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Your search keyword '"Picchio M"' showing total 94 results
Start Over Author "Picchio M" Publisher elsevier b.v.
94 results on '"Picchio M"'

3. SC267 - 99M-technetium-psma radio-guided surgery to detect nodal metastases in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node dissection: a phase 2 prospective, single-institution study

Author

Gandaglia, G., Mazzone, E., Pellegrino, A., Fossati, N., Stabile, A., Scuderi, S., Barletta, F., Leni, R., Robesti, D., D’Ambrosio, L., Vitale, L.M., Gajate, A.M. Samanes, Picchio, M., Gianolli, L., Montorsi, F., and Briganti, A.

Published
2022
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4. V28 - 99m-technetium-psma radio-guided surgery to detect nodal metastases in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node dissection: A phase 2 prospective, single-institution study

Author

Gandaglia, G., Mazzone, E., Pellegrino, A., Fossati, N., Stabile, A., Scuderi, S., Barletta, F., Leni, R., Robesti, D., D'Ambrosio, L., Vitale, L.M., Samanes Gajate, A.M., Picchio, M., Gianolli, L., Montorsi, F., and Briganti, A.

Published
2022
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6. Función pronóstica de los parámetros derivados de FDG PET en la estadificación preoperatoria del cáncer de endometrio.

Author

Mapelli, P., Bergamini, A., Fallanca, F., Rancoita, P.M.V., Cioffi, R., Incerti, E., Rabaiotti, E., Petrone, M., Mangili, G., Candiani, M., Gianolli, L., and Picchio, M.

Abstract

Resumen Objetivo Investigar el papel pronóstico preoperatorio de la PET/TC con 18F-FDG en pacientes con carcinoma de endometrio (CE). Material y métodos Se realizó PET/TC con 18F-FDG en 57 pacientes para el estudio preoperatorio del CE. Se evaluaron los valores de captación estandarizados máximos y medios (SUVmax, media), volumen tumoral metabólico (MTV) y glicólisis de lesión total (TLG) de tumores primarios, a diferentes umbrales de 40%, 50%, 60% (40-50-60), comparándose con las características anatomopatológicas. Se evaluó el rendimiento diagnóstico de los parámetros PET (categorizados por análisis ROC) en la discriminación de la enfermedad de bajo y mediano riesgo y el papel pronóstico en la supervivencia (supervivencia global-OS, supervivencia libre de enfermedad-SSE). Resultados Los TLG40-50-60 categorizados fueron los únicos parámetros relacionados con FIGO estadio I versus II-III-IV (p = 0,0035 para todos). Los puntos de corte para la estratificación del riesgo fueron 83,69, 61,81 y 41,32, respectivamente (sensibilidad: 60%; especificidad, 71,43% para todos los parámetros. El estadio patológico 1 (pT1) del tumor primario se predijo con MTV60 y TLG40-50 (p = 0,0328, 0,0240 y 0,0147, respectivamente). Los umbrales óptimos fueron 7,795, 99,55 y 77,58, respectivamente (sensibilidad: 38,46%, 53,85% y 53,85%, respectivamente; especificidad: 88,64%, 79,55% y 81,82%, respectivamente). SUVmax y SUVmean40-50-60 fueron los únicos parámetros que discriminaron el subtipo endometrioide del no endometrioide. La sensibilidad fue del 64,86% y 62,16% para SUVmax y SUVmean50-60, y 62,16% para SUVmean40; la especificidad fue del 70% para todos los parámetros. La SG media (DE) fue del 79,77% (3,34%) y la SSE media fue del 77,89% (3,73%). El tipo de tumor fue la única variable significativamente asociada a la SG (p = 0,0486). TLG50 > 77,58 cm3 fue la única variable asociada a un mayor riesgo de recaída (p = 0,0472). Conclusión TLG40-50-60 y MTV60 de EC primaria tienen valor pronóstico para discriminar FIGO y estadificación patológica. Estos resultados sugieren un posible papel de estos parámetros en la predicción de la agresividad de la CE, mejorando así la caracterización preoperatoria del cáncer de endometrio. Abstract Purpose To investigate the preoperative prognostic role of 18F-FDG PET/CT in patients with endometrial carcinoma (EC). Methods 18F-FDG PET/CT was performed in 57 patients for EC preoperative staging. Maximum and mean standardized uptake values (SUVmax, mean), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of primary tumors, at different thresholds of 40%, 50%, 60% (40–50–60), were evaluated and compared with anatomopathological features. The diagnostic performance of PET-parameters (categorized by ROC analysis) in discriminating low-intermediate and high-risk disease and the prognostic role on survival (overall survival –OS; disease free survival – DFS) was evaluated. Results The categorized TLG40-50-60 were the only parameters related to FIGO stage I versus II-III-IV (p = 0.0035 for all). The cut-off values for risk stratification were 83.69, 61.81 and 41.32, respectively (sensitivity: 60.00%; specificity; 71.43% for all parameters). Pathological stage 1 (pT1) of the primary tumor was predicted by MTV60 and TLG40-50 (p = 0.0328, 0.0240, 0.0147, respectively). The optimal thresholds were 7.795, 99.55 and 77.58, respectively (sensitivity: 38.46%, 53.85% and 53.85%, respectively; specificity: 88.64%, 79.55% and 81.82%, respectively). SUVmax and SUVmean40-50-60 were the only parameters discriminating endometrioid from non-endometrioid subtype. The corresponding sensitivity was 64.86% and 62.16% for SUVmax and SUVmean 50-60 and 62.16% for SUVmean40; specificity was 70.00% for all parameters. The mean (SD) OS was 79.77% (3.34%) and the mean DFS was 77.89% (3.73%). The tumor type was the only variable significantly associated with OS (p = 0.0486). TLG50 > 77.58 cm3 was the only variable associated with a higher risk of relapse (p = 0.0472). Conclusion TLG40–50–60 and MTV60 of primary EC have prognostic value in discriminating FIGO and pathological staging. These results suggest a possible role of these parameters in predicting EC aggressiveness, thus improving the preoperative characterization of endometrial cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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18. PET guidance in prostate cancer radiotherapy: Quantitative imaging to predict response and guide treatment.

Author

Cattaneo, G.M., Bettinardi, V., Mapelli, P., and Picchio, M.

Abstract

Positron emission tomography (PET) allows a monitoring and recording of the spatial and temporal distribution of molecular/cellular processes for diagnostic and therapeutic applications. The aim of this review is to describe the current applications and to explore the role of PET in prostate cancer management, mainly in the radiation therapy (RT) scenario. The state-of-the art of PET for prostate cancer will be presented together with the impact of new specific PET tracers and technological developments aiming at obtaining better imaging quality, increased tumor detectability and more accurate volume delineation. An increased number of studies have been focusing on PET quantification methods as predictive biomarkers capable of guiding individualized treatment and improving patient outcome; the sophisticated advanced intensity modulated and imaged guided radiation therapy techniques (IMRT/IGRT) are capable of boosting more radioresistant tumor (sub)volumes. The use of advanced feature analyses of PET images is an approach that holds great promise with regard to several oncological diseases, but needs further validation in managing prostate diseases. [ABSTRACT FROM AUTHOR]

Published
2016
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27. 237. Robustness of FDG-PET radiomic features against tumor delineation in two clinical relevant scenarios.

Author

Broggi, S., Belli, M.L., Cattaneo, G.M., Bettinardi, V., Dell'Oca, I., Fallanca, F., Passoni, P., Vanoli, E.G., Calandrino, R., Di Muzio, N.G., Picchio, M., and Fiorino, C.

Abstract

Purpose To assess the robustness of PET radiomic features (RF) against tumour/PET positive nodes (T/N) delineation uncertainty in two clinically relevant situations, namely head-and-neck (HNC) and pancreatic cancer. Methods Twenty-five HNC (T and N) and 25 pancreatic cancer (only T) patients previously treated with IMRT and 18FDG-PET/CT based planning optimization were included in the study. Seven contours were delineated for each lesion following manual (2 independent observers), semi-automatic (based on SUV_max gradient: PET_edge) and automatic (40%,50%,60%,70% SUV_max thresholds) methods using MIM software(MimVista). For each contour, 71 RF (12 of first and 59 of higher order) were extracted by using the CGITA (v1.4) software. The impact of delineation on volume agreement (DICE-index) and RF was assessed by Intra-class Correlation Coefficients (ICC), considering a threshold of 0.80. Semi-automatic contouring repeatability was also tested. Results A large disagreement between manual and automatic SUV_max method was found for threshold values ⩾50%. Inter-observer variability was moderately high with median DICE values between 0.81 (HN-T) and 0.73 (pancreas). Volumes defined by PET_Edge were in better agreement with the manual ones compared to SUV40%; the repeatability of PET_Edge was excellent (median DICE = 0.95). Regarding RF, 14/14/35 features showed an ICC < 0.80 between observers for HN-N, HN-T and pancreas respectively, mostly in the Voxel-alignment (VA) matrix and in the intensity-size zone (ISZ) matrix families. The number of RF with ICC < 0.80 for PET_Edge (considering the worst ICC value between the two observers) increased to 32/26/44 for HN-N, HN-T and pancreas respectively; worse results were found for SUV40% (50/38/54) (Fig. 2). Conclusions About 80%/50% of 72 RF extracted with the CGITA software were consistent with respect to manual delineation for HN/pancreas patients. PET_edge was sufficiently robust with about 60%/40% of RF consistent with manual delineation while a worse performance was found for SUV40%. This result suggests the possibility to replace manual delineation of HN and pancreas tumours in studies including PET radiomic analyses. [ABSTRACT FROM AUTHOR]

Published
2018
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