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4. Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

Author

Porter, Jeffery A., Ekker, Stephen C., Park, Woo-Jin, Kessler, Doris P. von, Young, Keith E., Chen, Chien-Huan, Ma, Yong, Woods, Amina S., Cotter, Robert J., Koonin, Eugene V., and Beachy, Philip A.

Subjects
Drosophila -- Genetic aspects, Proteins -- Research, Biological sciences
Abstract

The autoprocessing reaction is shown to proceed via an internal thioester intermediate and result in a covalent modification that increases the signaling domain's hydrophobic character and influences its subcellular and spatial distribution. Truncated unprocessed amino-terminal protein is shown to cause embryonic mispatterning even when expression is localized to cells that normally express Hh. This suggests the role of autoprocessing in the spatial regulation of hh signaling.

Published
1996

5. Association of platelet count with sarcopenic obesity in postmenopausal women: A nationwide population-based study.

Author

Park, Woo-Jin, Jung, Dong-Hyuk, Lee, Ji-Won, Shim, Jae-Yong, and Kwon, Yu-Jin

Subjects
*PLATELET count, *SARCOPENIA, *OBESITY in women, *POSTMENOPAUSE, *INSULIN resistance, *PATIENTS, *PHYSIOLOGY, *OBESITY risk factors
Abstract

Objectives The aim of this study was to examine the relationship between platelet count and sarcopenic obesity in postmenopausal women. Method This cross-sectional study was conducted using nationally representative data. A total of 2810 postmenopausal women who participated in the 2008–2011 Korea National Health and Nutrition Examination Survey were included in this study. Sarcopenic obesity was defined by a sarcopenia criterion and an obesity criterion. Platelet counts were divided into quartiles as follows: Q, 150–222; Q2, 223–257; Q3, 258–294, and Q4, 295–450 (10 3 /μl). Multiple logistic regression analysis was performed to examine the association between platelet count quartile and sarcopenic obesity after adjusting for confounding factors. Results The prevalence of sarcopenic obesity in postmenopausal women was 14.8%. Compared to the lowest platelet quartile, the odds ratios and 95% confidence intervals for sarcopenic obesity in the highest quartile were 1.98 (1.36–2.89) in the unadjusted model; 1.93 (1.31–2.83) after adjusting for age; and 1.65 (1.23–2.65) after adjusting for age, systolic blood pressure, homeostatic model assessment insulin resistance (HOMA-IR), triglyceride, total cholesterol, total calorie intake, regular exercise, current smoking status, and education level. Conclusions Elevated platelet count (i.e. towards the upper end of the normal range) was significantly associated with sarcopenic obesity in postmenopausal women. [ABSTRACT FROM AUTHOR]

Published
2018
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6. The ALICE Collaboration

Author

Abelev, Betty, Adam, Jaroslav, Adamova, Dagmar, Adare, Andrew Marshall, Aggarwal, Madan, Aglieri Rinella, Gianluca, Agocs, Andras Gabor, Agostinelli, Andrea, Aguilar Salazar, Saul, Ahammed, Zubayer, Ahmad, Arshad, Ahmad, Nazeer, Ahn, Sul-Ah, Ahn, Sang Un, Akindinov, Alexander, Aleksandrov, Dmitry, Alessandro, Bruno, Alfaro Molina, Jose Ruben, Alici, Andrea, Alkin, Anton, Avina, Erick Jonathan Almaraz, Alme, Johan, Alt, Torsten, Altini, Valerio, Altinpinar, Sedat, Altsybeev, Igor, Andrei, Cristian, Andronic, Anton, Anguelov, Venelin, Anielski, Jonas, Anson, Christopher Daniel, Anticic, Tome, Antinori, Federico, Antonioli, Pietro, Aphecetche, Laurent Bernard, Appelshauser, Harald, Arbor, Nicolas, Arcelli, Silvia, Arend, Andreas, Armesto, Nestor, Arnaldi, Roberta, Aronsson, Tomas Robert, Arsene, Ionut Cristian, Arslandok, Mesut, Asryan, Andzhey, Augustinus, Andre, Averbeck, Ralf Peter, Awes, Terry, Aysto, Juha Heikki, Azmi, Mohd Danish, Bach, Matthias Jakob, Badala, Angela, Baek, Yong Wook, Bailhache, Raphaelle Marie, Bala, Renu, Baldini Ferroli, Rinaldo, Baldisseri, Alberto, Baldit, Alain, Baltasar Dos Santos Pedrosa, Fernando, Ban, Jaroslav, Baral, Rama Chandra, Barbera, Roberto, Barile, Francesco, Barnafoldi, Gergely Gabor, Barnby, Lee Stuart, Barret, Valerie, Bartke, Jerzy Gustaw, Basile, Maurizio, Bastid, Nicole, Basu, Sumit, Bathen, Bastian, Batigne, Guillaume, Batyunya, Boris, Baumann, Christoph Heinrich, Bearden, Ian Gardner, Beck, Hans, Behera, Nirbhay Kumar, Belikov, Iouri, Bellini, Francesca, Bellwied, Rene, Belmont-Moreno, Ernesto, Bencedi, Gyula, Beole, Stefania, Berceanu, Ionela, Bercuci, Alexandru, Berdnikov, Yaroslav, Berenyi, Daniel, Bergognon, Anais Annick Erica, Berzano, Dario, Betev, Latchezar, Bhasin, Anju, Bhati, Ashok Kumar, Bhom, Jihyun, Bianchi, Nicola, Bianchi, Livio, Bianchin, Chiara, Bielcik, Jaroslav, Bielcikova, Jana, Bilandzic, Ante, Bjelogrlic, Sandro, Blanco, F., Blanco, Francesco, Blau, Dmitry, Blume, Christoph, Boccioli, Marco, Bock, Nicolas, Boettger, Stefan, Bogdanov, Alexey, Boggild, Hans, Bogolyubsky, Mikhail, Boldizsar, Laszlo, Bombara, Marek, Book, Julian, Borel, Herve, Borissov, Alexander, Bose, Suvendu Nath, Bossu, Francesco, Botje, Michiel, Botta, Elena, Boyer, Bruno Alexandre, Braidot, Ermes, Braun-Munzinger, Peter, Bregant, Marco, Breitner, Timo Gunther, Browning, Tyler Allen, Broz, Michal, Brun, Rene, Bruna, Elena, Bruno, Giuseppe Eugenio, Budnikov, Dmitry, Buesching, Henner, Bufalino, Stefania, Busch, Oliver, Buthelezi, Edith Zinhle, Caballero Orduna, Diego, Caffarri, Davide, Cai, Xu, Caines, Helen Louise, Calvo Villar, Ernesto, Camerini, Paolo, Canoa Roman, Veronica, Cara Romeo, Giovanni, Carena, Francesco, Carena, Wisla, Filho, Nelson Carlin, Carminati, Federico, Casanova Diaz, Amaya Ofelia, Castillo Castellanos, Javier Ernesto, Castillo Hernandez, Juan Francisco, Casula, Ester Anna Rita, Catanescu, Vasile, Cavicchioli, Costanza, Ceballos Sanchez, Cesar, Cepila, Jan, Cerello, Piergiorgio, Chang, Beomsu, Chapeland, Sylvain, Charvet, Jean-Luc Fernand, Chattopadhyay, Sukalyan, Chattopadhyay, Subhasis, Chawla, Isha, Cherney, Michael Gerard, Cheshkov, Cvetan, Cheynis, Brigitte, Chibante Barroso, Vasco Miguel, Chinellato, David, Chochula, Peter, Chojnacki, Marek, Choudhury, Subikash, Christakoglou, Panagiotis, Christensen, Christian Holm, Christiansen, Peter, Chujo, Tatsuya, Chung, Suh-Urk, Cicalo, Corrado, Cifarelli, Luisa, Cindolo, Federico, Cleymans, Jean Willy Andre, Coccetti, Fabrizio, Colamaria, Fabio, Colella, Domenico, Conesa Balbastre, Gustavo, Conesa del Valle, Zaida, Constantin, Paul, Contin, Giacomo, Contreras, Jesus Guillermo, Cormier, Thomas Michael, Corrales Morales, Yasser, Cortese, Pietro, Cortes Maldonado, Ismael, Cosentino, Mauro Rogerio, Costa, Filippo, Cotallo, Manuel Enrique, Crescio, Elisabetta, Crochet, Philippe, Cruz Alaniz, Emilia, Cuautle, Eleazar, Cunqueiro, Leticia, Dainese, Andrea, Dalsgaard, Hans Hjersing, Danu, Andrea, Debasish, Das, Das, Kushal, Das, Indranil, Dash, Sadhana, Dash, Ajay Kumar, De, Sudipan, de Barros, Gabriel, De Caro, Annalisa, de Cataldo, Giacinto, de Cuveland, Jan, De Falco, Alessandro, De Gruttola, Daniele, Delagrange, Hugues, Deloff, Andrzej, Demanov, Vyacheslav, De Marco, Nora, Denes, Ervin, De Pasquale, Salvatore, Deppman, Airton, DʼErasmo, Ginevra, de Rooij, Raoul Stefan, Diaz Corchero, Miguel Angel, Di Bari, Domenico, Dietel, Thomas, Di Giglio, Carmelo, Di Liberto, Sergio, Di Mauro, Antonio, Di Nezza, Pasquale, Divia, Roberto, Djuvsland, Oeystein, Dobrin, Alexandru Florin, Dobrowolski, Tadeusz Antoni, Dominguez, Isabel, Donigus, Benjamin, Dordic, Olja, Driga, Olga, Dubey, Anand Kumar, Dubla, Andrea, Ducroux, Laurent, Dupieux, Pascal, Dutta Majumdar, Mihir Ranjan, Dutta Majumdar, A.K., Elia, Domenico, Emschermann, David Philip, Engel, Heiko, Erazmus, Barbara, Erdal, Hege Austrheim, Espagnon, Bruno, Estienne, Magali Danielle, Esumi, Shinichi, Evans, David, Eyyubova, Gyulnara, Fabris, Daniela, Faivre, Julien, Falchieri, Davide, Fantoni, Alessandra, Fasel, Markus, Fearick, Roger Worsley, Fedunov, Anatoly, Fehlker, Dominik, Feldkamp, Linus, Felea, Daniel, Fenton-Olsen, Bo, Feofilov, Grigory, Fernandez Tellez, Arturo, Ferretti, Alessandro, Ferretti, Roberta, Festanti, Andrea, Figiel, Jan, Figueredo, Marcel, Filchagin, Sergey, Finogeev, Dmitry, Fionda, Fiorella, Fiore, Enrichetta Maria, Floris, Michele, Foertsch, Siegfried Valentin, Foka, Panagiota, Fokin, Sergey, Fragiacomo, Enrico, Francescon, Andrea, Frankenfeld, Ulrich Michael, Fuchs, Ulrich, Furget, Christophe, Fusco Girard, Mario, Gaardhoje, Jens Joergen, Gagliardi, Martino, Gago, Alberto, Gallio, Mauro, Gangadharan, Dhevan Raja, Ganoti, Paraskevi, Garabatos, Jose, Garcia-Solis, Edmundo, Garishvili, Irakli, Gerhard, Jochen, Germain, Marie, Geuna, Claudio, Gheata, Mihaela, Gheata, Andrei George, Ghidini, Bruno, Ghosh, Premomoy, Gianotti, Paola, Girard, Martin Robert, Giubellino, Paolo, Gladysz-Dziadus, Ewa, Glassel, Peter, Gomez, Ramon, Gonzalez Ferreiro, Elena, Gonzalez-Trueba, Laura Helena, Gonzalez-Zamora, Pedro, Gorbunov, Sergey, Goswami, Ankita, Gotovac, Sven, Grabski, Varlen, Graczykowski, Lukasz Kamil, Grajcarek, Robert, Grelli, Alessandro, Grigoras, Costin, Grigoras, Alina Gabriela, Grigoriev, Vladislav, Grigoryan, Smbat, Grigoryan, Ara, Grinyov, Boris, Grion, Nevio, Gros, Philippe, Grosse-Oetringhaus, Jan Fiete, Grossiord, Jean-Yves, Grosso, Raffaele, Guber, Fedor, Guernane, Rachid, Guerra Gutierrez, Cesar, Guerzoni, Barbara, Guilbaud, Maxime Rene Joseph, Gulbrandsen, Kristjan Herlache, Gunji, Taku, Gupta, Anik, Gupta, Ramni, Gutbrod, Hans, Haaland, Oystein Senneset, Hadjidakis, Cynthia Marie, Haiduc, Maria, Hamagaki, Hideki, Gergoe, Hamar, Han, Byounghee, Hanratty, Luke David, Hansen, Alexander, Harmanova, Zuzana, Harris, John William, Hartig, Matthias, Hasegan, Dumitru, Hatzifotiadou, Despoina, Hayrapetyan, Arsen, Heckel, Stefan Thomas, Heide, Markus Ansgar, Helstrup, Haavard, Herghelegiu, Andrei Ionut, Herrera Corral, Gerardo Antonio, Herrmann, Norbert, Hess, Benjamin Andreas, Hetland, Kristin Fanebust, Hicks, Bernard, Hille, Per Thomas, Hippolyte, Boris, Horaguchi, Takuma, Hori, Yasuto, Hristov, Peter Zahariev, Hrivnacova, Ivana, Meidana, Huang, Humanic, Thomas, Hwang, Dae Sung, Ichou, Raphaelle, Ilkaev, Radiy, Ilkiv, Iryna, Inaba, Motoi, Incani, Elisa, Innocenti, Pier Giorgio, Innocenti, Gian Michele, Ippolitov, Mikhail, Irfan, Muhammad, Ivan, Cristian George, Ivanov, Andrey, Ivanov, Marian, Ivanov, Vladimir, Ivanytskyi, Oleksii, Jacobs, Peter, Jang, Haeng Jin, Janik, Rudolf, Janik, Malgorzata Anna, Jayarathna, Sandun, Jena, Satyajit, Jha, Deeptanshu Manu, Jimenez Bustamante, Raul Tonatiuh, Jirden, Lennart, Jones, Peter Graham, Jung, Hyung Taik, Jusko, Anton, Kaidalov, Alexei, Kakoyan, Vanik, Kalcher, Sebastian, Kalinak, Peter, Kalliokoski, Tuomo Esa Aukusti, Kalweit, Alexander Philipp, Hwan Kang, Ju, Kaplin, Vladimir, Uysal, Ayben Karasu, Karavichev, Oleg, Karavicheva, Tatiana, Karpechev, Evgeny, Kazantsev, Andrey, Kebschull, Udo Wolfgang, Keidel, Ralf, Khan, Palash, Shuaib, Ahmad Khan, Khan, Mohisin Mohammed, Khanzadeev, Alexei, Kharlov, Yury, Kileng, Bjarte, Kim, Se Yong, Kim, Beomkyu, Kim, Taesoo, Kim, Dong Jo, Kim, Do Won, Kim, Jonghyun, Kim, Jin Sook, Kim, Mimae, Kim, Minwoo, Kirsch, Stefan, Kisel, Ivan, Kiselev, Sergey, Kisiel, Adam Ryszard, Klay, Jennifer Lynn, Klein, Jochen, Klein-Bosing, Christian, Kliemant, Michael, Kluge, Alexander, Knichel, Michael Linus, Knospe, Anders Garritt, Koch, Kathrin, Kohler, Markus, Kollegger, Thorsten, Kolojvari, Anatoly, Kondratiev, Valery, Kondratyeva, Natalia, Konevskih, Artem, Korneev, Andrey, Kour, Ravjeet, Kowalski, Marek, Kox, Serge, Koyithatta Meethaleveedu, Greeshma, Kral, Jiri, Kralik, Ivan, Kramer, Frederick, Kraus, Ingrid Christine, Krawutschke, Tobias, Krelina, Michal, Kretz, Matthias, Krivda, Marian, Krizek, Filip, Krus, Miroslav, Kryshen, Evgeny, Krzewicki, Mikolaj, Kucheriaev, Yury, Kugathasan, Thanushan, Kuhn, Christian Claude, Kuijer, Paul, Kulakov, Igor, Kumar, Jitendra, Kurashvili, Podist, Kurepin, A.B., Kurepin, A., Kuryakin, Alexey, Kushpil, Vasily, Kushpil, Svetlana, Kvaerno, Henning, Kweon, Min Jung, Kwon, Youngil, Ladron de Guevara, Pedro, Lakomov, Igor, Langoy, Rune, La Pointe, Sarah Louise, Lara, Camilo Ernesto, Lardeux, Antoine Xavier, La Rocca, Paola, Lea, Ramona, Le Bornec, Yves, Lechman, Mateusz, Lee, Sung Chul, Lee, Graham Richard, Lee, Ki Sang, Lefevre, Frederic, Lehnert, Joerg Walter, Lenhardt, Matthieu Laurent, Lenti, Vito, Leon, Hermes, Leoncino, Marco, Leon Monzon, Ildefonso, Leon Vargas, Hermes, Levai, Peter, Lien, Jorgen, Lietava, Roman, Lindal, Svein, Lindenstruth, Volker, Lippmann, Christian, Lisa, Michael Annan, Lijiao, Liu, Loggins, Vera, Loginov, Vitaly, Lohn, Stefan Bernhard, Lohner, Daniel, Loizides, Constantinos, Loo, Kai Krister, Lopez, Xavier Bernard, Lopez Torres, Ernesto, Lovhoiden, Gunnar, Xianguo, Lu, Luettig, Philipp, Lunardon, Marcello, Jiebin, Luo, Luparello, Grazia, Luquin, Lionel, Luzzi, Cinzia, Ma, Ke, Ma, Rongrong, Minthaka Madagodahettige-Don, Dilan, Maevskaya, Alla, Mager, Magnus, Mahapatra, Durga Prasad, Maire, Antonin, Malaev, Mikhail, Maldonado Cervantes, Ivonne Alicia, Malinina, Ludmila, MalʼKevich, Dmitry, Malzacher, Peter, Mamonov, Alexander, Mangotra, Lalit Kumar, Manko, Vladislav, Manso, Franck, Manzari, Vito, Yaxian, Mao, Marchisone, Massimiliano, Mares, Jiri, Margagliotti, Giacomo Vito, Margotti, Anselmo, Marin, Ana Maria, Tobon, Cesar Augusto Marin, Markert, Christina, Marquard, Marco, Martashvili, Irakli, Martinengo, Paolo, Martinez, Mario Ivan, Martinez Davalos, Arnulfo, Martinez Garcia, Gines, Martynov, Yevgen, Mas, Alexis Jean-Michel, Masciocchi, Silvia, Masera, Massimo, Masoni, Alberto, Massacrier, Laure Marie, Mastroserio, Annalisa, Matthews, Zoe Louise, Matyja, Adam Tomasz, Mayer, Christoph, Mazer, Joel, Mazzoni, Alessandra Maria, Meddi, Franco, Menchaca-Rocha, Arturo Alejandro, Mercado Perez, Jorge, Meres, Michal, Miake, Yasuo, Milano, Leonardo, Milosevic, Jovan, Mischke, Andre, Nath Mishra, Aditya, Miskowiec, Dariusz, Mitu, Ciprian Mihai, Mlynarz, Jocelyn, Mohanty, Bedangadas, Molnar, Levente, Montano Zetina, Luis Manuel, Monteno, Marco, Montes, Esther, Moon, Taebong, Morando, Maurizio, Moreira De Godoy, Denise Aparecida, Moretto, Sandra, Morsch, Andreas, Muccifora, Valeria, Mudnic, Eugen, Muhuri, Sanjib, Mukherjee, Maitreyee, Muller, Hans, Munhoz, Marcelo, Musa, Luciano, Musso, Alfredo, Nandi, Basanta Kumar, Nania, Rosario, Nappi, Eugenio, Nattrass, Christine, Naumov, Nikolay, Sparsh, Navin, Nayak, Tapan Kumar, Nazarenko, Sergey, Nazarov, Gleb, Nedosekin, Alexander, Nicassio, Maria, Niculescu, Mihai, Nielsen, Borge Svane, Niida, Takafumi, Nikolaev, Sergey, Nikolic, Vedran, Nikulin, Sergey, Nikulin, Vladimir, Nilsen, Bjorn Steven, Nilsson, Mads Stormo, Noferini, Francesco, Nomokonov, Petr, Nooren, Gerardus, Novitzky, Norbert, Nyanin, Alexandre, Nyatha, Anitha, Nygaard, Casper, Nystrand, Joakim Ingemar, Ochirov, Alexander, Oeschler, Helmut Oskar, Oh, Saehanseul, Oh, Sun Kun, Oleniacz, Janusz, Oppedisano, Chiara, Ortiz Velasquez, Antonio, Ortona, Giacomo, Oskarsson, Anders Nils Erik, Ostrowski, Piotr Krystian, Otwinowski, Jacek Tomasz, Oyama, Ken, Ozawa, Kyoichiro, Pachmayer, Yvonne Chiara, Pachr, Milos, Padilla, Fatima, Pagano, Paola, Paic, Guy, Painke, Florian, Pajares, Carlos, Pal, Susanta Kumar, Palaha, Arvinder Singh, Palmeri, Armando, Papikyan, Vardanush, Pappalardo, Giuseppe, Park, Woo Jin, Passfeld, Annika, Pastircak, Blahoslav, Patalakha, Dmitri Ivanovich, Paticchio, Vincenzo, Pavlinov, Alexei, Pawlak, Tomasz Jan, Peitzmann, Thomas, Pereira Da Costa, Hugo Denis Antonio, Pereira De Oliveira Filho, Elienos, Peresunko, Dmitri, Perez Lara, Carlos Eugenio, Perez Lezama, Edgar, Perini, Diego, Perrino, Davide, Peryt, Wiktor Stanislaw, Pesci, Alessandro, Peskov, Vladimir, Pestov, Yury, Petracek, Vojtech, Petran, Michal, Petris, Mariana, Petrov, Plamen Rumenov, Petrovici, Mihai, Petta, Catia, Piano, Stefano, Piccotti, Anna, Pikna, Miroslav, Pillot, Philippe, Pinazza, Ombretta, Pinsky, Lawrence, Pitz, Nora, Piyarathna, Danthasinghe, Planinic, Mirko, Ploskon, Mateusz Andrzej, Pluta, Jan Marian, Pocheptsov, Timur, Pochybova, Sona, Podesta Lerma, Pedro Luis Manuel, Poghosyan, Martin, Polak, Karel, Polichtchouk, Boris, Pop, Amalia, Porteboeuf-Houssais, Sarah, Pospisil, Vladimir, Potukuchi, Baba, Prasad, Sidharth Kumar, Preghenella, Roberto, Prino, Francesco, Pruneau, Claude Andre, Pshenichnov, Igor, Puchagin, Sergey, Puddu, Giovanna, Pulvirenti, Alberto, Punin, Valery, Putis, Marian, Putschke, Jorn Henning, Quercigh, Emanuele, Qvigstad, Henrik, Rachevski, Alexandre, Rademakers, Alphonse, Raiha, Tomi Samuli, Rak, Jan, Rakotozafindrabe, Andry Malala, Ramello, Luciano, Ramirez Reyes, Abdiel, Raniwala, Sudhir, Raniwala, Rashmi, Rasanen, Sami Sakari, Rascanu, Bogdan Theodor, Rathee, Deepika, Read, Kenneth Francis, Real, Jean-Sebastien, Redlich, Krzysztof, Reichelt, Patrick, Reicher, Martijn, Renfordt, Rainer Arno Ernst, Reolon, Anna Rita, Reshetin, Andrey, Rettig, Felix Vincenz, Revol, Jean-Pierre, Reygers, Klaus Johannes, Riccati, Lodovico, Ricci, Renato Angelo, Richert, Tuva, Richter, Matthias Rudolph, Riedler, Petra, Riegler, Werner, Riggi, Francesco, Rodrigues Fernandes Rabacal, Bartolomeu, Rodriguez Cahuantzi, Mario, Rodriguez Manso, Alis, Roed, Ketil, Rohr, David, Rohrich, Dieter, Romita, Rosa, Ronchetti, Federico, Rosnet, Philippe, Rossegger, Stefan, Rossi, Andrea, Roy, Pradip Kumar, Roy, Christelle Sophie, Rubio Montero, Antonio Juan, Rui, Rinaldo, Russo, Riccardo, Ryabinkin, Evgeny, Rybicki, Andrzej, Sadovsky, Sergey, Safarik, Karel, Sahoo, Raghunath, Sahu, Pradip Kumar, Saini, Jogender, Sakaguchi, Hiroaki, Sakai, Shingo, Sakata, Dosatsu, Salgado, Carlos Albert, Salzwedel, Jai, Sambyal, Sanjeev Singh, Samsonov, Vladimir, Sanchez Castro, Xitzel, Sandor, Ladislav, Sandoval, Andres, Sano, Masato, Sano, Satoshi, Santo, Rainer, Santoro, Romualdo, Sarkamo, Juho Jaako, Scapparone, Eugenio, Scarlassara, Fernando, Scharenberg, Rolf Paul, Schiaua, Claudiu Cornel, Schicker, Rainer Martin, Schmidt, Christian Joachim, Schmidt, Hans Rudolf, Schreiner, Steffen, Schuchmann, Simone, Schukraft, Jurgen, Schutz, Yves Roland, Schwarz, Kilian Eberhard, Schweda, Kai Oliver, Scioli, Gilda, Scomparin, Enrico, Scott, Rebecca, Segato, Gianfranco, Selioujenkov, Ilya, Senyukov, Serhiy, Seo, Jeewon, Serci, Sergio, Serradilla, Eulogio, Sevcenco, Adrian, Shabetai, Alexandre, Shabratova, Galina, Shahoyan, Ruben, Sharma, Natasha, Sharma, Satish, Sharma, Rohini, Shigaki, Kenta, Shimomura, Maya, Shtejer, Katherin, Sibiriak, Yury, Siciliano, Melinda, Sicking, Eva, Siddhanta, Sabyasachi, Siemiarczuk, Teodor, Silvermyr, David Olle Rickard, Silvestre, Catherine, Simatovic, Goran, Simonetti, Giuseppe, Singaraju, Rama Narayana, Singh, Ranbir, Singha, Subhash, Singhal, Vikas, Sinha, Bikash, Sinha, Tinku, Sitar, Branislav, Sitta, Mario, Skaali, Bernhard, Skjerdal, Kyrre, Smakal, Radek, Smirnov, Nikolai, Snellings, Raimond, Sogaard, Carsten, Soltz, Ron Ariel, Son, Hyungsuk, Song, Myunggeun, Song, Jihye, Soos, Csaba, Soramel, Francesca, Sputowska, Iwona, Spyropoulou-Stassinaki, Martha, Srivastava, Brijesh Kumar, Stachel, Johanna, Stan, Ionel, Stefanek, Grzegorz, Steinpreis, Matthew, Stenlund, Evert Anders, Steyn, Gideon Francois, Stiller, Johannes Hendrik, Stocco, Diego, Stolpovskiy, Mikhail, Strabykin, Kirill, Strmen, Peter, do Passo Suaide, Alexandre Alarcon, Subieta Vasquez, Martin Alfonso, Sugitate, Toru, Suire, Christophe Pierre, Sukhorukov, Mikhail, Sultanov, Rishat, Sumbera, Michal, Susa, Tatjana, Symons, Timothy, Szanto de Toledo, Alejandro, Szarka, Imrich, Szczepankiewicz, Adam, Szostak, Artur Krzysztof, Szymanski, Maciej, Takahashi, Jun, Tapia Takaki, Daniel Jesus, Tauro, Arturo, Tejeda Munoz, Guillermo, Telesca, Adriana, Terrevoli, Cristina, Thader, Jochen Mathias, Thomas, Deepa, Tieulent, Raphael Noel, Timmins, Anthony, Tlusty, David, Toia, Alberica, Torii, Hisayuki, Toscano, Luca, Trubnikov, Victor, Truesdale, David Christopher, Trzaska, Wladyslaw Henryk, Tsuji, Tomoya, Tumkin, Alexandr, Turrisi, Rosario, Tveter, Trine Spedstad, Ulery, Jason Glyndwr, Ullaland, Kjetil, Ulrich, Jochen, Uras, Antonio, Urban, Jozef, Urciuoli, Guido Marie, Usai, Gianluca, Vajzer, Michal, Vala, Martin, Valencia Palomo, Lizardo, Vallero, Sara, Vande Vyvre, Pierre, van Leeuwen, Marco, Vannucci, Luigi, Vargas, Aurora Diozcora, Varma, Raghava, Vasileiou, Maria, Vasiliev, Andrey, Vechernin, Vladimir, Veldhoen, Misha, Venaruzzo, Massimo, Vercellin, Ermanno, Vergara, Sergio, Vernet, Renaud, Verweij, Marta, Vickovic, Linda, Viesti, Giuseppe, Vikhlyantsev, Oleg, Vilakazi, Zabulon, Villalobos Baillie, Orlando, Vinogradov, Yury, Vinogradov, Alexander, Vinogradov, Leonid, Virgili, Tiziano, Viyogi, Yogendra, Vodopianov, Alexander, Voloshin, Sergey, Voloshin, Kirill, Volpe, Giacomo, von Haller, Barthelemy, Vranic, Danilo, Vrebekk, Gaute, Vrlakova, Janka, Vulpescu, Bogdan, Vyushin, Alexey, Wagner, Vladimir, Wagner, Boris, Wan, Renzhuo, Wang, Mengliang, Wang, Dong, Wang, Yifei, Wang, Yaping, Watanabe, Kengo, Weber, Michael, Wessels, Johannes, Westerhoff, Uwe, Wiechula, Jens, Wikne, Jon, Wilde, Martin Rudolf, Wilk, Alexander, Wilk, Grzegorz Andrzej, Williams, Crispin, Windelband, Bernd Stefan, Xaplanteris Karampatsos, Leonidas, Yaldo, Chris G., Yamaguchi, Yorito, Yang, Hongyan, Yang, Shiming, Yasnopolsky, Stanislav, Yi, JunGyu, Yin, Zhongbao, Yoo, In-Kwon, Yoon, Jongik, Yu, Weilin, Yuan, Xianbao, Yushmanov, Igor, Zaccolo, Valentina, Zach, Cenek, Zampolli, Chiara, Zaporozhets, Sergey, Zarochentsev, Andrey, Zavada, Petr, Zaviyalov, Nikolai, Zbroszczyk, Hanna Paulina, Zelnicek, Pierre, Zgura, Sorin Ion, Zhalov, Mikhail, Zhang, Xiaoming, Zhang, Haitao, Zhou, Daicui, Zhou, You, Zhou, Fengchu, Zhu, Jianhui, Zhu, Jianlin, Zhu, Xiangrong, Zichichi, Antonino, Zimmermann, Alice, Zinovjev, Gennady, Zoccarato, Yannick Denis, Zynovyev, Mykhaylo, and Zyzak, Maksym

Published
2013
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7. A 4-year retrospective study of facial fractures on Jeju, Korea.

Author

Lee, Jung Hoon, Cho, Byung Ki, and Park, Woo Jin

Subjects
FACIAL bone fractures, RETROSPECTIVE studies, QUANTITATIVE research, VIOLENCE, TRAFFIC accidents, MEDICAL statistics
Abstract

Summary: A number of researchers from various regions have reported statistical and clinical studies of facial fractures. The results of those studies show slight differences depending on regional, cultural, social and economic backgrounds. This report presents a statistical analysis of facial fractures occurring over 4 years on Jeju, Korea. The statistics come from the 318 patients who presented to Cheju National University Hospital for facial fractures, and ours is a retrospective study analyzing patient ages, gender, fracture etiology, alcohol involvement and the anatomical site of the fracture. The most common cause of facial fractures on Jeju was violence (40.9%), followed by traffic accidents (17%). The most frequently fractured site was the nasal bone (42.5%). According to the Jeju Statistics Agency, the people of Jeju are highly dependent on alcohol and previous research has reported the close relationship between alcohol consumption and violence. We paid close attention to violence as a primary cause for facial fractures in the cultural and social context of Jeju. Data analysis regarding facial fractures may provide crucial information for recognition of causes and planning for prevention. [Copyright &y& Elsevier]

Published
2010
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8. Fabrication of spray-formed hypereutectic Al–25Si alloy and its deformation behavior

Author

Ha, Tae Kwon, Park, Woo-Jin, Ahn, Sangho, and Chang, Young Won

Subjects
*ALUMINUM alloys, *EUTECTICS, *METALWORK
Abstract

This article reports the fabrication of hypereutectic Al–25Si alloy, which is expected to be applied to the cylinder liner part of the engine block of an automobile due to its excellent wear resistance, low density and low thermal expansion coefficient, through a spray casting process and the characterization of the microstructural and the mechanical properties of this alloy. The OSPREY process used in this study is one of spray forming techniques, which can produce semi-finished products such as billet, tube, and plate with rapid solidification (RS) structure and density in a single operation from molten metal. The obtained microstructure of the hypereutectic Al–25Si alloy appeared to consist of Al matrix and equiaxed Si particles with average diameter of 5–7 μm. To characterize the deformation behavior of this alloy, a series of load relaxation and compression tests have been conducted at temperatures ranging from RT to 500 °C. The strain rate sensitivity parameter (m) of this alloy has been found to be very low (≤0.1) below 300 °C and reached maximum value of about 0.2 at 500 °C. During the deformation above 300 °C in compression, remarkable strain softening has been observed. The extrusion has been successfully conducted at the temperatures of 300 °C and above with the ratio of area reduction of 28 and 40 in this study. [Copyright &y& Elsevier]

Published
2002
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10. Slope stability analysis model for the frost-susceptible soil based on thermal-hydro-mechanical coupling.

Author

Park, Dong-Su, Shin, Mun-Beom, Park, Woo-Jin, and Seo, Young-Kyo

Subjects
*SLOPE stability, *ROCK slopes, *FROZEN ground, *FREEZE-thaw cycles, *SOILS, *FINITE element method
Abstract

Slope stability analysis has been performed through various analysis methods ranging from general limit equilibrium methods, such as those proposed by Janbu, Bishop, and Fellenius, to finite element methods. Using these methods, analyzing the slope stability considering the change in soil stiffness due to the freezing or thawing conditions resulting from temperature changes is infeasible. Therefore, considering this shortcoming, a thermal-hydro-mechanical slope stability analysis model (THM-SSA model) is proposed for slope stability analysis. The main feature considered in the THM-SSA model was the slope of the critical state line based on the load angle. Additionally, this model could calculate the local factor of safety (LFS) for the slope based on the isotropic tensile strength of the unfrozen soil and the changes in it after being subjected to repeated freeze–thaw cycles. To verify the proposed THM-SSA model, the stress–strain results were compared with those of the experimental triaxial compression tests that were conducted under different temperatures of the frozen soil with a corresponding number of freeze–thaw cycles. Based on this, a simulation of slope stability analysis was performed as demonstration, and using the verified THM-SSA model, the LFS was calculated according to the freeze–thaw cycles of the slope. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Thermodynamic modeling of the Mg–Si–Sn system

Author

Jung, In-Ho, Kang, Dae-Hoon, Park, Woo-Jin, Kim, Nack J., and Ahn, SangHo

Subjects
*THERMODYNAMICS, *PHASE diagrams, *MAGNESIUM, *CHEMICAL systems, *GIBBS' free energy
Abstract

Abstract: All available thermodynamic and phase diagram data of the Mg–Si and Mg–Sn binary systems, and the Mg–Si–Sn ternary system have been critically evaluated and all reliable data have been simultaneously optimized to obtain one set of model parameters for the Gibbs energies of the liquid and all solid phases as functions of composition and temperature. The liquid phase was modeled using the Modified Quasichemical Model in order to describe the strong ordering in Mg–Si and Mg–Sn liquids. The Mg2Si–Mg2Sn solid solution phase was modeled with consideration of the solid miscibility gap. All calculations were performed using the FactSage thermochemical software. [Copyright &y& Elsevier]

Published
2007
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12. Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts.

Author

Ock, Sangmi, Lee, Wang Soo, Kim, Hyun Min, Park, Kyu-Sang, Kim, Young-Kook, Kook, Hyun, Park, Woo Jin, Lee, Tae Jin, Abel, E.D., and Kim, Jaetaek

Subjects
*HEART cells, *CONNEXIN 43, *CARDIAC arrest, *TAMOXIFEN, *HEART fibrosis
Abstract

While deletion of Akt1 results in a smaller heart size and Akt2 −/− mice are mildly insulin resistant, Akt1 −/− / Akt2 −/− mice exhibit perinatal lethality, indicating a large degree of functional overlap between the isoforms of the serine/threonine kinase Akt. The present study aimed to determine the cooperative contribution of Akt1 and Akt2 on the structure and contractile function of adult hearts. To generate an inducible, cardiomyocyte-restricted Akt2 knockout (KO) model, Akt2 flox/flox mice were crossed with tamoxifen-inducible MerCreMer transgenic (MCM) mice and germline Akt1 −/− mice to generate the following genotypes: Akt1 +/+ ; Akt2 flox/flox (WT), Akt2 flox/flox ; α-MHC-MCM ( iAkt2 KO), Akt1 −/− , and Akt1 −/− ; Akt2 flox/flox ; α-MHC-MCM mice ( Akt1 −/− / iAkt2 KO). At 28 days after the first tamoxifen injection, Akt1 −/− / iAkt2 KO mice developed contractile dysfunction paralleling increased atrial and brain natriuretic peptide (ANP and BNP) levels, and repressed mitochondrial gene expression. Neither cardiac fibrosis nor apoptosis were detected in Akt1 −/− / iAkt2 KO hearts. To explore potential molecular mechanisms for contractile dysfunction, we investigated myocardial microstructure before the onset of heart failure. At 3 days after the first tamoxifen injection, Akt1 −/− / iAkt2 KO hearts showed decreased expression of connexin43 (Cx43) and connexin-interacting protein zonula occludens-1 (ZO-1). Furthermore, Akt1/2 silencing significantly decreased both Cx43 and ZO-1 expression in cultured neonatal rat cardiomyocytes in concert with reduced beating frequency. Akt1 and Akt2 are required to maintain cardiac contraction. Loss of Akt signaling disrupts gap junction protein, which might precipitate early contractile dysfunction prior to heart failure in the absence of myocardial remodeling, such as hypertrophy, fibrosis, or cell death. [ABSTRACT FROM AUTHOR]

Published
2018
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13. Effect of silicon on microstructure and mechanical properties of Cu-Fe alloys.

Author

Jo, Hee Ra, Kim, Jeong Tae, Hong, Sung Hwan, Kim, Young Seok, Park, Hae Jin, Park, Woo Jin, Park, Jin Man, and Kim, Ki Buem

Subjects
*IRON-copper alloys, *MECHANICAL properties of metals, *SILICON, *MICROSTRUCTURE, *METAL compression testing
Abstract

The influence of Si addition on microstructure and compressive mechanical properties of as-cast (Cu-10Fe)-xSi (x = 0, 2 wt%) alloys has been investigated. The addition of Si leads to the microstructural refinement and the secondary separated phases, as a result of the change of diffusion process and solubility during solidification. Following the evolution of microstructure, the yield strength of the alloys is significantly enhanced from 180 MPa to 285 MPa. Accordingly, it is believed that the addition of only 2 wt% Si on the Cu-10Fe alloy can lead to the microstructural evolution such as the microstructural refinement and the formation of secondary separated phases with significantly improved mechanical properties. In this study, the relationship between microstructural features and mechanical properties will be discussed via hardening effects, such as Hall-Petch strengthening, solid-solution hardening and precipitation hardening effect. [ABSTRACT FROM AUTHOR]

Published
2017
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14. Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis.

Author

Jeong, Dongtak, Lee, Min-Ah, Li, Yan, Yang, Dong Kwon, Kho, Changwon, Oh, Jae Gyun, Hong, Gyeongdeok, Lee, Ahyoung, Song, Min Ho, LaRocca, Thomas J., Chen, Jiqiu, Liang, Lifan, Mitsuyama, Shinichi, D'Escamard, Valentina, Kovacic, Jason C., Kwak, Tae Hwan, Hajjar, Roger J., Park, Woo Jin, and D'Escamard, Valentina

Subjects
*CCN intercellular signaling proteins, *HEART fibrosis, *HEART failure patients, *MYOFIBROBLASTS, *APOPTOSIS, *HEART metabolism, *PROTEIN metabolism, *ANIMALS, *BIOCHEMISTRY, *CELL physiology, *FIBROBLASTS, *GENE therapy, *GENES, *GROWTH factors, *HEART failure, *PHENOMENOLOGY, *MICE, *MYOCARDIUM, *PROTEINS, *RESEARCH funding, *VIRUSES, *FIBROSIS
Abstract

Background: Cardiac fibrosis (CF) is associated with increased ventricular stiffness and diastolic dysfunction and is an independent predictor of long-term clinical outcomes of patients with heart failure (HF). We previously showed that the matricellular CCN5 protein is cardioprotective via its ability to inhibit CF and preserve cardiac contractility.Objectives: This study examined the role of CCN5 in human heart failure and tested whether CCN5 can reverse established CF in an experimental model of HF induced by pressure overload.Methods: Human hearts were obtained from patients with end-stage heart failure. Extensive CF was induced by applying transverse aortic constriction for 8 weeks, which was followed by adeno-associated virus-mediated transfer of CCN5 to the heart. Eight weeks following gene transfer, cellular and molecular effects were examined.Results: Expression of CCN5 was significantly decreased in failing hearts from patients with end-stage heart failure compared to nonfailing hearts. Trichrome staining and myofibroblast content measurements revealed that the established CF had been reversed by CCN5 gene transfer. Anti-CF effects of CCN5 were associated with inhibition of the transforming growth factor beta signaling pathway. CCN5 significantly inhibited endothelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation, which are 2 critical processes for CF progression, both in vivo and in vitro. In addition, CCN5 induced apoptosis in myofibroblasts, but not in cardiomyocytes or fibroblasts, both in vivo and in vitro. CCN5 provoked the intrinsic apoptotic pathway specifically in myofibroblasts, which may have been due the ability of CCN5 to inhibit the activity of NFκB, an antiapoptotic molecule.Conclusions: CCN5 can reverse established CF by inhibiting the generation of and enhancing apoptosis of myofibroblasts in the myocardium. CCN5 may provide a novel platform for the development of targeted anti-CF therapies. [ABSTRACT FROM AUTHOR]

Published
2016
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15. Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1.

Author

Kwon, So-Mi, Kim, Suji, Song, No-Joon, Chang, Seo-Hyuk, Hwang, Yu-Jin, Yang, Dong Kwon, Hong, Joung-Woo, Park, Woo Jin, and Park, Kye Won

Subjects
*LUTEOLIN, *HEAT shock proteins, *INSULIN resistance, *CANCER invasiveness, *FUNCTIONAL foods, *BIOACCUMULATION, *BONE diseases, *ADIPOSE tissues, *BONE growth, *COMPARATIVE studies, *RESEARCH methodology, *MEDICAL cooperation, *PROTEINS, *RESEARCH, *EVALUATION research, *FLAVONES
Abstract

Luteolin (3,4,5,7-tetrahydroxyflavones), a major dietary flavone, regulates a variety of biological effects including cancer progression, insulin resistance and inflammation. However, its exact actions on adipogenesis and osteogenesis and the underlying molecular mechanisms are yet to be clarified. In this study, we show that luteolin suppresses lipid accumulation but increases osteoblast differentiation. In mechanism studies, luteolin increases the expression of the heat shock proteins (Hsp) 40 (Dnajb1) and Hsp90 (Hsp90b1), but not those of other heat shock proteins including Hsp20, Hsp27, Hsp47, Hsp70, Hsp72, and Hsp90, and another type of Hsp40 (Dnaja1). Silencing Dnajb1 by using small interfering RNAs (siRNAs), but not against Hsp90b1, recapitulates the effects of luteolin in adipocyte and osteoblast differentiation. Consistently, the forced expression of Dnajb1 decreases the lipid accumulation and stimulates alkaline phosphatase (ALPL) activity. The antiadipogenic and proosteogenic effects of luteolin are significantly blunted in Dnajb1-deficient cells, further suggesting that Dnajb1 is, at least in part, required for luteolin's dual actions in adipogenesis and osteogenesis. Together, our data implicate luteolin as an ingredient and Dnajb1 as a molecular target for the development of functional foods and drugs in metabolic and bone-related diseases. [ABSTRACT FROM AUTHOR]

Published
2016
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16. Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice.

Author

Park, Sung Wook, Kim, Jin Hyoung, Mook-Jung, Inhee, Kim, Kyu-Won, Park, Woo Jin, Park, Kyu Hyung, and Kim, Jeong Hun

Subjects
*INTRACELLULAR membranes, *AMYLOID beta-protein, *RHODOPSIN, *EPITHELIUM, *LABORATORY mice, *AGE factors in disease
Abstract

Abstract: Extracellular deposit of amyloid beta (Aβ) is a common pathologic feature in both age-related macular degeneration (AMD) and Alzheimer's disease, but the role of intracellular Aβ on the tight junction of the retinal pigment epithelium (RPE) is unknown. In this study, we investigated the intracellular Aβ expression and its role on the outer blood retinal barrier in the retina of 5XFAD mice, a mouse model of Alzheimer's disease. The retina of 5XFAD mice showed the pathologic features of AMD with intracellular Aβ in the RPE. As intracellular Aβ accumulated, zonular occludens-1 and occludin were markedly attenuated and lost their integrity as tight junctions in the RPE of 5XFAD mice. Also, Aβ42 uptake by ARPE-19 cells induced the tight junction breakdown of zonular occludens-1 and occludin without cell death. These results implicate that intracellular Aβ42 could play a role in the breakdown of the outer blood retinal barrier in 5XFAD mice. Thus, we suggested that 5XFAD mice could be a mouse model of dry AMD with regard to the Aβ42 related pathology. [Copyright &y& Elsevier]

Published
2014
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17. Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.

Author

Seo, Cho-Rong, Yang, Dong Kwon, Song, No-Joon, Yun, Ui Jeong, Gwon, A-Ryeong, Jo, Dong-Gyu, Cho, Jae Youl, Yoon, Keejung, Ahn, Jee-Yin, Nho, Chu Won, Park, Woo Jin, Yang, Seung Yul, and Park, Kye Won

Subjects
*CUCURBITACINS, *FAT cells, *CELL differentiation, *STAT proteins, *ADIPOGENESIS, *OBESITY treatment
Abstract

Highlights: [•] Cucurbitacin B inhibits adipocyte differentiation of adipogenic cells. [•] STAT3 signaling acts as a mediator of anti-adipogenic effects of cucurbitacin B. [•] Cucurbitacin I also acts on STAT3 signaling to suppress adipogenesis. [•] We report potential uses of cucurbitacin B and C in obesity and related diseases. [Copyright &y& Elsevier]

Published
2014
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18. Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein

Author

Hong, Sunghee, Kim, Tae-Wan, Choi, Inchul, Woo, Jong-Min, Oh, Jungsu, Park, Woo Jin, Kim, Do Han, and Cho, Chunghee

Subjects
*PROTEINS, *SARCOPLASMIC reticulum, *MUSCLE contraction, *GENE expression
Abstract

Abstract: A protein complex present at the junctional sarcoplasmic reticulum (SR) membrane is implicated in the Ca2+ release process during muscle contraction. The histidine-rich Ca2+-binding protein (HRC) is an emerging component associated into the SR protein complex. We cloned cDNAs for rat and monkey HRCs, showing a conserved sequence organization in common with other mammalian HRCs. Genomic analysis revealed that each mammalian HRC gene is present as a single copy in the genome, consisting of 6 exons and 5 introns. Developmental expression analysis using mouse embryos and postnatal hearts demonstrated that Hrc transcription begins at 12.5 days postcoitum and its level increases gradually, reaching an adult level in the range 5–20 days after birth. Comparing the Hrc gene and other SR genes, we found that the timing and pattern of gene expression vary among the SR genes and the full-level expression of these genes is achieved in the heart after postnatal day 20. Collectively, our study provides comprehensive information about the structure and expression of the mammalian HRC gene, together with the comparative expression data of the related SR genes. [Copyright &y& Elsevier]

Published
2005
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