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Panax Notoginseng Saponins (PNS) has been widely used in the prevention and treatment of cardiovascular and cerebrovascular diseases such as myocardial infarction, heart failure and cerebral infarction. However, oral administration of PNS showed low bioavailability because of its instability and poor membrane permeability in the gastrointestinal tract. Here, lipoprotein-inspired hybrid nanoparticles of PNS-Lecithin-Zein (PLZ-NPs) were prepared by using a simple phase separation method, which possessed a core-shell structure, where zein was used as protein part to replace the animal origin protein to increase the resistance to acid and enzymes while lecithin was used as the lipid composition to improve the oral absorption of PNS as well as to increase the drug loading capacity of PNS into the nanocarriers. The results of stability test showed that PLZ-NPs had robust enzymolysis resistance ability for acid and digestive enzymes of gastrointestinal environments. The fluorescent resonance energy transfer (FRET) assay confirmed the ability of LZ-NPs to be intactly absorbed by Caco-2 cell monolayer. Cell transport studies demonstrated that the permeability of PLZ-NPs in Caco-2/HT29-MTX co-culture cell model was 1.5-fold that of PNS. Meanwhile, the single-pass intestinal perfusion assay proved the absorption parameter Peff of PLZ-NPs was 1.75 and 1.80 times higher than that of PNS in the ileum and jejunum, respectively. Finally, the in vivo pharmacokinetic experiment showed that the relative oral bioavailability of PLZ-NPs was 1.71-fold that of free PNS in SD rat. In summary, the employment of the Lecithin/Zein hybrid nanoparticles could be considered as a promising approach for PNS analogues. [ABSTRACT FROM AUTHOR]

The use of electric bicycles (EBs) for short- and medium-distance travel provides an opportunity to decarbonize the transport sector. Using life cycle assessment, this study evaluated and compared the environmental and economic performances of EBs powered by four different types of batteries in China. The results show that EBs powered by lead-acid batteries have the worst environmental performance, whereas those powered by lithium iron phosphate batteries have the best environmental performance. Motor production was found to have the highest potential for metal depletion and toxicity for humans and ecology, owing to the use of copper in its production. These environmental consequences can be mitigated by continuous promotion of circular economy. The use stage brings about the most environmental pressure related to energy use. Power cleaning will reduce most environmental indicators by 10–25%. EBs powered by lithium manganate batteries have been a mainstream technology, but the short lifetime and low economic value of recycling the battery may constrain their development. [Display omitted] • Environmental and economic performance of electric bicycles (EBs) are evaluated. • Lead-acid battery EBs have the worst performance but use the least metals. • Motor is the component with the greatest environmental impact due to copper use. • Promoting circular economy can reduce environmental impact related to metal use. • EBs powered lithium-ion batteries have higher total cost but lower cost per km. [ABSTRACT FROM AUTHOR]

• Establish a quantitative mathematical model of current and heat radiation based on Joule heat. • Design a new radiant sensor for current measurement by analyzing the properties of different materials, and the sensitivity, structure and specific size are given. • Realize a far-distance current measurement of power frequency AC, which provides a potential solution for safe current measurement in engineering. Ohm's law and Electromagnetic Induction law are two fundamental laws used for the current measurement. However, these two methods require putting resistance into the circuit or magnetic sensor close to the line, which is dangerous when the wireline has high voltages. To improve the safety, this paper proposes a non-contact far distance current measurement method, which is in conjunction with a fuse-like radiant sensor made of metal foil and an infrared radiation (IR) camera, without any additional conjunction line. Nature behind that is a mathematical model based on another law, Joule Heating. The mathematical model unifies the alternating current (AC) and heat conduction equation in the dynamic process, quantitatively determines the relationship between the sinuous temperature variation and current amplitude along the wireline. Experiments verify that the proposed method can measure current with the relative error within ± 3.66 % in the range of 1.05–3.45A rms at power frequency (50 Hz) from 1 m away. Therefore, the proposed method has a bright future for electric current measurement of tour inspection, especially in high voltage transmission systems. [ABSTRACT FROM AUTHOR]

[Display omitted] Most anticancer drugs are not orally bioavailable due to their undesirable physicochemical properties and inherent physiological barriers. In this study, a polymeric prodrug strategy was presented to enhance the oral bioavailability of BCS class IV drugs using paclitaxel (PTX) as the model drug. PTX was covalently conjugated with cholic acid-functionalized PEG by a redox-sensitive disulfide bond. Cholic acid-functionalized PEGylated PTX (CPP) achieved remarkably improved PTX solubility (>30,000-fold), as well as favorable stability under the physiological environment and controlled drug release in the tumor. Meanwhile, CPP could self-assemble into nanoparticles with an average size of 56.18 ± 2.06 nm and drug loading up to 17.6% (w/w). Then, permeability study on Caco-2 cell monolayers demonstrated that CPP obtained an approximately 4-fold increase by apical sodium-dependent bile acid transporter (ASBT) mediated transport, compared with Taxol®. Pharmacokinetic studies carried out in rats confirmed that the oral bioavailability of CPP was 10-fold higher than that of Taxol®. Finally, significant improvement in the antitumor efficacy of CPP against breast cancer was confirmed on MDA-MB-231 cells. In summary, this prodrug-based cascade strategy offers new ways for chemotherapeutic drugs whose oral delivery is limited by solubility and permeability, also endows drugs with the capacity of tumor-specific release. [ABSTRACT FROM AUTHOR]

Abstract: A method for the simulation and optimization of the source-field distribution of a diode bar laser (DBL) beam by using the stimulated annealing and experimental data in the far field is proposed and illustrated by an example of a DBL JOLD-60-CPNN-1L, showing the applicability of the method. As compared with the previous models, this method is not restricted to the type of diode lasers (DLs), and the reconstructed results are accurate so long as the experimental data are sufficiently accurate. [Copyright &y& Elsevier]