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12. Cosmology intertwined: A review of the particle physics, astrophysics, and cosmology associated with the cosmological tensions and anomalies

Author

Abdalla, Elcio, Abellán, Guillermo Franco, Aboubrahim, Amin, Agnello, Adriano, Akarsu, Özgür, Akrami, Yashar, Alestas, George, Aloni, Daniel, Amendola, Luca, Anchordoqui, Luis A., Anderson, Richard I., Arendse, Nikki, Asgari, Marika, Ballardini, Mario, Barger, Vernon, Basilakos, Spyros, Batista, Ronaldo C., Battistelli, Elia S., Battye, Richard, Benetti, Micol, Benisty, David, Berlin, Asher, de Bernardis, Paolo, Berti, Emanuele, Bidenko, Bohdan, Birrer, Simon, Blakeslee, John P., Boddy, Kimberly K., Bom, Clecio R., Bonilla, Alexander, Borghi, Nicola, Bouchet, François R., Braglia, Matteo, Buchert, Thomas, Buckley-Geer, Elizabeth, Calabrese, Erminia, Caldwell, Robert R., Camarena, David, Capozziello, Salvatore, Casertano, Stefano, Chen, Geoff C.-F., Chluba, Jens, Chen, Angela, Chen, Hsin-Yu, Chudaykin, Anton, Cicoli, Michele, Copi, Craig J., Courbin, Fred, Cyr-Racine, Francis-Yan, Czerny, Bożena, Dainotti, Maria, D'Amico, Guido, Davis, Anne-Christine, de Cruz Pérez, Javier, de Haro, Jaume, Delabrouille, Jacques, Denton, Peter B., Dhawan, Suhail, Dienes, Keith R., Di Valentino, Eleonora, Du, Pu, Eckert, Dominique, Escamilla-Rivera, Celia, Ferté, Agnès, Finelli, Fabio, Fosalba, Pablo, Freedman, Wendy L., Frusciante, Noemi, Gaztañaga, Enrique, Giarè, William, Giusarma, Elena, Gómez-Valent, Adrià, Handley, Will, Harrison, Ian, Hart, Luke, Hazra, Dhiraj Kumar, Heavens, Alan, Heinesen, Asta, Hildebrandt, Hendrik, Hill, J. Colin, Hogg, Natalie B., Holz, Daniel E., Hooper, Deanna C., Hosseininejad, Nikoo, Huterer, Dragan, Ishak, Mustapha, Ivanov, Mikhail M., Jaffe, Andrew H., Jang, In Sung, Jedamzik, Karsten, Jimenez, Raul, Joseph, Melissa, Joudaki, Shahab, Kamionkowski, Marc, Karwal, Tanvi, Kazantzidis, Lavrentios, Keeley, Ryan E., Klasen, Michael, Komatsu, Eiichiro, Koopmans, Léon V.E., Kumar, Suresh, Lamagna, Luca, Lazkoz, Ruth, Lee, Chung-Chi, Lesgourgues, Julien, Levi Said, Jackson, Lewis, Tiffany R., L'Huillier, Benjamin, Lucca, Matteo, Maartens, Roy, Macri, Lucas M., Marfatia, Danny, Marra, Valerio, Martins, Carlos J.A.P., Masi, Silvia, Matarrese, Sabino, Mazumdar, Arindam, Melchiorri, Alessandro, Mena, Olga, Mersini-Houghton, Laura, Mertens, James, Milaković, Dinko, Minami, Yuto, Miranda, Vivian, Moreno-Pulido, Cristian, Moresco, Michele, Mota, David F., Mottola, Emil, Mozzon, Simone, Muir, Jessica, Mukherjee, Ankan, Mukherjee, Suvodip, Naselsky, Pavel, Nath, Pran, Nesseris, Savvas, Niedermann, Florian, Notari, Alessio, Nunes, Rafael C., Ó Colgáin, Eoin, Owens, Kayla A., Özülker, Emre, Pace, Francesco, Paliathanasis, Andronikos, Palmese, Antonella, Pan, Supriya, Paoletti, Daniela, Perez Bergliaffa, Santiago E., Perivolaropoulos, Leandros, Pesce, Dominic W., Pettorino, Valeria, Philcox, Oliver H.E., Pogosian, Levon, Poulin, Vivian, Poulot, Gaspard, Raveri, Marco, Reid, Mark J., Renzi, Fabrizio, Riess, Adam G., Sabla, Vivian I., Salucci, Paolo, Salzano, Vincenzo, Saridakis, Emmanuel N., Sathyaprakash, Bangalore S., Schmaltz, Martin, Schöneberg, Nils, Scolnic, Dan, Sen, Anjan A., Sehgal, Neelima, Shafieloo, Arman, Sheikh-Jabbari, M.M., Silk, Joseph, Silvestri, Alessandra, Skara, Foteini, Sloth, Martin S., Soares-Santos, Marcelle, Solà Peracaula, Joan, Songsheng, Yu-Yang, Soriano, Jorge F., Staicova, Denitsa, Starkman, Glenn D., Szapudi, István, Teixeira, Elsa M., Thomas, Brooks, Treu, Tommaso, Trott, Emery, van de Bruck, Carsten, Vazquez, J. Alberto, Verde, Licia, Visinelli, Luca, Wang, Deng, Wang, Jian-Min, Wang, Shao-Jiang, Watkins, Richard, Watson, Scott, Webb, John K., Weiner, Neal, Weltman, Amanda, Witte, Samuel J., Wojtak, Radosław, Yadav, Anil Kumar, Yang, Weiqiang, Zhao, Gong-Bo, and Zumalacárregui, Miguel

Published
2022
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13. Snowmass2021 - Letter of interest cosmology intertwined IV: The age of the universe and its curvature

Author

Di Valentino, Eleonora, Anchordoqui, Luis A., Akarsu, Özgür, Ali-Haimoud, Yacine, Amendola, Luca, Arendse, Nikki, Asgari, Marika, Ballardini, Mario, Basilakos, Spyros, Battistelli, Elia, Benetti, Micol, Birrer, Simon, Bouchet, François R., Bruni, Marco, Calabrese, Erminia, Camarena, David, Capozziello, Salvatore, Chen, Angela, Chluba, Jens, Chudaykin, Anton, Colgáin, Eoin Ó, Cyr-Racine, Francis-Yan, de Bernardis, Paolo, de Cruz Pérez, Javier, Delabrouille, Jacques, Escamilla-Rivera, Celia, Ferté, Agnès, Finelli, Fabio, Freedman, Wendy, Frusciante, Noemi, Giusarma, Elena, Gómez-Valent, Adrià, Handley, Will, Harrison, Ian, Hart, Luke, Heavens, Alan, Hildebrandt, Hendrik, Holz, Daniel, Huterer, Dragan, Ivanov, Mikhail M., Joudaki, Shahab, Kamionkowski, Marc, Karwal, Tanvi, Knox, Lloyd, Kumar, Suresh, Lamagna, Luca, Lesgourgues, Julien, Lucca, Matteo, Marra, Valerio, Masi, Silvia, Matarrese, Sabino, Mazumdar, Arindam, Melchiorri, Alessandro, Mena, Olga, Mersini-Houghton, Laura, Miranda, Vivian, Moreno-Pulido, Cristian, Mota, David F., Muir, Jessica, Mukherjee, Ankan, Niedermann, Florian, Notari, Alessio, Nunes, Rafael C., Pace, Francesco, Paliathanasis, Andronikos, Palmese, Antonella, Pan, Supriya, Paoletti, Daniela, Pettorino, Valeria, Piacentini, Francesco, Poulin, Vivian, Raveri, Marco, Riess, Adam G., Salzano, Vincenzo, Saridakis, Emmanuel N., Sen, Anjan A., Shafieloo, Arman, Shajib, Anowar J., Silk, Joseph, Silvestri, Alessandra, Sloth, Martin S., Smith, Tristan L., Solà Peracaula, Joan, van de Bruck, Carsten, Verde, Licia, Visinelli, Luca, Wandelt, Benjamin D., Wang, Deng, Wang, Jian-Min, Yadav, Anil K., and Yang, Weiqiang

Published
2021
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14. Snowmass2021 - Letter of interest cosmology intertwined II: The hubble constant tension

Author

Di Valentino, Eleonora, Anchordoqui, Luis A., Akarsu, Özgür, Ali-Haimoud, Yacine, Amendola, Luca, Arendse, Nikki, Asgari, Marika, Ballardini, Mario, Basilakos, Spyros, Battistelli, Elia, Benetti, Micol, Birrer, Simon, Bouchet, François R., Bruni, Marco, Calabrese, Erminia, Camarena, David, Capozziello, Salvatore, Chen, Angela, Chluba, Jens, Chudaykin, Anton, Colgáin, Eoin Ó, Cyr-Racine, Francis-Yan, de Bernardis, Paolo, de Cruz Pérez, Javier, Delabrouille, Jacques, Dunkley, Jo, Escamilla-Rivera, Celia, Ferté, Agnès, Finelli, Fabio, Freedman, Wendy, Frusciante, Noemi, Giusarma, Elena, Gómez-Valent, Adrià, Guy, Julien, Handley, Will, Harrison, Ian, Hart, Luke, Heavens, Alan, Hildebrandt, Hendrik, Holz, Daniel, Huterer, Dragan, Ivanov, Mikhail M., Joudaki, Shahab, Kamionkowski, Marc, Karwal, Tanvi, Knox, Lloyd, Kumar, Suresh, Lamagna, Luca, Lesgourgues, Julien, Lucca, Matteo, Marra, Valerio, Masi, Silvia, Matarrese, Sabino, Mazumdar, Arindam, Melchiorri, Alessandro, Mena, Olga, Mersini-Houghton, Laura, Miranda, Vivian, Moreno-Pulido, Cristian, Mota, David F., Muir, Jessica, Mukherjee, Ankan, Niedermann, Florian, Notari, Alessio, Nunes, Rafael C., Pace, Francesco, Paliathanasis, Andronikos, Palmese, Antonella, Pan, Supriya, Paoletti, Daniela, Pettorino, Valeria, Piacentini, Francesco, Poulin, Vivian, Raveri, Marco, Riess, Adam G., Salzano, Vincenzo, Saridakis, Emmanuel N., Sen, Anjan A., Shafieloo, Arman, Shajib, Anowar J., Silk, Joseph, Silvestri, Alessandra, Sloth, Martin S., Smith, Tristan L., Solà Peracaula, Joan, van de Bruck, Carsten, Verde, Licia, Visinelli, Luca, Wandelt, Benjamin D., Wang, Deng, Wang, Jian-Min, Yadav, Anil K., and Yang, Weiqiang

Published
2021
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15. Snowmass2021 - Letter of interest cosmology intertwined I: Perspectives for the next decade

Author

Di Valentino, Eleonora, Anchordoqui, Luis A., Akarsu, Özgür, Ali-Haimoud, Yacine, Amendola, Luca, Arendse, Nikki, Asgari, Marika, Ballardini, Mario, Basilakos, Spyros, Battistelli, Elia, Benetti, Micol, Birrer, Simon, Bouchet, François R., Bruni, Marco, Calabrese, Erminia, Camarena, David, Capozziello, Salvatore, Chen, Angela, Chluba, Jens, Chudaykin, Anton, Colgáin, Eoin Ó, Cyr-Racine, Francis-Yan, de Bernardis, Paolo, de Cruz Pérez, Javier, Delabrouille, Jacques, Dunkley, Jo, Escamilla-Rivera, Celia, Ferté, Agnès, Finelli, Fabio, Freedman, Wendy, Frusciante, Noemi, Giusarma, Elena, Gómez-Valent, Adrià, Handley, Will, Harrison, Ian, Hart, Luke, Heavens, Alan, Hildebrandt, Hendrik, Holz, Daniel, Huterer, Dragan, Ivanov, Mikhail M., Joudaki, Shahab, Kamionkowski, Marc, Karwal, Tanvi, Knox, Lloyd, Kumar, Suresh, Lamagna, Luca, Lesgourgues, Julien, Lucca, Matteo, Marra, Valerio, Masi, Silvia, Matarrese, Sabino, Mazumdar, Arindam, Melchiorri, Alessandro, Mena, Olga, Mersini-Houghton, Laura, Miranda, Vivian, Moreno-Pulido, Cristian, Mota, David F., Muir, Jessica, Mukherjee, Ankan, Niedermann, Florian, Notari, Alessio, Nunes, Rafael C., Pace, Francesco, Paliathanasis, Andronikos, Palmese, Antonella, Pan, Supriya, Paoletti, Daniela, Pettorino, Valeria, Piacentini, Francesco, Poulin, Vivian, Raveri, Marco, Riess, Adam G., Salzano, Vincenzo, Saridakis, Emmanuel N., Sen, Anjan A., Shafieloo, Arman, Shajib, Anowar J., Silk, Joseph, Silvestri, Alessandra, Sloth, Martin S., Smith, Tristan L., Solà Peracaula, Joan, van de Bruck, Carsten, Verde, Licia, Visinelli, Luca, Wandelt, Benjamin D., Wang, Deng, Wang, Jian-Min, Yadav, Anil K., and Yang, Weiqiang

Published
2021
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16. Cosmology intertwined III: [formula omitted] and [formula omitted]

Author

Di Valentino, Eleonora, Anchordoqui, Luis A., Akarsu, Özgür, Ali-Haimoud, Yacine, Amendola, Luca, Arendse, Nikki, Asgari, Marika, Ballardini, Mario, Basilakos, Spyros, Battistelli, Elia, Benetti, Micol, Birrer, Simon, Bouchet, François R., Bruni, Marco, Calabrese, Erminia, Camarena, David, Capozziello, Salvatore, Chen, Angela, Chluba, Jens, Chudaykin, Anton, Colgáin, Eoin Ó, Cyr-Racine, Francis-Yan, de Bernardis, Paolo, de Cruz Pérez, Javier, Delabrouille, Jacques, Dunkley, Jo, Escamilla-Rivera, Celia, Ferté, Agnès, Finelli, Fabio, Freedman, Wendy, Frusciante, Noemi, Giusarma, Elena, Gómez-Valent, Adrià, Handley, Will, Harrison, Ian, Hart, Luke, Heavens, Alan, Hildebrandt, Hendrik, Holz, Daniel, Huterer, Dragan, Ivanov, Mikhail M., Joudaki, Shahab, Kamionkowski, Marc, Karwal, Tanvi, Knox, Lloyd, Kumar, Suresh, Lamagna, Luca, Lesgourgues, Julien, Lucca, Matteo, Marra, Valerio, Masi, Silvia, Matarrese, Sabino, Mazumdar, Arindam, Melchiorri, Alessandro, Mena, Olga, Mersini-Houghton, Laura, Miranda, Vivian, Moreno-Pulido, Cristian, Mota, David F., Muir, Jessica, Mukherjee, Ankan, Niedermann, Florian, Notari, Alessio, Nunes, Rafael C., Pace, Francesco, Paliathanasis, Andronikos, Palmese, Antonella, Pan, Supriya, Paoletti, Daniela, Pettorino, Valeria, Piacentini, Francesco, Poulin, Vivian, Raveri, Marco, Riess, Adam G., Salzano, Vincenzo, Saridakis, Emmanuel N., Sen, Anjan A., Shafieloo, Arman, Shajib, Anowar J., Silk, Joseph, Silvestri, Alessandra, Sloth, Martin S., Smith, Tristan L., Solà Peracaula, Joan, van de Bruck, Carsten, Verde, Licia, Visinelli, Luca, Wandelt, Benjamin D., Wang, Deng, Wang, Jian-Min, Yadav, Anil K., and Yang, Weiqiang

Published
2021
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19. Laparoscopic bariatric surgery is safe during phase 2–3 of COVID-19 pandemic in Italy: A multicenter, prospective, observational study

Author

Silecchia, Gianfranco, Boru, Cristian E., M. Marinari, Giuseppe, Gentileschi, Paolo, Morino, Mario, Olmi, Stefano, Foletto, Mirto, Bernante, Paolo, Morganti, Riccardo, Tascini, Carlo, Anselmino, Marco, Bianciardi, Emanuela, Campanelli, Michela, Fiorello, Luigi, Mancini, Rudj, Oldani, Alberto, Rottoli, Matteo, Salzano, Antonio, and Trotta, Manuela

Published
2021
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21. Predictive value of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and systemic inflammatory index for detection of recurrence of pleomorphic adenoma of the major salivary glands: a multicenter study.

Author

Salzano, Giovanni, Barone, Simona, De Luca, Pietro, Borriello, Gerardo, Vaira, Luigi Angelo, Troise, Stefania, Granata, Vincenza, Committeri, Umberto, Perri, Francesco, Esposito, Maria, di Blasi, Fabio, Petrocelli, Marzia, Ionna, Franco, Califano, Luigi, Orabona, Giovanni Dell'Aversana, and Stadio, Arianna Di

Abstract

The aim of this study was to investigate the correlation among inflammatory biomarkers, such as the systemic immune-inflammation index (SII), the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), and the recurrence of pleomorphic adenomas (PAs). This was a retrospective multicenter study. Six hundred eight patients diagnosed with PA and treated by tumor enucleation were included in the analyses. The patients were extracted from a 20-year database of 2 referral centers (January 2000 to January 2020). Data about age, gender, voluntary habits, tumor characteristics, tumor treatment, and values of NLR, PLR, and SII were collected. A receiver operating characteristic (ROC) curve was used to calculate the optimal cutoff values for SII, PLR, and NLR. A linear regression model (LRM) and a nonlinear logistic regression model (NLRM) were implemented for NLR, PLR, and SII. All 3 inflammatory parameters were statistically significant correlated to the recurrence of the tumor. The best performance was achieved by NLR (cutoff of 2.960) with area under the ROC curve (AUC) = 0.91, accuracy of 96.1%, sensitivity of 78.4% and specificity of 97.2%, PPV = 64.4%, and NPV = 98.6%. LRM and NLRM including all hematological parameters did not improve performance in terms of recurrence detection. The use of 3 inflammatory biomarkers could be a useful tool to predict recurrence of tumor in case of PA ≤ 3 cm. NLR in particular could be sensitive with a cutoff of 2.960. The use of NLR, PLR, and SII could be a good reference point for surgical decision making and follow-up in clinical practice. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range) [ABSTRACT FROM AUTHOR]

Published
2025
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23. Full-arch rehabilitation of severely atrophic maxilla with additively manufactured custom-made subperiosteal implants: A multicenter retrospective study.

Author

Vaira, Luigi Angelo, Biglio, Andrea, Roy, Marco, Salzano, Giovanni, Troise, Stefania, Abbate, Vincenzo, Mayo-Yanez, Miguel, Lechien, Jerome R., Piombino, Pasquale, and De Riu, Giacomo

Subjects
BONE resorption, GINGIVAL hemorrhage, MAXILLOFACIAL surgery, ORAL surgery, DENTAL implants
Abstract

The aim of this retrospective study was to analyze a series of patients who underwent full-arch rehabilitation of the atrophic maxilla using additively manufactured subperiosteal implants, between August 2018 and January 2023, at the Universities of Sassari and Poznan. In total, 36 patients and 72 implants were included, with no implants lost during follow-up, and a success rate of 90.3%. Seven (9.7%) of the implants showed class 1 exposure. Bleeding on probing was detected in 10.4% of the abutments at 6 months, 7.9% at 1 year, 10% at 2 years, 7% at 3 years, and 11.4% at 4 years. No significant bone resorption under the abutments was detected during the whole observation period. Based on the findings from this study, additively manufactured subperiosteal implants could represent a safe and reliable technique for full-arch rehabilitation in patients with severe maxillary atrophy. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Implant-prosthetic rehabilitation of the atrophic posterior mandible with additively manufactured custom-made subperiosteal implants: a cohort study.

Author

Vaira, L.A., Biglio, A., Favro, A., Salzano, G., Abbate, V., Lechien, J.R., and De Riu, G.

Subjects
OPERATIVE surgery, MAXILLOFACIAL surgery, MANDIBLE, COHORT analysis, REHABILITATION, SINUS augmentation, MANDIBLE surgery
Abstract

The aim of this study was to retrospectively analyse a series of patients with posterior mandibular atrophy rehabilitated with custom-made subperiosteal implants. The study included patients with severe posterior mandibular atrophy who had undergone rehabilitation with subperiosteal implants between September 2018 and August 2022 in the Maxillofacial Surgery Operative Unit of the University Hospital of Sassari. Complications and the success rate were reviewed. Data from 30 implants placed in 17 patients were included and analysed. There were no major complications during the surgeries. The main postoperative sequela was oedema, which was reported as moderate by most patients and had completely regressed within 10 days of surgery. No partial or complete exposures, infections, or loss of the implants were detected during follow-up (average follow-up 22.5 months). Control computed tomography scans, performed at 6 months and then annually in all cases, did not show significant bone loss below the abutments, displacement of the implants, or loss or loosening of the osteosynthesis screws. Subperiosteal implants may represent a safe and reliable technique for the rehabilitation of severe atrophy of the posterior mandible. Prospective studies with a long follow-up will be needed to establish the long-term results of this type of implant-prosthetic rehabilitation. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Epidemiological analysis of patients with isolated blowout fractures of orbital floor: Correlation between demographic characteristics and fracture area.

Author

Troise, Stefania, Committeri, Umberto, Barone, Simona, Gentile, Domenico, Arena, Antonio, Salzano, Giovanni, Bonavolontà, Paola, Abbate, Vincenzo, Romano, Antonio, Dell'Aversana Orabona, Giovanni, Vaira, Luigi Angelo, De Riu, Giacomo, Califano, Luigi, and Piombino, Pasquale

Subjects
EYE-socket fractures, DEMOGRAPHIC characteristics, STATISTICAL correlation, ROAD rage, EYE movements
Abstract

Isolated orbital floor fractures are more frequent due to low bone thickness (2 mm). The aim of this study was to conduct a retrospective epidemiological analysis on these fractures, investigating demographic variables and fractures' features and their statistical correlation. A total of 120 patients with isolated orbital floor fracture, admitted at the Maxillofacial Surgery Unit of University of Naples Federico II, from 2010 to 2022 were enrolled in the study. Patients were evaluated for age, sex, smoke, comorbidities, post-traumatic clinical manifestation,s and defect side and size. Statistical analysis was conducted using the Pearson regression coefficient (r). The fractures were more frequent in men (male:female 2.2:1) because of road accidents (30% of cases). The average age was 48 years. Enophthalmos, diplopia and ocular motility anomalies were observed in 31%, 23% and 21% of cases, respectively. Statistical analysis revealed that age was related to fracture area; in particular, older patients showed larger fractures (p < 0.001). Interpersonal violence and traffic accidents were related to younger age (p < 0.001). Data analysis revealed that isolated orbital floor fractures are more frequent in young men (<40 years) because of road accidents or interpersonal violence. There is a statistical correlation between fracture area and patient age; in particular, older age corresponds to larger defects. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Submental intubation in complex maxillofacial trauma: Pilot balloon protection.

Author

Troise, Stefania, Committeri, Umberto, Barone, Simona, Palumbo, Daniela, D'Auria, David, Arena, Antonio, Romano, Antonio, Salzano, Giovanni, Abbate, Vincenzo, Raccampo, Luca, Sembronio, Salvatore, Vaira, Luigi Angelo, Dell'Aversana Orabona, Giovanni, Califano, Luigi, and Piombino, Pasquale

Subjects
INTUBATION, SURGICAL complications, ANESTHESIOLOGISTS
Abstract

This study aims to describe our refined technique of submental intubation to avoid the recorded intraoperative complications related to tube passage and pilot balloon rupture. This is a retrospective case series of 21 patients with complex maxillofacial trauma who underwent submental intubation from January 2019 to January 2023. All the patients underwent to the same procedure with a new technique of pilot balloon protection: the pilot balloon was not deflated because, once the connector was removed, only the tube was curved and passed through the incision extraorally while the cuff remained inflated. The wire of the pilot balloon was passed behind the last tooth so as not to interfere with the maxillary-mandibular fixation, remaining extraorally under the anesthetist's view. Only 2 patients (9.5%) reported complications related to submental intubation: in particular a patient (4.8%) reported oral floor infection, and in another patient (4.8%) an unesthetic skin scar was observed. No patients reported intraoperative complications related to the procedure. The technique of pilot balloon protection that we have proposed seems to be effective in reducing the intraoperative complications related to the passage of the pilot balloon, such as rupture, damage or early extubation. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Surgical management and side effects of parotid gland surgery for benign lesions: a retrospective analysis of our experience from 2012 to 2021.

Author

Committeri, Umberto, Arena, Antonio, Iaquino, Vincenzo, Salzano, Giovanni, Blasi, Fabio Di, Esposito, Maria, Giovacchini, Francesco, Calvanese, Carlo, Abbate, Vincenzo, Bonavolontà, Paola, Califano, Luigi, and Orabona, Giovanni Dell'Aversana

Subjects
PAROTID gland surgery, PAROTIDECTOMY, SURGICAL wound dehiscence, FACIAL paralysis, PAROTID gland tumors, PLEOMORPHIC adenoma
Abstract

Surgery is the treatment of choice for tumours in the parotid gland. We evaluated complications following parotid surgery. We conducted a retrospective study on 554 patients undergoing parotid surgery for benign parotid tumours from 2012 to 2021. We analysed complication rates between extracapsular dissection (ECD) and superficial parotidectomy (SP). We found 19 capsular ruptures in patients undergoing ECD (5.34%) and five among those undergoing SP (2.52%) [p < 0,05]; 16 cases of temporary facial paralysis among those undergoing ECD (4.49%) and 35 in patients undergoing SP (17.67%) [p < 0,05]; and eight instances of permanent facial nerve paralysis in patients undergoing ECD (2.25%) [p > 0,05] and 13 in patients undergoing SP (6.56%). Among the mid-term complications described were: 22 salivary fistulas among patients operated with ECD (6.18%) [p > 0,05] and 17 in patients with SP (8.58%) 17 sialoceles in those who underwent ECD (4.77%) and seven with SP (3.53%) [p > 0,05]. Regarding late complications, we found: surgical wound dehiscence, pathological scarring (keloid), Frey's syndrome, and recurrence, which affected 45 patients with ECD (12.64%) and 21 with SP for dehiscence (10.6%) [p < 0,05]; 28 keloids in patients with ECD (7.86%) and 15 in patients with SP (7.57%) [p > 0,05]; 12 cases of Frey's syndrome in patients with ECD (3.37%) and 36 with SP (18.18%) [p < 0,05]; and finally 22 recurrences in patients who underwent ECD (6.18%) and 13 in patients who underwent SP (6.56%) [p > 0,05], including 30 in the 273 patients with pleomorphic adenoma and five in the 214 patients with Warthin's tumour. We can conclude that the onset of the different complications after parotid gland surgery are related to the surgery performed. Our data confirm that there is a tight relationship between type of surgery performed and type of complication. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Evaluation of sarcopenia and sarcopenic obesity in patients affected by oral squamous cell carcinoma: A retrospective single-center study.

Author

Bonavolontà, Paola, Improta, Giovanni, Dell'Aversana Orabona, Giovanni, Goglia, Federica, Abbate, Vincenzo, Sorrentino, Alfonso, Piloni, Sara, Salzano, Giovanni, Iaconetta, Giorgio, and Califano, Luigi

Subjects
SQUAMOUS cell carcinoma, SARCOPENIA, PROPORTIONAL hazards models, BODY mass index, PROGNOSIS
Abstract

This retrospective single-center study aimed to evaluate the relevance of sarcopenia and sarcopenic obesity as negative prognostic factors in patients with oral squamous cell carcinoma (OSCC). The study was performed on patients who underwent oral squamous cell carcinoma resection surgery. Patients' demographic and clinical variables were collected at diagnosis (sex, age, height, weight, comorbidities, smoke and alcohol consumption, HPV positivity, TNM-stage) and corrected for known prognostic factors (age, body mass index, TNM-stage). The Skeletal Muscle Mass (SMM) and the Cross-Sectional Area (CSA) on pre-treatment CT scans and Body Mass Index (BMI) were measured to assess sarcopenia and sarcopenic obesity correlated to overall survival (OS). Chi-square statistics were used to analyze the differences between the frequencies of each categorical variable with the presence or absence of sarcopenia and sarcopenic obesity. The cumulative overall survival was calculated by the Kaplan-Meier method, and the differences between curves were evaluated by the log-rank test. A Cox proportional hazard regression model was used for univariate and multivariate analysis of the overall survival. Within the limitations of the study, in this sample, sarcopenia did not seem to cause a statistically significant reduction in the overall survival in patients with oral squamous cell carcinoma (Log Rank χ2 = 3.67, p = 0.055; HR 0.996, 95% CI 0.732–1.354, p = 0.979), however, sarcopenic obesity showed a meaningful negative prognostic impact on it (Log Rank χ2 = 5.71, p = 0.017; HR 0.985, 95% CI 0.424–2.286, p = 0.972). Within the limitations of the study it seems that sarcopenic obesity, age, BMI, and TNM-stage are more relevant negative prognostic factors, influencing overall survival in surgically treated OSCC, than sarcopenia. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Prevalence of use and appropriateness of antidepressants prescription in acutely hospitalized elderly patients

Author

Carlotta, F, Raffaella, R, Ilaria, A, Alessandro, N, Mannuccio, M, Mannucci, P, Nobili, A, Pietrangelo, A, Perticone, F, Licata, G, Violi, F, Corazza, G, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Cortesi, L, Miglio, G, Ardoino, I, Novella, A, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Caterina, C, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Lupattelli, G, Mannarino, E, Bianconi, V, Paciullo, F, Alcidi, R, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Natoli, G, Mularo, S, Raspanti, M, Cavallaro, F, Zoli, M, Lazzari, I, Brunori, M, Fabbri, E, Magalotti, D, Arno, R, Pasini, F, Capecchi, P, Palasciano, G, Modeo, M, Gennaro, C, Cappellini, M, Maira, D, Di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, De Amicis, M, De Luca, G, Scaramellini, N, Rossi, P, Damanti, S, Clerici, M, Conti, F, Bonini, G, Ottolini, B, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Dominioni, C, Murialdo, G, Marra, A, Cattaneo, F, Pontremoli, R, Beccati, V, Nobili, G, Secchi, M, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Valeriani, E, Rossi, I, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Pes, C, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccala, G, D'Aurizio, G, Romanelli, G, Zucchelli, A, Manzoni, F, Volpini, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Tassone, B, Sesti, G, Interna, M, Serra, M, Bleve, M, Gasbarrone, L, Sajeva, M, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Cosi, E, Scarinzi, P, Amabile, A, Omenetto, E, Prandini, T, Manfredini, R, Fabbian, F, Boari, B, Giorgi, A, Tiseo, R, De Giorgio, R, Paolisso, G, Rizzo, M, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Sabba, C, Vella, F, Suppressa, P, Schilardi, A, Loparco, F, De Vincenzo, G, Comitangelo, A, Amoruso, E, Fenoglio, L, Falcetta, A, Bracco, C, Fracanzani, A, Fargion, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Agosti, P, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, N, Tognin, T, Bianchi, G, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Peasso, P, Favale, E, Poletto, C, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Dondi, G, Pellegrini, E, Carulli, L, Galassi, M, Grassi, Y, Perticone, M, Battaglia, R, Filice, M, Maio, R, Stanghellini, V, Ruggeri, E, del Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Capeci, W, Gabrielli, A, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ghio, R, Col, A, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Pignataro, S, Gennaro, A, Blanco, J, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, M, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffre, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Ceda, G, Maggio, M, Morganti, S, Artoni, A, Del Giacco, S, Firinu, D, Losa, F, Paoletti, G, Costanzo, G, Montalto, G, Licata, A, Malerba, V, Montalto, F, Lasco, A, Basile, G, Catalano, A, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, G, Sola, D, Porta, M, Riva, P, Quadri, R, Larovere, E, Novelli, M, Scanzi, G, Mengoli, C, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Napoli, F, Carlotta F., Raffaella R., Ilaria A., Alessandro N., Mannuccio M. P., Mannucci P. M., Nobili A., Pietrangelo A., Perticone F., Licata G., Violi F., Corazza G. R., Corrao S., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Cortesi L., Miglio G., Ardoino I., Novella A., Prisco D., Silvestri E., Emmi G., Bettiol A., Caterina C., Biolo G., Zanetti M., Guadagni M., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Lupattelli G., Mannarino E., Bianconi V., Paciullo F., Alcidi R., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Cocita F., Beneduce V., Plances L., Natoli G., Mularo S., Raspanti M., Cavallaro F., Zoli M., Lazzari I., Brunori M., Fabbri E., Magalotti D., Arno R., Pasini F. L., Capecchi P. L., Palasciano G., Modeo M. E., Gennaro C. D., Cappellini M. D., Maira D., Di Stefano V., Fabio G., Seghezzi S., Mancarella M., De Amicis M. M., De Luca G., Scaramellini N., Rossi P. D., Damanti S., Clerici M., Conti F., Bonini G., Ottolini B. B., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Dominioni C. C., Murialdo G., Marra A., Cattaneo F., Pontremoli R., Beccati V., Nobili G., Secchi M. B., Ghelfi D., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Valeriani E., Rossi I., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Pes C., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Zuccala G., D'Aurizio G., Romanelli G., Zucchelli A., Manzoni F., Volpini A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Annoni G., Corsi M., Bellelli G., Zazzetta S., Mazzola P., Szabo H., Bonfanti A., Arturi F., Succurro E., Rubino M., Tassone B., Sesti G., Interna M., Serra M. G., Bleve M. A., Gasbarrone L., Sajeva M. R., Brucato A., Ghidoni S., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Cosi E., Scarinzi P., Amabile A., Omenetto E., Prandini T., Manfredini R., Fabbian F., Boari B., Giorgi A. D., Tiseo R., De Giorgio R., Paolisso G., Rizzo M. R., Borghi C., Strocchi E., Ianniello E., Soldati M., Sabba C., Vella F. S., Suppressa P., Schilardi A., Loparco F., De Vincenzo G. M., Comitangelo A., Amoruso E., Fenoglio L., Falcetta A., Bracco C., Fracanzani A. L., Fargion S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Peyvandi F., Rossio R., Ferrari B., Colombo G., Agosti P., Monzani V., Savojardo V., Folli C., Ceriani G., Pallini G., Dallegri F., Ottonello L., Liberale L., Caserza L., Salam K., Liberato N. L., Tognin T., Bianchi G. B., Giaquinto S., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Spazzini E., Ferrandina C., Montrucchio G., Petitti P., Peasso P., Favale E., Poletto C., Salmi R., Gaudenzi P., Perri L., Landolfi R., Montalto M., Mirijello A., Guasti L., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Dondi G., Pellegrini E., Carulli L., Galassi M., Grassi Y., Perticone M., Battaglia R., FIlice M., Maio R., Stanghellini V., Ruggeri E., del Vecchio S., Salvi A., Leonardi R., Damiani G., Capeci W., Gabrielli A., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ghio R., Col A. D., Minisola S., Colangelo L., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Pignataro S., Gennaro A., Blanco J., Saracco V., Fogliati M., Bussolino C., Mete F., Gino M., Cittadini A., Vigorito C., Arcopinto M., Salzano A., Bobbio E., Marra A. M., Sirico D., Moreo G., Gasparini F., Prolo S., Pina G., Ballestrero A., Ferrando F., Berra S., Dassi S., Nava M. C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Galanti G., Mascherini G., Petri C., Stefani L., Girino M., Piccinelli V., Nasso F., Gioffre V., Pasquale M., Scattolin G., Martinelli S., Turrin M., Sechi L., Catena C., Colussi G., Passariello N., Rinaldi L., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Ceda G. P., Maggio M. G., Morganti S., Artoni A., Del Giacco S., Firinu D., Losa F., Paoletti G., Costanzo G., Montalto G., Licata A., Malerba V., Montalto F. A., Lasco A., Basile G., Catalano A., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Lauretani F., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Pirisi M., Fra G. P., Sola D., Porta M., Riva P., Quadri R., Larovere E., Novelli M., Scanzi G., Mengoli C., Provini S., Ricevuti L., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Tedeschi A., Trotta L., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Cattaneo M., Napoli F., Carlotta, F, Raffaella, R, Ilaria, A, Alessandro, N, Mannuccio, M, Mannucci, P, Nobili, A, Pietrangelo, A, Perticone, F, Licata, G, Violi, F, Corazza, G, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Cortesi, L, Miglio, G, Ardoino, I, Novella, A, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Caterina, C, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Lupattelli, G, Mannarino, E, Bianconi, V, Paciullo, F, Alcidi, R, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Natoli, G, Mularo, S, Raspanti, M, Cavallaro, F, Zoli, M, Lazzari, I, Brunori, M, Fabbri, E, Magalotti, D, Arno, R, Pasini, F, Capecchi, P, Palasciano, G, Modeo, M, Gennaro, C, Cappellini, M, Maira, D, Di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, De Amicis, M, De Luca, G, Scaramellini, N, Rossi, P, Damanti, S, Clerici, M, Conti, F, Bonini, G, Ottolini, B, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Dominioni, C, Murialdo, G, Marra, A, Cattaneo, F, Pontremoli, R, Beccati, V, Nobili, G, Secchi, M, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Valeriani, E, Rossi, I, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Pes, C, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccala, G, D'Aurizio, G, Romanelli, G, Zucchelli, A, Manzoni, F, Volpini, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Tassone, B, Sesti, G, Interna, M, Serra, M, Bleve, M, Gasbarrone, L, Sajeva, M, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Cosi, E, Scarinzi, P, Amabile, A, Omenetto, E, Prandini, T, Manfredini, R, Fabbian, F, Boari, B, Giorgi, A, Tiseo, R, De Giorgio, R, Paolisso, G, Rizzo, M, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Sabba, C, Vella, F, Suppressa, P, Schilardi, A, Loparco, F, De Vincenzo, G, Comitangelo, A, Amoruso, E, Fenoglio, L, Falcetta, A, Bracco, C, Fracanzani, A, Fargion, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Agosti, P, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, N, Tognin, T, Bianchi, G, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Peasso, P, Favale, E, Poletto, C, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Dondi, G, Pellegrini, E, Carulli, L, Galassi, M, Grassi, Y, Perticone, M, Battaglia, R, Filice, M, Maio, R, Stanghellini, V, Ruggeri, E, del Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Capeci, W, Gabrielli, A, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ghio, R, Col, A, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Pignataro, S, Gennaro, A, Blanco, J, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, M, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffre, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Ceda, G, Maggio, M, Morganti, S, Artoni, A, Del Giacco, S, Firinu, D, Losa, F, Paoletti, G, Costanzo, G, Montalto, G, Licata, A, Malerba, V, Montalto, F, Lasco, A, Basile, G, Catalano, A, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, G, Sola, D, Porta, M, Riva, P, Quadri, R, Larovere, E, Novelli, M, Scanzi, G, Mengoli, C, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Napoli, F, Carlotta F., Raffaella R., Ilaria A., Alessandro N., Mannuccio M. P., Mannucci P. M., Nobili A., Pietrangelo A., Perticone F., Licata G., Violi F., Corazza G. R., Corrao S., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Cortesi L., Miglio G., Ardoino I., Novella A., Prisco D., Silvestri E., Emmi G., Bettiol A., Caterina C., Biolo G., Zanetti M., Guadagni M., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Lupattelli G., Mannarino E., Bianconi V., Paciullo F., Alcidi R., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Cocita F., Beneduce V., Plances L., Natoli G., Mularo S., Raspanti M., Cavallaro F., Zoli M., Lazzari I., Brunori M., Fabbri E., Magalotti D., Arno R., Pasini F. L., Capecchi P. L., Palasciano G., Modeo M. E., Gennaro C. D., Cappellini M. D., Maira D., Di Stefano V., Fabio G., Seghezzi S., Mancarella M., De Amicis M. M., De Luca G., Scaramellini N., Rossi P. D., Damanti S., Clerici M., Conti F., Bonini G., Ottolini B. B., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Dominioni C. C., Murialdo G., Marra A., Cattaneo F., Pontremoli R., Beccati V., Nobili G., Secchi M. B., Ghelfi D., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Valeriani E., Rossi I., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Pes C., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Zuccala G., D'Aurizio G., Romanelli G., Zucchelli A., Manzoni F., Volpini A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Annoni G., Corsi M., Bellelli G., Zazzetta S., Mazzola P., Szabo H., Bonfanti A., Arturi F., Succurro E., Rubino M., Tassone B., Sesti G., Interna M., Serra M. G., Bleve M. A., Gasbarrone L., Sajeva M. R., Brucato A., Ghidoni S., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Cosi E., Scarinzi P., Amabile A., Omenetto E., Prandini T., Manfredini R., Fabbian F., Boari B., Giorgi A. D., Tiseo R., De Giorgio R., Paolisso G., Rizzo M. R., Borghi C., Strocchi E., Ianniello E., Soldati M., Sabba C., Vella F. S., Suppressa P., Schilardi A., Loparco F., De Vincenzo G. M., Comitangelo A., Amoruso E., Fenoglio L., Falcetta A., Bracco C., Fracanzani A. L., Fargion S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Peyvandi F., Rossio R., Ferrari B., Colombo G., Agosti P., Monzani V., Savojardo V., Folli C., Ceriani G., Pallini G., Dallegri F., Ottonello L., Liberale L., Caserza L., Salam K., Liberato N. L., Tognin T., Bianchi G. B., Giaquinto S., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Spazzini E., Ferrandina C., Montrucchio G., Petitti P., Peasso P., Favale E., Poletto C., Salmi R., Gaudenzi P., Perri L., Landolfi R., Montalto M., Mirijello A., Guasti L., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Dondi G., Pellegrini E., Carulli L., Galassi M., Grassi Y., Perticone M., Battaglia R., FIlice M., Maio R., Stanghellini V., Ruggeri E., del Vecchio S., Salvi A., Leonardi R., Damiani G., Capeci W., Gabrielli A., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ghio R., Col A. D., Minisola S., Colangelo L., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Pignataro S., Gennaro A., Blanco J., Saracco V., Fogliati M., Bussolino C., Mete F., Gino M., Cittadini A., Vigorito C., Arcopinto M., Salzano A., Bobbio E., Marra A. M., Sirico D., Moreo G., Gasparini F., Prolo S., Pina G., Ballestrero A., Ferrando F., Berra S., Dassi S., Nava M. C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Galanti G., Mascherini G., Petri C., Stefani L., Girino M., Piccinelli V., Nasso F., Gioffre V., Pasquale M., Scattolin G., Martinelli S., Turrin M., Sechi L., Catena C., Colussi G., Passariello N., Rinaldi L., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Ceda G. P., Maggio M. G., Morganti S., Artoni A., Del Giacco S., Firinu D., Losa F., Paoletti G., Costanzo G., Montalto G., Licata A., Malerba V., Montalto F. A., Lasco A., Basile G., Catalano A., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Lauretani F., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Pirisi M., Fra G. P., Sola D., Porta M., Riva P., Quadri R., Larovere E., Novelli M., Scanzi G., Mengoli C., Provini S., Ricevuti L., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Tedeschi A., Trotta L., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Cattaneo M., and Napoli F.

Published
2019

50. Mortality rate and risk factors for gastrointestinal bleeding in elderly patients

Author

Lenti, M, Pasina, L, Cococcia, S, Cortesi, L, Miceli, E, Dominioni, C, Pisati, M, Mengoli, C, Perticone, F, Nobili, A, Di Sabatino, A, Corazza, G, Mannucci, P, Tettamanti, M, Franchi, C, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Licata, G, Violi, F, Ardoino, I, Prisco, D, Silvestri, E, Cenci, C, Emmi, G, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Vanoli, M, Grignani, G, Pulixi, E, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Mannarino, E, Lupattelli, G, Bianconi, V, Paciullo, F, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Olivieri, O, Girelli, D, Matteazzi, T, Barbagallo, M, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Zoli, M, Lazzari, I, Brunori, M, Pasini, F, Capecchi, P, Palasciano, G, Modeo, M, Di Gennaro, C, Cappellini, M, Maira, D, Di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, Rossi, P, Damanti, S, Clerici, M, Conti, F, Murialdo, G, Marra, A, Cattaneo, F, Pontremoli, R, Secchi, M, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Angelucci, E, Valeriani, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccala, G, D'Aurizio, G, Romanelli, G, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Serra, M, Bleve, M, Gasbarrone, L, Sajeva, M, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Borghi, C, Strocchi, E, De Sando, V, Pareo, I, Sabba, C, Vella, F, Suppressa, P, Agosti, P, Schilardi, A, Loparco, F, Fenoglio, L, Bracco, C, Giraudo, A, Fargion, S, Periti, G, Porzio, M, Tiraboschi, S, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, N, Tognin, T, Bianchi, G, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Molaro, M, Grossi, A, Bertolotti, M, Mussi, C, Libbra, M, Dondi, G, Pellegrini, E, Carulli, L, Colangelo, L, Falbo, T, Stanghellini, V, Giorgio, R, Ruggeri, E, Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Gabrielli, A, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ghio, R, Col, A, Minisola, S, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Blanco, J, Zanoli, L, Pignataro, S, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, M, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffra, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Patrizia, T, Castello, R, Pasino, M, Ceda, G, Maggio, M, Morganti, S, Artoni, A, Giacco, S, Firinu, D, Losa, F, Paoletti, G, Montalto, G, Licata, A, Malerba, V, Antonino, L, Basile, G, Antonino, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, G, Sola, D, Porta, M, Riva, P, Quadri, R, Scanzi, G, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Lenti M. V., Pasina L., Cococcia S., Cortesi L., Miceli E., Dominioni C. C., Pisati M., Mengoli C., Perticone F., Nobili A., Di Sabatino A., Corazza G. R., Mannucci P. M., Tettamanti M., Franchi C., Corrao S., Marengoni A., Salerno F., Cesari M., Licata G., Violi F., Ardoino I., Prisco D., Silvestri E., Cenci C., Emmi G., Biolo G., Zanetti M., Guadagni M., Zaccari M., Vanoli M., Grignani G., Pulixi E. A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Mannarino E., Lupattelli G., Bianconi V., Paciullo F., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Olivieri O., Girelli D., Matteazzi T., Barbagallo M., Dominguez L., Cocita F., Beneduce V., Plances L., Zoli M., Lazzari I., Brunori M., Pasini F. L., Capecchi P. L., Palasciano G., Modeo M. E., Di Gennaro C., Cappellini M. D., Maira D., Di Stefano V., Fabio G., Seghezzi S., Mancarella M., Rossi P. D., Damanti S., Clerici M., Conti F., Murialdo G., Marra A., Cattaneo F., Pontremoli R., Secchi M. B., Ghelfi D., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Angelucci E., Valeriani E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Muscaritoli M., Molfino A., Petrillo E., ZuccalA G., D'aurizio G., Romanelli G., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'unto C., Annoni G., Corsi M., Bellelli G., Zazzetta S., Mazzola P., Szabo H., Bonfanti A., Arturi F., Succurro E., Rubino M., Serra M. G., Bleve M. A., Gasbarrone L., Sajeva M. R., Brucato A., Ghidoni S., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Cosi E., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., Paolisso G., Rizzo M. R., Borghi C., Strocchi E., De Sando V., Pareo I., SabbA C., Vella F. S., Suppressa P., Agosti P., Schilardi A., Loparco F., Fenoglio L., Bracco C., Giraudo A. V., Fargion S., Periti G., Porzio M., Tiraboschi S., Peyvandi F., Rossio R., Ferrari B., Colombo G., Monzani V., Savojardo V., Folli C., Ceriani G., Pallini G., Dallegri F., Ottonello L., Liberale L., Caserza L., Salam K., Liberato N. L., Tognin T., Bianchi G. B., Giaquinto S., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Spazzini E., Ferrandina C., Montrucchio G., Petitti P., Salmi R., Gaudenzi P., Perri L., Landolfi R., Montalto M., Mirijello A., Guasti L., Castiglioni L., Maresca A., Squizzato A., Molaro M., Grossi A., Bertolotti M., Mussi C., Libbra M. V., Dondi G., Pellegrini E., Carulli L., Colangelo L., Falbo T., Stanghellini V., Giorgio R. D., Ruggeri E., Vecchio S., Salvi A., Leonardi R., Damiani G., Gabrielli A., Capeci W., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ghio R., Col A. D., Minisola S., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Blanco J., Zanoli L., Pignataro S., Saracco V., Fogliati M., Bussolino C., Mete F., Gino M., Cittadini A., Vigorito C., Arcopinto M., Salzano A., Bobbio E., Marra A. M., Sirico D., Moreo G., Gasparini F., Prolo S., Pina G., Ballestrero A., Ferrando F., Berra S., Dassi S., Nava M. C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Galanti G., Mascherini G., Petri C., Stefani L., Girino M., Piccinelli V., Nasso F., GioffrA V., Pasquale M., Scattolin G., Martinelli S., Turrin M., Sechi L., Catena C., Colussi G., Passariello N., Rinaldi L., Berti F., Famularo G., Patrizia T., Castello R., Pasino M., Ceda G. P., Maggio M. G., Morganti S., Artoni A., Giacco S. D., Firinu D., Losa F., Paoletti G., Montalto G., Licata A., Malerba V., Antonino L., Basile G., Antonino C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Lauretani F., Ticinesi A., Minuz P., Fondrieschi L., Pirisi M., Fra G. P., Sola D., Porta M., Riva P., Quadri R., Scanzi G., Provini S., Ricevuti L., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Tedeschi A., Trotta L., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Cattaneo M., Lenti, M, Pasina, L, Cococcia, S, Cortesi, L, Miceli, E, Dominioni, C, Pisati, M, Mengoli, C, Perticone, F, Nobili, A, Di Sabatino, A, Corazza, G, Mannucci, P, Tettamanti, M, Franchi, C, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Licata, G, Violi, F, Ardoino, I, Prisco, D, Silvestri, E, Cenci, C, Emmi, G, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Vanoli, M, Grignani, G, Pulixi, E, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Mannarino, E, Lupattelli, G, Bianconi, V, Paciullo, F, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Olivieri, O, Girelli, D, Matteazzi, T, Barbagallo, M, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Zoli, M, Lazzari, I, Brunori, M, Pasini, F, Capecchi, P, Palasciano, G, Modeo, M, Di Gennaro, C, Cappellini, M, Maira, D, Di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, Rossi, P, Damanti, S, Clerici, M, Conti, F, Murialdo, G, Marra, A, Cattaneo, F, Pontremoli, R, Secchi, M, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Angelucci, E, Valeriani, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccala, G, D'Aurizio, G, Romanelli, G, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Serra, M, Bleve, M, Gasbarrone, L, Sajeva, M, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Borghi, C, Strocchi, E, De Sando, V, Pareo, I, Sabba, C, Vella, F, Suppressa, P, Agosti, P, Schilardi, A, Loparco, F, Fenoglio, L, Bracco, C, Giraudo, A, Fargion, S, Periti, G, Porzio, M, Tiraboschi, S, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, N, Tognin, T, Bianchi, G, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Molaro, M, Grossi, A, Bertolotti, M, Mussi, C, Libbra, M, Dondi, G, Pellegrini, E, Carulli, L, Colangelo, L, Falbo, T, Stanghellini, V, Giorgio, R, Ruggeri, E, Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Gabrielli, A, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ghio, R, Col, A, Minisola, S, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Blanco, J, Zanoli, L, Pignataro, S, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, M, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffra, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Patrizia, T, Castello, R, Pasino, M, Ceda, G, Maggio, M, Morganti, S, Artoni, A, Giacco, S, Firinu, D, Losa, F, Paoletti, G, Montalto, G, Licata, A, Malerba, V, Antonino, L, Basile, G, Antonino, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, G, Sola, D, Porta, M, Riva, P, Quadri, R, Scanzi, G, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Lenti M. V., Pasina L., Cococcia S., Cortesi L., Miceli E., Dominioni C. C., Pisati M., Mengoli C., Perticone F., Nobili A., Di Sabatino A., Corazza G. R., Mannucci P. M., Tettamanti M., Franchi C., Corrao S., Marengoni A., Salerno F., Cesari M., Licata G., Violi F., Ardoino I., Prisco D., Silvestri E., Cenci C., Emmi G., Biolo G., Zanetti M., Guadagni M., Zaccari M., Vanoli M., Grignani G., Pulixi E. A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Mannarino E., Lupattelli G., Bianconi V., Paciullo F., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Olivieri O., Girelli D., Matteazzi T., Barbagallo M., Dominguez L., Cocita F., Beneduce V., Plances L., Zoli M., Lazzari I., Brunori M., Pasini F. L., Capecchi P. L., Palasciano G., Modeo M. E., Di Gennaro C., Cappellini M. D., Maira D., Di Stefano V., Fabio G., Seghezzi S., Mancarella M., Rossi P. D., Damanti S., Clerici M., Conti F., Murialdo G., Marra A., Cattaneo F., Pontremoli R., Secchi M. B., Ghelfi D., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Angelucci E., Valeriani E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Muscaritoli M., Molfino A., Petrillo E., ZuccalA G., D'aurizio G., Romanelli G., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'unto C., Annoni G., Corsi M., Bellelli G., Zazzetta S., Mazzola P., Szabo H., Bonfanti A., Arturi F., Succurro E., Rubino M., Serra M. G., Bleve M. A., Gasbarrone L., Sajeva M. R., Brucato A., Ghidoni S., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Cosi E., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., Paolisso G., Rizzo M. R., Borghi C., Strocchi E., De Sando V., Pareo I., SabbA C., Vella F. S., Suppressa P., Agosti P., Schilardi A., Loparco F., Fenoglio L., Bracco C., Giraudo A. V., Fargion S., Periti G., Porzio M., Tiraboschi S., Peyvandi F., Rossio R., Ferrari B., Colombo G., Monzani V., Savojardo V., Folli C., Ceriani G., Pallini G., Dallegri F., Ottonello L., Liberale L., Caserza L., Salam K., Liberato N. L., Tognin T., Bianchi G. B., Giaquinto S., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Spazzini E., Ferrandina C., Montrucchio G., Petitti P., Salmi R., Gaudenzi P., Perri L., Landolfi R., Montalto M., Mirijello A., Guasti L., Castiglioni L., Maresca A., Squizzato A., Molaro M., Grossi A., Bertolotti M., Mussi C., Libbra M. V., Dondi G., Pellegrini E., Carulli L., Colangelo L., Falbo T., Stanghellini V., Giorgio R. D., Ruggeri E., Vecchio S., Salvi A., Leonardi R., Damiani G., Gabrielli A., Capeci W., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ghio R., Col A. D., Minisola S., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Blanco J., Zanoli L., Pignataro S., Saracco V., Fogliati M., Bussolino C., Mete F., Gino M., Cittadini A., Vigorito C., Arcopinto M., Salzano A., Bobbio E., Marra A. M., Sirico D., Moreo G., Gasparini F., Prolo S., Pina G., Ballestrero A., Ferrando F., Berra S., Dassi S., Nava M. C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Galanti G., Mascherini G., Petri C., Stefani L., Girino M., Piccinelli V., Nasso F., GioffrA V., Pasquale M., Scattolin G., Martinelli S., Turrin M., Sechi L., Catena C., Colussi G., Passariello N., Rinaldi L., Berti F., Famularo G., Patrizia T., Castello R., Pasino M., Ceda G. P., Maggio M. G., Morganti S., Artoni A., Giacco S. D., Firinu D., Losa F., Paoletti G., Montalto G., Licata A., Malerba V., Antonino L., Basile G., Antonino C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Lauretani F., Ticinesi A., Minuz P., Fondrieschi L., Pirisi M., Fra G. P., Sola D., Porta M., Riva P., Quadri R., Scanzi G., Provini S., Ricevuti L., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Tedeschi A., Trotta L., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., and Cattaneo M.

Abstract

Background: Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB in elderly patients. Methods: Since 2008, samples of elderly patients (age ≥ 65 years) with multimorbidity admitted to 101 internal medicine wards across Italy have been prospectively enrolled and followed-up (REPOSI registry). Diagnoses of GIB, length of stay (LOS), mortality rate, and possible risk factors, including drugs, index of comorbidity (Cumulative Illness Rating Scale [CIRS]), polypharmacy, and chronic diseases were assessed. Adjusted multivariate logistic regression models were computed. Results: 3872 patients were included (mean age 79 ± 7.5 years, F:M ratio 1.1:1). GIB was reported in 120 patients (mean age 79.6 ± 7.3 years, F:M 0.9:1), with a crude prevalence of 3.1%. Upper GIB occurred in 72 patients (mean age 79.3 ± 7.6 years, F:M 0.8:1), lower GIB in 51 patients (mean age 79.4 ± 7.1 years, F:M 0.9:1), and both upper/lower GIB in 3 patients. Hemorrhagic gastritis/duodenitis and colonic diverticular disease were the most common causes. The LOS of patients with GIB was 11.7 ± 8.1 days, with a 3.3% in-hospital and a 9.4% 3-month mortality rates. Liver cirrhosis (OR 5.64; CI 2.51–12.65), non-ASA antiplatelet agents (OR 2.70; CI 1.23–5.90), and CIRS index of comorbidity >3 (OR 2.41; CI 1.16–4.98) were associated with GIB (p < 0.05). Conclusions: A high index of comorbidity is associated with high odds of GIB in elderly patients. The use of non-ASA antiplatelet agents should be discussed in patients with multimorbidity.

Published
2019

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