ISSUE: Opportunities for improvement exist for the prevention of surgical site infections (SSIs) in patients undergoing total hip (THA) and total knee arthroplasty (TKA) in the National Health Service (NHS) of the United Kingdom (UK). PROJECT: In 2000, Hospital for Special Surgery (HSS), a 160-bed specialty center for musculoskeletal diseases located in New York City (NYC), partnered with four NHS trusts in Southwest London that were in the process of constructing an elective orthopedic facility, known as SWLEOC. Infection control was one of the outcome measurements selected for implementation as part of this best practice knowledge transfer project. Physical rehabilitation, preoperative patient education, and leadership were also selected. Infection control was integrated into this project at all levels, including facility design and construction, protocol development, and staff education. Numerous site visits, consultations, and education sessions were conducted in the United States at HSS and in London at SWLEOC during a 12-month period. RESULTS: The new orthopedic center opened in January 2004, as a 50-bed elective orthopedic center performing predominantly hip and knee surgery. As per data reported by the center, 1128 patients underwent surgery from April through November 2004. The center has reported an infection rate of 0.33%. All patients are followed 4 weeks post discharge as part of the National Surgical Site Surveillance (UK). All patients are swabbed for MRSA at pre-assessment. No cases of hospital-acquired MRSA have occurred to date. LESSONS LEARNED: Knowledge and understanding of the receiving facility''s culture and system are necessary for a successful transfer of knowledge to occur. It was essential for the NYC team to become familiar with UK/NHS patient care practices, occupational health standards, and environmental and construction protocols. Infection control data collection and reporting systems in the United Kingdom are evolving; retrieval of post-discharge information is critical for accurate outcome measurement. Infection control impacts all aspects of the orthopedic center, from operational flow to patient outcomes; therefore it was an essential component of this project. [Copyright &y& Elsevier]