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Start Over Author "Limal, David" Publisher elsevier b.v.
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2. A synthetic triacylated pseudo-dipeptide molecule promotes Th1/TReg immune responses and enhances tolerance induction via the sublingual route

Author

Mascarell, Laurent, Van Overtvelt, Laurence, Lombardi, Vincent, Razafindratsita, Alain, Moussu, Hélène, Horiot, Stéphane, Chabre, Henri, Limal, David, Moutel, Stéphane, Bauer, Jacques, Chiavaroli, Carlo, and Moingeon, Philippe

Subjects
*IMMUNE response, *T cells, *DENDRITIC cells, *GENETIC regulation
Abstract

Summary: In this study, we tested two triacylated pseudo-dipeptidic molecules, OM-197-MP-AC and OM-294-BA-MP as candidate adjuvants for allergy vaccines. Both molecules induce human dendritic cell (h-DC) maturation and polarize naïve T cells toward the Th1 type with IFNγ production. Only OM-294-BA-MP induces IL10 gene expression both in monocyte-derived DCs and CD4+ naïve T cells. Sublingual administration of OM-294-BA-MP plus the antigen enhances tolerance induction in BALB/c mice with established asthma to ovalbumin with an impact on both airways hyperresponsiveness and lung inflammation. Given its Th1/Treg polarizing properties, OM-294-BA-MP is a valid candidate for sublingual allergy vaccines. [Copyright &y& Elsevier]

Published
2007
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