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Start Over Author "Morimoto, K." Publisher elsevier b.v.
150 results on '"Morimoto, K."'

23. Status of super heavy element research using GARIS at RIKEN

Author

Morimoto, K., Morita, K., Kaji, D., Goto, S., Haba, H., Ideguchi, E., Kanungo, R., Katori, K., Koura, H., Kudo, H., Ohnishi, T., Ozawa, A., Peter, J.C., Suda, T., Sueki, K., Tanihata, I., Tokanai, F., Xu, H., Yeremin, A.V., Yoneda, A., Yoshida, A., Zhao, T.-L., and Zheng, T.

Published
2004
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26. Parity-violating gamma-ray asymmetry in the neutron-proton capture

Author

Masuda, Y., Bowman, J.D., Carlini, R.D., Case, T., Chupp, T.E., Coulter, K.P., Freedman, S.J., Gentile, T.R., Gericke, M., Greene, G.L., Hersmann, F.W., Ino, T., Ishimoto, S., Jones, G.L., Leuschner, M.B., Mitchell, G.S., Morimoto, K., Muto, S., Nann, H., Page, S.A., Pentilla, S.I., Ramsay, W.D., Sharapov, E.I., Smith, T.B., Snow, W.M., Wilburn, S.W., and Yuan, Y.W.

Published
2003
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42. High-K multi-quasiparticle states in 254No

Author

Clark, R.M., Gregorich, K.E., Berryman, J.S., Ali, M.N., Allmond, J.M., Beausang, C.W., Cromaz, M., Deleplanque, M.A., Dragojević, I., Dvorak, J., Ellison, P.A., Fallon, P., Garcia, M.A., Gates, J.M., Gros, S., Jeppesen, H.B., Kaji, D., Lee, I.Y., Macchiavelli, A.O., Morimoto, K., Nitsche, H., Paschalis, S., Petri, M., Stavsetra, L., Stephens, F.S., Watanabe, H., and Wiedeking, M.

Published
2010
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49. Effect of enterotoxigenic Escherichia coli vaccine on innate immune function of bovine mammary gland infused with lipopolysaccharide.

Author

Morimoto, K., Kanda, N., Shinde, S., and Isobe, N.

Subjects
*CATTLE genetics, *ENTEROTOXINS, *ESCHERICHIA coli, *NATURAL immunity, *MAMMARY glands, *LIPOPOLYSACCHARIDES
Abstract

The effects of using an enterotoxigenic Escherichia coli vaccine on innate immune responses following intramammary infusion of lipopolysaccharide (LPS) were investigated in midlactation Holstein-Friesian cows. Seven out of 14 cows were inoculated with E. coli vaccine. Three weeks later, 100 μg of LPS dissolved in 10 mL of saline was infused into 1 quarter of all cows. Milk was collected every hour from infusion to 12 h after infusion, and twice daily (at 0900 and 1600 h) for 4 d. Blood samples were collected 0, 4, 8, 24, 48, 72, and 96 h after infusion. Rectal temperatures and milk yields were measured. The somatic cell count (SCC), lingual antimicrobial peptide concentration, lactoperoxidase (LPO) activity, and lactoferrin (LF) concentration in milk, and haptoglobin concentration in serum were determined. The mean rectal temperature in vaccinated cows was higher than in control cows at 10 h. The mean milk yield was decreased significantly in the infused quarter of control cows at 24 h compared with pretreatment, but not in vaccinated cows. The mean SCC in milk from vaccinated cows at 12 and 55 h was significantly lower than that of control cows. The lingual antimicrobial peptide and LF concentrations were significantly lower at 8 h and 55 h, respectively, in vaccinated cows than in control cows. The mean antibody titer in the serum against the vaccine at the time of LPS infusion into vaccinated cows was significantly higher than in control cows. These antibody titers were positively correlated with the peak concentrations of LPO and LF in milk following challenge; therefore, cows with a high antibody titer were accompanied by high LPO activity and LF concentration in milk. These results suggest that vaccination suppresses the innate immune reaction after intramammary LPS infusion; however, the elevated antibody titer was unlikely to be responsible for the modification of the innate immune reaction. [ABSTRACT FROM AUTHOR]

Published
2012
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50. Intramammary challenge of lipopolysaccharide stimulates secretion of lingual antimicrobial peptide into milk of dairy cows.

Author

Isobe, N., Morimoto, K., Nakamura, J., Yamasaki, A., and Yoshimura, Y.

Subjects
*DAIRY cattle physiology, *ANTIMICROBIAL peptides, *MAMMARY gland secretions, *ENDOTOXINS, *GRAM-negative bacteria
Abstract

Lingual antimicrobial peptide (LAP) belongs to the β-defensin family in cattle and is found in bovine milk. However, it is unclear whether LAP is involved in the early immune response to mammary infection. The aim of the study was to investigate the changes of LAP concentration in milk after intramammary challenge with lipopolysaccharide (LPS), the gram-negative bacteria cell membrane component, in dairy cows. Milk was collected before and after LPS or phosphate-buffered saline (control) challenge every hour for 12 h on d 0 and twice daily from d 1 to 7. Somatic cell count (SCC), LAP concentration, and lactoperoxidase (LPO) activity in the milk were measured. Somatic cell count started to increase at 2 h postchallenge and remained high until d 5 (694 ± 187 × 103 to >1,000 ± 0 × 103 cells/mL at d 0; >1,000 ± 0 × 103 cells/mL at d 1 to 3; 684 ± 194 × 103 to 829 ± 108 × 103 cells/mL at d 4; 527 ± 197 × 103 to 656 ± 145 × 103 cells/mL at d 5). Somatic cell count increased in the control cows, although the levels were lower compared with those in the LPS challenge group. The LAP concentration in milk increased significantly at 2 h post-LPS-challenge and was maintained at high levels until d 2 (8.6 ± 0.6 to 17.5 ± 2.3 nM). In the control cow infused with phosphate-buffered saline, there was no increase of LAP concentration in milk (5.1 ± 0.6 to 7.2 ± 0.8 nM). Increase of LPO activity in the milk was observed at 6 h after LPS challenge and continued until d 3 (4.7 ± 0.3 to 9.4 ± 1.1 U). No increase of LPO activity was observed in the milk of control cows. The increase and subsequent decrease in LAP concentration after LPS challenge occurred earlier than those of LPO activity. In multiparous cows with LPS infusion, there was a significantly negative relationship between the days leading to the basal levels in LAP concentration and LPO activity (r = -0.75). These results suggest that LPS induces secretion of LAP into milk within hours and that LPO may have a synergistic antimicrobial function with LAP in mammary glands of dairy cows. [ABSTRACT FROM AUTHOR]

Published
2009
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