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Start Over Author "Martin, Cedric" Publisher elsevier b.v.
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4. Controversies on the role of 5-HT2C receptors in the mechanisms of action of antidepressant drugs.

Author

Martin, Cedric B.P., Hamon, Michel, Lanfumey, Laurence, and Mongeau, Raymond

Subjects
*SEROTONIN receptors, *BIOCHEMICAL mechanism of action, *MENTAL depression, *THERAPEUTICS, *CELLULAR signal transduction, *GENETIC transcription regulation, PHYSIOLOGICAL effects of antidepressants
Abstract

Highlights: [•] Depression/suicide seem associated with increased 5-HT2C receptor (5-HT2CR) density. [•] Antidepressant drugs (AD) often appear to decrease 5-HT2CR-signaling. [•] Therapeutic effects of AD may occur by reducing stress/anxiety through 5-HT2CR. [•] Direct evidence of AD-induced 5-HT2CR desensitization in the brain remains scarce. [•] Could post-transcriptional regulation of 5-HT2CR underlie, in part, AD action? [Copyright &y& Elsevier]

Published
2014
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