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Introduction ST2 is known to be heightened in the early phase after myocardial infarction, and associated with left ventricular remodeling (LVR). Objective Explore the potential role of ST2 as a predictor for late LVR. Method Patients with a reperfused ST-segment elevation myocardial infarction (STEMI) were included in a prospective cohort. They underwent cardiac magnetic resonance (CMR) at 3 days (baseline), 3 and 12 months. Among 163 patients, 33 presented LVR as defined as a 10% change in LV end-systolic volume during follow-up. All patients were matched to 33 STEMI patients without LVR (non-remodelers) in term of age, gender, anterior infarction, baseline LV ejection fraction (LVEF) and infarct size. Early LVR ( n = 15) was defined as LVR occurring between baseline and 3 months, and Late LVR ( n = 18) as LVR occurring between 3 and 12 months. Usual CMR parameters were measured, so as global systolic wall stress (SWS). A biomarker analysis was performed at baseline and 3 months. Results Patients were 57 ± 10 years old, 85% were male. Early LVR patients presented with mean LVEF and infarct size of 48 ± 10.4% and 28 ± 15.6% LV; and Late LVR with 51 ± 11% and 16 ± 14.5% LV, respectively. At baseline, ST2 (46 ± 54.1 ng/mL), NT-proBNP (869 ± 1702 ng/L) and SWS (16.2 ± 7.1 10 3 N·m −2 ) were not different among the groups. At 3 months, Early LVR patients presented higher ST2, NT-proBNP and SWS (26 ± 12.7 ng/mL, 652 ± 1069 ng/L, 23 ± 9.7 10 3 N·m −2 for Early LVR, versus 21 ± 8.6 ng/mL, 354 ± 272.8 ng/L, 18 ± 7.3 10 3 N·m −2 for the corresponding non-remodelers, with P = 0.017, 0.040, and 0.036, respectively). Late LVR patients presented higher ST2 at 3 months than non-remodelers (34.4 ± 15.9 versus 22.1 ± 8.7 ng/mL, P = 0.046), while NT-proBNP and SWS were not different between groups at both time points ( Fig. 1 ). Conclusion ST2 can be useful to predict LVR after STEMI. [ABSTRACT FROM AUTHOR]