23 results on '"Pariente, Jérémie"'
Search Results
2. The long-term impact of irradiation on functional connectivity in brain circuits involved in memory processes after pediatric posterior fossa tumor
- Author
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BAUDOU, Eloïse, PERAN, Patrice, TENSAOUTI, Fatima, ARRIBARAT, Germain, PARIENTE, Jérémie, COURBIERES, Nicolas, POLLIDORO, Lisa, BERTOZZI, Anne-Isabelle, GAMBART, Marion, SEVELY, Annick, ROQUES, Margaux, DUCASSOU, Anne, DANNA, Jérémy, TALLET, Jessica, DUFOUR, Christelle, CHAIX, Yves, and LAPRIE, Anne
- Published
- 2024
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3. Grey Matter changes in treatment-resistant depression during electroconvulsive therapy
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Yrondi, Antoine, Nemmi, Federico, Billoux, Sophie, Giron, Aurélie, Sporer, Marie, Taib, Simon, Salles, Juliette, Pierre, Damien, Thalamas, Claire, Rigal, Emilie, Danet, Lola, Pariente, Jérémie, Schmitt, Laurent, Arbus, Christophe, and Péran, Patrice
- Published
- 2019
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4. Neuronal spiking activity highlights a gradient of epileptogenicity in human tuberous sclerosis lesions
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Despouy, Elodie, Curot, Jonathan, Denuelle, Marie, Deudon, Martin, Sol, Jean-Christophe, Lotterie, Jean-Albert, Reddy, Leila, Nowak, Lionel G., Pariente, Jérémie, Thorpe, Simon J., Valton, Luc, and Barbeau, Emmanuel J.
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- 2019
- Full Text
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5. Effects of sociodemographic and player characteristics on baseline cognitive performance in 1000 rugby players: A retrospective 8-year follow-up study.
- Author
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Julien, Adeline, Tessier, Samuel, Tisserand, Camille, Péran, Patrice, Planton, Mélanie, Pariente, Jérémie, and Brauge, David
- Abstract
To analyze the effects of sociodemographic and player characteristics on the Sport Concussion Assessment Tool and neuropsychological scores over 8 years in a large sample of rugby players. An 8-year retrospective study of preseason clinical assessments of professional rugby players and players enrolled in training academies at professional clubs. The Sport Concussion Assessment Tool-3 or -5, Trail Making Test and Digit Symbol Substitution Test were administered prior to the start of the competition season for each player. Statistical analyses included: (i) descriptive analyses of sociodemographic, player and neuropsychological characteristics; (ii) multivariate models to identify factors influencing cognitive scores at the first visit; and (iii) linear mixed models to assess the evolution of the scores over the years. One thousand players were included (mean age: 22.8, males: 92 %). Twenty-two percent of the athletes reported baseline symptoms. A higher level of education was associated with better cognitive scores at the first visit and over the years. Forwards had poorer processing speed performances compared to backs at the first visit and over repeated assessments. Finally, the number of examinations was associated with improved cognitive scores showing a practice effect on all the neuropsychological tests, except for the Standardized Assessment of Concussion 5th edition. Results from this retrospective study could help to improve the management of athletes and return-to-play decision-making in collision sports. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Alteration of rhythmic unimanual tapping and anti-phase bimanual coordination in Alzheimer’s disease: A sign of inter-hemispheric disconnection?
- Author
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Martin, Elodie, Blais, Mélody, Albaret, Jean-Michel, Pariente, Jérémie, and Tallet, Jessica
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- 2017
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7. N270 sensitivity to conflict strength and working memory: A combined ERP and sLORETA study
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Scannella, Sébastien, Pariente, Jérémie, De Boissezon, Xavier, Castel-Lacanal, Evelyne, Chauveau, Nicolas, Causse, Mickaël, Dehais, Frédéric, and Pastor, Josette
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- 2016
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8. Impact of a pediatric posterior fossa tumor and its treatments on motor procedural learning.
- Author
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Baudou, Eloïse, Danna, Jérémy, Tallet, Jessica, Pollidoro, Lisa, Tensaouti, Fatima, Bertozzi, Anne-Isabelle, Pariente, Jérémie, Courbieres, Nicolas, Dufour, Christelle, Grill, Jacques, Chaix, Yves, and Laprie, Anne
- Subjects
MOTOR learning ,INFRATENTORIAL brain tumors ,LONG-term memory ,PERCEPTUAL motor learning ,TUMOR treatment - Abstract
Posterior fossa tumor (PFT) survivors have difficulty learning new skills. Procedural memory is a skill learning system that allows, through training, the automatization of procedures and progressive improvement of performance. It underlies most of the motor procedures in everyday life that we perform automatically, such as riding a bike or writing. Motor procedural memory is divided into two components: motor sequence learning involving mainly cortico-striatal networks, and motor adaptation involving mainly cortico-cerebellar networks. The aim of this work was to explore the impact of a tumor and its treatment during childhood on procedural learning hypothesizing that sequence learning would be impaired in PFT survivors who have been treated with radiotherapy, whereas motor adaptation would be impaired in all PFT survivors. 22 irradiated survivors of PFT, 17 non-irradiated survivors and 21 healthy controls from the IMPALA study (NCT04324450) performed a motor sequence learning task and a motor adaptation task. Doses received by striatal and cerebellar structures were reported from the initial dosimetry plans. Sequence learning was preserved in both tumor groups, but at the individual level 7/22 irradiated, and 4/17 non-irradiated participants failed to learn the motor sequence. Motor adaptation was impaired in both tumor groups, predominantly in the irradiated group. This study sheds new light on the long-term impact of PFT treatments in childhood on a rarely-studied part of memory, which is perceptual-motor procedural learning. Our results suggest that the cerebellum and striatum could be considered as organs at risk with regard to procedural learning. [Display omitted] • Motor sequence learning is globally preserved in posterior fossa tumor survivors. • Motor adaptation is altered in posterior fossa tumor survivors. • Radiotherapy is a risk factor for impaired performance in procedural memory. • Young age at treatment and cerebellar deficit are risk factors for motor adaptation. • Striatum and cerebellum should be considered as organs at risk for learning. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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9. A prospective behavioral and imaging study exploring the impact on long-term memory of radiotherapy delivered for a brain tumor in childhood and adolescence
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Baudou, Eloïse, Pariente, Jérémie, Péran, Patrice, Tensaouti, Fatima, Pollidoro, Lisa, Meligne, Déborah, Ducassou, Anne, Gros-Dagnac, Hélène, Arribarat, Germain, Desirat, Jean-Pierre, Bertozzi, Anne-Isabelle, Gambart, Marion, Larrieu-Ciron, Delphine, Barbolosi, Dominique, Muracciole, Xavier, Lemesle, Béatrice, Sevely, Annick, Roques, Margaux, Cazaux, Mathilde, Tallet, Jessica, Danna, Jeremy, Chaix, Yves, and Laprie, Anne
- Published
- 2022
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10. Update on the Efficacy of Cognitive Rehabilitation After Moderate to Severe Traumatic Brain Injury: A Scoping Review.
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Julien, Adeline, Danet, Lola, Loisel, Mallaury, Brauge, David, Pariente, Jérémie, Péran, Patrice, and Planton, Mélanie
- Abstract
: To identify, categorize, and analyze the methodological issues of cognitive rehabilitation of patients with moderate to severe traumatic brain injury and its efficacy. Pubmed and PsycINFO were searched for studies published between 2015 and 2021 using keywords for cognitive intervention and traumatic brain injury. Two independent reviewers selected articles concerning cognitive rehabilitation for adults with traumatic brain injury. Of 458 studies, 97 full-text articles were assessed and 46 met the inclusion criteria. Data were analyzed by 1 reviewer according to criteria concerning the methodological quality of studies. Results showed a large scope of 7 cognitive domains targeted by interventions, delivered mostly in individual sessions (83%) with an integrative cognitive approach (48%). Neuroimaging tools as a measure of outcome remained scarce, featuring in only 20% of studies. Forty-three studies reported significant effects of cognitive rehabilitation, among which 7 fulfilled a high methodological level of evidence. : Advances and shortcomings in cognitive rehabilitation have both been highlighted and led us to develop methodological key points for future studies. The choice of outcome measures, the selection of control interventions, and the use of combined rehabilitation should be investigated in further studies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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11. N°383 – Sleep-related epileptic activities in Alzheimer disease are sparse and do not have a major impact on cognition
- Author
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Szabo, Anna B., Curot, Jonathan, Denuelle, Marie, Debs, Rachel, Barbeau, Emmanuel, Lemesle, Béatrice, Gerard, Fleur, Péran, Patrice, Pariente, Jérémie, Dahan, Lionel, and Valton, Luc
- Published
- 2023
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12. Déjà-rêvé: Prior dreams induced by direct electrical brain stimulation.
- Author
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Curot, Jonathan, Valton, Luc, Denuelle, Marie, Vignal, Jean-Pierre, Maillard, Louis, Pariente, Jérémie, Trébuchon, Agnès, Bartolomei, Fabrice, and Barbeau, Emmanuel J.
- Abstract
Background Epileptic patients sometimes report experiential phenomena related to a previous dream they had during seizures or electrical brain stimulation (EBS). This has been alluded to in the literature as “déjà-rêvé” (“already dreamed”). However, there is no neuroscientific evidence to support its existence and this concept is commonly mixed up with déjà-vu. We hypothesized that déjà-rêvé would be a specific entity, i.e., different from other experiential phenomena reported in epileptic patients, induced by EBS of specific brain areas. Methods We collected all experiential phenomena related to dreams induced by electrical brain stimulations (EBS) in our epileptic patients (2003–2015) and in a review of the literature. The content of these déjà-rêvé and the location of EBS were analyzed. Results We collected 7 déjà-rêvé in our database and 35 from the literature, which corresponds to an estimated prevalence of 0.3‰ of all EBS-inducing déjà-rêvé. Déjà-rêvé is a generic term for three distinct entities: it can be the recollection of a specific dream (“episodic-like”), reminiscence of a vague dream (“familiarity-like”) or experiences in which the subject feels like they are dreaming (literally “a dreamy state”). EBS-inducing “episodic-like” and “familiarity-like” déjà-rêvé were mostly located in the medial temporal lobes. “Dreamy states” were induced by less specific EBS areas although still related to the temporal lobes. Conclusions This study demonstrates that déjà-rêvé is a heterogeneous entity that is different from déjà-vu, the historical “dreamy state” definition and other experiential phenomena. This may be relevant for clinical practice as it points to temporal lobe dysfunction and could be valuable for studying the neural substrates of dreams. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
13. Selective serotonin reuptake inhibitor paroxetine modulates motor behavior through practice. A double-blind, placebo-controlled, multi-dose study in healthy subjects
- Author
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Loubinoux, Isabelle, Pariente, Jérémie, Rascol, Olivier, Celsis, Pierre, and Chollet, François
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NEUROTRANSMITTER uptake inhibitors , *AUTOMATISM (Consciousness) - Abstract
We hypothesized that selective serotonin reuptake inhibitors (SSRIs) could modulate motor activity in healthy subjects in a dose-dependent manner. The effects of a single dose of paroxetine were tested in a double-blind, placebo-controlled study. Six randomized and counterbalanced subjects performed behavioral tests in three sessions 1 week apart (E1, E2 and E3) at peak plasma concentration (5 h after drug intake). Each subject was given 20 mg or 60 mg of the drug, or a placebo. Tasks were the Nine Peg Hole test (three trials), Moede dexteritymeter (two trials), and compatible and incompatible reaction time tasks. The results show that at the first trials, performance did not differ after placebo or paroxetine intake. However, 20 and 60 mg of paroxetine improved performance significantly at the third trial of the Nine Peg Hole test and subjects receiving the drug performed 7% faster than those under placebo. An amount of 20 mg, but not 60 mg, of paroxetine improved dexterity significantly at the second trial of the Moede test and subjects performed 30% faster. Conversely, the drug did not affect reaction time for the compatible task and subjects were 11% slower under 20 mg with the incompatible task. Thus, paroxetine decreased the ability to inhibit automatism. Thus, it was concluded that a single dose of paroxetine improved motor performance through practice. But negative effects occurred on tasks including the inhibition of an automatism. Paroxetine enhanced brain motor output (motor activity in S1M1) [NeuroImage, 15 (2002) 26]. This S1M1 hyperactivation is likely to be responsible for the better performance. The brain effect and motor improvement were dose dependent. For both, 20 mg was the optimal dose. [Copyright &y& Elsevier]
- Published
- 2002
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14. Increased functional connectivity supports language performance in healthy aging despite gray matter loss.
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Pistono, Aurélie, Guerrier, Laura, Péran, Patrice, Rafiq, Marie, Giméno, Mélanie, Bézy, Catherine, Pariente, Jérémie, and Jucla, Mélanie
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AGING , *GRAY matter (Nerve tissue) , *FUNCTIONAL connectivity , *FUNCTIONAL magnetic resonance imaging , *OLDER people , *NEUROLINGUISTICS - Abstract
Although language is quite preserved from aging, it remains unclear whether age-related differences lead to a deterioration or reorganization in language functional networks, or to different dynamics with other domains (e.g., the multiple-demand system). The present study is aimed at examining language networks, using resting-state functional magnetic resonance imaging in typical aging in relation to language performance. Twenty-three (23) younger adults and 24 healthy older adults were recruited. Volumetric gray matter differences between the 2 groups were assessed using voxel-based morphometry. Then, seed-based analyses, integrated local correlations in core regions of the language network, and within- and between-network connectivity were performed. We expected less extended connectivity maps, local coherence diminution, and higher connectivity with the multiple-demand system in older adults. On the contrary, analyses showed language network differences in healthy aging (i.e., increased connectivity with areas inside and outside language network), but no deterioration, despite widespread atrophy in older adults. Integrated local correlation revealed alterations that were unnoticeable with other analyses. Although gray matter loss was not correlated with language performance, connectivity differences were positively correlated with fluency performance in the older group. These results differ from the literature concerning other cognitive networks in aging in that they show extra internetwork connections without a decrease in intranetwork language connections. This reorganization could explain older adults' good language performance and could be interpreted in accordance with the scaffolding theory of aging and cognition. • Despite widespread atrophy older adults have minimal language functional network changes. • Local connectivity is reduced in language network during typical aging. • Age-related differences in language network are correlated with fluency performance. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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15. The Regulatory Role of the Human Mediodorsal Thalamus.
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Pergola, Giulio, Danet, Lola, Pitel, Anne-Lise, Carlesimo, Giovanni A., Segobin, Shailendra, Pariente, Jérémie, Suchan, Boris, Mitchell, Anna S., and Barbeau, Emmanuel J.
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THALAMUS , *BRAIN imaging , *PREFRONTAL cortex , *NEUROPSYCHOLOGICAL tests , *COGNITION - Abstract
The function of the human mediodorsal thalamic nucleus (MD) has so far eluded a clear definition in terms of specific cognitive processes and tasks. Although it was at first proposed to play a role in long-term memory, a set of recent studies in animals and humans has revealed a more complex, and broader, role in several cognitive functions. The MD seems to play a multifaceted role in higher cognitive functions together with the prefrontal cortex and other cortical and subcortical brain areas. Specifically, we propose that the MD is involved in the regulation of cortical networks especially when the maintenance and temporal extension of persistent activity patterns in the frontal lobe areas are required. Highlights The mediodorsal thalamic nucleus is involved in the cognitive deficits observed in several neurological and psychiatric disorders. The long-standing belief in a role of the mediodorsal thalamic nucleus mainly in long-term memory is now being reconsidered. Recent studies emphasize its function in many cognitive tasks related to the prefrontal cortex. The mediodorsal thalamic nucleus is required for the rapid and accurate performance of cognitive tasks and temporally extends the efficiency of cortical networks involving the prefrontal cortex. We propose that the common ground of multiple lines of evidence from human studies points to a role of the mediodorsal thalamic nucleus in regulating prefrontal activity patterns. These hypotheses can be tested by developing specific neuropsychological tasks, parceling the thalamus with high-resolution MRI, and using intracranial recordings in humans. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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16. Familiarity and recollection vs representational models of medial temporal lobe structures: A single-case study.
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Lacot, Emilie, Vautier, Stéphane, Kőhler, Stefan, Pariente, Jérémie, Martin, Chris B., Puel, Michèle, Lotterie, Jean-Albert, and Barbeau, Emmanuel J.
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TEMPORAL lobe , *EXPLICIT memory , *NEURAL circuitry , *NEURAL transmission , *HIPPOCAMPUS (Brain) , *VISUAL perception - Abstract
Although it is known that medial temporal lobe (MTL) structures support declarative memory, the fact these structures have different architectonics and circuitry suggests they may also play different functional roles. Selective lesions of MTL structures offer an opportunity to understand these roles. We report, in this study, on JMG, a patient who presents highly unusual lesions that completely affected all MTL structures except for the right hippocampus and parts of neighbouring medial parahippocampal cortex. We first demonstrate that JMG shows preserved recall for visual material on 5 experimental tasks. This finding suggests that his right hippocampus is functional, even though it appears largely disconnected from most of its MTL afferents. In contrast, JMG performed very poorly, as compared to control subjects, on 7 tasks of visual recognition memory for single items. Although he sometimes performed above chance, neither familiarity nor recollection appeared fully preserved. These results indicate that extrahippocampal structures, damaged bilaterally in JMG, perform critical operations for item recognition; and that the hippocampus cannot take over that role, including recollection, when these structures are largely damaged. Finally, in a set of 3 recognition memory tasks with scenes as stimuli, JMG performed at the level of control participants and obtained normal indices of familiarity and recollection. Overall, our findings suggest that the right hippocampus and remnants of parahippocampal cortex can support recognition memory for scenes in the absence of preserved item-recognition memory. The patterns of dissociations, which we report in the present study, provide support for a representational account of the functional organization of MTL structures. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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17. Memory scrutinized through electrical brain stimulation: A review of 80 years of experiential phenomena.
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Curot, Jonathan, Busigny, Thomas, Valton, Luc, Denuelle, Marie, Vignal, Jean-Pierre, Maillard, Louis, Chauvel, Patrick, Pariente, Jérémie, Trebuchon, Agnès, Bartolomei, Fabrice, and Barbeau, Emmanuel J.
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BRAIN stimulation , *REMINISCENCE , *EPISODIC memory , *EXPLICIT memory , *PREDICTION models - Abstract
Electrical brain stimulations (EBS) sometimes induce reminiscences, but it is largely unknown what type of memories they can trigger. We reviewed 80 years of literature on reminiscences induced by EBS and added our own database. We classified them according to modern conceptions of memory. We observed a surprisingly large variety of reminiscences covering all aspects of declarative memory. However, most were poorly detailed and only a few were episodic. This result does not support theories of a highly stable and detailed memory, as initially postulated, and still widely believed as true by the general public. Moreover, memory networks could only be activated by some of their nodes: 94.1% of EBS were temporal, although the parietal and frontal lobes, also involved in memory networks, were stimulated. The qualitative nature of memories largely depended on the site of stimulation: EBS to rhinal cortex mostly induced personal semantic reminiscences, while only hippocampal EBS induced episodic memories. This result supports the view that EBS can activate memory in predictable ways in humans. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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18. Challenging diagnosis and treatment decision of a long-history autoantibody-negative autoimmune encephalitis.
- Author
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Calvat, Pauline, Leung, Clémence, Bost, Chloé, Fortenfant, Francoise, Simonetta-Moreau, Marion, Pariente, Jérémie, Rafiq, Marie, Brefel-Courbon, Christine, Rascol, Olivier, Fabbri, Margherita, and Ory-Magne, Fabienne
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ENCEPHALITIS , *DIAGNOSIS , *THERAPEUTICS , *ATAXIA , *DYSTONIA - Published
- 2023
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19. Peritraumatic distress predicts acute posttraumatic stress disorder symptoms after a first stroke
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Letamendia, Clara, LeBlanc, Nicole J., Pariente, Jérémie, Simon, Naomi M., Thomas, Charmaine L., Chabrol, Henri, Chollet, François, Raposo, Nicolas, Schmitt, Laurent, Birmes, Philippe, and Bui, Eric
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POST-traumatic stress disorder , *SEVERITY of illness index , *STROKE patients - Published
- 2012
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20. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial
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Chollet, François, Tardy, Jean, Albucher, Jean-François, Thalamas, Claire, Berard, Emilie, Lamy, Catherine, Bejot, Yannick, Deltour, Sandrine, Jaillard, Assia, Niclot, Philippe, Guillon, Benoit, Moulin, Thierry, Marque, Philippe, Pariente, Jérémie, Arnaud, Catherine, and Loubinoux, Isabelle
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FLUOXETINE , *PHYSIOLOGICAL therapeutics , *HEMIPLEGICS , *PARALYSIS , *PLACEBOS , *HEPATOTOXICOLOGY , *HEART diseases , *RANDOMIZED controlled trials , *CEREBROVASCULAR disease , *DRUG efficacy - Abstract
Summary: Background: Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that fluoxetine enhances motor recovery but its clinical efficacy is unknown. We therefore aimed to investigate whether fluoxetine would enhance motor recovery if given soon after an ischaemic stroke to patients who have motor deficits. Methods: In this double-blind, placebo-controlled trial, patients from nine stroke centres in France who had ischaemic stroke and hemiplegia or hemiparesis, had Fugl-Meyer motor scale (FMMS) scores of 55 or less, and were aged between 18 years and 85 years were eligible for inclusion. Patients were randomly assigned, using a computer random-number generator, in a 1:1 ratio to fluoxetine (20 mg once per day, orally) or placebo for 3 months starting 5–10 days after the onset of stroke. All patients had physiotherapy. The primary outcome measure was the change on the FMMS between day 0 and day 90 after the start of the study drug. Participants, carers, and physicians assessing the outcome were masked to group assignment. Analysis was of all patients for whom data were available (full analysis set). This trial is registered with ClinicalTrials.gov, number NCT00657163. Findings: 118 patients were randomly assigned to fluoxetine (n=59) or placebo (n=59), and 113 were included in the analysis (57 in the fluoxetine group and 56 in the placebo group). Two patients died before day 90 and three withdrew from the study. FMMS improvement at day 90 was significantly greater in the fluoxetine group (adjusted mean 34·0 points [95% CI 29·7–38·4]) than in the placebo group (24·3 points [19·9–28·7]; p=0·003). The main adverse events in the fluoxetine and placebo groups were hyponatraemia (two [4%] vs two [4%]), transient digestive disorders including nausea, diarrhoea, and abdominal pain (14 [25%] vs six [11%]), hepatic enzyme disorders (five [9%] vs ten [18%]), psychiatric disorders (three [5%] vs four [7%]), insomnia (19 [33%] vs 20 [36%]), and partial seizure (one [<1%] vs 0). Interpretation: In patients with ischaemic stroke and moderate to severe motor deficit, the early prescription of fluoxetine with physiotherapy enhanced motor recovery after 3 months. Modulation of spontaneous brain plasticity by drugs is a promising pathway for treatment of patients with ischaemic stroke and moderate to severe motor deficit. Funding: Public French National Programme for Clinical Research. [Copyright &y& Elsevier]
- Published
- 2011
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- View/download PDF
21. Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience.
- Author
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Sellami, Leila, Rucheton, Benoît, Ben Younes, Imen, Camuzat, Agnès, Saracino, Dario, Rinaldi, Daisy, Epelbaum, Stephane, Azuar, Carole, Levy, Richard, Auriacombe, Sophie, Hannequin, Didier, Pariente, Jérémie, Barbier, Mathieu, Boutoleau-Bretonnière, Claire, Couratier, Philippe, Pasquier, Florence, Deramecourt, Vincent, Sauvée, Mathilde, Sarazin, Marie, and Lagarde, Julien
- Subjects
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FRONTOTEMPORAL dementia , *FRONTOTEMPORAL lobar degeneration , *PROGRANULIN , *AGE of onset , *PATIENT-family relations - Abstract
GRN mutations are frequent causes of familial frontotemporal degeneration. Although there is no clear consensual threshold, plasma progranulin levels represent an efficient biomarker for predicting GRN mutations when decreased. We evaluated plasma levels to determine whether it could also predict age at onset, clinical phenotype, or disease progression in 160 GRN carriers. Importantly, progranulin levels were influenced by gender, with lower levels in male than in female patients in our study. Although we found no correlation with age at onset or with clinical phenotype, we confirmed that decreased level predicts GRN mutations, even in presymptomatic carriers more than four decades before disease onset. We also provided first evidence for the stability of levels throughout longitudinal trajectory in carriers, over a 4-year time span. Finally, we confirmed that progranulin levels constitute a reliable, cost-effective marker, suitable as a screening tool in patients with familial frontotemporal degeneration, and more broadly in patients without family history or with atypical presentations who are less likely to be referred for molecular diagnosis. • Plasma progranulin levels were analyzed in 293 GRN carriers and controls. • Progranulin levels were stable in carriers and controls over a 4-year time span. • Plasma progranulin did not correlate with age at onset and FTD phenotypes. • Different thresholds were suggested for male and female carriers. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
22. Screening UBQLN-2 in French frontotemporal lobar degeneration and frontotemporal lobar degeneration–amyotrophic lateral sclerosis patients
- Author
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Lattante, Serena, Le Ber, Isabelle, Camuzat, Agnès, Pariente, Jérémie, Brice, Alexis, and Kabashi, Edor
- Subjects
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TEMPORAL lobe , *AMYOTROPHIC lateral sclerosis , *GENE mapping , *GENETIC mutation , *X chromosome , *NEURODEGENERATION - Abstract
Abstract: The ubiquilin-2 gene (UBQLN-2) is the only amyotrophic lateral sclerosis (ALS)-related gene mapping on the X chromosome. Mutations in the PXX domain of UBQLN-2 have been first described in ALS patients with a mutational frequency of 2.6% in familial ALS cases with no evidence of male-to-male transmission. Different populations have been further tested with mutations largely distributed in the gene and lower frequency of positive cases. To determine the genetic contribution of UBQLN-2 in frontotemporal lobar degeneration (FTLD) and FTLD-ALS, we screened a cohort of 136 French patients, identifying a missense variant (c.1006A>G; p.T336A) in 1 FTLD patient whose biological relevance to disease is questionable. We conclude that UBQLN-2 mutations related to ALS/FTLD are extremely rare in French FTLD and FTLD-ALS patients and should not be analyzed systematically. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
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23. Errata
- Author
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Chollet, François, Tardy, Jean, Albucher, Jean-François, Thalamas, Claire, Berard, Emilie, Lamy, Catherine, Bejot, Yannick, Deltour, Sandrine, Jaillard, Assia, Niclot, Philippe, Guillon, Benoit, Moulin, Thierry, Marque, Philippe, Pariente, Jérémie, Arnaud, Catherine, and Loubinoux, Isabelle
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CONVALESCENCE , *FLUOXETINE , *LONGITUDINAL method , *MOTOR ability , *STROKE , *RANDOMIZED controlled trials , *TREATMENT effectiveness , *BLIND experiment , *ACUTE diseases , *PHARMACODYNAMICS , *THERAPEUTICS - Abstract
Background: Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that fluoxetine enhances motor recovery but its clinical efficacy is unknown. We therefore aimed to investigate whether fluoxetine would enhance motor recovery if given soon after an ischaemic stroke to patients who have motor deficits.Methods: In this double-blind, placebo-controlled trial, patients from nine stroke centres in France who had ischaemic stroke and hemiplegia or hemiparesis, had Fugl-Meyer motor scale (FMMS) scores of 55 or less, and were aged between 18 years and 85 years were eligible for inclusion. Patients were randomly assigned, using a computer random-number generator, in a 1:1 ratio to fluoxetine (20 mg once per day, orally) or placebo for 3 months starting 5-10 days after the onset of stroke. All patients had physiotherapy. The primary outcome measure was the change on the FMMS between day 0 and day 90 after the start of the study drug. Participants, carers, and physicians assessing the outcome were masked to group assignment. Analysis was of all patients for whom data were available (full analysis set). This trial is registered with ClinicalTrials.gov, number NCT00657163.Findings: 118 patients were randomly assigned to fluoxetine (n=59) or placebo (n=59), and 113 were included in the analysis (57 in the fluoxetine group and 56 in the placebo group). Two patients died before day 90 and three withdrew from the study. FMMS improvement at day 90 was significantly greater in the fluoxetine group (adjusted mean 34·0 points [95% CI 29·7-38·4]) than in the placebo group (24·3 points [19·9-28·7]; p=0·003). The main adverse events in the fluoxetine and placebo groups were hyponatraemia (two [4%] vs two [4%]), transient digestive disorders including nausea, diarrhoea, and abdominal pain (14 [25%] vs six [11%]), hepatic enzyme disorders (five [9%] vs ten [18%]), psychiatric disorders (three [5%] vs four [7%]), insomnia (19 [33%] vs 20 [36%]), and partial seizure (one [<1%] vs 0).Interpretation: In patients with ischaemic stroke and moderate to severe motor deficit, the early prescription of fluoxetine with physiotherapy enhanced motor recovery after 3 months. Modulation of spontaneous brain plasticity by drugs is a promising pathway for treatment of patients with ischaemic stroke and moderate to severe motor deficit.Funding: Public French National Programme for Clinical Research. [ABSTRACT FROM AUTHOR]- Published
- 2011
- Full Text
- View/download PDF
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