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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jss.2008.03.064 Byline: Umar Farooq, Shikharesh Majumdar, Eric W. Parsons Keywords: Grid resource management; Quality of service in distributed systems; Grid scheduling; Uncertain runtimes management; Grid middleware Abstract: Scalability, flexibility, quality of service provisioning, efficiency and robustness are the desired characteristics of most computing systems. Although the emerging Grid computing paradigm is scalable and flexible, achieving both efficiency and quality of service provisioning in Grids is a challenging task but is necessary for the wide adoption of Grids. Grid middleware should also be robust to uncertainties such as those in user-estimated runtimes of Grid applications. In this paper, we present a complete middleware framework for Grids that achieves user satisfaction by providing QoS guarantees for Grid applications, cost effectiveness by efficiently utilizing resources and robustness by intelligently handling uncertain runtimes of applications. Author Affiliation: Department of Systems and Computer Engineering, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6 Article History: Received 28 May 2007; Revised 22 February 2008; Accepted 7 March 2008

Superior capsular reconstruction (SCR) addresses massive, irreparable rotator cuff tears in young patients. The purpose of this study was to retrospectively evaluate clinical outcomes and graft integrity in patients following SCR. Thirty-four consecutive patients undergoing SCR by 2 surgeons with minimum 2-year follow-up were identified. Functional outcomes were obtained, including Simple Shoulder Test (SST), American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES), visual analog scale (VAS), and Single Assessment Numeric Evaluation (SANE) scores. Graft integrity was evaluated on magnetic resonance images (MRIs). Thirty-five shoulders in 34 patients were identified. Four patients underwent subsequent surgery. The mean preoperative scores were SST 21.6 ± 17.6, ASES 28.3 ± 10.1, SANE 50.6 ± 22.1, and VAS 6.6 ± 1.7. The mean postoperative outcomes were SST 79.1 ± 19.6, ASES 79.9 ± 17.4, SANE 74.3 ± 18.7, and VAS 1.5 ± 2.2. There was statistically significant improvement in SST, ASES, and VAS following SCR. MRI revealed graft failure in 62% (n = 13 of 21) of shoulders. Radiographic evidence of graft healing did not have any effect on SST, ASES, SANE, or VAS scores. Given the high rate of graft failure without a significant difference in clinical outcomes, graft healing after SCR might not be an independent predictor of success. The improved clinical improvement in patients undergoing SCR may be due to other known beneficial aspects of the procedure, including partial rotator cuff repair, débridement, and biceps management. [ABSTRACT FROM AUTHOR]

Abstract: A retrospective review of rotating-platform (n = 113) and fixed-bearing (n = 100) total knee arthroplasties at a minimum 2-year follow-up was performed. All patients in both groups in this study had osteoarthritis and underwent surgery by 1 of the 2 senior authors at 1 of 2 institutions. A cruciate-retaining total knee arthroplasty was implanted with patellar resurfacing in all cases. The only difference between the 2 groups was the design of the tibial bearing and its tibial tray. Through minimization of confounding variables relating to pathology, surgeon, institution, soft-tissue balancing, and type of prosthesis, this study isolates articular design as a variable. We could not demonstrate any significant difference in knee flexion after either fixed-bearing or rotating-platform cruciate-retaining total knee arthroplasty. [Copyright &y& Elsevier]

Free and reduced-price meal (FRM) enrollment is commonly used in education research and policy applications as an indicator of student poverty. However, using multiple data sources external to the school system, we show that FRM status is a poor proxy for poverty, with enrollment rates far exceeding what would be expected based on stated income thresholds for program participation. This is true even without accounting for community eligibility for free meals, although community eligibility has exacerbated the problem in recent years. Over the course of showing the limitations of using FRM data to measure poverty, we also provide early evidence on the potential value of two alterative measures of school poverty. [ABSTRACT FROM AUTHOR]

Antibacterial drug resistance is a global health concern that requires multiple solution approaches including development of new antibacterial compounds acting at novel targets. Targeting regulatory RNA is an emerging area of drug discovery. The T-box riboswitch is a regulatory RNA mechanism that controls gene expression in Gram-positive bacteria and is an exceptional, novel target for antibacterial drug design. We report the design, synthesis and activity of a series of conformationally restricted oxazolidinone-triazole compounds targeting the highly conserved antiterminator RNA element of the T-box riboswitch. Computational binding energies correlated with experimentally-derived K d values indicating the predictive capabilities for docking studies within this series of compounds. The conformationally restricted compounds specifically inhibited T-box riboswitch function and not overall transcription. Complex disruption, computational docking and RNA binding specificity data indicate that inhibition may result from ligand binding to an allosteric site. These results highlight the importance of both ligand affinity and RNA conformational outcome for targeted RNA drug design. [ABSTRACT FROM AUTHOR]