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Start Over Author "Lei Yi" Publisher elsevier b.v.
169 results on '"Lei Yi"'

43. Expression of aldose reductase in mouse endometrial epithelial cells and its role in sperm capacitation.

Author

Lei, Yi, Nie, Li, Long, Yun, Zhao, Dan, Liu, Min, Wang, Yi-cheng, Zhang, Xue-qin, Xu, Miao-miao, Liu, Huan, Zhang, Jin-hu, Yuan, Dong-zhi, and Yue, Li-min

Subjects
*ALDOSE reductase, *EPITHELIAL cells, *ENDOMETRIUM, *SPERMATOZOA, *GENITALIA, *SORBITOL, *SPERM motility, *HORMONE regulation
Abstract

The survival, motility and capacitation of sperm in the female reproductive tract are important prerequisites for fertilization. The uterus is the main location for sperm capacitation. One of the most important physiological functions of the endometrial epithelium is to create a suitable uterine environment under the regulation of ovarian hormones, to ensure sperm capacitation. The composition of uterine fluid directly affects sperm capacitation. Fructose is an important component of semen that supports sperm viability and motility. Aldose reductase, a rate-limiting enzyme in the polyol pathway, metabolizes sorbitol and fructose, thereby supplying cells with necessary energy for functional activities. Existing studies have reported the presence aldose reductase in the endometrium, leading us to hypothesize that its expression in endometrial epithelium might promote sperm capacitation by maintaining the uterine environment. Yet, the mechanism of regulation has not been clarified. In this study, we investigated the expression of aldose reductase in mouse endometrial epithelium and its potential role in sperm capacitation. We initially investigated the periodic characteristics of glucose, fructose and sorbitol in uterine fluid. We then studied the temporal and spatial characteristics of aldose reductase in the endometrial epithelium. Next, we examined the effect of aldose reductase on glucose, fructose and sorbitol in uterine fluid. Finally, we explored the effect of aldose reductase on sperm capacitation and fertilization. The results showed that glucose and fructose content in uterine fluid and the expression of aldose reductase fluctuated periodically during physiological periods. Inhibition of aldose reductase in the endometrial epithelium interfered with sperm capacitation and fertilization by reducing the fructose levels in the uterine fluid. To conclude, the aldose reductase-mediated polyol pathway in endometrial epithelial cells is essential to maintain an appropriate fructose environment in the uterine fluid for sperm capacitation and fertilization. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Characterizing the effects of self-compassion interventions on anxiety: Meta-analytic evidence from randomized controlled studies.

Author

Luo, Xi, Che, Xianwei, and Lei, Yi

Abstract

Self-compassion interventions may be able to reduce anxiety symptoms. However, the clinical implications of self-compassion interventions remain unclear due to a large variability in treatment protocols. This study was therefore designed to quantify and delineate the effects of self-compassion interventions on anxiety symptoms. Forty-two randomized controlled studies were included through systematic searches. The overall synthesis indicated a moderate effect (42 trials; SMD, −0.73; 95% CI, −0.94 to −0.53; I 2 = 88.7%), and this effect could be maintained to as long as six months following treatment (15 trials; SMD, −0.65; 95% CI, −0.86 to −0.44; I 2 = 72.6%). Specifically, self-compassion interventions were more efficacious in reducing anxiety in samples with mental disorders compared to these with physical illnesses. In terms of treatment delivery, there was comparable efficacy between Internet-based and face-to-face interventions. There was also a positive relationship between treatment sessions and improvement in anxiety symptoms. In addition, we found that an increased but not baseline self-compassion score was associated with better treatment outcomes. Overall, these findings provide direct implications for the management of anxiety symptoms with self-compassion interventions. • We characterized the effects of self-compassion interventions on anxiety symptoms. • Self-compassion interventions had a medium effect on anxiety for up to six months. • Number of sessions was associated with better treatment outcomes. • Self-compassion interventions largely reduced anxiety in samples with mental illness. • Increased self-compassion score was associated with better treatment outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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