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Process-based crop models provide ways to predict crop growth, evaluate environmental impacts on crops, test various crop management options, and guide crop breeding. They can be used to explore options for mitigating climate change impacts when combined with climate projections and explore mitigation of environmental impacts of production. The Agricultural Production Systems SIMulator (APSIM) is a widely adopted crop model that offers modules for simulation of various crops, soil processes, climate, and grazing within a modelling system that enables robust addition of new components. This study uses APSIM Classic-Wheat as an example to examine yield prediction accuracy of biophysically based crop yield modelling and to analyse the factors influencing the model performance. We analysed yield prediction results of APSIM Classic-Wheat from 76 published studies across thirteen countries on four continents. In addition, a meta-database of modelled and observed yields from 30 studies was established and used to identify factors that influence yield prediction uncertainty. Our analysis indicates that, with site-specific calibration, APSIM predicts yield with a root mean squared error (RMSE) smaller than 1 t/ha and a normalised RMSE (NRMSE) of about 28%, across a wide range of environmental conditions for independent evaluation periods. The results show increasing errors in yield with limited modelling information and adverse environmental conditions. Using soil hydraulic parameters derived from site-specific measurements and/or tuning cultivar parameters improves yield prediction accuracy: RMSE decreases from 1.25 t/ha to 0.64 t/ha and NRMSE from 32% to 14%. Lower model accuracy was found where APSIM overestimates yield under high water deficit condition and when it underestimates yield under nitrogen limitation. APSIM severely over-predicts yield when some abiotic stresses such as heatwaves and frost affect the crop growth. This paper uses APSIM-Wheat as an example to provide perspectives on crop model yield prediction performance under different conditions covering a wide spectrum of management practices, and environments. The findings deepen the understanding of model uncertainty associated with different calibration processes or under various stressed conditions. The results also indicate the need to improve the model's predictive skill by filling functional gaps in the wheat simulations and by assimilating external observations (e.g., biomass information estimated by remote sensing) to adjust the model simulation for stressed crops. [Display omitted] • Crop model is a tool to simulate crop growth, seek solutions for mitigating negative environmental impacts on production. • APSIM Classic has been used as an example to explore wheat yield prediction performance and the influential factors. • Reviewed and established a meta-database from 76 published studies. • Overall: the model predicts wheat yield with RMSE=1 t/ha. Fully calibrated and under stress-free condition: RMSE=0.64 t/ha. • Calibration method, heat, frost, water, and nitrogen stresses were identified as factors causing the model to mis-simulate. [ABSTRACT FROM AUTHOR]