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Your search keyword '"Ge, Jian"' showing total 264 results
Start Over Author "Ge, Jian" Publisher elsevier b.v.
264 results on '"Ge, Jian"'

23. Engineering design of the CFETR machine

Author

Song, Yuntao, Li, Jiangang, Wan, Yuanxi, Liu, Yong, Wang, Xiaolin, Wan, Baonian, Fu, Peng, Weng, Peide, Wu, Songtao, Duan, Xuru, Yang, Qingwei, Feng, Kaiming, Li, Qiang, Ye, Mingyou, Zhuang, Ge, Liang, Yunfeng, Gao, Xiang, Chen, Changan, Wang, Heyi, Zheng, Guoyao, Xu, Yuhong, Qian, Tianlin, Chan, Vincent, Xiao, Bingjia, Lu, Kun, Zheng, Jinxing, Lu, Mingxuan, Liu, Dequan, Liu, Jian, Wu, Yu, Liu, Xufeng, Shi, Yi, Hou, Binglin, Liu, Chen, Ge, Jian, Zhou, Caipin, Ran, Hong, Wang, Qijie, Wang, Xiaoyu, Liu, Songlin, Liu, Sumei, Yao, Damao, Cheng, Yong, Hu, Liqun, Hu, Chundong, Liu, Fukun, and Chen, Gen

Published
2022
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38. Dumbbell-shaped bimetallic AuPd nanoenzymes for NIR-II cascade catalysis-photothermal synergistic therapy.

Author

Tang, Zhe, Hou, Yike, Huang, Shuqi, Hosmane, Narayan S., Cui, Mingyue, Li, Xianan, Suhail, Muhammad, Zhang, Han, Ge, Jian, Iqbal, M Zubair, and Kong, Xiangdong

Subjects
CATALYSTS, PHOTOTHERMAL conversion, GLUCOSE oxidase, OXIDATION of glucose, TUMOR growth, PEROXIDASE
Abstract

The noble metal NPs that are currently applied to photothermal therapy (PTT) have their photoexcitation location mainly in the NIR-I range, and the low tissue penetration limits their therapeutic effect. The complexity of the tumor microenvironment (TME) makes it difficult to inhibit tumor growth completely with a single therapy. Although TME has a high level of H 2 O 2 , the intratumor H 2 O 2 content is still insufficient to catalyze the generation of sufficient hydroxide radicals (‧OH) to achieve satisfactory therapeutic effects. The AuPd-GOx-HA (APGH) was obtained from AuPd bimetallic nanodumbbells modified by glucose oxidase (GOx) and hyaluronic acid (HA) for photothermal enhancement of tumor starvation and cascade catalytic therapy in the NIR-II region. The CAT-like activity of AuPd alleviates tumor hypoxia by catalyzing the decomposition of H 2 O 2 into O 2. The GOx-mediated intratumoral glucose oxidation on the one hand can block the supply of energy and nutrients essential for tumor growth, leading to tumor starvation. On the other hand, the generated H 2 O 2 can continuously supply local O 2 , which also exacerbates glucose depletion. The peroxidase-like activity of bimetallic AuPd can catalyze the production of toxic ‧OH radicals from H 2 O 2 , enabling cascade catalytic therapy. In addition, the high photothermal conversion efficiency (η = 50.7 %) of APGH nanosystems offers the possibility of photothermal imaging-guided photothermal therapy. The results of cell and animal experiments verified that APGH has good biosafety, tumor targeting, and anticancer effects, and is a precious metal nanotherapeutic system integrating glucose starvation therapy, nano enzyme cascade catalytic therapy, and PTT therapy. This study provides a strategy for photothermal-cascade catalytic synergistic therapy combining both exogenous and endogenous processes. AuPd-GOx-HA cascade nanoenzymes were prepared as a potent cascade catalytic therapeutic agent, which enhanced glucose depletion, exacerbated tumor starvation and promoted cancer cell apoptosis by increasing ROS production through APGH-like POD activity. The designed system has promising photothermal conversion ability in the NIR-II region, simultaneously realizing photothermal-enhanced catalysis, PTT, and catalysis/PTT synergistic therapy both in vitro and in vivo. The present work provides an approach for designing and developing catalytic-photothermal therapies based on bimetallic nanoenzymatic cascades. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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