44 results on '"Perkins, Stephen J."'
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2. Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23
3. Complement Factor H–ligand interactions: Self-association, multivalency and dissociation constants
4. The SCR-17 and SCR-18 glycans in human complement factor H enhance its regulatory function.
5. Genetic and Protein Structural Evaluation of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.
6. The solution structure of the heavy chain–only C5-Fc nanobody reveals exposed variable regions that are optimal for COVID-19 antigen interactions.
7. A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin.
8. The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted β-sheet flanked by α-helices found in human ras-p21
9. β-Sheet secondary structure of an LDL receptor domain from complement factor I by consensus structure predictions and spectroscopy
10. Factor VIIa and the extracellular domains of human tissue factor form a compact complex: A study by X-ray and neutron solution scattering
11. The Concave Face of Decorin Mediates Reversible Dimerization and Collagen Binding.
12. Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4
13. Functional and structural characterisation of human colostrum free secretory component
14. Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses.
15. The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy.
16. The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions.
17. Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces.
18. Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
19. TED and CUB domain movements between complement C3 and C3u by constrained X-ray scattering modelling provide insight into C3 activation
20. The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands.
21. A Revised Mechanism for the Activation of Complement C3 to C3b.
22. The Fab Conformations in the Solution Structure of Human Immunoglobulin G4 (IgG4) Restrict Access to Its Fc Region.
23. The Solution Structure of Heparan Sulfate Differs from That of Heparin.
24. Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement.
25. The Solution Structure of Heparan Sulfate Differs from That of Heparin.
26. Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations.
27. C-reactive Protein Exists in an NaCI Concentration-dependent Pentamer-Decamer Equilibrium in Physiological Buffer.
28. The Nonpianar Secretory lgA2 and Near Planar Secretory IgAl Solution Structures Rationalize Their Different Mucosal Immune Responses.
29. Solution Structure of Human Secretory Component and Implications for Biological Function.
30. His-384 All.otypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form.
31. The solution structure of the human complement regulator CFHR5 reveals a compact dimeric structure by X-ray scattering and analytical ultracentrifugation.
32. Oligomerisation of complement factor H, heparin and zinc links the high-risk His402 allotype of complement factor H with age-related macular degeneration.
33. Database of Complement Gene Variants: A comprehensive database providing insights on function, structure and allele frequency for genetic variants identified in complement-mediated diseases.
34. Solution structures for the regulatory SCR-1/5 and cell-surface-binding SCR-16/20 fragments of Factor H reveal different self-associative properties
35. The factor H-aHUS mutation database and website: Update and integration of MCP and FI mutations with structural models
36. The partly-folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) indicates inter-SCR flexibility
37. The AMD disease-associated His384Tyr polymorphism of factor H is predicted to be exposed in the bent solution structure of SCR 6–8
38. Oligomeric solution structures of factor H in the presence of heparin fragments
39. The His402 allotype of complement factor H show similar self-association to the Tyr402 allotype but exhibits greater self-association in the presence of zinc
40. Evidence for a monomer-dimer equilibrium in native human Factor H
41. The structurally altered Sle1c allele of Crry has enhanced complement regulatory function
42. Solution structures for the SCR 1–5 and SCR 16–20 fragments of factor H reveal unexpected conformational properties
43. The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions
44. Solution structure of recombinant human secretory component and its two- and three-domain fragments by scattering, ultracentrifugation and constrained modeling
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