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Start Over Author "Gerald W" Publisher elsevier b.v.
538 results on '"Gerald W"'

9. Prognostic Factors for Early Recurrence After Resection of Pancreatic Cancer: A Systematic Review and Meta-Analysis.

Author

Leonhardt, Carl-Stephan, Gustorff, Charlotte, Klaiber, Ulla, Le Blanc, Solange, Stamm, Tanja A., Verbeke, Caroline S., Prager, Gerald W., and Strobel, Oliver

Abstract

More than half of pancreatic ductal adenocarcinomas (PDACs) recur within 12 months after curative-intent resection. This systematic review and meta-analysis was conducted to identify all reported prognostic factors for early recurrence in resected PDACs. After a systematic literature search, a meta-analysis was conducted using a random effects model. Separate analyses were performed for adjusted vs unadjusted effect estimates as well as reported odds ratios (ORs) and hazard ratios (HRs). Risk of bias was assessed using the Quality in Prognostic Studies tool, and evidence was rated according to Grading of Recommendations Assessment, Development and Evaluation recommendations. After 2903 abstracts were screened, 65 studies were included. Of these, 28 studies (43.1%) defined early recurrence as evidence of recurrence within 6 months, whereas 34 (52.3%) defined it as evidence of recurrence within 12 months after surgery. Other definitions were uncommon. Analysis of unadjusted ORs and HRs revealed 41 and 5 prognostic factors for early recurrence within 6 months, respectively. When exclusively considering adjusted data, we identified 25 and 10 prognostic factors based on OR and HR, respectively. Using a 12-month definition, we identified 38 (OR) and 15 (HR) prognostic factors from unadjusted data and 38 (OR) and 30 (HR) prognostic factors from adjusted data, respectively. On the basis of frequency counts of adjusted data, preoperative carbohydrate antigen 19-9, N status, nondelivery of adjuvant therapy, grading, and tumor size based on imaging were identified as key prognostic factors for early recurrence. Reported prognostic factors of early recurrence vary considerably. Identified key prognostic factors could aid in the development of a risk stratification framework for early recurrence. However, prospective validation is necessary. [Display omitted] Pancreatic cancer frequently recurs after surgery, this work identified all risk factors reported in the literature that lead to early recurrence and can thus help identify vulnerable patient groups. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Glycomics Hits the Big Time

Author

Hart, Gerald W. and Copeland, Ronald J.

Subjects
Polysaccharides, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2010.11.008 Byline: Gerald W. Hart (1), Ronald J. Copeland (1) Abstract: Cells run on carbohydrates. Glycans, sequences of carbohydrates conjugated to proteins and lipids, are arguably the most abundant and structurally diverse class of molecules in nature. Recent advances in glycomics reveal the scope and scale of their functional roles and their impact on human disease. Author Affiliation: (1) Department of Biological Chemistry, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA

Published
2010

46. Uric acid level and allopurinol use as risk markers of mortality and morbidity in systolic heart failure

Author

Wu, Audrey H., Ghali, Jalal K., Neuberg, Gerald W., O'Connor, Christopher M., Carson, Peter E., and Levy, Wayne C.

Subjects
Oxidases -- Health aspects, Heart failure -- Health aspects, Uric acid -- Health aspects, Molybdenum compounds -- Health aspects, Gout -- Care and treatment, Gout -- Health aspects, Mortality, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2010.08.006 Byline: Audrey H. Wu, Jalal K. Ghali, Gerald W. Neuberg, Christopher M. O'Connor, Peter E. Carson, Wayne C. Levy Abstract: Previous studies have not extensively examined the association of hyperuricemia and adverse outcomes in systolic heart failure (HF) in relation to xanthine oxidase inhibitor therapy. Article History: Received 19 April 2010; Accepted 9 August 2010

Published
2010

47. Treatment of perioperative anaphylaxis: room for improvement?

Author

Savic, Louise, Volcheck, Gerald W., and Garvey, Lene H.

Subjects
*ANAPHYLAXIS, *ADRENALINE, *ALLERGIES
Abstract

Perioperative anaphylaxis is associated with significant morbidity and mortality. Prompt and appropriate treatment is required for optimal outcome. Despite general knowledge of this condition, delays occur in the administration of epinephrine and in particular the use of i.v. route of administration in the perioperative setting. Barriers should be addressed to allow prompt utilisation of i.v. epinephrine in perioperative anaphylaxis. [ABSTRACT FROM AUTHOR]

Published
2023
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