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Your search keyword '"Giorgino, Toni"' showing total 15 results
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15 results on '"Giorgino, Toni"'

2. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Author

Jennison, Christopher, Ehrhardt, Beate, Baum, Patrick, Schoelsch, Corinna, Freijer, Jan, Grempler, Rolf, Graefe-Mody, Ulrike, Hennige, Anita, Dings, Christiane, Lehr, Thorsten, Scherer, Nina, Sihinecich, Iryna, Pattou, Francois, Raverdi, Violeta, Caiazzo, Robert, Torres, Fanelly, Verkindt, Helene, Mari, Andrea, Tura, Andrea, Giorgino, Toni, Bizzotto, Roberto, Froguel, Philippe, Bonneford, Amelie, Canouil, Mickael, Dhennin, Veronique, Brorsson, Caroline, Brunak, Soren, De Masi, Federico, Gudmundsdóttir, Valborg, Pedersen, Helle, Banasik, Karina, Thomas, Cecilia, Sackett, Peter, Staerfeldt, Hans-Henrik, Lundgaard, Agnete, Nilsson, Birgitte, Nielsen, Agnes, Mazzoni, Gianluca, Karaderi, Tugce, Rasmussen, Simon, Johansen, Joachim, Allesøe, Rosa, Fritsche, Andreas, Thorand, Barbara, Adamski, Jurek, Grallert, Harald, Haid, Mark, Sharma, Sapna, Troll, Martina, Adam, Jonathan, Ferrer, Jorge, Eriksen, Heather, Frost, Gary, Haussler, Ragna, Hong, Mun-gwan, Schwenk, Jochen, Uhlen, Mathias, Nicolay, Claudia, Pavo, Imre, Steckel-Hamann, Birgit, Thomas, Melissa, Adragni, Kofi, Wu, Han, Hart, Leen't, Roderick, Slieker, van Leeuwen, Nienke, Dekkers, Koen, Frau, Francesca, Gassenhuber, Johann, Jablonka, Bernd, Musholt, Petra, Ruetten, Hartmut, Tillner, Joachim, Baltauss, Tania, Bernard Poenaru, Oana, de Preville, Nathalie, Rodriquez, Marianne, Arumugam, Manimozhiyan, Allin, Kristine, Engelbrechtsen, Line, Hansen, Torben, Hansen, Tue, Forman, Annemette, Jonsson, Anna, Pedersen, Oluf, Dutta, Avirup, Vogt, Josef, Vestergaard, Henrik, Laakso, Markku, Kokkola, Tarja, Kuulasmaa, Teemu, Franks, Paul, Giordano, Nick, Pomares-Millan, Hugo, Fitipaldi, Hugo, Mutie, Pascal, Klintenberg, Maria, Bergstrom, Margit, Groop, Leif, Ridderstrale, Martin, Atabaki Pasdar, Naeimeh, Deshmukh, Harshal, Heggie, Alison, Wake, Dianne, McEvoy, Donna, McVittie, Ian, Walker, Mark, Hattersley, Andrew, Hill, Anita, Jones, Angus, McDonald, Timothy, Perry, Mandy, Nice, Rachel, Hudson, Michelle, Thorne, Claire, Dermitzakis, Emmanouil, Viñuela, Ana, Cabrelli, Louise, Loftus, Heather, Dawed, Adem, Donnelly, Louise, Forgie, Ian, Pearson, Ewan, Palmer, Colin, Brown, Andrew, Koivula, Robert, Wesolowska-Andersen, Agata, Abdalla, Moustafa, McRobert, Nicky, Fernandez, Juan, Jiao, Yunlong, Robertson, Neil, Gough, Stephen, Kaye, Jane, Mourby, Miranda, Mahajan, Anubha, McCarthy, Mark, Shah, Nisha, Teare, Harriet, Holl, Reinhard, Koopman, Anitra, Rutters, Femke, Beulens, Joline, Groeneveld, Lenka, Bell, Jimmy, Thomas, Louise, Whitcher, Brandon, Wilman, Henry R., Parisinos, Constantinos A., Atabaki-Pasdar, Naeimeh, Kelly, Matt, Thomas, E. Louise, Neubauer, Stefan, Hingorani, Aroon D., Patel, Riyaz S., Hemingway, Harry, Franks, Paul W., Bell, Jimmy D., Banerjee, Rajarshi, and Yaghootkar, Hanieh

Published
2019
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10. Phenotype variability of patients with post polycythemia vera and post essential thrombocythemia myelofibrosis is associated with the time to progression from polycythemia vera and essential thrombocythemia.

Author

Mora, Barbara, Giorgino, Toni, Guglielmelli, Paola, Rumi, Elisa, Maffioli, Margherita, Rambaldi, Alessandro, Caramella, Marianna, Komrokji, Rami, Gotlib, Jason, Kiladjian, Jean Jacques, Cervantes, Francisco, Devos, Timothy, Palandri, Francesca, De Stefano, Valerio, Ruggeri, Marco, Silver, Richard T., Benevolo, Giulia, Albano, Francesco, Cavalloni, Chiara, and Barraco, Daniela

Subjects
*POLYCYTHEMIA, *THROMBOCYTOSIS, *THROMBOCYTOPENIA treatment, *PHENOTYPES, *DISEASE progression, *DIAGNOSIS
Published
2018
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11. Automated spoken dialogue system for hypertensive patient home management

Author

Giorgino, Toni, Azzini, Ivano, Rognoni, Carla, Quaglini, Silvana, Stefanelli, Mario, Gretter, Roberto, and Falavigna, Daniele

Subjects
*AUTOMATIC speech recognition, *SPEECH processing systems, *PATTERN recognition systems, *TELECOMMUNICATION, *MEDICAL informatics
Abstract

Summary: Recent advances in automatic speech recognition and related technologies allow computers to carry on conversations by telephone. We developed an intelligent dialogue system that interacts with hypertensive patients to collect data about their health status. Patients thus avoid the inconvenience of traveling for frequent face to face visits to monitor the clinical variables they can easily measure at home; the physician is facilitated in acquiring patient information and cardiovascular risk, which is evaluated from the data according to noted guidelines. Controlled trials to assess the clinical efficacy are under way. [Copyright &y& Elsevier]

Published
2005
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12. Distributed computing as a virtual supercomputer: Tools to run and manage large-scale BOINC simulations

Author

Giorgino, Toni, Harvey, M.J., and de Fabritiis, Gianni

Subjects
*DISTRIBUTED computing, *VIRTUAL machine systems, *SUPERCOMPUTERS, *LARGE scale systems, *WORKFLOW, *SIMULATION methods & models, *MICROCOMPUTER workstations (Computers), *MIDDLEWARE
Abstract

Abstract: Distributed computing (DC) projects tackle large computational problems by exploiting the donated processing power of thousands of volunteered computers, connected through the Internet. To efficiently employ the computational resources of one of world''s largest DC efforts, GPUGRID, the project scientists require tools that handle hundreds of thousands of tasks which run asynchronously and generate gigabytes of data every day. We describe RBoinc, an interface that allows computational scientists to embed the DC methodology into the daily work-flow of high-throughput experiments. By extending the Berkeley Open Infrastructure for Network Computing (BOINC), the leading open-source middleware for current DC projects, with mechanisms to submit and manage large-scale distributed computations from individual workstations, RBoinc turns distributed grids into cost-effective virtual resources that can be employed by researchers in work-flows similar to conventional supercomputers. The GPUGRID project is currently using RBoinc for all of its in silico experiments based on molecular dynamics methods, including the determination of binding free energies and free energy profiles in all-atom models of biomolecules. [Copyright &y& Elsevier]

Published
2010
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13. Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes.

Author

Grespan, Eleonora, Giorgino, Toni, Natali, Andrea, Ferrannini, Ele, and Mari, Andrea

Subjects
TYPE 2 diabetes, TREATMENT effectiveness, SECRETION, PANCREATIC beta cells, ORAL examinations (Education)
Abstract

The reduced action of incretin hormones in type 2 diabetes (T2D) is mainly attributed to GIP insensitivity, but efficacy estimates of GIP and GLP-1 differ among studies, and the negligible effects of pharmacological GIP doses remain unexplained. We aimed to characterize incretin action in vivo in subjects with normal glucose tolerance (NGT) or T2D and provide an explanation for the different insulinotropic activity of GIP and GLP-1 in T2D subjects. We used in vivo data from ten studies employing hormone infusion or an oral glucose test (OGTT). To homogeneously interpret and compare the results of the studies we performed the analysis using a mathematical model of the β-cell incorporating the effects of incretins on the triggering and amplifying pathways. The effect on the amplifying pathway was quantified by a time-dependent factor that is greater than one when insulin secretion (ISR) is amplified by incretins. To validate the model results for GIP in NGT subjects, we performed an extensive literature search of the available data. a) the stimulatory effects of GIP and GLP-1 differ markedly: ISR potentiation increases linearly with GLP-1 over the whole dose range, while with GIP infusion it reaches a plateau at ~100 pmol/L GIP, with ISR potentiation of ~2 fold; b) ISR potentiation in T2D is reduced by ~50% for GIP and by ~40% for GLP-1; c) the literature search of GIP in NGT subjects confirmed the saturative effect on insulin secretion. We show that incretin potentiation of ISR is reduced in T2D, but not abolished, and that the lack of effects of pharmacological GIP doses is due to saturation of the GIP effect more than insensitivity to GIP in T2D. • Potentiation of insulin secretion by GIP and GLP-1 can be quantified by modeling. • Potentiation by GIP and GLP-1 follow different dose-response patterns. • Potentiation by GLP-1 is linear with the dose, while it saturates with GIP. • In type 2 diabetes, GIP and GLP-1 efficacy is reduced by 40–50%, but not abolished. • Lack of GIP efficacy in type 2 diabetes is mainly attributable to effect saturation. [ABSTRACT FROM AUTHOR]

Published
2021
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14. Clinical Phenotype and Genotype Correlations with Time to Progression into Post Polycythemia Vera and Post Essential Thrombocythemia Myelofibrosis.

Author

Mora, Barbara, Giorgino, Toni, Guglielmelli, Paola, Rumi, Elisa, Maffioli, Margherita, Caramazza, Domenica, Rambaldi, Alessandro, Caramella, Marianna, Komrokji, Rami, Gotlib, Jason, Kiladjian, Jean Jacques, Cervantes, Francisco, Devos, Timothy, Palandri, Francesca, De Stefano, Valerio, Ruggeri, Marco, Silver, Richard, Benevolo, Giulia, Albano, Francesco, and Merli, Michele

Published
2017
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15. Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists.

Author

Stepniewski, Tomasz Maciej, Torrens-Fontanals, Mariona, Rodríguez-Espigares, Ismael, Giorgino, Toni, Primdahl, Karoline G., Vik, Anders, Stenstrøm, Yngve, Selent, Jana, and Hansen, Trond Vidar

Subjects
*G protein coupled receptors, *INFLAMMATION, *CARCINOGENESIS, *MOLECULAR models, *MEMBRANE proteins
Abstract

The oxoeicosanoid receptor 1 (OXER1) is a member of the G-protein coupled receptors (GPCR) family, and is involved in inflammatory processes and oncogenesis. As such it is an attractive target for pharmacological intervention. The present study aimed to shed light on the molecular fundaments of OXER1 modulation using chemical probes structurally related to the natural agonist 5-oxo-ETE. In a first step, 5-oxo-ETE and its closely related derivatives (5-oxo-EPE and 4-oxo-DHA) were obtained by conducting concise and high-yielding syntheses. The biological activity of obtained compounds was assessed in terms of potency (EC 50 ) and efficacy (E max ) for arrestin recruitment. Finally, molecular modelling and simulation were used to explore binding characteristics of 5-oxo-ETE and derivatives with the aim to rationalize biological activity. Our data suggest that the tested 5-oxo-ETE derivatives (i) insert quickly into the membrane, (ii) access the receptor via transmembrane helices (TMs) 5 and 6 from the membrane side and (iii) drive potency and efficacy by differential interaction with TM5 and 7. Most importantly, we found that the methyl ester of 5-oxo-ETE ( 1a ) showed even a higher maximum response than the natural agonist ( 1 ). In contrast, shifting the 5-oxo group into position 4 results in inactive compounds (4-oxo DHA compounds ( 3 ) and ( 3a )). All in all, our study provides relevant structural data that help understanding better OXER1 functionality and its modulation. The structural information presented herein will be useful for designing new lead compounds with desired signalling profiles. [ABSTRACT FROM AUTHOR]

Published
2018
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