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In order to synthesize nanoparticles of galactomannan- g -poly- N -isopropylacrylamide copolymers, galactomannan from fava d'anta was partially hydrolyzed using hydrochloric acid. Degradation reduced the molar mass and increase mannose/galactose molar ratio. This study shows that high molar mass of galatomannan lead to formation of copolymers with particle size in the order of micrometer, however reducing molar mass from 106 to 104 g mol−1, thermo-sensitive copolymer with low critical aggregation concentration, transition temperature close to body temperature (37 °C) and particle size in the range of 300–170 nm can be obtained. As a proof of concept, partially degraded galactomannan- g -NIPAm copolymer was used to incorporated indomethacin. Good encapsulation efficiency and a controlled release were observed indicating that this material has potential to be used as nanocarrier system. [ABSTRACT FROM AUTHOR]