1. Current state and upcoming opportunities for immunoPET biomarkers in lung cancer.
- Author
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Slebe, Maarten, Pouw, Johanna E.E., Hashemi, Sayed M.S., Menke-van der Houven van Oordt, C. Willemien, Yaqub, Maqsood M., and Bahce, Idris
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TUMOR markers , *LUNG cancer , *NON-small-cell lung carcinoma , *POSITRON emission tomography , *TUMOR microenvironment - Abstract
• An overview of relevant PET imaging targets in the tumor microenvironment. • Features and clinical validation of immunoPET tracers in NSCLC. • Challenges and upcoming opportunities for immunoPET. Immune oncology therapy (IO) has now become an important treatment option for patients with a non-small cell lung cancer (NSCLC). However, a substantial proportion of patients still fails to benefit from IO. Predictive biomarkers and biomarkers that provide insights in the biological processes at the tumor microenvironment (TME) level could enhance the beneficial impact of IO, and lead to improved drug development strategies. Immune positron emission tomography (immunoPET) has the potential to provide such biomarkers, by using highly-specific, radiolabeled tracers to investigate key targets in the TME with PET imaging. This review will highlight developments in immunoPET biomarkers, and the corresponding tracers and radionuclides used in cancer, and more specifically NSCLC. We will focus on available clinical tracers as well as those under development, providing an overview of each TME target, and the available clinical validation. Recent advances that could improve immunoPET in the upcoming years will be discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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