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This study was performed to investigate the age at onset, clinical manifestations, pathological types and features, treatment, and prognosis of pleuropulmonary blastoma (PPB) in children in an attempt to reduce the misdiagnosis rate and achieve early detection and timely intervention. We retrospectively studied the clinical data of 41 pediatric patients with PPB who were treated in our center from March 2002 to November 2018. The data comprised the age at onset, clinical manifestations, characteristics of familial diseases, pathological types, surgical procedures, and prognosis. Twenty male and 21 female patients were included, with a 0.95:1.00 male:female ratio. In total, 51.2% of the patients were misdiagnosed as having nonneoplastic lesions at the first presentation. The interval from symptom onset to surgery/chemotherapy ranged from 5 to 210 days. The pathological types were type I (cystic) PPB (n = 5, 11.9%), for which the median age at diagnosis was 21 months (range, 8–24 months); (solid/cystic) II PPB (n = 12, 28.6%), for which the median age at diagnosis was 37 months (range, 22–112 months); and type III (solid) PPB (n = 23, 54.8%), for which the median age at diagnosis was 39 months (range, 19–156 months). The pathologic type was undefined in one patient (2.4%). The patients were mainly treated by surgery and chemotherapy. The 5-year disease-free survival rate was 69.2%. The clinical manifestations of PPB are nonspecific, its misdiagnosis rate is high, and it has a poor prognosis. Pediatricians should be aware of the seriousness of PPB. The possibility of PPB should be considered in children with pneumothorax, multiple pulmonary cystic lesions, a family history of pulmonary cysts, a family history of PPB, or space-occupying lesions associated with DICER1 syndromes. The lesion should be closely monitored and surgically removed if necessary. The nature of the lesion should be identified early to minimize the risk of progression of the PPB to worse types because of misdiagnosis and missed diagnosis. Multidisciplinary treatment including surgery, chemotherapy, and/or radiotherapy can be applied to patients with PPB. Treatment study. Level III. [ABSTRACT FROM AUTHOR]

• Experimental and numerical investigations are carried out to analyze the cement hydration in different temperature. • Coupled heat and mass transfer model between cement and hydrate layer is proposed. • Numerical study on multi-field coupling mechanisms between cement and hydrate layer is conducted. Exploitation of natural gas hydrates from horizontal wells can significantly improve the production rate and final recovery. However, the long interaction surfaces of horizontal wells may easily disturb the hydrate reservoir. Cement hydration in wellbore is an exothermic reaction, which may lead to the premature dissociation of hydrate, thereby threatening the wellbore integrity. In the present study, experimental and numerical investigations are carried out to analyze the cement hydration in a wide range of temperatures. Then, a coupled model is established considering the multi-field coupling mechanisms between horizontal wells and the hydrate reservoir during well cementing. In the proposed model, the cement hydration, phase change of hydrate, and the multiphase flow in porous hydrate layer are considered. The cement hydration process, transient temperature and pressure distributions, and the hydrate phase change are analyzed by numerical simulations. Results show that the temperature of wellbore and hydrate increases rapidly. The saturation of the hydrate layer within the region 3 times of wellbore diameter decreases significantly. The pressure at the wellbore-hydrate layer interface increases significantly, which may lead to gas penetration into the wellbore. Moreover, threats imposed by the premature dissociation of hydrate last even for a long period after well cementing. [ABSTRACT FROM AUTHOR]

• Magnetic sludge-derived biochar offer the feasibility of an integrated process. • Ethanol-water system decouples the adsorption and degradation. • ·OH and h+ are the main active radicals involved in reactions. • Degradation and regeneration can be obtained in MW + H 2 O 2 under certain conditions. Based on the multi-functional magnetic sludge-derived biochar (MSBC), an innovative integrated process–coupling accumulation by adsorbing, degradation by microwave (MW)-induced catalytic oxidation in the presence of H 2 O 2 and the regeneration of adsorbent simultaneously, was proposed. In this study, bisphenol S (4,4′-sulfonyldiphenol) was chosen as the pollutant model, its behaviors and related mechanism of BPS and MSBC in MW + H 2 O 2 system were investigated. The BPS effective degradation on MSBC was proved by decoupling the adsorption and degradation with solvent extraction. OH and h+ play vital roles based on the scavenger tests. The synergistic effects of hot-spot of microwave irradiation, activation of H 2 O 2 , and charge transfer-induced doping effects of MSBC were attributed to the reactions. This work proves the feasibility in economics and energy-save treatment approach for low concentration organic pollutants in water. [ABSTRACT FROM AUTHOR]