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Dispersion is an inherent property of optical elements, and can be controlled via different kinds of optical glasses or binary optics conventionally. In this paper, we show that this property can be manipulated by the dielectric metasurfaces. In addition, we design the metalenses and beam deflectors with positive, zero, and negative dispersion in the mid-infrared. Unit cells of different sizes and different rotation angles have been introduced to facilitate simultaneous manipulation of phase and its dispersion characteristics. Simulation results show that, the designed metasurfaces demonstrate desired chromatic dispersion. This work paves the way to the practical application of metasurfaces. [ABSTRACT FROM AUTHOR]

The dysregulated expression of immune checkpoint molecules enables cancer cells to evade immune destruction. While blockade of inhibitory immune checkpoints like PD-L1 forms the basis of current cancer immunotherapies, a deficiency in costimulatory signals can render these therapies futile. CD58, a costimulatory ligand, plays a crucial role in antitumor immune responses, but the mechanisms controlling its expression remain unclear. Using two systematic approaches, we reveal that CMTM6 positively regulates CD58 expression. Notably, CMTM6 interacts with both CD58 and PD-L1, maintaining the expression of these two immune checkpoint ligands with opposing functions. Functionally, the presence of CMTM6 and CD58 on tumor cells significantly affects T cell-tumor interactions and response to PD-L1−PD-1 blockade. Collectively, these findings provide fundamental insights into CD58 regulation, uncover a shared regulator of stimulatory and inhibitory immune checkpoints, and highlight the importance of tumor-intrinsic CMTM6 and CD58 expression in antitumor immune responses. [Display omitted] • CMTM6 maintains the expression of CD58 • CMTM6 co-regulates and interacts with both CD58 and PD-L1 • Tumor cell-intrinsic CMTM6 and CD58 are important for antitumor T cell response Miao et al. reveal CMTM6 as a positive regulator and interaction partner of CD58, an important costimulatory ligand in antitumor immune responses. They highlight the critical roles of tumor-intrinsic CMTM6 and CD58 expression in modulating T cell-tumor cell interactions and their potential impact on T cell-based immunotherapy. [ABSTRACT FROM AUTHOR]

In this paper, the geometry and aberration characteristics of von Karman conformal domes have been investigated. Based on the theory of differential geometry, the uniform formulas of curvature, which are suitable for von Karman surface, were deduced in the meridian plane and sagittal plane, respectively. According to the formula, the geometry characteristics were analyzed. By using ray tracing, the geometric aberrations and wave aberrations of the von Karman dome were obtained. Further, the aberration characteristics of the von Karman dome with different design parameters were analyzed in depth. The results showed that for the viewing angle changing from 0° to 15°, numerous aberrations, namely, defocus, astigmatism, coma, spherical, trefoil, and tetrafoil were introduced by the von Karman, whose law is similar to its geometric characteristics. The factors with a high impact on aberrations were the aspect ratio, material, and diameter of the entrance pupil. • Apply the von Karman surface to the conformal dome configuration design. • Clarify the geometric characteristics of the von Karman conformal dome. • Comprehensive study the various primary and high-order aberrations introduced by the von Karman conformal dome. [ABSTRACT FROM AUTHOR]