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2. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

Falconi, Massimo, Zou, Wen-Bin, Engjom, Trond, Ooi, Chee Y., Sutton, Robert, Frulloni, Luca, Neoptolemos, John, Wilcox, Charles, Miroslav, Vujasinovic, Trikudanathan, Guru, Liao, Zhuan, Hauge, Truls, Mössner, Joachim, Hoge, Chantal, Fockens, Paul, Mieog, Sven, Capurso, Gabriele, Cui, Yunfeng, de Madaria, Enrique, Distler, Marius, Aghdassi, Ali, Whitcomb, David C., Russell, Kylie, Beyer, Georg, Kunovsky, Lumír, Kwanten, Wilhelmus, Nava, Andrea Kazemi, Conlon, Kevin, Siriwardena, A.K., Paiella, Salvatore, Alconchel, Felipe, Marino, Marco Vito, de Meijer, Vincent E., Domingo, Carlos, Kleeff, Jorg, Lakshmanan, Aarti, Lie Chu, Michael Jen, Bouwense, Stefan, Nashidengo, Pueya Rashid, Konstantinos, Perivoliotis, Muttillo, Edoardo Maria, Umar, Garzali Ibrahim, Castro Santiago, Maria Jesus, Lopez-Lopez, Victor, Torri, Francesco, Schmelzle, Moritz, Ignatavicius, Povilas, Wicherts, Dennis, Gomes, Antonio, Machairas, Nikolaos A., Dorovinis, Panagiotis I., Serrablo, Alejandro, Soreide, Kjetil, Rahbari, Mohammad, Jie Chu, Michael Jen, Ptasnuka, Margarita, Petrulionis, Marius, Noel, Colin Byron, Castro, Ernest, Di Martino, Marcello, Recordare, Alfonso, Stättner, Stefan, Ausania, Fabio, Hartman, Vera, Roeyen, Geert, Egorov, Viacheslav, Vanagas, Tomas, Ebrahim, Mohamed, Arabadzhieva, Elena, Malleo, Giuseppe, Li, Liang, Adams, David, Oracz, Grzegorz, Nageshwar, Reddy D., Waldthaler, Alexander, Masamune, Atsushi, Drewes, Asbjorn Mohr, Amodio, Antonio, Tirkes, Temel, Srivastava, Anshu, Beilman, Gregory J., Berger, Zoltan, Lindkvist, Bjorn, Cavestro, Giulia Martina, Gariepy, Cheryl, Czakó, Laszlo, Di Leo, Milena, Sharma, Vishal, Lakhtakia, Sundeep, Rana, Surinder Singh, Duggan, Sinaed N., Kwon, Chang-Il, Phillips, Anna Evans, Forsmark, Christopher E., Gleeson, Ferga C., Lehman, Glen A., Greenhalf, William, Costamagna, Guido, Halloran, Christopher M., Friess, Helmut, Rasmussen, Henrik Hojgaard, Ikeura, Tsukasa, Haldorsen, Ingfrid S., Itoi, Takao, Izbicki, Jacob R., Windsor, John, Poulsen, Jakob Lykke, Frokjaer, Jens Brondum, Larino-Noia, Jose, Wang, Dan, Garcia, Julio Iglesias, Kalaitzakis, Evangelos, Wertheim-Tysarowska, Kararzyna, Kubota, Kensuke, Larusch, Jessica, Lerch, Markus M., Hu, Liang-Hao, Erkan, Mert, Machicado, Jorg D., Arvanitakis, Marianna, Buchler, Markus W., Levy, Marlon F., Heyman, Melvin B., Nojgaard, Camilla, Khashab, Mouen A., Delhaye, Myriam, Ogura, Takeshi, Okazaki, Kazuichi, Ghaneh, Paula, Banks, Peter A., Gupta, Pankaj, Papachristou, Georgios I., Michl, Patrick, Levy, Philippe, Pukitis, Aldis, Pezzilli, Raffaele, Baron, Ryan D., Amann, Stephen T., Schwarzenberg, Sarah Jane, Isaji, Shuiji, Olesen, Soren Schou, Novovic, Srdan, Hughes, Steven J., Werlin, Steven L., Gonska, Tanja, Gardner, Timothy B., Topazian, Mark D., Weiss, Frank Ulrich, Akshintala, Venakata S., Morinville, Veronique D., Rebours, Vinciane, Vincze, Aron, Singh, Vikesh K., Cui, Naiqiang, Zhang, Hong, Li, Zhao-shen, de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., Hegyi, Peter, Löhr, J-Matthias, Dominguez-Munoz, Juan E., de Jonge, Pieter Jan F., Bruno, Marco J., and Verdonk, Robert C.

Published
2022
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3. HLA-DRB1∗16 and -DQB1∗05 alleles are strongly associated with autoimmune pancreatitis in a cohort of hundred patients

Author

Goni, Elisabetta, Regel, Ivonne, Mahajan, Ujjwal Mukund, Amodio, Antonio, De Marchi, Giulia, Beyer, Georg, Zuppardo, Raffaella Alessia, Di Leo, Milena, Lanzillotta, Marco, Bonatti, Francesco, Kauke, Teresa, Dick, Andrea, Weiss, Frank Ulrich, Schönermarck, Ulf, Lerch, Markus M., Frulloni, Luca, Cavestro, Giulia Martina, and Mayerle, Julia

Published
2022
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5. Analysis of GPRC6A variants in different pancreatitis etiologies

Author

Kaune, Tom, Ruffert, Claudia, Hesselbarth, Nico, Damm, Marko, Krug, Sebastian, Cardinal von Widdern, Julian, Masson, Emmanuelle, Chen, Jian-Min, Rebours, Vinciane, Buscail, Louis, Férec, Claude, Grützmann, Robert, te Morsche, Rene H.M., Drenth, Joost PH., Cavestro, Giulia Martina, Zuppardo, Raffaella Alessia, Saftoiu, Adrian, Malecka-Panas, Ewa, Głuszek, Stanislaw, Bugert, Peter, Lerch, Markus M., Sendler, Matthias, Weiss, Frank Ulrich, Zou, Wen-Bin, Deng, Shun-Jiang, Liao, Zhuan, Scholz, Markus, Kirsten, Holger, Hegyi, Peter, Witt, Heiko, Michl, Patrick, Griesmann, Heidi, and Rosendahl, Jonas

Published
2020
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6. International consensus guidelines on surveillance for pancreatic cancer in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club

Author

Greenhalf, William, Lévy, Philippe, Gress, Thomas, Rebours, Vinciane, Brand, Randall E., Pandol, Steve, Chari, Suresh, Jørgensen, Maiken Thyregod, Mayerle, Julia, Lerch, Markus M., Hegyi, Péter, Kleeff, Jörg, Castillo, Carlos Fernández-del, Isaji, Shuiji, Shimosegawa, Tooru, Sheel, Andrea, Halloran, Christopher M, Garg, Pramod, Takaori, Kyoichi, Besselink, Marc G., Forsmark, Chris E., Wilcox, C.Mel, Maisonneuve, Patrick, Yadav, Dhiraj, Whitcomb, David, and Neoptolemos, John

Published
2020
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7. International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club

Author

Hegyi, Péter, Párniczky, Andrea, Lerch, Markus M., Sheel, Andrea R.G., Rebours, Vinciane, Forsmark, Chris E., Del Chiaro, Marco, Rosendahl, Jonas, de-Madaria, Enrique, Szücs, Ákos, Takaori, Kyoichi, Yadav, Dhiraj, Gheorghe, Cristian, Rakonczay, Zoltán, Jr., Molero, Xavier, Inui, Kazuo, Masamune, Atsushi, Fernandez-Del Castillo, Carlos, Shimosegawa, Tooru, Neoptolemos, John P., Whitcomb, David C., and Sahin-Tóth, Miklós

Published
2020
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10. Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas

Author

Lukas, Jan, Pospech, Jola, Oppermann, Christina, Hund, Christina, Iwanov, Katharina, Pantoom, Supansa, Petters, Janine, Frech, Moritz, Seemann, Susanne, Thiel, Franziska-Gisela, Modenbach, Jana-Marielle, Bolsmann, Robert, de Freitas Chama, Laura, Kraatz, Franziska, El-Hage, Firas, Gronbach, Manuel, Klein, Annelie, Müller, Regina, Salloch, Sabine, Weiss, Frank-Ulrich, Simon, Peter, Wagh, Preshit, Klemenz, Almuth, Krüger, Elke, Mayerle, Julia, Delcea, Mihaela, Kragl, Udo, Beller, Matthias, Rolfs, Arndt, Lerch, Markus M., and Sendler, Matthias

Published
2019
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12. Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis

Author

Löhr, Matthias, Dominguez-Munoz, J. Enrique, Besselink, Marc, Mayerle, Julia, Rosendahl, Jonas, Lerch, Markus M., Akisik, Fatih, Kartalis, Nikolaos, Manfredi, Riccardo, Iglesias-Garcia, Julio, Haas, Stephan L., Keller, Jutta, Boermeester, Marja A., Werner, Jens, Dumonceau, Jean-Marc, Fockens, Paul, Drewes, Asbjørn, Cheyan, Güralp O., Lindkvist, Björn, Drenth, Joost P., Ewald, Nils, Hardt, Philip, de Madaria, Enrique, Gheorghe, Christian, Lindgren, Fredrik, Schneider, Alexander, Witt, Heiko, Bollen, Thomas, Boraschi, Piero, Frøkjær, Jens B., Rudolf, Sasa, Bruno, Marco, Dimcevski, Georg, Giovannini, Marc, Pukitis, Aldis, Petrone, Mariachiara, Oppong, Kofi, Ammori, Basil, Friess, Helmut, Izbiki, Jakob R., Ganeh, Paula, Salvia, Roberto, Sauvanet, Alain, Barbu, Sorin, Lyadov, Vladimir, Deprez, Pierre, Gubergrits, Natalja, Okhlobystiy, Alexey V., Arvanitakis, Marianna, Costamagna, Guido, Pap, Akos, Andersson, Roland, Hauge, Truls, McKay, Colin, Pukitis, Aldos, Regnér, Sara, Dite´, Peter, Olesen, Søren S., Duggan, Sinead, Hopper, Andrew, Phillips, Mary, Shvets, Oleg, Vujasinovic, Miroslav, Czako, Laszlo, Piemonti, Lorenzo, Kocher, Hemant, Rebours, Vinciane, Stimac, Davor, Hegyi, Peter, Drewes, Asbjørn M., Czakó, László, and Löhr, J. Matthias

Published
2018
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13. International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club

Author

Whitcomb, David C., Shimosegawa, Tooru, Chari, Suresh T., Forsmark, Christopher E., Frulloni, Luca, Garg, Pramod, Hegyi, Peter, Hirooka, Yoshiki, Irisawa, Atsushi, Ishikawa, Takuya, Isaji, Shuiji, Lerch, Markus M., Levy, Philippe, Masamune, Atsushi, Wilcox, Charles M., Windsor, John, Yadav, Dhiraj, Sheel, Andrea, and Neoptolemos, John P.

Published
2018
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14. Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis

Author

Weiss, Frank Ulrich, Hesselbarth, Nico, Párniczky, Andrea, Mosztbacher, Dora, Lämmerhirt, Felix, Ruffert, Claudia, Kovacs, Peter, Beer, Sebastian, Seltsam, Katharina, Griesmann, Heidi, Böhme, Richard, Kaune, Tom, Hollenbach, Marcus, Schulz, Hans-Ulrich, Simon, Peter, Mayerle, Julia, Lerch, Markus M., Cavestro, Giulia Martina, Zuppardo, Raffaella Alessia, Di Leo, Milena, Testoni, Pier Alberto, Malecka-Panas, Ewa, Gasirowska, Anita, Głuszek, Stanislaw, Bugert, Peter, Szentesi, Andrea, Mössner, Joachim, Witt, Heiko, Michl, Patrick, Hégyi, Peter, Scholz, Markus, and Rosendahl, Jonas

Published
2018
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19. Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade

Author

Partecke, Lars Ivo, Speerforck, Sven, Käding, André, Seubert, Florian, Kühn, Sandra, Lorenz, Eric, Schwandke, Sebastian, Sendler, Matthias, Keßler, Wolfram, Trung, Dung Nguyen, Oswald, Stefan, Weiss, Frank Ulrich, Mayerle, Julia, Henkel, Christin, Menges, Pia, Beyer, Katharina, Lerch, Markus M., Heidecke, Claus-Dieter, and von Bernstorff, Wolfram

Published
2016
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22. Orally compensated short bowel patients are thin, potentially malnourished but rarely sarcopenic.

Author

Bannert, Karen, Karbe, Cathleen, Förster, Robert H., Sautter, Lea F., Meyer, Fatuma, Valentini, Luzia, Wiese, Mats L., Ehlers, Luise, Berlin, Peggy, Jaster, Robert, Aghdassi, Ali A., Lerch, Markus M., and Lamprecht, Georg

Abstract

In short bowel syndrome, insufficient absorptive capacity of the remnant bowel may lead to metabolic and nutritional consequences including electrolyte disturbances, severe diarrhea and malnutrition. While intestinal failure requires parenteral nutrition, short bowel patients with intestinal insufficiency (SB/II) have achieved oral autonomy. The aim of this exploratory study was to assess the nutritional, muscular and functional status of orally compensated SB/II patients. 28 orally compensated SB/II patients with a mean of 46 months after termination of parenteral nutrition and 56 age- and sex-matched healthy controls (HC) were compared regarding anthropometric parameters, body composition using bioelectrical impedance analysis, handgrip strength and gait speed, blood parameters as well as nutritional intake and physical activity using validated questionnaires. Malnutrition and sarcopenia were diagnosed according to the criteria of the GLIM or EWGSOP2. SB/II patients had lower body mass index (BMI) and anthropometric parameters than HC but were within the normal weight range. The GLIM algorithm operationally diagnosed malnutrition in 39% (n = 11) of SB/II patients. Reduced skeletal muscle mass index and phase angle were rarely accompanied by a reduction of handgrip strength below cut-off values and the subsequent diagnosis of sarcopenia in SB/II patients (15%, n = 4). Compared to 11% of HC, 37% of SB/II patients had low physical activity level. Female SB/II patients had higher caloric and macronutrient intake. Caloric intake negatively correlated with body weight indicating compensatory hyperphagia in patients with lower body weight. Some of the SB/II patients showed signs of dehydration. Orally compensated SB/II patients are thinner than HC but have mostly normal BMI. Malnutrition is frequently diagnosed but may be overestimated due to the underlying malabsorption and its interplay with hyperphagia. Muscle mass is often reduced but is rarely accompanied by functional impairment leading to sarcopenia diagnosis. Thus, SB/II patients long term after termination of parenteral support may be malnourished but usually do not develop sarcopenia. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Plasma renalase levels are associated with the development of acute pancreatitis.

Author

Wang, Melinda, Weiss, Frank Ulrich, Guo, Xiaojia, Kolodecik, Thomas, Bewersdorf, Jan Philipp, Laine, Loren, Lerch, Markus M., Desir, Gary, and Gorelick, Fred S.

Abstract

Severe acute pancreatitis is associated with significant morbidity and mortality. Identifying factors that affect the risk of developing severe disease could influence management. Plasma levels of renalase, an anti-inflammatory secretory protein, dramatically decrease in a murine acute pancreatitis model. We assessed this response in hospitalized acute pancreatitis patients to determine if reduced plasma renalase levels occur in humans. Plasma samples were prospectively and sequentially collected from patients hospitalized for acute pancreatitis. Two forms of plasma renalase, native (no acid) and acidified, were measured by ELISA and RNLS levels were compared between healthy controls and patients with mild and severe disease (defined as APACHE-II score ≥7) using nonparametric statistical analysis. Control (33) and acute pancreatitis (mild, 230 (76.7%) and severe, 70 (23.3%) patients were studied. Acidified RNLS levels were lower in pancreatitis patients: Control: 10.1 μg/ml, Mild 5.1 μg/ml, Severe 6.0 μg/ml; p < 0.001. Native RNLS levels were increased in AP: Control: 0.4 μg/ml, Mild 0.9 μg g/ml, Severe 1.2 μg/ml p < 0.001; those with severe AP trended to have higher native RNLS levels than those with mild disease (p = 0.056). In patients with severe AP, higher APACHE-II scores at 24 h after admission correlated with lower acid-sensitive RNLS levels on admission (r = −0.31, p = 0.023). Low plasma acidified RNLS levels, and increased native RNLS levels are associated with AP. Additional studies should assess the clinical correlation between plasma RNLS levels and AP severity and outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Links between ectopic and abdominal fat and systemic inflammation: New insights from the SHIP-Trend study.

Author

Ponce-de-Leon, Mariana, Hannemann, Anke, Linseisen, Jakob, Nauck, Matthias, Lerch, Markus M., Bülow, Robin, Völzke, Henry, Friedrich, Nele, Kassubek, Jan, Müller, Hans-Peter, Baumeister, Sebastian-Edgar, and Meisinger, Christa

Abstract

Excessive fat accumulation in adipose tissue depots and organs such as the pancreas and the liver is associated with systemic low-grade chronic inflammation. To investigate the association between abdominal, hepatic, and pancreatic fat and the circulating level of inflammatory biomarkers. We used data from a subsample of the Study of Health in Pomerania (SHIP-Trend, n = 469). The plasma concentration of 37 inflammatory biomarkers was measured using the Bio-Plex-Pro™-Human-Inflammation-Panel-1. Subcutaneous and visceral adipose tissue (SAT and VAT), as well as hepatic and pancreatic fat, were determined by magnetic resonance imaging. We assessed the associations between fat content and inflammatory biomarkers using multiple linear regression. Hepatic fat was associated with MMP-2 (β -0.11), PTX3 (β -0.14), and TNFSF12 (β -0.06). Pancreatic fat was associated with sTNFR1 (β 0.15), sTNFR2 (β 0.11), and sCD163 (β 0.13). VAT and SAT were associated with sCD163 (βVAT 0.20, βSAT 0.16), MMP-2 (βVAT -0.12, βSAT -0.10), OSTCN (βVAT -0.16, βSAT -0.10), sTNFR1 (βVAT 0.13, βSAT 0.13), sTNFR2 (βVAT 0.13, βSA 0.12), TNFSF12 (βVAT -0.11, βSAT -0.08), and TNFSF14 (βVAT 0.21, βSAT 0.20). VAT was additionally associated with TNFSF13B (β 0.08) and CHI3L1 (β 0.07). Our findings provide new insights into the involvement of hepatic and pancreatic fat on systemic inflammation. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti–Helicobacter pylori IgG Titers.

Author

Lam, Suk Yee, Mommersteeg, Michiel C., Yu, Bingting, Broer, Linda, Spaander, Manon C.W., Frost, Fabian, Weiss, Stefan, Völzke, Henry, Lerch, Markus M., Schöttker, Ben, Zhang, Yan, Stocker, Hannah, Brenner, Hermann, Levy, Daniel, Hwang, Shih-Jen, Wood, Alexis C., Rich, Stephen S., Rotter, Jerome I., Taylor, Kent D., and Tracy, Russell P.

Abstract

A genome-wide significant association between anti– Helicobacter pylori (H pylori) IgG titers and Toll-like receptor (TLR1/6/10) locus on 4p14 was demonstrated for individuals of European ancestry, but not uniformly replicated. We re-investigated this association in an updated genome-wide association study (GWAS) meta-analysis for populations with low gastric cancer incidence, address potential causes of cohort heterogeneity, and explore functional implications of genetic variation at the TLR1/6/10 locus. The dichotomous GWAS (25% individuals exhibiting highest anti– H pylori IgG titers vs remaining 75%) included discovery and replication sampls of, respectively, n = 15,685 and n = 9676, all of European ancestry. Longitudinal analysis of serologic data was performed on H pylori –eradicated subjects (n = 132) and patients under surveillance for premalignant gastric lesions (n = 107). TLR1/6/10 surface expression, TLR1 mRNA, and cytokine levels were measured in leukocyte subsets of healthy subjects (n = 26) genotyped for TLR1/6/10 variants. The association of the TLR1/6/10 locus with anti– H pylori IgG titers (rs12233670; β = −0.267 ± SE 0.034; P = 4.42 × 10−15) presented with high heterogeneity and failed replication. Anti– H pylori IgG titers declined within 2–4 years after eradication treatment (P = 0.004), and decreased over time in patients with premalignant gastric lesions (P < 0.001). Variation at the TLR1/6/10 locus affected TLR1-mediated cytokine production and TLR1 surface expression on monocytes (P = 0.016) and neutrophils (P = 0.030), but not mRNA levels. The association between anti– H pylori IgG titers and TLR1/6/10 locus was not replicated across cohorts, possibly owing to dependency of anti– H pylori IgG titers on therapy, clearance, and antibody decay. H pylori –mediated immune cell activation is partly mediated via TLR1 signaling, which in turn is affected by genetic variation. [Display omitted] Genetic variation of bacterial sensor gene Toll-like receptor (TLR) as host factor associated with Helicobacter pylori infection affects host immunologic responses, but validation of this genetic association is challenging. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Results of intersphincteric resection of the rectum with direct coloanal anastomosis for rectal carcinoma

Author

Braun, Joseph, Treutner, Karl H., Winkeltau, Gerd, Heidenreich, Ursula, Lerch, Markus M., and Schumpelick, Volker

Subjects
Colorectal cancer -- Care and treatment, Rectum, Surgical anastomosis -- Health aspects, Health
Abstract

Between 1977 and 1987, 519 patients underwent operation for rectal carcinoma. Sixty-three patients underwent intersphincteric resection with direct coloanal anastomosis (CAA), and 77 had an abdominoperineal resection (APR). Curative surgery was achieved in 57 and 65 patients, respectively. Both groups were comparable regarding age, stage of tumors and localization of tumors. During the mean period of 6.7 years (range: 3 to 13.6 years), all patients were examined according to a predefined follow-up plan. From these patients with curative surgery, 11% presented with pelvic recurrence and 33% with distant metastases after coloanal anastomosis; the rates of recurrence and distant metastases after APR were 17% and 35%, respectively. The corrected 5-year survival rates were 62% following CAA and 53% following APR. Eighty-five percent of the patients with CAA reported good functional results regarding anal continence. Our study demonstrates that the intersphincteric resection with CAA is a valuable surgical technique for rectal carcinoma with the benefit of preservation of continence. It is suitable for neoplasms with high-and medium-grade differentiation (G1 to G2) and a location that allows a minimum distal clearance of 3 cm.

Published
1992

35. Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity.

Author

Frost, Fabian, Kacprowski, Tim, Rühlemann, Malte, Bülow, Robin, Kühn, Jens-Peter, Franke, Andre, Heinsen, Femke-Anouska, Pietzner, Maik, Nauck, Matthias, Völker, Uwe, Völzke, Henry, Aghdassi, Ali A., Sendler, Matthias, Mayerle, Julia, Weiss, Frank U., Homuth, Georg, and Lerch, Markus M.

Abstract

Background & Aims Changes in intestinal microbiome composition are associated with inflammatory, metabolic, and malignant disorders. We studied how exocrine pancreatic function affects intestinal microbiota. Methods We performed 16S ribosomal RNA gene sequencing analysis of stool samples from 1795 volunteers from the population-based Study of Health in Pomerania who had no history of pancreatic disease. We also measured fecal pancreatic elastase by enzyme-linked immunosorbent assay and performed quantitative imaging of secretin-stimulated pancreatic fluid secretion. Associations of exocrine pancreatic function with microbial diversity or individual genera were calculated by permutational analysis of variance or linear regression, respectively. Results Differences in pancreatic elastase levels associated with significantly (P <.0001) greater changes in microbiota diversity than with participant age, body mass index, sex, smoking, alcohol consumption, or dietary factors. Significant changes in the abundance of 30 taxa, such as an increase in Prevotella (q <.0001) and a decrease of Bacteroides (q <.0001), indicated a shift from a type-1 to a type-2 enterotype. Changes in pancreatic fluid secretion alone were also associated with changes in microbial diversity (P =.0002), although to a lesser degree. Conclusions In an analysis of fecal samples from 1795 volunteers, pancreatic acinar cell, rather than duct cell, function is presently the single most significant host factor to be associated with changes in intestinal microbiota composition. [ABSTRACT FROM AUTHOR]

Published
2019
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36. LIFEStyle, prevention and risk of acute PANcreatitis (LIFESPAN): Protocol of a prospective, multicentre and multinational observational case-control study

Author

Darvasi, Erika, Koncz, Balázs, Erdösi, Dalma, Szentesi, Andrea, Márta, Katalin, Erőss, Bálint, Pécsi, Dániel, Gyöngyi, Zoltán, Girán, János, Farkas, Nelli, Papp, Mária, Fehér, Eszter, Vitális, Zsuzsanna, Janka, Tamás, Vincze, Áron, Izbéki, Ferenc, Dunás-Varga, Veronika, Gajdán, László, Török, Imola, Antal, Judit, Zádori, Noémi, Lerch, Markus M., Neoptolemos, John P., Sahin-Tóth, Miklós, Petersen, Ole H., and Hegyi, Péter

Published
2019
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37. Investigating the early phase of chronic pancreatitis: the Goulash-Plus trial protocol and the results of the first 10 months

Author

Kató, Dorottya, Mikó, Alexandra, Lillik, Veronika, Erőss, Bálint, Sarlós, Patrícia, Hegyi, Péter, Jr., Pécsi, Dániel, Márta, Kata, Vincze, Aron, Bódis, Beáta, Nemes, Orsolya, Faluhelyi, Nándor, Farkas, Orsolya, Szentesi, Andrea, Sahin-Tóth, Miklós, Lerch, Markus M., Neoptolemos, John P., Petersen, Ole H., and Hegyi, Péter

Published
2019
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42. Cathepsin D expression mediates gemcitabine resistance in pancreatic cancer

Author

Mahajan, Ujjwal Mukund, Goni, Elisabetta, Langhoff, Enno, Li, Qi, Costello, Eithne, Greenhalf, William, Kruger, Stephan, Ormanns, Steffen, Halloran, Christopher, Ganeh, Paula, Marron, Manuela, Lämmerhirt, Felix, Zhao, Yue, Beyer, Georg, Weiss, Frank Ulrich, Sendler, Matthias, Bruns, Christine J., Kohlmann, Thomas, Kirchner, Thomas, Werner, Jens, D'Haese, Jan, von Bergwelt-Baildon, Michael, Heinemann, Volker, Neoptolemos, John P., Büchler, Markus W., Belka, Claus, Boeck, Stefan, Lerch, Markus M., and Mayerle, Julia

Published
2019
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