14 results on '"Lima, Camila Nayane"'
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2. F41. STEPS TOWARD A COMBINED CLINICAL-EPIGENETIC PREDICTOR OF SUICIDE ATTEMPT RISK IN BIPOLAR DISORDER: PRELIMINARY INSIGHTS FROM CROSS-SECTIONAL AND RETROSPECTIVE ASSESSMENTS
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Mirza, Salahudeen, Lima, Camila Nayane De Carvalho, Favero-Campbell, Alexandra Del, Rubinstein, Alexandre, Topolski, Natasha, Cabrera-Mendoza, Brenda, Kovács, Emese, Richards, Jenny Gringer, Williams, Aislinn, Wemmie, John, Walss-Bass, Consuelo, Quevedo, Joao, Gaine, Marie, Soares, Jair, and Fries, Gabriel
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- 2023
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3. 98. Transcriptomic Changes Associated With Suicide Death in the Postmortem Prefrontal Cortex of Individuals With Bipolar Disorder.
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Lima, Camila Nayane, Rubinstein, Alexandre, Stertz, Laura, Mirza, Salahudeen, Kluwe-Schiavon, Bruno, Busby, Christopher, Jha, Rohit, Del Favero-Campbell, Alexandra, Kumar, Apurva, Farhan, Mohammad, Soyebo, Esther, Walss-Bass, Consuelo, Soares, Jair C., and Fries, Gabriel R.
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PREFRONTAL cortex , *BIPOLAR disorder , *TRANSCRIPTOMES , *SUICIDE - Published
- 2024
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4. IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity.
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Chaves Filho, Adriano José Maia, Lima, Camila Nayane Carvalho, Vasconcelos, Silvânia Maria Mendes, de Lucena, David Freitas, Maes, Michael, and Macedo, Danielle
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OBESITY , *MENTAL depression , *UNSATURATED fatty acids , *EDINBURGH Postnatal Depression Scale , *CELLULAR immunity , *TRYPTOPHAN - Abstract
Obesity and depression are among the most pressing health problems in the contemporary world. Obesity and depression share a bidirectional relationship, whereby each condition increases the risk of the other. By inference, shared pathways may underpin the comorbidity between obesity and depression. Activation of cell-mediated immunity (CMI) is a key factor in the pathophysiology of depression. CMI cytokines, including IFN-γ, TNFα and IL-1β, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs). In the CNS, TRYCATs have been related to oxidative damage, inflammation, mitochondrial dysfunction, cytotoxicity, excitotoxicity, neurotoxicity and lowered neuroplasticity. The pathophysiology of obesity is also associated with a state of aberrant inflammation that activates aryl hydrocarbon receptor (AHR), a pathway involved in the detection of intracellular or environmental changes as well as with increases in the production of TRYCATs, being KYN an agonists of AHR. Both AHR and TRYCATS are involved in obesity and related metabolic disorders. These changes in the TRYCAT pathway may contribute to the onset of neuropsychiatric symptoms in obesity. This paper reviews the role of immune activation, IDO stimulation and increased TRYCAT production in the pathophysiology of depression and obesity. Here we suggest that increased synthesis of detrimental TRYCATs is implicated in comorbid obesity and depression and is a new drug target to treat both diseases. [ABSTRACT FROM AUTHOR]
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- 2018
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5. Association Between Accelerated Epigenetic Aging and Poorer Functional Status in Bipolar Disorder.
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Lima, Camila Nayane, Soares, Jair, Walss-Bass, Consuelo, Quevedo, Joao, and Fries, Gabriel
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FUNCTIONAL status , *BIPOLAR disorder , *EPIGENETICS - Published
- 2021
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6. Long-term Environmental Enrichment Normalizes Schizophrenia-like Abnormalities and Promotes Hippocampal Slc6a4 Promoter Demethylation in Mice Submitted to a Two-hit Model.
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Arraes, Greicy Coelho, Barreto, Francisco Stefânio, Vasconcelos, Germana Silva, Lima, Camila Nayane de Carvalho, da Silva, Francisco Eliclécio Rodrigues, Ribeiro, Wesley Lyeverton Correia, de Sousa, Francisca Cléa Florenço, Furtado, Cristiana Libardi Miranda, and Macêdo, Danielle S.
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ENVIRONMENTAL enrichment , *DEVELOPMENTAL neurobiology , *HIPPOCAMPUS (Brain) , *DEMETHYLATION , *SEROTONIN transporters , *BEHAVIORAL assessment - Abstract
• Two-hit model of schizophrenia-induced hippocampal Slc6a4 promoter methylation. • EE over 50 days alleviated sensorimotor gating deficits and working memory impairments in mice exposed to the two-hit. • EE normalized hippocampal Iba-1 expression induced by the two-hit model pointing to a reduction in microglial activation. • Hippocampal Slc6a4 promoter demethylation was observed in two-hit animals subjected to EE. Here, we explored the impact of prolonged environmental enrichment (EE) on behavioral, neurochemical, and epigenetic changes in the serotonin transporter gene in mice subjected to a two-hit schizophrenia model. The methodology involved administering the viral mimetic PolyI:C to neonatal Swiss mice as a first hit during postnatal days (PND) 5–7, or a sterile saline solution as a control. At PND21, mice were randomly assigned either to standard environment (SE) or EE housing conditions. Between PND35-44, the PolyI:C-treated group was submitted to various unpredictable stressors, constituting the second hit. Behavioral assessments were conducted on PND70, immediately after the final EE exposure. Following the completion of behavioral assessments, we evaluated the expression of proteins in the hippocampus that are indicative of microglial activation, such as Iba-1, as well as related to neurogenesis, including doublecortin (Dcx). We also performed methylation analysis on the serotonin transporter gene (Slc6a4) to investigate alterations in serotonin signaling. The findings revealed that EE for 50 days mitigated sensorimotor gating deficits and working memory impairments in two-hit mice and enhanced their locomotor and exploratory behaviors. EE also normalized the overexpression of hippocampal Iba-1 and increased the expression of hippocampal Dcx. Additionally, we observed hippocampal demethylation of the Slc6a4 gene in the EE-exposed two-hit group, indicating epigenetic reprogramming. These results contribute to the growing body of evidence supporting the protective effects of long-term EE in counteracting behavioral disruptions caused by the two-hit schizophrenia model, pointing to enhanced neurogenesis, diminished microglial activation, and epigenetic modifications of serotonergic pathways as underlying mechanisms. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations.
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Rodrigues, Francisca Taciana Sousa, de Souza, Marcos Romário Matos, Lima, Camila Nayane de Carvalho, da Silva, Francisco Eliclécio Rodrigues, Costa, Deiziane Viana da Silva, dos Santos, Cláudio Costa, Miyajima, Fábio, de Sousa, Francisca Cléa F., Vasconcelos, Silvânia Maria Mendes, Barichello, Tatiana, Quevedo, João, Maes, Michael, de Lucena, David F., and Macedo, Danielle
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INFLAMMATION , *MENTAL depression , *LIPOPOLYSACCHARIDES , *QUINOLINIC acid , *TRYPTOPHAN , *ANHEDONIA - Abstract
Abstract Major depressed patients show increased bacterial translocation with elevated plasma levels of lipopolysaccharide (LPS), which may trigger immune-inflammatory and neuro-oxidative responses. Recently, an animal model based on chronic LPS administration was developed which was associated with long-lasting depressive-like and neuro-oxidative alterations in female mice. The aim of the current study was to investigate behavioral, neuroimmune and neuroprogressive alterations in female mice 6 weeks after LPS chronic exposure. Female mice received increasing doses of LPS during 5 days at one-month intervals repeated for 4 consecutive months. Six weeks after the last LPS-exposure, we assessed behavioral despair and anhedonia, microglial activation, alterations in tryptophan, 5-HT, kynurenine, quinolinic acid (QUIN) levels and spermidine/spermine N1-acetyltransferase (SAT1) expression in the hippocampus, both with and without fluoxetine administration. Our results show that six weeks post-LPS, mice present behavioral despair and anhedonia in association with increased IBA1 expression (a microglia activation marker), NF-kB p65 and IL-1β levels, indoleamine 2,3-dioxygenase (IDO1) mRNA expression, kynurenine, QUIN levels and QUIN/tryptophan ratio, and lowered tryptophan, 5-HT levels and SAT1 mRNA expression. Fluoxetine reversed the behavioral and neuroimmune alterations but had no effect in the reversal of IDO1 increased expression, QUIN levels and QUIN/tryptophan ratio. In conclusion, our results support the validity of the chronic LPS model of major depression and additionally shows its translational relevance with respect to neuroimmune and neuroprogressive pathways. Highlights • Chronic LPS exposure causes long-lasting behavioral alterations in females. • Chronic LPS induces long-lasting hippocampal neuroinflammatory changes. • LPS decreased tryptophan and 5-HT while increased quinolinic acid levels. • Fluoxetine completely reversed the behavioral while partially reversed the neurochemical alterations. [ABSTRACT FROM AUTHOR]
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- 2018
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8. 360. Is Age Really Just a Number? Accelerated Aging in Bipolar Disorder.
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Topolski, Natasha, Boscutti, Andrea, Lima, Camila Nayane, Fries, Gabriel, Mwangi, Benson, and Soares, Jair
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BIPOLAR disorder - Published
- 2023
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9. P168. Mitochondrial Health Index Correlates With Plasma Circulating Cell-Free Mitochondrial DNA in Bipolar Disorder.
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Scaini, Giselli, Costa, Ana Paula, Lima, Camila Nayane, Fries, Gabriel, Sanches, Marsal, Soares, Jair, and Quevedo, Joao
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MITOCHONDRIAL DNA abnormalities , *MITOCHONDRIA , *MITOCHONDRIAL DNA - Published
- 2022
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10. The effects of the Brazilian ant Dinoponera quadriceps venom on chemically induced seizure models.
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Lopes, Kamila Soares, Rios, Emiliano Ricardo Vasconcelos, Lima, Camila Nayane de Carvalho, Linhares, Maria Isabel, Torres, Alba Fabíola Costa, Havt, Alexandre, Quinet, Yves Patric, Fonteles, Marta Maria de França, and Martins, Alice Maria Costa
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SPASMS , *ANTS , *NEUROPROTECTIVE agents , *NEUROTOXICOLOGY , *AZEPINES , *VENOM - Abstract
Highlights: [•] This study showed the effects of DqV in chemically induced seizure models. [•] The i.p. treatment showed neuroprotective effects on seizures induced by PTZ. [•] The e.v. treatment showed neurotoxic effects on seizures induced by PTZ. [ABSTRACT FROM AUTHOR]
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- 2013
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11. Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: Involvement of cholinergic, nitrergic and pro-oxidant mechanisms.
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de Carvalho, Michele Albuquerque Jales, Chaves-Filho, Adriano, de Souza, Alana Gomes, de Carvalho Lima, Camila Nayane, de Lima, Klistenes Alves, Rios Vasconcelos, Emiliano Ricardo, Feitosa, Mariana Lima, Souza Oliveira, João Victor, de Souza, Denia Alves Albuquerque, Macedo, Danielle S., de Souza, Francisca Cléa Florenço, and de França Fonteles, Marta Maria
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ACETYLCHOLINESTERASE , *TEMPORAL lobe epilepsy , *NITRITES , *MUSCARINIC receptors , *PHOSPHODIESTERASE inhibitors , *NITRIC-oxide synthases , *CYCLIC guanylic acid - Abstract
• Sildenafil has a clear proconvulsant effect in pilocarpine-induced seizures. • Sildenafil inhibits acetylcholinesterase in the brain of pilocarpine-treated animals. • Sildenafil boosts brain nitrite contents, mainly in the hippocampus. • Scopolamine markedly attenuated sildenafil proconvulsant action. • Sildenafil accentuates pilocarpine-induced brain oxidative stress. Sildenafil is a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. Proconvulsant effect is a serious adverse event associated with sildenafil use. Here, we investigated the possible proconvulsant effects of sildenafil in pilocarpine (PILO)-induced seizures model, which mimics some aspects of temporal lobe epilepsy. We also evaluated sildenafil's effects on hippocampal markers related to PILO-induced seizure, for instance, acetylcholinesterase (AChE) activity, oxidative stress and nitric oxide (NO) markers, namely nitrite, inducible NO synthase (iNOS) and neuronal NOS (nNOS). The influences of muscarinic receptors blockade on sildenafil proconvulsant effects and brain nitrite levels were also evaluated. Male mice were submitted to single or repeated (7 days) sildenafil administration (2.5, 5, 10 and 20 mg/kg). Thirty minutes later, PILO was injected and mice were further evaluated for 1 h for seizure activity. Sildenafil induced a dose- and time-progressive proconvulsant effect in PILO-induced seizures. Sildenafil also potentiated the inhibitory effect of PILO in AChE activity and induced a further increase in nitrite levels and pro-oxidative markers, mainly in the hippocampus. Repeated sildenafil treatment also increased the hippocampal expression of iNOS and nNOS isoforms, while the blockade of muscarinic receptors attenuated both sildenafil-induced proconvulsant effect and brain nitrite changes. Our data firstly demonstrated the proconvulsant effect of sildenafil in PILO-model of seizures. This effect seems to be related to an increased cholinergic-nitrergic tone and pro-oxidative brain changes. Also, our findings advert to caution in using sildenafil for patients suffering from neurological conditions that reduces seizure threshold, such as epilepsy. [ABSTRACT FROM AUTHOR]
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- 2019
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12. Antimanic activity of minocycline in a GBR12909-induced model of mania in mice: Possible role of antioxidant and neurotrophic mechanisms.
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de Queiroz, Ana Isabelle G, Chaves Filho, Adriano José Maia, Araújo, Tatiane da Silva, Lima, Camila Nayane Carvalho, Machado, Michel de Jesus Souza, Carvalho, André F, Vasconcelos, Silvania Maria Mendes, de Lucena, David Freitas, Quevedo, João, and Macedo, Danielle
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THERAPEUTIC use of lithium , *ANIMAL experimentation , *ANTIOXIDANTS , *BIOLOGICAL models , *BRAIN , *HIPPOCAMPUS (Brain) , *LITHIUM , *BIPOLAR disorder , *LIPID peroxidation (Biology) , *MICE , *TRANQUILIZING drugs , *VALPROIC acid , *MINOCYCLINE , *PHARMACODYNAMICS , *THERAPEUTICS - Abstract
Background: Mania/hypomania is the cardinal feature of bipolar disorder. Recently, single administration of the dopamine transporter (DAT) inhibitor, GBR12909, was related to mania-like alterations. In the present study we aimed at testing behavioral and brain oxidant/neurotrophic alterations induced by the repeated administration of GBR12909 and its prevention/reversal by the mood stabilizing drugs, lithium (Li) and valproate (VAL) as well as by the neuroprotective drug, minocycline (Mino).Methods: Adult Swiss mice were submitted to 14 days protocols namely prevention and reversal. In the reversal protocol mice were given GBR12909 or saline and between days 8 and 14 received Li, VAL, Mino (25 or 50mg/kg) or saline. In the prevention treatment, mice were pretreated with Li, VAL, Mino or saline prior to GBR12909.Results: GBR12909 repeated administration induced hyperlocomotion and increased risk taking behavior that were prevented and reversed by the mood stabilizers and both doses of Mino. Li, VAL or Mino were more effective in the reversal of striatal GSH alterations induced by GBR12909. Regarding lipid peroxidation Mino was more effective in the prevention and reversal of lipid peroxidation in the hippocampus whereas Li and VAL prevented this alteration in the striatum and PFC. Li, VAL and Mino25 reversed the decrease in BDNF levels induced by GBR12909.Conclusion: GBR12909 repeated administration resembles manic phenotype. Similarly to classical mood-stabilizing agents, Mino prevented and reversed GBR12909 manic-like behavior in mice. Thus, our data provide preclinical support to the design of trials investigating Mino's possible antimanic effects. [ABSTRACT FROM AUTHOR]- Published
- 2017
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13. HIV antiretroviral drug Efavirenz induces anxiety-like and depression-like behavior in rats: evaluation of neurotransmitter alterations in the striatum.
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Cavalcante, Giuliana Ignácio Teixeira, Chaves Filho, Adriano José Maia, Linhares, Maria Isabel, de Carvalho Lima, Camila Nayane, Venâncio, Edith Teles, Rios, Emiliano Ricardo Vasconcelos, de Souza, Francisca Cléa Florenço, Vasconcelos, Silvânia Maria Mendes, Macêdo, Danielle, and de França Fonteles, Marta Maria
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EFAVIRENZ , *ANTIRETROVIRAL agents , *PHARMACOKINETICS , *MENTAL depression , *ANXIETY , *THERAPEUTICS - Abstract
Efavirenz (EFV) is an effective antiretroviral drug with a favorable pharmacokinetic profile and widely used in combination regimens to treat HIV infection. However, there are major concerns about the safety of this drug. Patients treated with EFV often experience neuropsychiatric adverse effects, which frequently lead to switching to alternative EFV-free regimens. The mechanisms involved in the central action of EFV are intrinsically unclear. Thus, this study aimed to investigate the effects of acute and subchronic (2 weeks) EFV administration in a series of behavioral tests for anxiety-like and depression-like behavior in healthy rats. We also evaluated the effect of EFV treatment in striatal concentrations of monoamine neurotransmitters (serotonin, dopamine and noradrenaline) and their metabolites and the amino acid neurotransmitters glutamate and GABA. Our results showed that acute treatment with EFV induced an anxiogenic-like effect, while sub-chronic treatment induced both anxiogenic-like and depressive-like behavior which was dose related.. Additionally, EFV treatment caused marked alterations in the striatal concentrations of monoamines and their metabolites (and turnover rates) and the amino acid neurotransmitters glutamate and GABA. These changes were influenced by treatment duration and dose. These findings add more evidence about the neuropsychiatric adverse effects of EFV and propose potential new mechanisms for the toxic action of this drug in the central nervous system. [ABSTRACT FROM AUTHOR]
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- 2017
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14. Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia.
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Vasconcelos, Germana Silva, dos Santos Júnior, Manuel Alves, Monte, Aline Santos, da Silva, Francisco Eliclécio Rodrigues, Lima, Camila Nayane de Carvalho, Moreira Lima Neto, Abelardo Barbosa, Medeiros, Ingridy da Silva, Teixeira, Antonio Lucio, de Lucena, David Freitas, Vasconcelos, Silvânia Maria Mendes, and Macedo, Danielle S.
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CANDESARTAN , *SEX change in animals , *SCHIZOPHRENIA , *ANGIOTENSIN II , *BLOOD lipids , *MENTAL illness , *THETA rhythm - Abstract
Schizophrenia is a severe mental disorder with complex etiopathogenesis. Based on its neurodevelopmental features, an animal model induced by "two-hit" based on perinatal immune activation followed by peripubertal unpredictable stress was proposed. Sex influences the immune response, and concerning schizophrenia, it impacts the age of onset and symptoms severity. The neurobiological mechanisms underlying the influence of sex in schizophrenia is poorly understood. Our study aimed to evaluate sex influence on proinflammatory and oxidant alterations in male and female mice exposed to the two-hit model of schizophrenia, and its prevention by candesartan, an angiotensin II type 1 receptor (AT1R) blocker with neuroprotective properties. The two-hit model induced schizophrenia-like behavioral changes in animals of both sexes. Hippocampal microglial activation alongside the increased expression of NF-κB, and proinflammatory cytokines, namely interleukin (IL)-1β and TNF-α, were observed in male animals. Conversely, females presented increased hippocampal and plasma levels of nitrite and plasma lipid peroxidation. Peripubertal administration of low-dose candesartan (0.3 mg/kg PO) prevented behavioral, hippocampal, and systemic changes in male and female mice. While these results indicate the influence of sex on inflammatory and oxidative changes induced by the two-hit model, candesartan was effective in both males and females. The present study advances the neurobiological mechanisms underlying sex influence in schizophrenia and opens new avenues to prevent this devasting mental disorder. • The two-hit model induced schizophrenia-like behavioral changes in both sexes' animals. • Male two-hit mice had hippocampal microglial activation and high levels of pro-inflammatory cytokines. • Low-dose candesartan peripubertal administration prevented behavioral changes induced by two-hit. • Low-dose candesartan prevented hippocampal and systemic changes in male and female mice. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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