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Abstract New sustainable, cost-effective solutions are urgently needed for river management since conventional practices have posed serious ecological threats on streams, rivers and the surrounding riparian areas. Besides addressing the societal needs e.g. for flood management, river management should increasingly address the ecosystem requirements for improved water quality and biodiversity. We argue that it is not feasible to solve existing and future river management challenges with intensive restoration projects. Instead, we believe that less resource-intensive solutions using natural channel processes and features, including vegetation, should be investigated. Besides directly supporting biota, aquatic and riparian vegetation traps, takes up and helps to process nutrients and harmful substances, and thus this paper emphasizes vegetation as a tool for nature-based solutions (NBS) in river management. We synthesize findings from key literature, showing that the fate of substances in channel systems is largely controlled by abiotic and biotic processes facilitated and modified by vegetation, including flow hydrodynamics, channel morphology, and sediment transport. Subsequently, we demonstrate how vegetation can be incorporated into channel designs, focusing on a two-stage (compound) design to improve resilience to flooding, control the transport of substances, and enhance the ecological status. As a conclusion, clever use and maintenance of vegetation present an unused potential to obtain large-scale positive environmental impacts in rivers and streams experiencing anthropogenic pressures. [ABSTRACT FROM AUTHOR]

Background Although there is a relationship between the extent of striatal dopaminergic defect and the severity of motor symptoms in Parkinson's disease (PD), studies investigating associations between dopamine and mortality in PD have been scarce. If a relationship were established, dopamine restoring neuroprotective treatments could be used to decrease mortality. The objective of this study was to determine whether the initial degree of hypodopaminergic defect, as measured by 6-[ 18 F]fluoro-L-DOPA positron emission tomography (FDOPA-PET), can predict patient survival. Methods The study population included a cohort of 88 recently diagnosed and untreated patients with PD who were clinically examined and scanned with FDOPA-PET between the years 1998 and 2000. The date of exit for the survival analysis was in April 2013 with a follow-up interval of 13-15 years. The survival model included FDOPA uptake, age, sex and symptom severity as explaining factors. Death certificates of the patients were obtained, and causes of death were analyzed. Results Mortality rate was 56.8%. Although higher age ( p < 0.001) and greater motor symptom severity ( p < 0.05) were associated with increased mortality, there was no association between survival and FDOPA uptake in any striatal subregion ( p > 0.48). Conclusion Unlike age and early motor symptom severity, dopamine synthesis capacity, as measured with PET, does not predict survival in PD. [ABSTRACT FROM AUTHOR]

Abstract: In the postnatal rodent hippocampus status epilepticus (SE) leads to age- and region-specific excitotoxic neuronal damage, the precise mechanisms of which are still incompletely known. Recent studies suggest that the activation of inflammatory responses together with glial cell reactivity highly contribute to excitotoxic neuronal damage. However, pharmacological tools to attenuate their activation in the postnatal brain are still poorly elucidated. In this study, we investigated the role of inflammatory mediators in kainic acid (KA)-induced neuronal damage in organotypic hippocampal slice cultures (OHCs). A specific cyclooxygenase-2 (COX-2) inhibitor N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (NS-398) was used to study whether or not it could ameliorate neuronal death. Our results show that KA treatment (24 h) resulted in a dose-dependent degeneration of CA3a/b pyramidal neurons. Furthermore, COX-2 immunoreactivity was pronouncedly enhanced particularly in CA3c pyramidal neurons, microglial and astrocyte morphology changed from a resting to active appearance, the expression of the microglial specific protein, Iba1, increased, and prostaglandin E2 (PGE2) production increased. These indicated the activation of inflammatory processes. However, the expression of neither proinflammatory cytokines, i.e. tumour necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), nor the anti-inflammatory cytokine IL-10 mRNA was significantly altered by KA treatment as studied by real-time PCR. Despite activation of an array of inflammatory processes, neuronal damage could not be rescued either with the combined pre- and co-treatment with a specific COX-2 inhibitor, NS-398. Our results suggest that KA induces activation of a repertoire of inflammatory processes in immature OHCs, and that the timing of anti-inflammatory treatment to achieve neuroprotection is a challenge due to developmental properties and the complexity of inflammatory processes activated by noxious stimuli. This article is part of a Special Issue entitled ‘Trends in Neuropharmacology: In Memory of Erminio Costa’. [Copyright &y& Elsevier]

Abstract: Cross-flooding ducts are used to equalize asymmetric flooding and, thus, to decrease the heel angle of a ship in an emergency. The present design guidelines for cross-flooding arrangements involve uncertainties associated with the effect of variable structural factors. In this study, scale model experiments were carried out to determine discharge coefficients of a typical cross-duct, with a focus on the effect of structural components such as the girders, stiffeners, and web frame. Flow conditions and configuration of the components were varied in the experiments. The structural stiffeners in the cross-duct were found to notably increase the discharge coefficient whereas the effects of the web frame and the inclination of the duct at an angle of 7° were negligible. The experimentally obtained discharge coefficient values for the cross-duct were considerably lower than the corresponding values computed according to the generally used guidelines of the IMO Resolution MSC.245(83). This indicates that the geometrical properties of the girders in the cross-ducts need to be properly addressed to avoid overestimating the discharge coefficients. Overall, the experimental results formed an indispensable dataset for the validation and further development of CFD approaches. [Copyright &y& Elsevier]

Abstract Riparian shrubs and trees present a complex, seasonally variable morphology, with flexible stems and leaves efficiently adapting to the flow forcing (reconfiguration). The aim of this paper is to investigate how foliage and reconfiguration affect the flow and mixing in a partly vegetated channel. Specific attention was placed on the velocity statistics, onset and coherence of turbulent structures, and lateral momentum transport at the horizontal interface between vegetation and open water. The experimental flume arrangement was novel in that it allowed investigating the lateral shear layer induced by flexible riparian plants. The natural-like vegetation consisted of emergent woody plants and a grassy understory, with density, morphology and reconfiguration behavior comparable to those found in real riparian areas. Investigations were conducted under foliated and leafless conditions to determine the seasonality effects. The mean and turbulent flow structure was determined with acoustic Doppler velocimetry, and dynamic plant motions were investigated from video footage. The presence of foliage enhanced the drag discontinuity at the interface, resulting in more pronounced velocity gradients between the vegetated and open areas compared to the leafless conditions. Foliation induced stronger shear layer-scale mixing, whereas, under leafless conditions, the local mixing induced by stems was more important. The reconfiguration decreased the coherence of the two-dimensional large-scale vortices at the interface while their characteristic frequency was consistent with the canonical mixing layer theory. Our results indicated that shear layer dynamics in partly vegetated channels was influenced strongly by morphology and reconfiguration of complex plants, with more efficient lateral momentum transport at the interface in the foliated conditions than previously reported for shear layers induced by simpler vegetation. [ABSTRACT FROM AUTHOR]

This paper investigates the structural properties of four common riparian tree species and their reconfiguration under hydrodynamic loading in a towing tank in foliated and defoliated conditions. 3D tree models were generated by digitizing twenty 0.8–3.3 m tall specimens at branch level. Branch diameters and lengths were measured in order to calculate the one-sided stem area and stem volume over the plant height. The novelty of the investigations originated from the characterization of the reconfiguration which was achieved by combining the contracted width, the deflected height, and the underwater projected area in order to determine the porosity at different velocities. The results showed that the basal diameter could be used to predict the entire total one-sided stem area, although this method was not capable of reproducing the observed non-linear vertical distributions. The flow-induced width contraction contributed significantly to the reduction of the rectangular cross-sectional area occupied by the plant. The porosity of the foliated trees increased at the lower velocities, and then decreased at the higher velocities. Overall, detailed spatial–structural analyses of woody vegetation provided valuable information about plant behaviour under load, and thus are helpful for improving the determination of the physically based parameters of complex vegetative elements which is highly relevant for environmental modelling in order to fill the gap of knowledge concerning the hydrodynamic and aerodynamic flow around trees. [ABSTRACT FROM AUTHOR]