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Toonasinemines A–K ( 1 – 12 ), 12 new azadirone- and gedunin-type limonoids with eight-classes of modified furan rings, were isolated from the root barks of Toona sinensis (A. Juss.) Roem. Their structures were elucidated based on detailed spectroscopic analyses, and the absolute configurations of 1 – 9 were established by the electronic circular dichroism exciton chirality method. The lactam-bearing moieties in compounds 1 – 7 were rare in limonoids family. Results of bioactivities screening exhibited that 1 , 4 , and 8 showed moderate cytotoxicities against HepG2, MCF-7, and U2OS human cancer cell lines, and 1 , 2 , 6 , 8 , and 9 exhibited marked inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages at nontoxic concentration. [ABSTRACT FROM AUTHOR]

The plants of genus Toona are well known for diverse limonoid secondary metabolites, while polyacetylenes are rarely found from Toona species. In this work, six new polyacetylenes toonasindiynes A-F (1 – 6) and six known analogues (7 – 12) were isolated from the root bark of Toona sinensis. Their structures and absolute configurations were elucidated by HRESIMS, 1D and 2D NMR spectroscopic analysis, modified Mosher's method, and biosynthetic consideration. These polyacetylenes share the same 4,6-diyne moiety with different side chain length and different oxidation degree. Bioactivity screening revealed the cytotoxic activity of 3 , 5 , 9 , and 11 against U2OS cells, and the inhibitory effects on nitric oxide (NO) production of 1 , 2 , 5 , 8 , 9 , and 11 in lipopolysaccharide-induced RAW 264.7 cells. Unlabelled Image • Six new polyacetylenes were isolated from the edible plant Toona sinensis. • Absolute configurations were determined by modified Mosher's method. • Some polyacetylenes showed potent cytotoxic and anti-inflammatory activities. [ABSTRACT FROM AUTHOR]

Nine new euphane- and apotirucallane-type triterpenoids (Toosendines A–I; 1–9 ), along with three known tirucallane-type compounds were isolated from the barks of Melia toosendan . Their structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and circular dichroism spectra. Results of bioactivities screening exhibited that compounds 1 , 4 and 5 showed remarkable NO inhibitory activities in LPS-activated RAW 264.7 macrophages, meanwhile, compounds 1 and 4 showed moderate cytotoxicities against U2OS human cancer cell line. [ABSTRACT FROM AUTHOR]