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Understanding the flow processes that form gravity-flow deposits is vital for modeling and predicting sandstone bodies in the subsurface, which is of great significance for conventional and unconventional oil and gas exploration and development in lacustrine basins. This study analyses gravity-flow deposits of the Late Triassic Chang 7 oil member of the Yanchang Formation in the Ordos Basin, using a combination of well-log analysis, core observations, thin-section analysis, and laboratory measurements. The sedimentary facies, formation mechanisms, distribution patterns, and depositional models of gravity-flow deposits are investigated. Thirteen facies and eight bed-types are recognized in the gravity-flow deposits. Bed types represent deposits of sandy slides, sandy slumps, debrites, high-density turbidites, hybrid event beds, transitional flow deposits, surge-like low-density turbidites, and quasi-steady low-density turbidites. Gravity-flow deposits, particularly those caused by sediment failure, are composed of slides, slumps, debrites, high-density turbidites, hybrid event beds, transitional flow deposits, and surge-like low-density turbidites. These deposits form as isolated lenticular sand bodies, with retrogradational internal stacking patterns. In contrast, gravity-flow deposits caused by flooding rivers are composed of high-density turbidites, hybrid event beds, transitional flow deposits, and quasi-steady low-density turbidites. These deposits exhibit elongate morphologies with progradation stacking patterns internally. The collision between the North China Block and the South China Block, which occurred during the closing of the Qinling Ocean, lead to frequent volcanic eruptions and earthquakes. These activities promoted the development of gravity-flow deposits associated with sediment failure from delta fronts in both the northeastern and southwestern parts of the basin. Concurrently, extremely humid climatic conditions promoted increased fluvial drainage, leading to enhanced hyperpycnal flows into the deep-lacustrine basin depocenters in the Late Triassic. This study emphasized that detailed facies analysis and distribution pattern analysis are the fundamental way to identify the formation mechanisms of gravity flow deposits in lacustrine depression basins. • Thirteen facies and eight bed-types are recognized amongst the gravity-flow deposits in the Late Triassic Chang 7 oil member of the Yanchang Formation in the Ordos Basin, which are composed of sandy slide, sandy slump, muddy debrites, sandy debrites, hybrid event beds, transitional flow deposits, surge-like low-density turbidite, quasi-steady low-density turbidite. • Gravity-flow deposits in the late Triassic Chang 7 oil member of the Yanchang Formation in the Ordos Basin are due to both sediment failure and flooding river. • The collision between the north China block and the south China block during the closing of Qinling Ocean, and extremely humid environment in the Late Triassic promotes the development of gravity-flow deposits in the Ordos Basin. [ABSTRACT FROM AUTHOR]

The present-day in-situ stress field has many important and practical applications during the exploration and development of hydrocarbon resources. The Ordos Basin is a significant petroliferous basin in China, within which, the Yanchang Formation serves as the most significant tight oil reservoir. However, an overview of previous studies indicates that little was known as to the present-day stress state in the Yanchang Formation. Therefore, the present-day stress field in the Yanchang Formation tight oil reservoir of the Ordos Basin is systematically analyzed in this study. The orientation of horizontal maximum principal stress (S Hmax) within the Yanchang Formation of Ordos Basin ranges between north-northeast-south-southwest-trending (NNE-SSW) and east-northeast-west-southwest-trending (ENE-WSW) based on interpretations of borehole breakouts and drilling-induced fractures from borehole imaging logs. The S Hmax orientation shows various tendencies in different wells, which may result from differential development in lithology, natural fracture and bedding plane over various regions. The estimated magnitudes of vertical stress (S v), S Hmax and horizontal minimum principal stress (S hmin) in the studied wells indicate that the normal faulting stress regime is dominant within the Yanchang Formation. In addition, the geomechanical assessments of wellbore stability and natural fracture reactivation are also performed. Natural fractures in the Yanchang Formation Chang 7 tight oil reservoir of Ordos Basin are developed striking mainly in the northeast-southwest-trending (NE-SW) and west-northwest-east-southeast-trending (WNW-ESE). Among them, those fractures with NE-SW-trending strikes are more conductive with reference to the present-day stress state, contributing more to tight oil production in the Ordos Basin. In addition, within the Yanchang Formation, if horizontal wells are drilled towards the NNE-SSW-trending to ENE-WSW-trending, they are more likely to have wellbore instability issues. The results in this study provide important geological information for tight oil production in the Yanchang Formation of Ordos Basin. • The S Hmax orientation in the Yanchang Formation of Ordos Basin is investigated. • Stress magnitude variations with burial depth are analyzed in the Yanchang Formation. • Effects of present-day stress field on natural fracture reactivation are studied. • Implications of stress field on wellbore stability and fracturing are discussed. [ABSTRACT FROM AUTHOR]

Abstract Overactivation of beta-catenin/TCF signaling in prostate cancer is very common. However, how the beta-catenin/TCF complex is regulated in the nucleus remains largely unknown. In this study, we have shown that NOL8, a binding protein of beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin/TCF signaling. NOL8 is up-regulated in the prostate cancer, and promoted the growth, migration and colony formation of cancer cells. Knocking down the expression of NOL8 inhibited the growth, migration and colony formation of prostate cancer cells. The molecular mechanism study demonstrated that NOL8 promoted the migration and colony formation of cancer cells by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of NOL8 in prostate cancer and suggested that NOL8 might be an important therapeutic target for prostate cancer. Highlights • NOL8 was up-regulated in the prostate cancer. • NOL8 activated beta-catenin/TCF signaling. • NOL8 enhanced the interaction between beta-catenin and TCF4. [ABSTRACT FROM AUTHOR]

Compared to conventional reservoirs, pore structure and diagenetic alterations of unconventional tight sand oil reservoirs are highly heterogeneous. The Upper Triassic Yanchang Formation is a major tight-oil-bearing formation in the Ordos Basin, providing an opportunity to study the factors that control reservoir heterogeneity and the heterogeneity of oil accumulation in tight oil sandstones. The Chang 8 tight oil sandstone in the study area is comprised of fine-to medium-grained, moderately to well-sorted lithic arkose and feldspathic litharenite. The reservoir quality is extremely heterogeneous due to large heterogeneities in the depositional facies, pore structures and diagenetic alterations. Small throat size is believed to be responsible for the ultra-low permeability in tight oil reservoirs. Most reservoirs with good reservoir quality, larger pore-throat size, lower pore-throat radius ratio and well pore connectivity were deposited in high-energy environments, such as distributary channels and mouth bars. For a given depositional facies, reservoir quality varies with the bedding structures. Massive- or parallel-bedded sandstones are more favorable for the development of porosity and permeability sweet zones for oil charging and accumulation than cross-bedded sandstones. Authigenic chlorite rim cementation and dissolution of unstable detrital grains are two major diagenetic processes that preserve porosity and permeability sweet zones in oil-bearing intervals. Nevertheless, chlorite rims cannot effectively preserve porosity-permeability when the chlorite content is greater than a threshold value of 7%, and compaction played a minor role in porosity destruction in the situation. Intensive cementation of pore-lining chlorites significantly reduces reservoir permeability by obstructing the pore-throats and reducing their connectivity. Stratigraphically, sandstones within 1 m from adjacent sandstone-mudstone contacts are usually tightly cemented (carbonate cement > 10%) with low porosity and permeability (lower than 10% and 0.1 mD, respectively). The carbonate cement most likely originates from external sources, probably derived from the surrounding mudstone. Most late carbonate cements filled the previously dissolved intra-feldspar pores and the residual intergranular pores, and finally formed the tight reservoirs. The petrophysical properties significantly control the fluid flow capability and the oil charging/accumulation capability of the Chang 8 tight sandstones. Oil layers usually have oil saturation greater than 40%. A pore-throat radius of less than 0.4 μm is not effective for producible oil to flow, and the cut off of porosity and permeability for the net pay are 7% and 0.1 mD, respectively. [ABSTRACT FROM AUTHOR]

Abstract: β-Microseminoprotein (MSMB) is one of the most abundant proteins in human seminal plasma. It has been identified that MSMB increased significantly in oligoasthenoteratozoospermic patients compared with fertile controls. We hypothesized that the functional polymorphism (rs10993994) of MSMB gene could be a risk factor for spermatogenic failure. For this study, 338 patients with idiopathic oligozoospermia or azoospermia and 382 fertile controls were recruited from an infertility clinic. Semen analysis was performed by computer-assisted semen analysis system. The functional polymorphism of MSMB gene was genotyped using TaqMan method. Sixty three seminal plasma samples were used to test the expression of MSMB by enzyme-linked immunosorbent assay (ELISA). The TT genotype and T allele were associated with an increased risk of idiopathic infertility with azoospermia (TT genotype: OR, 1.75; 95% CI, 1.03–2.95; T allele: OR, 1.34; 95% CI, 1.03–1.75). However, no differences were found in risk for the TT genotype or T allele among men with oligozoospermia. In addition, idiopathic infertile males have significantly higher MSMB expression levels than fertile controls. We present the first epidemiologic evidence supporting the involvement of common genetic polymorphism in MSMB gene in spermatogenic failure. These results suggest that men carrying the variant have an increased risk of spermatogenic failure associated with male infertility. Further studies are needed to confirm the roles of the polymorphism in idiopathic azoospermia and investigate the biological mechanism of elevated MSMB expression in infertile males. [Copyright &y& Elsevier]

Abstract: Studies of the relationship between male infertility and polymorphisms in the regions of FSHR G-29A (rs1394205), 919A>G (Thr307Ala, rs6165) and 2039A>G (Asn680Ser, rs6166) have reported inconsistent results. To assess the association between them, a meta-analysis was conducted. PubMed and CBMdisc literature search were conducted to identify all eligible studies investigating such a relationship. The pooled ORs were performed for co-dominant model, dominant model and recessive model in FSHR G-29A, Thr307Ala and Asn680Ser respectively to assess the strength of association. A total of 1644 male infertility cases and 1748 controls were collected from seven case–control studies. In the overall analysis, no significant association between the three polymorphisms and risk of male infertility was observed. Stratified analysis showed that there were no significantly increased risks of azoospermia and oligoasthenoteratozoospermia (OAT) in any of the genetic models. This meta-analysis supports that FSHR G-29A, Thr307Ala and Asn680Ser polymorphisms may not be capable of causing male infertility susceptibility. [Copyright &y& Elsevier]

Authigenic chlorite plays an important controlling role in reservoir quality, and is widely distributed in the tight sandstone reservoirs of the Triassic Yanchang Formation in the Southwestern Ordos Basin, China. The occurrence and origins of authigenic chlorite were investigated using an integrated approach of optical microscopy, scanning electron microscopy, X-ray diffraction, electron probe microanalysis, and fluid inclusion analysis. The sandstones are fine-grained lithic arkoses and feldspathic litharenite with 11.5% volcanic rock fragments. Authigenic chlorite occurs in two morphotypes, including pore-lining and pore-filling chlorite. Pore-lining chlorite occurs as coatings on the framework grains and covers the entire fining-upward sandstones. Pore-filling chlorite is restricted to the middle to upper part of the fining-upward sandstones and appears as discrete flaky plates or rosettes in the pores or attaches to the surfaces of pore-lining chlorite. Pore-lining chlorite originated from smectite precursors that were derived from volcanic material alteration in the early stage of diagenesis, with temperatures primarily about 90 °C. In contrast, pore-filling chlorite was precipitated in pore spaces with higher concentrations of Mg2+ and Fe2+ released from volcanic rock fragments and mica debris dissolution. Moreover, the chemical composition of pore-filling chlorite was affected by early calcite cementation which consumed some ions at temperatures lower than about 110 °C. The thin and continuous pore-lining chlorite is the only chlorite type with a positive effect on reservoir quality, whereas the very thick pore-lining chlorite (>6.7 μm) or pore-filling chlorite significantly reduce the porosity and permeability. Systematic studies of authigenic chlorite can provide important insights into the reservoir heterogeneity and are applicable to the exploration and development of tight oil. • Performed a detailed investigation on types and distribution of authigenic chlorite. • Clarified the origin of two generations of authigenic chlorite. • Determined the impact of authigenic chlorite on reservoir heterogeneity. [ABSTRACT FROM AUTHOR]