20 results on '"Komatsu, Shohei"'
Search Results
2. Clinicopathological variables and risk factors for lung recurrence after resection of pancreatic ductal adenocarcinoma
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Asakura, Yu, Toyama, Hirochika, Ishida, Jun, Asari, Sadaki, Terai, Sachio, Shirakawa, Sachiyo, Yamashita, Hironori, Shimizu, Takashi, Ogura, Yuta, Matsumoto, Ippei, Gon, Hidetoshi, Tsugawa, Daisuke, Komatsu, Shohei, Kuramitsu, Kaori, Yanagimoto, Hiroaki, Kido, Masahiro, Ajiki, Tetsuo, and Fukumoto, Takumi
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- 2023
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3. Statement on use of generative artificial intelligence by adolescents
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Sakuraya, Asuka, Matsumura, Masayo, Komatsu, Shohei, Imamura, Kotaro, Iida, Mako, and Kawakami, Norito
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- 2024
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4. Advantages of the Laparoscopic Approach for the Initial Operation in Patients who Underwent Repeat Hepatectomy.
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Gon, Hidetoshi, Komatsu, Shohei, Kido, Masahiro, Fukushima, Kenji, Urade, Takeshi, So, Shinichi, Yoshida, Toshihiko, Arai, Keisuke, Ishida, Jun, Nanno, Yoshihide, Tsugawa, Daisuke, Yanagimoto, Hiroaki, Toyama, Hirochika, and Fukumoto, Takumi
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HEPATECTOMY , *LAPAROSCOPIC surgery , *TISSUE adhesions , *SURGICAL complications , *BLOOD volume - Abstract
Background: Less intra-abdominal adhesions are expected following laparoscopic surgery. Although an initial laparoscopic approach for primary liver tumors may have advantages in patients who require repeat hepatectomies for recurrent liver tumors, this has not been sufficiently investigated. Methods: Patients who underwent repeat hepatectomies for recurrent liver tumors at our hospital between 2010 and 2022 were retrospectively analyzed. Of 127 patients, 76 underwent laparoscopic repeat hepatectomy (LRH), of whom 34 patients initially underwent laparoscopic hepatectomy (L-LRH) and 42, open hepatectomy (O-LRH). Fifty-one patients underwent open hepatectomy as both the initial and second operation (O-ORH). We analyzed surgical outcomes between L-LRH and O-LRH groups and between L-LRH and O-ORH groups using propensity-matching analysis for each pattern. Results: Twenty-one patients each were included in L-LRH and O-LRH propensity-matched cohorts. The L-LRH group had a lower rate of postoperative complications than the O-LRH group (0 vs 19%, P = 0.036). When we compared surgical outcomes between L-LRH and O-ORH groups in another matched cohort with 18 patients in each group, in addition to the lower rate of postoperative complications, the L-LRH group had additional favorable surgical outcomes including shorter operation time and lower blood loss volume than the O-ORH group (291 vs 368 min, P = 0.037 and 10 vs 485 mL, P < 0.0001). Conclusions: An initial laparoscopic approach would be favorable for patients undergoing repeat hepatectomies, as it leads to lower risk of postoperative complications. Compared with O-ORH, the advantage of the laparoscopic approach may be enhanced when it is repeatedly adopted. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Suitability of Laparoscopic Liver Resection of Segment VII: a Retrospective Two-Center Study.
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Gon, Hidetoshi, Yamane, Hisoka, Yoshida, Toshihiko, Kido, Masahiro, Tanaka, Motofumi, Kuramitsu, Kaori, Komatsu, Shohei, Fukushima, Kenji, Urade, Takeshi, So, Shinichi, Nanno, Yoshihide, Tsugawa, Daisuke, Goto, Tadahiro, Yanagimoto, Hiroaki, Toyama, Hirochika, and Fukumoto, Takumi
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Background: Resecting liver tumors located in Couinaud's segment VII is challenging; the efficacy and safety of laparoscopic liver resection for segment VII lesions compared to open liver resection remain unclear. Methods: Medical records of 84 patients who underwent liver resection of segment VII at Kobe University Hospital and Hyogo Cancer Center between 2010 and 2021 were retrospectively analyzed. Surgical outcomes were compared between laparoscopic liver resection and open liver resection groups using propensity matching analysis. Results: Thirty-one and 53 patients underwent laparoscopic liver resection and open liver resection, respectively. After propensity matching, 29 patients were included in each group. The laparoscopic liver resection group had a significantly longer operation time (407 vs. 305 min, P = 0.002), lower blood loss (100 vs. 230 mL, P = 0.004), and higher postoperative alanine aminotransferase levels (436 vs. 252 IU/L, P = 0.008) than the open liver resection group. In patients with liver cirrhosis, the proportion of patients with postoperative liver-specific complications was higher in the laparoscopic liver resection group than in the open liver resection group (57% vs 11%, P = 0.049), although there was no significant difference in postoperative liver-specific complication rates between the groups in patients without liver cirrhosis. Conclusions: For liver resection of segment VII, laparoscopic liver resection led to higher postoperative liver damage than open liver resection. Open liver resection may be better for patients with liver cirrhosis to avoid postoperative liver-specific complications. Laparoscopic liver resection could be an acceptable procedure for patients without liver cirrhosis, with some merits such as less blood loss. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Impact of Hepatectomy for Advanced Hepatocellular Carcinoma with Major Portal Vein Tumor Thrombus.
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Komatsu, Shohei, Kido, Masahiro, Kuramitsu, Kaori, Tsugawa, Daisuke, Gon, Hidetoshi, Fukushima, Kenji, Urade, Takeshi, Yanagimoto, Hiroaki, Toyama, Hirochika, and Fukumoto, Takumi
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Background: Optimal treatment strategies for advanced hepatocellular carcinoma (HCC) with macroscopic portal vein tumor thrombus (PVTT) remain controversial. Therefore, this study aimed to assess the impact and predictive factors of hepatectomy for HCC with macroscopic PVTT. Methods: This study included 100 patients who presented with intraoperatively confirmed PVTT extending to the first portal branch (Vp3), main portal trunk, or opposite-side portal branch (Vp4) between June 2000 and December 2019. Their postoperative outcomes and predictive factors for survival were evaluated. Results: Of the 100 patients, 37 (37%) and 63 (63%) had Vp3 and Vp4 PVTTs, respectively. Moreover, 42 (42%) and 58 (58%) patients underwent R0/1 and R2 hepatectomies, respectively. The median survival time (MST) of all patients with Vp3/4 PVTT was 14.5 months; the 1- and 3-year overall survival rates were 59.6 and 16.8%, respectively. The MSTs of patients with Vp3 and Vp4 PVTTs were 16.1 and 14.3 months, respectively (P = 0.7098). The MSTs of patients who underwent R0/1 and R2 hepatectomies were 14.3 and 14.9 months, respectively (P = 0.3831). All assessed tumor factors (including the Vp status [Vp3 or Vp4], type of resection [R0/1 or R2], intrahepatic maximal tumor size, intrahepatic tumor number, and the existence of extrahepatic metastasis) did not influence the overall survival significantly. Conclusions: Tumor factors, such as the presence of a Vp3/4 PVTT, have a strong impact on survival; however, other multiple tumor factors have a limited impact. Hepatectomy can be an effective treatment option for HCC with Vp3/4 PVTT, and its indications should be considered. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Assessment of lenvatinib treatment for unresectable hepatocellular carcinoma with liver cirrhosis.
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Komatsu, Shohei, Yano, Yoshihiko, Sofue, Keitaro, Kido, Masahiro, Tanaka, Motofumi, Kuramitsu, Kaori, Awazu, Masahide, Gon, Hidetoshi, Yamamoto, Atsushi, Yanagimoto, Hiroaki, Toyama, Hirochika, Kodama, Yuzo, Murakami, Takamichi, and Fukumoto, Takumi
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CIRRHOSIS of the liver , *PREVENTIVE medicine , *LIVER - Abstract
The present study aimed to assess the clinical features of patients who received lenvatinib treatment for unresectable hepatocellular carcinoma (HCC). The clinical characteristics, adverse events, and radiological responses were evaluated for 51 consecutive patients. Of the study subjects, 37 patients had Child–Pugh class A (CPA) liver function, and 14 patients had Child–Pugh class B (CPB) liver function. The overall response rates in the CPA and CPB groups were 42.9% and 25.0%, respectively, and disease control rates were 82.9% and 83.3%, respectively, without significant difference (p = 0.2621 and 0.9697). There was no significant difference between CPA and CPB groups regarding the incidence of adverse events, except for hepatic coma. No significant difference was observed in the relative dose intensity between the CPA and CPB groups, for the first month, 1–2 months, or 2–3 months (p = 0.2368, 0.9368, and 0.9293). The comparable outcomes between the CPA and CPB groups suggest the acceptability of lenvatinib treatment in patients with impaired liver function, at least in the acute phase. With careful follow-up, the dose can be relatively intensified, even in patients with impaired liver function and this may contribute to offering comparable treatment. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Space-making particle therapy for sarcomas derived from the abdominopelvic region.
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Komatsu, Shohei, Demizu, Yusuke, Sulaiman, Nor Shazrina, Terashima, Kazuki, Suga, Masaki, Kido, Masahiro, Toyama, Hirochika, Tokumaru, Sunao, Okimoto, Tomoaki, Sasaki, Ryohei, and Fukumoto, Takumi
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SARCOMA , *GASTROINTESTINAL tumors , *PARTICLES , *GASTROINTESTINAL system - Abstract
• Space-making particle therapy provides a rational combination treatment. • Effectiveness of space-making particle therapy has been demonstrated. The primary definitive treatment for abdominopelvic sarcomas (APSs) is resection, although incomplete resection has a negative prognostic impact. Although the effectiveness of particle therapy (PT) as a treatment for APS has already been demonstrated, its application for tumors adjacent to the gastrointestinal tract is frequently restricted, due to extremely low tolerance. Space-making PT, consisting of surgical spacer placement and subsequent PT, has been developed to overcome this limitation. Between June 2006 and June 2018, a total of 75 patients with 12 types of APS underwent space-making PT. The 3-year local control rate of all patients was 90.3%. Fourteen surgery-related complications were observed in 12 patients (16%), and complications of Grade 3b or higher were observed in 3 patients. Ninety-five PT-related complications were seen in 66 patients (88.0%), and 13 patients (17.3%) had complications of Grade 3 or higher. The median V95% (volume irradiated with 95% of the treatment planning dose) of the gross tumor volume and clinical target volume were 99.9% and 99.5%, respectively. The median D95% (dose intensity covering 95% of the target volume) of the gross tumor volume/planned dose and clinical target volume/planned dose were 99.4%, and 99.1%, respectively. The feasibility and effectiveness of space-making PT have been demonstrated via dosimetric evaluation, and our results indicate that this new strategy may potentially provide an effective and innovative treatment option for advanced APS. [ABSTRACT FROM AUTHOR]
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- 2020
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9. Space-Making Particle Therapy with Surgical Spacer Placement in Patients with Sacral Chordoma.
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Tsugawa, Daisuke, Komatsu, Shohei, Demizu, Yusuke, Sulaiman, Nor Shazrina, Suga, Masaki, Kido, Masahiro, Toyama, Hirochika, Okimoto, Tomoaki, Sasaki, Ryohei, and Fukumoto, Takumi
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CHORDOMA , *BONE cancer , *PARTICLES , *PROGRESSION-free survival , *CANCER , *GASTROINTESTINAL system , *GERM cell tumors , *BONE tumors , *TREATMENT effectiveness , *SACRUM , *RADIATION injuries , *RADIOTHERAPY - Abstract
Background: Sacral chordomas are rare malignant bone tumors and are often very large for complete resection. Particle therapy for these tumors, which are adjacent to the gastrointestinal tract, is restricted because the tolerance dose of the intestine is low. This study aimed to demonstrate the technical aspects and treatment results of space-making particle therapy with surgical spacer placement for sacral chordoma. We aimed to investigate the dosimetric change in the particle therapy before and after spacer placement and the safety, efficacy, and long-term outcomes of space-making particle therapy.Study Design: Twenty-one patients with sacral chordomas who were excluded from typical particle therapy were enrolled between 2007 and 2015. Gore-Tex sheets (WL Gore & Assoc) were folded and placed between the sacral and rectum. Particle therapy with 70.4 Gy (relative biologic effectiveness) was then performed.Results: The mean volume that allows 95% of the treatment plan dose of the gross tumor volume and clinical tumor volume after spacer placement was improved to 97.7% and 96.4% from preoperative values of 91.0% and 89.5%, respectively. The recurrence rate within the gross tumor volume was only 4.8%. The 4-year local progression-free survival rate was 68.4%. The 5-year overall survival rate was 100% and the adverse events were acceptable.Conclusions: Considering improvements in the dose-volume histogram after spacer placement, low recurrence rates within the gross tumor volume, good survival rates, and low incidences of side effects, treatment of sacral chordoma with space-making particle therapy shows promise. [ABSTRACT FROM AUTHOR]- Published
- 2020
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10. Growth velocity of the portal vein tumor thrombus accelerated by its progression, alpha-fetoprotein level, and liver fibrosis stage in patients with hepatocellular carcinoma.
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Gon, Hidetoshi, Kido, Masahiro, Tanaka, Motofumi, Kinoshita, Hisoka, Komatsu, Shohei, Tsugawa, Daisuke, Awazu, Masahide, Toyama, Hirochika, Matsumoto, Ippei, Itoh, Tomoo, and Fukumoto, Takumi
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Background Progression of portal vein tumor thrombus directly affects the prognosis and treatment for patients with hepatocellular carcinoma; there are no data on the growth velocity of portal vein tumor thrombus. We analyzed the growth velocity of portal vein tumor thrombus and its risk factors to propose the best timing of surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus. Methods We retrospectively collected data on 57 hepatocellular carcinoma patients with portal vein tumor thrombus who underwent computed tomography twice preoperatively and hepatectomy between 2005 and 2015. To calculate the growth velocity of portal vein tumor thrombus, migration lengths of portal vein tumor thrombus were divided by the number of days. To identify risk factors for rapid growth of portal vein tumor thrombus, patients were classified according to the velocity: rapid (≥ 1.0 mm/day, n = 23) and slow (< 1.0 mm/day, n = 34). Results Median survival times of patients with portal vein tumor thrombus that invaded the ipsilateral second portal branch, ipsilateral first portal branch, and portal trunk were 42.9, 11.7, and 12.3 months, respectively. The average growth velocity of portal vein tumor thrombus was 0.9 ± 1.0 mm/day. Median estimated times required from ipsilateral second portal branch to ipsilateral first portal branch and ipsilateral first portal branch to portal trunk were 8.2 and 11.5 days, respectively. Liver fibrosis, alpha-fetoprotein, and extent of portal vein tumor thrombus were independent risk factors for rapid progression of portal vein tumor thrombus. Proteins induced by vitamin K absence or antagonist II, extent of portal vein tumor thrombus, and liver fibrosis, not rapid growth of portal vein tumor thrombus, were independent prognostic factors. Conclusion An understanding of the rapid progression of portal vein tumor thrombus and its risk factors can be helpful in deciding an appropriate timing of surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus. [ABSTRACT FROM AUTHOR]
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- 2018
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11. Particle radiotherapy, a novel external radiation therapy, versus liver resection for hepatocellular carcinoma accompanied with inferior vena cava tumor thrombus: A matched-pair analysis.
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Komatsu, Shohei, Kido, Masahiro, Asari, Sadaki, Toyama, Hirochika, Ajiki, Tetsuo, Demizu, Yusuke, Terashima, Kazuki, Okimoto, Tomoaki, Sasaki, Ryohei, and Fukumoto, Takumi
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Background Hepatocellular carcinoma accompanied with inferior vena cava tumor thrombus carries a dismal prognosis, and the feasibility of local treatment has remained controversial. The present study aimed to compare the outcomes of particle radiotherapy and liver resection in patients with hepatocellular carcinoma with inferior vena cava tumor thrombus. Methods Thirty-one and 19 patients, respectively, underwent particle radiotherapy and liver resection for hepatocellular carcinoma with inferior vena cava tumor thrombus. A matched-pair analysis was undertaken to compare the short- and long-term outcomes according to tumor stage determined using the tumor-node-metastasis classification. Results Both stages IIIB and IV (IVA and IVB) patients were well-matched for 12 factors, including treatment policy and patient and tumor characteristics. The median survival time of matched patients with stage IIIB tumors in the particle radiotherapy group was greater than that in the liver resection group (748 vs 272 days, P = .029), whereas no significant difference was observed in the median survival times of patients with stage IV tumors (239 vs 311 days, respectively). There were significantly fewer treatment-related complications of grade 3 or greater in the particle radiotherapy group (0%) than in the liver resection group (26%). Conclusion Particle radiotherapy is potentially preferable in hepatocellular carcinoma patients with stage IIIB inferior vena cava tumor thrombus and at least equal in efficiency to liver resection in those with stage IV disease, while causing significantly fewer complications. Considering the relatively high survival and low invasiveness of particle radiotherapy when compared to liver resection, this approach may represent a novel treatment modality for hepatocellular carcinoma with inferior vena cava tumor thrombus. [ABSTRACT FROM AUTHOR]
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- 2017
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12. Impact of GLIM criteria-based malnutrition diagnosis on outcomes following liver resection for hepatocellular carcinoma.
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Omiya, Satoshi, Urade, Takeshi, Komatsu, Shohei, Kido, Masahiro, Kuramitsu, Kaori, Yanagimoto, Hiroaki, Toyama, Hirochika, and Fukumoto, Takumi
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PROPORTIONAL hazards models , *MALNUTRITION - Abstract
The Global Leadership Initiative on Malnutrition (GLIM), comprising several of the major global clinical nutrition societies, suggested the world's first criteria for diagnosis of the severity of malnutrition. However, the impact of the resulting diagnosis on patient outcomes for those with hepatocellular carcinoma (HCC) following liver resection (LR) has not been investigated. A retrospective analysis of 293 patients with HCC who underwent LR between January 2011 and December 2018 was performed. We compared overall survival (OS) and recurrence-free survival (RFS) and evaluated prognostic factors after LR using Cox proportional hazards regression models. Preoperative patient nutritional status, n (%), was classified as follows: normal, 130 (44%), moderate malnutrition, 116 (40%), and severe malnutrition, 47 (16%). The median OS (129 vs. 43 months, p < 0.001) and median RFS (54 vs. 20 months, p = 0.001) were significantly greater in the normal group than in the severe malnutrition group. Multivariate analysis showed that severe malnutrition was a significant risk factor for OS (p = 0.006) and RFS (p = 0.010) after initial LR. Severe malnutrition, as diagnosed by the GLIM criteria, is a significant prognostic factor for survival and recurrence in patients with HCC after LR. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2023
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13. Development Process and Technical Aspects of Laparoscopic Hepatectomy: Learning Curve Based on 15 Years of Experience.
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Komatsu, Shohei, Scatton, Olivier, Goumard, Claire, Sepulveda, Ailton, Brustia, Raffaele, Perdigao, Fabiano, and Soubrane, Olivier
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HEPATECTOMY , *LAPAROSCOPIC surgery , *LIVER cancer , *LEARNING curve , *LONGITUDINAL method , *HEPATOCELLULAR carcinoma , *LAPAROSCOPY , *LEARNING , *LIVER tumors , *TREATMENT effectiveness , *RETROSPECTIVE studies - Abstract
Background: Laparoscopic hepatectomy continues to be a challenging operation associated with a steep learning curve. This study aimed to evaluate the learning process during 15 years of experience with laparoscopic hepatectomy and to identify approaches to standardization of this procedure.Study Design: Prospectively collected data of 317 consecutive laparoscopic hepatectomies performed from January 2000 to December 2014 were reviewed retrospectively. The operative procedures were classified into 4 categories (minor hepatectomy, left lateral sectionectomy [LLS], left hepatectomy, and right hepatectomy), and indications were classified into 5 categories (benign-borderline tumor, living donor, metastatic liver tumor, biliary malignancy, and hepatocellular carcinoma).Results: During the first 10 years, the procedures were limited mainly to minor hepatectomy and LLS, and the indications were limited to benign-borderline tumor and living donor. Implementation of major hepatectomy rapidly increased the proportion of malignant tumors, especially hepatocellular carcinoma, starting from 2011. Conversion rates decreased with experience for LLS (13.3% vs 3.4%; p = 0.054) and left hepatectomy (50.0% vs 15.0%; p = 0.012), but not for right hepatectomy (41.4% vs 35.7%; p = 0.661).Conclusions: Our 15-year experience clearly demonstrates the stepwise procedural evolution from LLS through left hepatectomy to right hepatectomy, as well as the trend in indications from benign-borderline tumor/living donor to malignant tumors. In contrast to LLS and left hepatectomy, a learning curve was not observed for right hepatectomy. The ongoing development process can contribute to faster standardization necessary for future advances in laparoscopic hepatectomy. [ABSTRACT FROM AUTHOR]- Published
- 2017
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14. Recurrent hepatocellular carcinoma: A Western strategy that emphasizes the impact of pathologic profile of the first resection.
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Meniconi, Roberto L., Komatsu, Shohei, Perdigao, Fabiano, Boëlle, Pierre-Yves, Soubrane, Olivier, and Scatton, Olivier
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Background Hepatocellular carcinoma (HCC) often recurs after curative resection, and thus the optimal treatment strategy to treat recurrences remains uncertain. We analyzed the results of different options to treat recurrent HCC and emphasized the impact of pathologic patterns of the tumor at initial resection. Methods Between 2000 and 2014, 293 patients underwent potentially curative hepatic resection for HCC. Among them, 150 experienced a recurrence and have been treated by repeat resection (RR), radiofrequency ablation (RFA), salvage liver transplantation (SLT), transarterial chemoembolization (TACE), or conservative treatment, including systemic or targeted chemotherapy. Clinical outcomes were analyzed and compared between the treatment groups, focusing on clinical and pathologic characteristics of the tumor at initial resection. Results After a median follow-up of 26 months, the overall survival (OS) at 1, 3, and 5 years after recurrence was 62%, 48%, and 40%, respectively. Survival rates were greater in patients treated by a curative approach (RR, RFA, SLT) than those treated by TACE, with 5-year OS of >70% and 37%, respectively. Univariate analysis showed satellitosis and microvascular invasion (MVI) at initial resection as negative prognostic factors of survival after recurrence ( P < .05). On multivariate analysis, type of treatment was the only independent factor associated with survival. A subgroup analysis showed that RR/RFA led to better survival outcomes than TACE for early stage intrahepatic recurrences in the absence of satellitosis or MVI on the primary resected tumor. Conclusion Curative treatments of recurrent HCC improve patient survival. Satellitosis and MVI on the primary resected specimen may be used as selection criteria for the best treatment strategy for intrahepatic recurrences. [ABSTRACT FROM AUTHOR]
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- 2015
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15. Standardization of the Side-to-Side Cavo-Caval Anastomosis in Orthotopic Liver Transplantation Based on the Causal Analysis of Outflow Obstruction.
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Kuramitsu, Kaori, Kido, Masahiro, Komatsu, Shohei, Tsugawa, Daisuke, Gon, Hidetoshi, Fukushima, Kenji, Urade, Takeshi, So, Shinichi, Mizumoto, Takuya, Nanno, Yoshihide, Yamashita, Hironori, Goto, Tadahiro, Yanagimoto, Hiroaki, Asari, Sadaki, Ajiki, Tetsuo, Toyama, Hirochika, and Fukumoto, Takumi
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BUDD-Chiari syndrome , *LIVER transplantation , *VENA cava inferior , *HEPATIC veins , *STANDARDIZATION - Abstract
Although liver transplantation is widely accepted as the therapeutic strategy for end-stage liver failure, complication of hepatic venous outflow obstruction remains lethal. Currently, ensuring a single wide orifice in both the graft and recipient inferior vena cava has been proposed to avoid hepatic venous outflow obstruction with no theoretical concept. We herein report a standardization technique for the reconstruction of the hepatic vein based on the causal analysis. During the put-in process, the graft must be positioned in contact with the recipient diaphragm and slightly pushed to the cranial direction to simulate the state after abdominal closure. Because there is no extra space between the graft and diaphragm, the graft could not rotate about the anastomotic site of the inferior vena cava toward the diaphragm after abdominal closure as the intestinal pressure increases, and accordingly hepatic venous outflow obstruction does not develop. With this concept, all transplant surgeons can successfully and easily perform hepatic vein reconstruction without total clamping of the inferior vena cava and without outflow block. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Indication of Liver Transplantation in the Treatment of Newly Categorized Acute-on-Chronic Liver Failure In Japan.
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Kuramitsu, Kaori, Yano, Yoshihiko, Komatsu, Shohei, Tanaka, Motofumi, Kido, Masahiro, and Fukumoto, Takumi
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LIVER failure , *LIVER transplantation , *SURVIVAL rate , *TRANSPLANTATION of organs, tissues, etc. , *PROTHROMBIN time , *UNIVARIATE analysis - Abstract
This study aims to validate Japanese diagnostic criteria for acute-on-chronic liver failure (ACLF) and confirm the feasibility of performing transplantation. We included 60 patients with acute liver injury. Demographic and clinical features were retrospectively collected, and the primary outcome was compared among 4 types: acute liver failure (ALF) with hepatic coma (n = 23), ALF without hepatic coma (n = 12), acute liver injury (n = 20), and ACLF (n = 5). Moreover, 80 transplanted patients were enrolled to compare the difficulty of transplantation between ALF (n = 8) vs non-ALF (n = 72) patients. Seven patients in the ALF with hepatic coma group and 1 patient in the ACLF with hepatic coma group were transplanted. Ten patients who could not be registered for transplantation died. In univariate analysis, liver failure type (P <.0001), total bilirubin level (P =.05), and prothrombin time internationalized ratio (P <.0001) were associated with patient survival. In multivariate analysis, liver failure type was associated with patient survival (P <.0001). The respective 1-, 3-, and 5-year patient survival rates were 45.9%, 45.9%, and 45.9% for ALF patients with hepatic coma; 100.0%, 100.0%, and 100.0% for ALF patients without hepatic coma and acute liver injury; and 80.0%, 80.0%, and 80.0% for ACLF patients (P <.0001). Chronic liver disease did not affect operation time (P =.46) and bleeding volume (P =.49). Patients diagnosed with ACLF via Japanese criteria presented significantly higher survival rates than ALF patients with hepatic coma. [ABSTRACT FROM AUTHOR]
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- 2021
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17. Factors Predicting Over-Time Weight Increase After Liver Transplantation: A Retrospective Study.
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Shimura, Yuhi, Kuramitsu, Kaori, Kido, Masahiro, Komatsu, Shohei, Gon, Hidetoshi, Fukushima, Kenji, Urade, Takeshi, So, Shinichi, Yoshida, Toshihiko, Arai, Keisuke, Tsugawa, Daisuke, Goto, Tadahiro, Asari, Sadaki, Yanagimoto, Hiroaki, Toyama, Hirochika, Ajiki, Tetsuo, and Fukumoto, Takumi
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LIVER transplantation , *WEIGHT gain , *BODY mass index , *OVERTIME , *BODY weight , *KIDNEY transplantation - Abstract
• Post-transplant weight control is an important factor affecting long-term outcomes. • Younger patients and those with a body mass index <25 were at risk of post-transplant weight gain. • Education on post-transplant weight control is necessary for good outcomes. • This is important for improving long-term prognosis after liver transplantation. Post-transplantation weight control is important for long-term outcomes; however, few reports have examined postoperative weight change. This study aimed to identify perioperative factors contributing to post-transplantation weight change. Twenty-nine patients who underwent liver transplantation between 2015 and 2019 with an overall survival of >3 years were analyzed. The median age, model for end-stage liver disease score, and preoperative body mass index (BMI) of the recipients were 57, 25, and 23.7, respectively. Although all but one recipient lost weight, the percentage of recipients who gained weight increased to 55% (1 month), 72% (6 months), and 83% (12 months). Among perioperative factors, recipient age ≤50 years and BMI ≤25 were identified as risk factors for weight gain within 12 months (P <.05), and patients with age ≤50 years or BMI ≤25 recipients gained weight more rapidly (P <.05). The recovery time of serum albumin level ≥4.0 mg/dL was not statistically different between the 2 groups. The weight change during the first 3 years after discharge was represented by an approximately straight line, with 18 and 11 recipients showing a positive and negative slope, respectively. Body mass index ≤23 was identified as a risk factor for a positive slope of weight gain (P <.05). Although postoperative weight gain implies recovery after transplantation, recipients with a lower preoperative BMI should strictly manage body weight as they may be at higher risk of rapid weight increase. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2023
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18. Assessment of serum and drain fluid bilirubin concentrations in liver transplantation patients.
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Soyama, Hirotoshi, Kuramitsu, Kaori, Kido, Masahiro, Komatsu, Shohei, Gon, Hidetoshi, Fukushima, Kenji, Urade, Takeshi, So, Shinichi, Nanno, Yoshihide, Tsugawa, Daisuke, Goto, Tadahiro, Yanagimoto, Hiroaki, Asari, Sadaki, Toyama, Hirochika, Ajiki, Tetsuo, and Fukumoto, Takumi
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LIVER transplantation , *BILIRUBIN , *LIVER surgery , *UNIVERSITY hospitals , *KIDNEY transplantation - Abstract
Bile leakage is a major complication after liver transplantation and remains as a significant source of morbidity and mortality. In 2011, the International Study Group of Liver Surgery (ISGLS) defined bile leakage as a drain/serum bilirubin ratio ≥3. However, to our knowledge there is no literature assessing serum and drain bilirubin concentrations after liver transplantation. The aim of this study was to describe the natural postoperative changes in serum and drain fluid bilirubin concentrations in patients after liver transplantation. We included 32 patients who underwent liver transplantation at Kobe University Hospital from January 2007 to December 2020. We enrolled 34 living donors who had no complications as the control group. The recipient serum total/direct bilirubin concentration were higher compared with the donors from postoperative day (POD) 1 to 5 with a statistical difference (P <.05). The recipient drain/serum total bilirubin ratio was lower than donors on POD 3 (0.89 ± 0.07 vs 1.53 ± 0.07: P <.0001), which was also confirmed by the recipient drain/serum direct bilirubin ratio (0.64 ± 0.10 vs 1.18 ± 0.09: P <.0001). On POD 3, the drain fluid volume (647.38 ± 89.47 vs 113.43 ± 86.8 mL: P <.001) and serum total bilirubin concentration (6.73 ± 0.61 vs 1.23 ± 0.60 mg/dL: P <.001) was higher in the recipients than in donors. Categorized in 2 groups, the higher drain fluid volume and bilirubin concentration recipients showed lower drain/serum total bilirubin ratio compared with the other group (P =.03) The drain/serum bilirubin ratio in the transplanted patients could be calculated lower compared with the hepatectomy patients because of high drain fluid volume and hyperbilirubinemia. Great care should be taken when assessing the bile leakage in liver transplant recipients using the ISGLS definition. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Prediction of post-hepatectomy liver failure using gadoxetic acid-enhanced magnetic resonance imaging for hepatocellular carcinoma with portal vein invasion.
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Tsujita, Yushi, Sofue, Keitaro, Komatsu, Shohei, Yamaguchi, Takeru, Ueshima, Eisuke, Ueno, Yoshiko, Kanda, Tomonori, Okada, Takuya, Nogami, Munenobu, Yamaguchi, Masato, Tsurusaki, Masakatsu, Hori, Masatoshi, Fukumoto, Takumi, and Murakami, Takamichi
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MAGNETIC resonance imaging , *PORTAL vein , *LIVER failure , *HEPATOCELLULAR carcinoma , *FORECASTING , *LIVER function tests , *LIVER tumors , *MULTIVARIATE analysis , *CANCER invasiveness , *SURGICAL complications , *CONTRAST media , *RETROSPECTIVE studies , *LOGISTIC regression analysis , *RECEIVER operating characteristic curves , *HEPATECTOMY - Abstract
Purpose: Accurate prediction of post-hepatectomy liver failure (PHLF) is important in advanced hepatocellular carcinoma (HCC). We aimed to retrospectively evaluate the utility of gadoxetic acid-enhanced MRI for predicting PHLF in patients who underwent anatomic hepatectomy for HCC with portal vein invasion.Methods: Forty-one patients (32 men, 9 women) were included. Hepatobiliary-phase MR images were acquired 20 min after injection of gadoxetic acid using a 3D fat-suppressed T1-weighted spoiled gradient-echo sequence. Liver-spleen ratio (LSR), remnant hepatocellular uptake index (rHUI), and HUI were calculated. The severity of PHLF was defined according to the International Study Group of Liver Surgery. Differences in LSR between the resected liver and the remnant liver, and HUI and rHUI/HUI between no/mild and severe PHLF were compared using the Wilcoxon signed-rank test and Wilcoxon rank-sum test, respectively. Univariate and multivariate logistic regression analyses were performed to identify predictors of severe PHLF. Areas under the receiver operating characteristic curves (AUCs) of rHUI and rHUI/HUI were calculated for predicting severe PHLF.Results: Nine patients developed severe PHLF. LSR of the remnant liver was significantly higher than that of the resected liver (P < 0.001). Severe PHLF demonstrated significantly lower rHUI (P < 0.001) and rHUI/HUI (P < 0.001) compared with no/mild PHLF. Multivariate logistic regression analysis showed that decreased rHUI (P = 0.012, AUC=0.885) and rHUI/HUI (P = 0.002, AUC=0.852) were independent predictors of severe PHLF.Conclusion: Gadoxetic acid-enhanced MRI can be a promising noninvasive examination for assessing global and regional liver function, allowing estimation of the functional liver remnant and accurate prediction of severe PHLF before hepatic resection. [ABSTRACT FROM AUTHOR]- Published
- 2020
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20. Impact of Albumin-Bilirubin Score on Short- and Long-Term Survival After Living-Donor Liver Transplantation: A Retrospective Study.
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Tai, Kentaro, Kuramitsu, Kaori, Kido, Masahiro, Tanaka, Motofumi, Komatsu, Shohei, Awazu, Masahide, Gon, Hidetoshi, So, Shinichi, Tsugawa, Daisuke, Mukubo, Hideyo, Terai, Sachio, Yanagimoto, Hiroaki, Toyama, Hirochika, Ajiki, Tetsuo, and Fukumoto, Takumi
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LIVER transplantation , *HEPATOCELLULAR carcinoma , *UNIVARIATE analysis , *RETROSPECTIVE studies , *MULTIVARIATE analysis , *HEPATORENAL syndrome - Abstract
The albumin-bilirubin (ALBI) grade, stratified from the ALBI score, may have prognostic value in patients with hepatocellular carcinoma. We aim to evaluate the prognostic abilities of the ALBI score/grade among living-donor liver transplantation patients. We retrospectively collected data of 81 patients who underwent living-donor liver transplant at Kobe University Hospital between June 2000 and October 2018. The efficacy of the ALBI score/grade as a prognostic factor was assessed and compared with that of the well-established Model for End-Stage Liver Disease (MELD) score. Multivariate analysis indicated that recipient age (P =.003), donor age (P =.003), ALBI score ≥ −1.28 (P =.002), and ALBI grade III (P =.004) were independently associated with post-transplant survival. A high MELD score was not associated with post-transplant survival in univariate or multivariate analyses. Although there was no significant difference in the overall survival rate relative to recipient and donor age, ALBI score/grade was significantly associated with the 1- and 5-year survival rates (P =.023, P =.005). ALBI scores specifically detected fatal complications of post-transplant graft dysfunction (P =.031) and infection (P =.020). ALBI score/grade predicted patient survival more precisely than the MELD score did, suggesting that it is a more useful prognostic factor compared to the MELD score in living-donor liver transplantation cases. • An albumin-bilirubin score predicts recipient survival after living-donor transplantation. • An albumin-bilirubin score is more useful than Model for End-Stage Liver Disease score. • An albumin-bilirubin score of ≥ −1.28 is independently associated with worth survival. • A high albumin-bilirubin score predicts an incidence of infection and graft dysfunction. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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