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Start Over Author "Kuipers H" Publisher elsevier b.v.
33 results on '"Kuipers H"'

1. Value of routine intraoperative frozen sections of proximal bile duct margins in perihilar cholangiocarcinoma, a retrospective multicenter and matched case-control study.

Author

Nooijen, L.E., Franken, L.C., de Boer, M.T., Buttner, S., van Dieren, S., Koerkamp, B. Groot, Hoogwater, F.J.H., Kazemier, G., Klümpen, H.J., Kuipers, H., Olthof, P.B., Swijnenburg, R.J., Verheij, J., Zonderhuis, B.M., van Gulik, T.M., and Erdmann, J.I.

Subjects
BILE ducts, CHOLANGIOCARCINOMA, CASE-control method, SURGICAL margin, OVERALL survival
Abstract

Currently, the potential benefits of additional resection after positive proximal intraoperative frozen sections (IFS) in perihilar cholangiocarcinoma (pCCA) on residual disease and oncological outcome remain uncertain. Therefore, the aim of this study is to investigate the number of R0 resections after additional resection of a positive proximal IFS and the influence of additional resections on overall survival (OS) in patients with pCCA. A retrospective, multicenter, matched case-control study was performed, including patients undergoing resection for pCCA between 2000 and 2019 at three tertiary centers. Primary outcome was the number of achieved 'additional' R0 resections. Secondary outcomes were OS, recurrence, severe morbidity and mortality. Forty-four out of 328 patients undergoing resection for pCCA had a positive proximal IFS. An additional resection was performed in 35 out of 44 (79.5%) patients, which was negative in 24 (68.6%) patients. Nevertheless, seven out of these 24 patients were eventually classified as R1 resection due to other positive resection margins. Therefore, 17 (48.6%) patients could be classified as "true" R0 resection after additional resection. Ninety-day mortality after R1 resections was high (25%) and strongly influenced OS. After correction for 90-day mortality, median OS after negative additional resection was 33 months (95%CI:29.5–36.5) compared to 30 months (95%CI:24.4–35.6) after initial R1 (P = 0.875) and 46 months (95%CI:32.7–59.3) after initial R0 (P = 0.348). There were only 17 patients (out of a total of 328 patients) that potentially benefitted from routine IFS. Additional resection for a positive IFS leading to R0 resection was not associated with improved long-term survival. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma: Is Neo-Adjuvant Chemo-Radiation Therapy Really Necessary? An International, Multicenter Comparison.

Author

Hoogwater, F.J., Kuipers, H., de Meijer, V.E., Maulat, C., Muscari, F., Polak, W.G., van Hoek, B., Jézéquel, C., Alwayn, I.P., IJzermans, J.N., Mohkam, K., Mabrut, J.-Y., van Vilsteren, F.G., Adam, J.-P., Chiche, L., Chebaro, A., Boleslawski, E., Dubbeld, J., Darwish Murad, S., and Rayar, M.

Subjects
*LIVER transplantation, *CHEMORADIOTHERAPY, *CHOLANGIOCARCINOMA
Published
2022
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4. Insulin resistance, physical fitness, body composition and leptin concentration in 7-8 year-old children.

Author

Slinger JD, van Breda E, Keizer H, Rump P, Hornstra G, Kuipers H, Slinger, Jantine D, van Breda, Eric, Keizer, Hans, Rump, Patrick, Hornstra, Gerard, and Kuipers, Harm

Abstract

The aim of this study was to investigate the association between insulin resistance and physical fitness, leptin concentration, body composition and family history for diabetes in non-selected young children. Physical fitness, fasting plasma glucose, insulin and leptin concentrations, anthropometric characteristics and medical history were available in two hundred and fifty-seven 7-year-old Dutch children. Correlations with the homeostasis model assessment (HOMA) index for insulin resistance were studied. A multiple regression model was calculated for HOMA. The differences between children with or without a family history for diabetes were not significant. Boys scored higher on glucose concentration and aerobic fitness and lower on sum of skin folds and leptin concentration (p<.05). After adjustment for sum of skin folds, HOMA was significantly associated with leptin in both genders (boys r=.184 p=.031; girls r=.430 p=.000). The association between physical fitness and HOMA was mediated by sum of skin folds. The associations were stronger in girls than in boys. In the regression model (R(2)=.205) the leptin concentration was the only significant predictor for HOMA. The influence of family history for diabetes on insulin resistance is shown as a trend at this age. Our findings suggest that plasma leptin concentration is independently associated with the development of insulin resistance in a non-selected prepubertal population. The association of physical fitness with insulin resistance seems to be mediated by the sum of skin folds. [ABSTRACT FROM AUTHOR]

Published
2008
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5. A search for the electric dipole moment of the τ-lepton

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Reßing, D., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Thurn, H., Töpfer, D., Wegener, D., Frankl, C., Graf, J., Schmidtler, M., Schramm, M., Schubert, K.R., Schwierz, R., Spaan, B., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Rohde, A., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Schneider, M., Weseler, S., Bračko, M., Kernel, G., Križan, P., Križnič, E., Medin, G., Podobnik, T., Živko, T., Balagura, V., Barsuk, S., Belyaev, I., Chistov, R., Danilov, M., Eiges, V., Gershtein, L., Gershtein, Yu., Golutvin, A., Igonkina, O., Korolko, I., Kostina, G., Litvintsev, D., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
2000
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10. Observation of polarization effects in Λc+ semileptonic decay

Author

Albrecht, H., Ehrlichmann, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Wegener, D., Eckstein, P., Schubert, K.R., Schwierz, R., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Schnidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Khan, S., Knöpfle, K.T., Seeger, M., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Frankl, C., Reβing, D., Schmidtler, M., Schneider, M., Weseler, S., Kernel, G., Križan, P., Križnič, E., Podobnik, T., Živko, T., Balagura, V., Belyaev, I., Chechelnitsky, S., Danilov, M., Droutskoy, A., Gershtein, Yu., Golutvin, A., Korolko, I., Kostina, G., Litvintsev, D., Lubimov, V., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1994
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11. The first measurement of the Michel parameter η in τ decays

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Wegener, D., Eckstein, P., Schubert, K.R., Schwierz, R., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Frankl, C., Reßing, D., Schmidtler, M., Schneider, M., Weseler, S., Kernel, G., Križan, P., Križnič, E., Podobnik, T., Živko, T., Balagura, V., Belyaev, I., Chechelnitsky, S., Danilov, M., Droutskoy, A., Gershtein, Yu., Golutvin, A., Korolko, I., Kostina, G., Litvintsev, D., Lubimov, V., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1995
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12. Reconstruction of the decay B− → D10(2414) π −

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Wegener, D., Eckstein, P., Schubert, K.R., Schwierz, R., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Frankl, C., Reβing, D., Schmidtler, M., Schneider, M., Weseler, S., Kernel, G., Križan, P., Križnič, E., Podobnik, T., Živko, T., Balagura, V., Belyaev, I., Chechelnitsky, S., Danilov, M., Droutskoy, A., Gershtein, Yu., Golutvin, A., Korolko, I., Kostina, G., Litvintsev, D., Lubimov, V., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1994
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13. Determination of the radiative decay width of the ηc meson

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Reβing, D., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Wegener, D., Eckstein, P., Schmidtler, M., Schramm, M., Schubert, K.R., Schwierz, R., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Frankl, C., Schneider, M., Weseler, S., Kernel, G., Kržan, P., Križnič, E., Podobnik, T., Živko, T., Balagura, V., Belyaev, I., Chechelnitsky, S., Danilov, M., Droutskoy, A., Gershtein, Yu., Golutvin, A., Korolko, I., Kostina, G., Litvintsev, D., Lubimov, V., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1994
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14. Determination of the structure of τ decays in the reaction [formula omitted] and a precision measurement of the τ-neutrino helicity

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Reßing, D., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Wegener, D., Eckstein, P., Schmidtler, M., Schramm, M., Schubert, K.R., Schwierz, R., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Frankl, C., Schneider, M., Weseler, S., Kernel, G., Križan, P., Križnič, E., Podobnik, T., Živko, T., Balagura, V., Belyaev, I., Chechelnitsky, S., Danilov, M., Droutskoy, A., Gershtein, Yu., Golutvin, A., Korolko, I., Kostina, G., Litvintsev, D., Lubimov, V., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1994
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15. Determination of the Michel parameters ρ, ξ, and δ in τ-lepton decays with τ→ ρν tags

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Reßing, D., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Thurn, H., Töpfer, D., Wegener, D., Frankl, C., Graf, J., Schmidtler, M., Schramm, M., Schubert, K.R., Schwierz, R., Spaan, B., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Rohde, A., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Schneider, M., Weseler, S., Bračko, M., Kernel, G., Križan, P., Križnič, E., Medin, G., Podobnik, T., Živko, T., Balagura, V., Barsuk, S., Belyaev, I., Chistov, R., Danilov, M., Eiges, V., Gershtein, L., Gershtein, Yu., Golutvin, A., Igonkina, O., Korolko, I., Kostina, G., Litvintsev, D., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1998
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16. Evidence for Λc(2593) + production

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Reßing, D., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Thurn, H., Töpfer, D., Wegener, D., Frankl, C., Graf, J., Schmidtler, M., Schramm, M., Schubert, K.R., Schwierz, R., Spaan, B., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Rohde, A., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Schneider, M., Weseler, S., Bračko, M., Kernel, G., Križan, P., Križnič, E., Medin, G., Podobnik, T., Živko, T., Balagura, V., Barsuk, S., Belyaev, I., Chistov, R., Danilov, M., Eiges, V., Gershtein, L., Gershtein, Yu., Golutvin, A., Igonkina, O., Korolko, I., Kostina, G., Litvintsev, D., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1997
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17. Evidence for W-exchange in charmed baryon decays

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Wegener, D., Eckstein, P., Schubert, K.R., Schwierz, R., Waldi, R., Reim, K., Wegener, H., Eckmanm, P., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Schmidt-Parzefall, W., Becker, U., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Charlesworth, C.E.K., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Seidel, S.C., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Frankl, C., Reßing, D., Schmidtler, M., Schneider, M., Weseler, S., Kernel, G., Križan, P., Križnič, E., Podobnik, T., Živko, T., Balagura, V., Belyaev, I., Chechelnitsky, S., Danilov, M., Droutskoy, A., Gershtein, Yu., Golutvin, A., Korolko, I., Kostina, G., Litvintsev, D., Lubimov, V., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1995
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18. Determination of the Michel parameters ξ and δ in leptonic τ decays

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Reßing, D., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Wegener, D., Eckstein, P., Frankl, C., Graf, J., Schmidtler, M., Schramm, M., Schubert, K.R., Schwierz, R., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., schneider, M., Weseler, S., Kernel, G., Križan, P., Križnič, E., Podobnik, T., Živko, T., Balagura, V., Barsuk, S., Belyaev, I., Chistov, R., Danilov, M., Gershtein, L., Gershtein, Yu., Golutvin, A., Korolko, I., Kostina, G., Litvintsev, D., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1995
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19. Search for rare B decays

Author

Albrecht, H., Hamacher, T., Hofmann, R.P., Kirchhoff, T., Mankel, R., Nau, A., Nowak, S., Reßing, D., Schröder, H., Schulz, H.D., Walter, M., Wurth, R., Hast, C., Kapitza, H., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Schieber, M., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Wegener, D., Eckstein, P., Frankl, C., Graf, J., Schmidtler, M., Schramm, M., Schubert, K.R., Schwierz, R., Waldi, R., Reim, K., Wegener, H., Eckmann, R., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Schmidt-Parzefall, W., Stiewe, J., Werner, S., Ehret, K., Hofmann, W., Hüpper, A., Knöpfle, K.T., Spengler, J., Krieger, P., MacFarlane, D.B., Prentice, J.D., Saull, P.R.B., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Schneider, M., Weseler, S., Kernel, G., Križan, P., Križnič, E., Podobnik, T., Živko, T., Balagura, V., Barsuk, S., Belyaev, I., Chistov, R., Danilov, M., Gershtein, L., Gershtein, Yu., Golutyin, A., Korolko, I., Kostina, G., Litvintsev, D., Pakhlov, P., Semenov, S., Snizhko, A., Tichomirov, I., and Zaitsev, Yu.

Published
1995
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20. Physics with ARGUS

Author

Albrecht, H., Andam, A.A., Binder, U., Böckmann, P., Drews, G., Ehrlichmann, H., Gläser, R., Hamacher, T., Harder, G., Hasemann, H., Hofmann, R.P., Kapitza, H., Kirchhoff, T., Krüger, A., Lembke-Koppitz, I., Nau, A., Nilsson, A.W., Nippe, A., Nowak, S., Philipp, A., Reidenbach, M., Schäfer, M., Schröder, H., Schulz, H.D., Sefkow, F., Selonke, F., Volland, U., Walter, M., Wurth, R., Yagil, A., Appuhn, R.D., Buchner, U., Donker, J.P., Drescher, A., Graf, H.J., Gräwe, B., Hast, C., Herrera, G., Kamp, D., Kolanoski, H., Kosche, A., Lange, A., Lindner, A., Mankel, R., Markees, A., Matthiesen, U., Scheck, H., Schieber, M., Schweda, G., Siegmund, T., Spaan, B., Thurn, H., Töpfer, D., Walther, A., Wegener, D., Westerhoff, S., Bittner, M., Eckstein, P., Frankl, C., Graf, J., Holtzhauer, R., Schmidtler, M., Schramm, M., Schubert, K.R., Schwierz, R., Töpfer, M., Waldi, R., Paulini, M., Reim, K., Wegener, H., Behnke, O., Eckmann, R., Hapke, M., Kuipers, H., Mai, O., Mundt, R., Oest, T., Reiner, R., Rohde, A., Schmidt-Parzefall, W., Weyers, P., Becker, U., Ehmann, C., Fritz, K., Funk, W., Heintz, F., Heller, R., Klinger, T., Salomon, R., Schwingenheuer, B., Stiewe, J., Utzat, P., Werner, S., Ball, S., Ehret, K., Gabriel, J.C., Geyer, C., Hofmann, W., Hölscher, A., Holzer, B., Hüpper, A., Khan, S., Knöpfle, K.T., Seeger, M., Spahn, M., Spengler, J., Britton, D.I., Brown, N.N., Charlesworth, C.E.K., Edwards, K.W., Fernholz, R., Frisken, W., Fukunaga, C., Gilkinson, D.J., Gingrich, D.M., Goddard, M., Hyatt, E.R.F., Kim, P.C.H., Krieger, P., Kutschke, R., MacFarlane, D.B., McKenna, J.A., McLean, K.W., Orr, R.S., Padley, P., Parsons, J.A., Patel, P.M., Prentice, J.D., Saull, P.R.B., Seidel, S.C., Seywerd, H.C.J., Stacey, B.J., Swain, J.D., Tsipolitis, G., Tzamariudaki, K., Van de Water, R.G., Yoon, T.-S., Yun, J.C., Ammar, R., Coppage, D., Davis, R., Kanekal, S., Kwak, N., Ratz, C., Reßing, D., Ruf, T., Schael, S., Schneider, M., Strahl, K., Tamminga, J., Weseler, S., Boštjančič, B., Kernel, G., Križan, P., Križnič, E., Pleško, M., Podobnik, T., Živko, T., Cronström, H.I., Jönsson, L., Oku, Y., Arefiev, A., Babaev, A., Balagura, V., Barsuk, S., Belyaev, I., Blinov, V., Chechelnitsky, S., Chistov, R., Danilov, M., Droutskoy, A., Eiges, V., Fominykh, B., Gershtein, E., Gershtein, Yu., Golutvin, A., Gorelov, I., Igonkina, O., Korolko, I., Kostina, G., Litvintsev, D., Lubimov, V., Matveev, V., Murat, P., Nagovitsin, V., Pakhlov, P., Ratnikov, F., Root, N., Rostovtsev, A., Ryltsov, V., Semenov, A., Semenov, S., Semenov, Yu., Shevchenko†, V., Shibaev, V., Snizhko, A., Soloshenko, V., Sopov, V., Tchistilin, V., Tichomirov, I., Undrus, A., Zaitsev, Yu., Zhilich, V., Childers, R., Darden, C.W., and Gennow, H.

Published
1996
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23. Rapid visuomotor preparation in the human brain: a functional MRI study

Author

Adam, Jos J., Backes, W., Rijcken, J., Hofman, P., Kuipers, H., and Jolles, J.

Subjects
*BASAL ganglia, *NEURONS
Abstract

An important feature of human motor behaviour is anticipation and preparation. We report a functional magnetic resonance imaging study of the neuronal activation patterns in the human brain that are associated with the rapid visuomotor preparation of discrete finger responses. Our imaging results reveal a large-scale distributed network of neural areas involved in fast visuomotor preparation, including specific areas in the frontal cortex (middle frontal gyrus, premotor and supplementary motor cortex), the parietal cortex (intra-parietal sulcus, inferior and superior parietal lobe) and the basal ganglia. Our reaction time results demonstrate that it is easier to prepare two fingers on one hand than on two hands. This hand-advantage phenomenon was associated with relatively enhanced levels of activity in the basal ganglia and relatively reduced levels of activity in the parietal cortex. These findings provide direct evidence for differential activity in a distributed brain system associated with specific neuro-computational operations subserving fast visuomotor preparation. [Copyright &y& Elsevier]

Published
2003
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32. Is minimally invasive surgery less invasive in total hip replacement? A pilot study

Author

Pilot, P, Kerens, B., Draijer, W.F., Kort, N.P., ten Kate, J., Buurman, W.A., and Kuipers, H.

Subjects
*TOTAL hip replacement, *HIP surgery, *ARTIFICIAL hip joints, *ARTHROPLASTY
Abstract

Summary: It has been suggested that minimally invasive surgery (MIS) in total hip replacement (THR) is less traumatic than standard techniques. This study was designed to address the question of whether an anterior MIS approach generates less inflammation and muscle damage than the standard posterolateral (PL) approach. Inflammation parameters such as interleukin-6 (IL-6), muscle damage parameters like heart type fatty acid binding protein (H-FABP), and haemoglobin (Hb) levels were determined pre-operatively and at five consecutive points post-operatively in 10 patients operated through a MIS anterior approach and in 10 patients operated through a PL approach. The mean IL-6 concentration increased from 3 pg/ml in both groups pre-operatively to 78.5 pg/ml (PL group) vs 74.8 pg/ml (MIS group) at 6 hours post-operatively and reached a maximum of 100 pg/ml (PL group) vs 90.5 pg/ml pg/ml (MIS group) after 24 hours. Up to this time point, there was a decrease in both groups. The post-operative mean H-FABP concentration increased to 10.7μg/l in the PL group vs 15.8 μg/l in the MIS group. It formed a plateau and decreased after 24 hours post-operatively. The Hb levels were 14.5 g/dl before surgery and decreased to 10.7 g/dl (PL group) and 10.0 g/dl (MIS group) at 72 hours post-operatively. No significant differences were found between the two approaches either in inflammation and muscle damage or blood loss. Although the absence of a learning curve may explain the lack of a difference between both techniques, we speculate that the term MIS is at least doubtful in terms of being less traumatic. [Copyright &y& Elsevier]

Published
2006
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33. Experience in the first four years of Rapid Recovery; is it safe?

Author

Pilot, P., Bogie, R., Draijer, W.F., Verburg, A.D., van Os, J.J., and Kuipers, H.

Subjects
*TOTAL hip replacement, *WOUND care, *OPERATIVE surgery, *HOSPITAL admission & discharge
Abstract

Summary: The average length of hospital stay after Total Hip Replacement (THR) has been decreasing over time. Recently, many hospitals have commenced rapid recovery programs such as Joint Care®. In Joint Care® the patients are usually discharged on the fifth post-operative day with relatively fresh surgical wounds. The aim of this study is to evaluate the Joint Care® program after THR. Between February 2000 and February 2004, the Joint Care® program was used in 611 patients after THR. The average age of the patients was 66.3 yrs (SD9.3; range 24-86 yrs) and 68% (n= 415) of them were female. All clinical and outpatient charts as well as nursery records were evaluated. The follow up was from 6 months to 4 years (average: 2.5 years). At the planned fifth post-operative day, 92% (n = 562) of patients were discharged from hospital (SD 1.7 days; range 6-25 days). 3.8% (n= 23) of the remaining cases faced wound problems - prolonged wound drainage in 2.3% (n = 14) and potential superficial infection in 1.5% (n = 9)- causing a delay in their discharge. The readmission rate was 6.4% (n = 39) due to hip dislocation (3.4%; n = 21), re-evaluation of wound (1.5%; n= 9), deep infection (1.2%; n = 7)) and cardiac events (0.3%; n = 2). All the infection cases were treated effectively with debridement and antibiotics and no revision for any reason was reported. The Joint Care® program seems to be effective after THR. Post-operative hip dislocation was the main reason for post-operative readmission. However, no clear signs that the intensive rehabilitation program caused more complications compared to previous regimens were evident. The above results encourage the application of rapid recovery programs in Orthopaedic surgery and joint replacement. [Copyright &y& Elsevier]

Published
2006
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