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The rapid single flux quantum (RSFQ) mixed-signal technology offers a way to enhance performance and reduce complexity and cost of SQUID systems. Ultra-sensitive analog SQUID front ends can be combined with low-power and ultra-fast RSFQ digital circuits on a single chip to form mixed-signal circuits combining the sensitivity and noise level of an “analog SQUID” and the increased slew-rate, dynamic range, linearity, and simple multi-channel readout electronics of digital RSFQ circuits. We have developed several RSFQ-based circuits to perform sensing, digitization, and timing of various weak signals including outputs of detector arrays. The key enabling factor for the implementation of all these SQUID-RSFQ circuits is the availability of a high-yield, low-noise fabrication process. [Copyright &y& Elsevier]