1. Dyslipidemia in breast cancer patients increases the risk of SAR-CoV-2 infection
- Author
-
Ola D. A. Shammout, Zainab M. Al Shareef, Sarra B. Shakartalla, Sameh S. M. Soliman, Razan B. Alhumaidi, and Naglaa S. Ashmawy
- Subjects
0301 basic medicine ,lysoPC, Lyso-phosphatidylcholine ,viruses ,ERK, Extracellular signal-regulated kinases ,Disease ,Review ,HETEs, Hydroxyeicosatetraenoic acids ,Gastroenterology ,Lipid-lowering agents ,chemistry.chemical_compound ,Breast cancer ,Th, T helper cells ,EETs, Epoxyeicosatrienoic acids ,SR-BI, Scavenger receptor class B type I ,LOX, Lipoxygenases ,PE, Phosphatidylethanolamine ,Respiratory system ,Cause of death ,Hypolipidemic Agents ,lysoPE, Lyso-phosphatidylethanolamine ,VLDL, Very-low-density lipoproteins ,CT, CTP-choline cytidylyltransferase ,Incidence (epidemiology) ,COVID-19, Corona virus disease-19 ,HDL, High- density lipoproteins ,S1PR1, Sphingosine kinase 1 receptor 1 ,Infectious Diseases ,mPGES-1, Microsomal prostaglandin E synthase-1 ,ChoK, Choline kinases ,ATP, Adenosine triphosphate ,Female ,Microbiology (medical) ,medicine.medical_specialty ,COX, Cyclooxygenases ,PC, Phosphatidylcholine ,030106 microbiology ,CHPT, CDP-choline diacylglycerol phosphocholinetransferase ,PG, Prostaglandins ,Breast Neoplasms ,Biology ,TX, Thromboxanes ,Microbiology ,HMGCR, Hydroxymethylglutaryl-coenzyme A reductase ,LDL, Low-density lipoproteins ,SARS-CoV, Severe acute respiratory syndrome coronavirus ,03 medical and health sciences ,Internal medicine ,Genetics ,medicine ,Humans ,MAPK, Mitogen-activated protein kinases ,PLA2G2D, Phospholipase A2 group IID ,Molecular Biology ,C1P, Ceramide-1-phophate ,LT, Leukotrienes ,Ecology, Evolution, Behavior and Systematics ,Dyslipidemias ,DMVs, Double membrane vesicles ,cPLA2α, Cytosolic phospholipase A2α enzyme ,S1P, Sphingosine-1-phophate ,Cholesterol ,SARS-CoV-2 ,PCho, Phosphocholine ,TNF, Tumor necrosis factor ,Cancer ,COVID-19 ,IL-1β, Interleukin-1β ,PI3K, Phosphatidylinositol-3-kinase ,medicine.disease ,SK1, Sphingosine kinase 1 ,030104 developmental biology ,chemistry ,Dyslipidemia ,ACE-2, Angiotensin converting enzyme-2 ,IDL, Intermediate-density lipoproteins ,HPETEs, Hydroperoxyeicosatetraenoic acids - Abstract
Breast cancer (BC) is the most diagnosed and second leading cause of death among women worldwide. Elevated levels of lipids have been reported in BC patients. On the other hand, lipids play an important role in coronavirus infections including the newly emerged disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and designated COVID-19 by WHO. Cancer patients including BC have been reported to be at higher risk of SARS-CoV-2 infection, which is mostly attributed to the chronic immunosuppressive status of cancer patients along with the use of cytotoxic drugs. Here in this review, we highlighted the role of dyslipidemia associated with BC patients in the incidence and severity of SARS-CoV-2 infection. Elevated levels of lipids namely phospholipids, cholesterol, sphingolipids, and eicosanoids in the serum of BC patients and their re-localization to the alveolar spaces can increase susceptibility and/or severity due to SARA-CoV-2 infection. Therefore, manipulation of dyslipidemia in BC patients should be recommended as prophylactic and therapy against SARS-CoV-2 infection.
- Published
- 2021