuals. • Seniors and those with underlying medical conditions may benefit from booster doses. With the uptake of COVID-19 vaccines, there is a need for population-based studies to assess risk factors for COVID-19-related hospitalization after vaccination and how they differ from unvaccinated individuals. We used data from the British Columbia COVID-19 Cohort, a population-based cohort that includes all individuals (aged ≥18 years) who tested positive for SARS-CoV-2 by real-time reverse transcription-polymerase chain reaction from January 1, 2021 (after the start of vaccination program) to December 31, 2021. We used multivariable logistic regression models to assess COVID-19-related hospitalization risk by vaccination status and age group among confirmed COVID-19 cases. Of the 162,509 COVID-19 cases included in the analysis, 8,546 (5.3%) required hospitalization. Among vaccinated individuals, an increased odds of hospitalization with increasing age was observed for older age groups, namely those aged 50-59 years (odds ratio [OR] = 2.95, 95% confidence interval [CI]: 2.01-4.33), 60-69 years (OR = 4.82, 95% CI: 3.29, 7.07), 70-79 years (OR = 11.92, 95% CI: 8.02, 17.71), and ≥80 years (OR = 24.25, 95% CI: 16.02, 36.71). However, among unvaccinated individuals, there was a graded increase in odds of hospitalization with increasing age, starting at age group 30-39 years (OR = 2.14, 95% CI: 1.90, 2.41) to ≥80 years (OR = 41.95, 95% CI: 35.43, 49.67). Also, comparing all the age groups to the youngest, the observed magnitude of association was much higher among unvaccinated individuals than vaccinated ones. Alongside a number of comorbidities, our findings showed a strong association between age and COVID-19-related hospitalization, regardless of vaccination status. However, age-related hospitalization risk was reduced two-fold by vaccination, highlighting the need for vaccination in reducing the risk of severe disease and subsequent COVID-19-related hospitalization across all population groups. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Cross-Cultural Adaptation and Validation of the Pain Scale for Plantar Fasciitis to Spanish.

Author

Agudiez-Calvo, Sergio, Ballesteros-Frutos, Jorge, Cabezas-García, Héctor Raúl, Pecos-Martin, Daniel, and Gallego-Izquierdo, Tomás

Abstract

The aim of this study was the validation and transcultural adaptation of the Pain Scale for Plantar Fasciitis to Spanish, following the steps defined by "Guidelines for the process of cross-cultural adaptation of self-report measures." A cross-sectional study was driven in 153 patients with unilateral plantar fasciitis diagnosis. Statistical analysis measured the internal consistency, the test-retest reliability, the construct validity with the Spanish version of Foot and Function Index, and a factorial analysis. The questionnaire Pain Scale for Plantar Fasciitis was also given to a group of 10 people who received a physiotherapy treatment based on manual therapy, therapeutic exercise, and health education, which aim was to determine the questionnaire's sensitivity to changes. The questionnaire showed high internal consistency and test-retest reliability (Cronbach's α = 0.99, intraclass correlation coefficient = 0.98 [0.97-0.98]), good convergent validity with a moderate correlation with the Foot and Function Index (rho = 0.677, p <.0001) and no floor or ceiling effects were detected. The factorial analysis revealed that the first 3 factors showed 42.47% of variance, finding only 1 latent feature. Statistically significant differences were found in those patients who received physiotherapy treatment after 1 month, revealing that the questionnaire was sensitive to changes in the symptoms of subjects with plantar fasciitis. The Spanish version of Pain Scale for Plantar Fasciitis has proved to be a valid, reliable, and change-sensitive tool for patients with plantar fasciitis. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Enabling industrial production of electrodes by use of slot-die coating for HT-PEM fuel cells.

Author

Bodner, Merit, García, Héctor R., Steenberg, Thomas, Terkelsen, Carina, Alfaro, Silvia M., Avcioglu, Gokce S., Vassiliev, Anton, Primdahl, Søren, and Hjuler, Hans Aage

Subjects
*PROTON exchange membrane fuel cells, *FUEL cells, *OVERPRODUCTION, *MANUFACTURING processes, *TAPE casting, *ELECTRODES
Abstract

With high temperature polymer electrolyte membrane fuel cell systems gradually penetrating the commercial market, material manufacturing processes demand re-evaluation for big scale production. Three different methods for electrode production are compared in terms of their suitability and performance. Homogeneity, reproducibility and durability of coated electrodes using hydrogen as well as wet reformate fuel in selected cases are investigated. This shows that the slot-die process has clear advantages in comparison to spraying and tape casting with regard to upscaling potential and film homogeneity. These electrodes have proven to be durable over more than 6000 h, with degradation rates as low as 1 μV h−1 over 3000 h of testing. • Three electrode manufacturing processes were compared. • Evaluation of performance, reproducibility, durability and homogeneity. • Single cell measurements with wet reformate fuel. • Slot-die casting has been identified as most promising for upscaling. [ABSTRACT FROM AUTHOR]

Published
2019
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48. Effective elastic thickness in the Central Andes. Correlation to orogenic deformation styles and lower crust high-gravity anomaly.

Author

García, Héctor P.A., Gianni, Guido M., Lupari, Marianela N., Sánchez, Marcos A., Soler, Santiago R., Ruiz, Francisco, and Lince Klinger, Federico G.

Subjects
*OROGENIC belts, *PLATE tectonics, *METHODOLOGY, *ROCK deformation, *MOHOROVICIC discontinuity
Abstract

Abstract Global studies have assessed the importance of elastic thickness (T e) on orogenic evolution, showing that the style and nature of upper crustal shortening are influenced by the inherited lithospheric strength. Thus, pioneer works have identified that the upper crustal deformation style in the easternmost sector of the Central Andes in South America are related to the elastic thickness (T e). There, the thick-skinned and pure-shear style of Santa Bárbara system was initially related to the existence of low T e values. In contrast, the thin-skinned and simple-shear style of deformation in the Subandean system involves high T e values. However, more recent T e studies in the Central Andes present conflicting results which lead to question this straightforward relation. Results from these studies show a strong dependence on the applied methodology hampering the general understanding of the lithospheric thermo-mechanical state of the Central Andes. To contribute to this issue, we perform a high-resolution T e map, using forward modeling by solving flexural equation of infinite plate model in two dimensions. To achieve this, the crust-mantle interface was calculated using a high-resolution gravity anomaly dataset which combines satellite and terrestrial data, and an average density contrast. Additionally, the gravity anomaly and the foreland basin depth in the Central Andes were best predicted by considering that lower crustal rocks fill the space deflected downward in the plate model. The obtained T e values show an inverse correlation with previous heat flow studies, and a strong spatial correlation with the styles and mechanisms of deformation in the easternmost sector of the Central Andes. In the Santa Bárbara system T e values less than 10 km predominate, whereas in the Subandean system high T e values were observed. Such high values correlate with the orogenic curvature and with an shallower gravity Moho zone, which breaks the regional trend of the Central Andes. This shallower gravity Moho is linked to a high-gravity anomaly located in the east part of the Eastern Cordillera and Subandean system. These results are also correlated with a high-velocity zone in the upper mantle previously found by receiver functions studies. This correlation could indicate changes in the properties of the lower crustal rocks that justify the shallower gravity Moho zone and explain in part the highest T e values. Highlights • Gravity inversion to obtain the geometry of Moho in The Central Andes of South America. • Determination of effective elastic thickness from a high resolution gravity dataset (Eigen-6C4 model). • Correlation between styles and mechanisms of deformation in the easternmost sector of the Central Andes and the elastic thickness. • Inverse correlation between the elastic thickness and heat flow. • Shallower gravity Moho linked to a high-gravity anomaly and a high-velocity in the uppermost mantle. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Plume overriding triggers shallow subduction and orogeny in the southern Central Andes.

Author

Gianni, Guido M., García, Héctor P.A., Lupari, Marianela, Pesce, Agustina, and Folguera, Andrés

Abstract

Plate tectonic theory implies that mantle plumes may be eventually overridden by lithosphere during continental drift. These events have particular tectonomagmatic consequences for active margins and hence related orogenic processes. Since the first documentation of plume overriding and the definition of the plume-modified orogeny concept, only few examples have been recognized in the geologic record. In this study, we analyze the Neogene tectonic evolution of the Southern Central Andes between 35° and 38°S and its potential relation to the subduction of the Payenia plume as a recent analogue of this process. Through a series of tectonic reconstructions we show that progressive Payenia plume overriding correlates with Neogene arc-front migrations linked to slab shallowing, fold belt reactivation in the Main Cordillera and intraplate contraction in the San Rafael block. Additionally, Nazca slab tear determined from tomographic analyses and subsequent diachronous steepening of the subducted plate may also be an aftermath of plume subduction as often described in the final stages of plume-modified orogeny. Finally, we propose a modern analogue for processes previously described, dating back to the Mesoproterozoic, which provides further insights into these complex settings. [ABSTRACT FROM AUTHOR]

Published
2017
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