1. Pregnancy and estradiol modulate myometrial G-protein pathways in the guinea pig
- Author
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Weiner, Carl P., Mason, Clifford, Hall, Gentzon, Ahmad, Usma, Swaan, Peter, and Buhimschi, Irina A.
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Guanosine ,Pregnancy ,Estradiol ,Pharmacy ,Phenols ,Health - Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2005.12.050 Byline: Carl P. Weiner (a), Clifford Mason (b), Gentzon Hall (c), Usma Ahmad (d), Peter Swaan (b), Irina A. Buhimschi (d) Abstract: Coupled to hundreds of receptors, G-proteins modulate signal transduction pathways and are important hormonal targets. The first objective was to determine the effect of pregnancy and estradiol on myometrial guanosine triphosphatase activity. The second objective was to begin dissecting the molecular mechanism(s) underlying alterations in guanosine triphosphatase activity. Author Affiliation: (a) Departments of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, KS (b) Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy (c) Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine Baltimore, MD (d) Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT Article History: Received 3 October 2005; Revised 9 December 2005; Accepted 22 December 2005 Article Note: (footnote) Supported by Grants HL49041 (to C.P.W.), HD049185 (to C.P.W.), and U01-DP000187 (to C.P.W.) from the United States Public Health Service.
- Published
- 2006