1. Cytotoxic metabolites from the leaves of the mangrove Rhizophora apiculata.
- Author
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Thao, Nguyen Phuong, Linh, Kieu Thi Phuong, Quan, Nguyen Huu, Trung, Vu Thanh, Binh, Pham Thanh, Cuong, Nguyen The, Nam, Nguyen Hoai, and Van Thanh, Nguyen
- Abstract
[Display omitted] • Two new and twenty-one known compounds were isolated from R. apiculata leaves. • The structures were elucidated by spectroscopic methods and computational studies. • All isolated compounds were evaluated for their cytotoxicity. One new 8,4'-oxyneolignan (1) and one new 7,8-dihydrobenzofuranone (2), together with twenty-one known compounds (3 ‒ 23) were isolated from the methanol extract of Rhizophora apiculata leaves. The structures of new compounds, as well as their absolute configuration, were determined by a combination of spectroscopic methods and quantum chemical calculations of NMR and ECD data. All isolated compounds were evaluated for their cytotoxicity, and only 2,6-dimethoxy-1,4-benzoquinone (8) exhibited inhibitory effects against SK-LU-1, HepG2, and MCF7 cells with IC 50 values in the range of 8.33–14.82 μ M. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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