1. Mineralized collagen scaffolds for regenerative engineering applications.
- Author
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Kolliopoulos, Vasiliki and Harley, Brendan AC
- Subjects
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BONE regeneration , *COLLAGEN , *BIOMATERIALS , *TISSUE scaffolds , *TISSUE engineering , *EXTRACELLULAR matrix , *BONE diseases , *ENGINEERING - Abstract
Collagen is a primary constituent of the tissue extracellular matrix. As a result, collagen has been a common component of tissue engineering biomaterials, including those to promote bone regeneration or to investigate cell-material interactions in the context of bone homeostasis or disease. This review summarizes key considerations regarding current state-of-the-art design and use of collagen biomaterials for these applications. We also describe strategic opportunities for collagen biomaterials to address a new era of challenges, including immunomodulation and appropriate consideration of sex and other patient characteristics in biomaterial design. • Collagen biomaterials to study fundamental processes underlying bone regeneration. • Biomaterial design rules to induce endogenous production of cells and biomolecules. • Shaping reciprocal, multicellular interactions to achieve bone regeneration. • Age, sex, and underlying disease offer insight for improving regenerative healing. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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