Su, Emily J., Lin, Zhi-Hong, Zeine, Rana, Yin, Ping, Reierstad, Scott, Innes, Joy E., and Bulun, Serdar E.
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2009.01.025 Byline: Emily J. Su (a), Zhi-Hong Lin (b), Rana Zeine (c), Ping Yin (b), Scott Reierstad (b), Joy E. Innes (b), Serdar E. Bulun (b) Keywords: cyclooxygenase-2; estrogen receptor-beta; fetoplacental; villous endothelial cell Abstract: Regulation of fetoplacental blood flow is likely mediated by factors such as prostanoids. Estrogen and its receptors affect prostanoid biosynthesis. Previously, we demonstrated that villous endothelial cells express estrogen receptor-beta (ESR2), and we sought to determine its role in the mediation of fetoplacental vascular function. Author Affiliation: (a) Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL (b) Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL (c) Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL Article History: Received 22 November 2008; Revised 7 January 2009; Accepted 21 January 2009 Article Note: (footnote) Support for this research was provided by the AAOGF/SMFM Scholarship Award 2007-10 and Northwestern Memorial Foundation Private Donor Grant 2007-08., Cite this article as: Su EJ, Lin Z-H, Zeine R, et al. Estrogen receptor-beta mediates cyclooxygenase-2 expression and vascular prostanoid levels in human placental villous endothelial cells. Am J Obstet Gyncol 2009;200:427.e1-427.e8.