1. Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: A systematic review and meta-analysis.
- Author
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Bustamante, Alejandro, Sobrino, Tomás, Giralt, Dolors, García-Berrocoso, Teresa, Llombart, Victor, Ugarriza, Iratxe, Espadaler, Marc, Rodríguez, Noelia, Sudlow, Cathie, Castellanos, Mar, Smith, Craig J., Rodríguez-Yánez, Manuel, Waje-Andreassen, Ulrike, Tanne, David, Oto, Jun, Barber, Mark, Worthmann, Hans, Wartenberg, Katja E., Becker, Kyra J., and Chakraborty, Baidarbhi
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INTERLEUKIN-6 , *BLOOD testing , *HEALTH outcome assessment , *STROKE , *SYSTEMATIC reviews , *REACTIVE oxygen species - Abstract
We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592–5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR = 2.346 (1.814–3.033), p < 0.0001). However, the additional predictive value of IL-6 was moderate (IDI = 1.5%, NRI = 5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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