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Abstract: This study investigated the effect of an acute bout of exercise (>85% ) on biochemical, hemodynamic and oxidative stress variables in sedentary and physically active subjects with type 2 diabetes (T2D). Blood measurements were taken before and after a treadmill test on 12 sedentary non-diabetes subjects (ND), 12 sedentary type 2 diabetes (T2S) and 9 physically active T2D subjects (T2DA). T2DS subjects before and after the treadmill test showed a higher plasma glucose (123.2±19.0mg/dL versus 108.9±16.8mg/dL, p <0.001), HbA1C (8.7±2.4% versus 7.3±1.2%, p <0.001) and body fat% (21.3±5.7% versus 34.6±4.5%, p <0.001) than T2DA subjects. T2DA had higher (37.7±3.5 versus 29.5±3.2, p <0.05), time on treadmill (22.3±2.1min versus 16.1±2.1min, p <0.05), hemoglobin (17.9±0.9g/dL, p <0.05) and lower blood pressure levels in comparison to ND and T2DS subjects. Thiobarbituric acid substances (TBARS) in T2DS were higher than in T2DA subjects (0.27±0.1nmol/mL versus 0.21±0.1nmol/mL, p <0.05). Glutathione (GSH) levels were similar among the groups. Physically active type 2 diabetes subjects had a more favorable biochemical, hemodynamic and oxidative stress profile than sedentary subjects. The coexistence of a poor cardiopulmonary performance and high oxidative stress environment can determine a profile of high risk for serious cardiovascular events in patients with diabetes. [Copyright &y& Elsevier]