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• Ag nanoclusters- SiO 2 /Al 2 O 3 /ZrO 2 coatings were obtained on SS316L, Tigr4 and Tigr5 by co-sputtering. • All coatings have a mean roughness <0.2 µm and good mechanical adhesion to the substrate. • ZrO 2 based coatings are the most stable in wet environment. • ZrO 2 -Ag coatings can reduce S. aureus adhesion even if Ag release is negligible. • ZrO 2 -Ag coatings are promising for temporary fixation devices. Bacterial contamination and bone tissue overgrowth are currently the main issues for temporary fixation devices. The aim of this research is the development of innovative inorganic coatings able to reduce bacterial adhesion and bone tissue overgrowth without hampering cytocompatibility. 316L stainless-steel, Titanium grade4 and Titanium grade5 were selected as substrates, as currently used in temporary fixation devices. Starting from previous results on silica, alumina and zirconia were selected as coating matrices, according to their higher chemical stability, reduced bacterial adhesion and possible reduction of tissue overgrowth. Coatings were produced by co-sputtering. Coating adhesion was evaluated by tape test. Samples were immersed in ultrapure water up to 28 days to investigate silver release and chemical stability in fluids. Surface roughness was measured by contact profilometry. Surface wettability was determined by contact angle measurements and antibacterial activity was studied against antibiotic resistant S aureus. The research demonstrates the possibility to obtain coatings with roughness lower than the critical threshold for the increase of bacterial adhesion (0.2 µm) and optimal mechanical adhesion to metallic substrates. Coating chemical stability in water is strongly affected by the coating matrix composition. Silver release can be tailored to obtain antibacterial and biocompatible surfaces. [ABSTRACT FROM AUTHOR]