1. Comparison between adult and infant lung injury in a rabbit ischemia-reperfusion model
- Author
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Qiu, Wanshan, Zheng, Liang, Gu, Haiyong, Chen, Duan, and Chen, Yijiang
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Health - Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2008.01.014 Byline: Wanshan Qiu (a)(b)(c), Liang Zheng (a), Haiyong Gu (a), Duan Chen (c), Yijiang Chen (a) Abbreviations: GSH-PX, glutathione peroxidase; IL, interleukin; IR, ischemia-reperfusion; MDA, malondialdehyde; MyD, myeloid differentiation factor; NF-[kappa]B, nuclear factor-[kappa]B; ROS, reactive oxygen species; ROS-HR, reactive oxygen species-hydroxyl radical; SOD, superoxide dismutase; TNF, tumor necrosis factor Abstract: Ischemia-reperfusion causes lung damage to patients with congenital heart disease who undergo open surgery under total cardiopulmonary bypass. The aim of the present study was to compare ischemia-reperfusion-induced lung damage between adults and infants. Author Affiliation: (a) Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (b) Department of Thoracic and Cardiovascular Surgery, The Affiliated Children's Hospital of Nanjing Medical University, Nanjing, China (c) Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway Article History: Received 25 October 2007; Revised 2 January 2008; Accepted 7 January 2008 Article Note: (footnote) This study was supported by grants from the Nature Science Fund of Jiangsu Province and the Fund for Strategic Development of Medical Science and Technology of Nanjing, China.
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- 2008