172 results on '"Hubbuch, Jürgen"'
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2. Antibody sequence-based prediction of pH gradient elution in multimodal chromatography
3. Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation
4. Bio-based material formulation for extrusion printing by dityrosine crosslinking of unmodified casein
5. Automated and dynamic extrusion pressure adjustment based on real-time flow rate measurements for precise ink dispensing in 3D bioprinting
6. Integrated process model for the prediction of biopharmaceutical manufacturing chromatography and adjustment steps
7. Steric exclusion chromatography of lentiviral vectors using hydrophilic cellulose membranes
8. Modeling the Gibbs–Donnan effect during ultrafiltration and diafiltration processes using the Poisson–Boltzmann theory in combination with a basic Stern model
9. Exploration of fiber-based cation exchange adsorbents for the removal of monoclonal antibody aggregates
10. Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model
11. Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach
12. High throughput screening of fiber-based adsorbents for material and process development
13. Image analysis as PAT-Tool for use in extrusion-based bioprinting
14. On the analysis of chromatographic biopharmaceutical data by curve resolution techniques in the framework of the area of feasible solutions
15. Modeling of hydrophobic interaction chromatography for the separation of antibody-drug conjugates and its application towards quality by design
16. Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation
17. Kinetic reaction modeling for antibody-drug conjugate process development
18. Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography
19. Prediction uncertainty assessment of chromatography models using Bayesian inference
20. Factorization of preparative protein chromatograms with hard-constraint multivariate curve resolution and second-derivative pretreatment
21. Monitoring of antibody-drug conjugation reactions with UV/Vis spectroscopy
22. 3D bioprinting – Flow cytometry as analytical strategy for 3D cell structures
23. Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates
24. Packing characteristics of winged shaped polymer fiber supports for preparative chromatography
25. In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography
26. An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration
27. Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a hybrid process vs. a conventional batch process
28. Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks
29. Orientation of monoclonal antibodies in ion-exchange chromatography: A predictive quantitative structure–activity relationship modeling approach
30. Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology
31. Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks
32. An orientation sensitive approach in biomolecule interaction quantitative structure–activity relationship modeling and its application in ion-exchange chromatography
33. Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure–activity relationship models
34. A mechanistic model of ion-exchange chromatography on polymer fiber stationary phases
35. Water on hydrophobic surfaces: Mechanistic modeling of hydrophobic interaction chromatography
36. High-throughput downstream process development for cell-based products using aqueous two-phase systems
37. Concentration-dependent changes in apparent diffusion coefficients as indicator for colloidal stability of protein solutions
38. Prediction of salt effects on protein phase behavior by HIC retention and thermal stability
39. Quantification of PEGylated proteases with varying degree of conjugation in mixtures: An analytical protocol combining protein precipitation and capillary gel electrophoresis
40. Impact of polymer surface characteristics on the microrheological measurement quality of protein solutions – A tracer particle screening
41. Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography
42. High-throughput process development of an alternative platform for the production of virus-like particles in Escherichia coli
43. Modeling and simulation of anion-exchange membrane chromatography for purification of Sf9 insect cell-derived virus-like particles
44. Manipulation of lysozyme phase behavior by additives as function of conformational stability
45. Effect of lysozyme solid-phase PEGylation on reaction kinetics and isoform distribution
46. Custom-tailored adsorbers: A molecular dynamics study on optimal design of ion exchange chromatography material
47. Light extinction and scattering by agarose based resin beads and applications in high-throughput screening
48. Influence of binding pH and protein solubility on the dynamic binding capacity in hydrophobic interaction chromatography
49. Integrated development of up- and downstream processes supported by the Cherry-Tag™ for real-time tracking of stability and solubility of proteins
50. Robust high-throughput batch screening method in 384-well format with optical in-line resin quantification
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