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Abstract: Objective: Integrative neuroscience research needs a scalable informatics framework that enables semantic integration of diverse types of neuroscience data. This paper describes the use of the Web Ontology Language (OWL) and other Semantic Web technologies for the representation and integration of molecular-level data provided by several of SenseLab suite of neuroscience databases. Methods: Based on the original database structure, we semi-automatically translated the databases into OWL ontologies with manual addition of semantic enrichment. The SenseLab ontologies are extensively linked to other biomedical Semantic Web resources, including the Subcellular Anatomy Ontology, Brain Architecture Management System, the Gene Ontology, BIRNLex and UniProt. The SenseLab ontologies have also been mapped to the Basic Formal Ontology and Relation Ontology, which helps ease interoperability with many other existing and future biomedical ontologies for the Semantic Web. In addition, approaches to representing contradictory research statements are described. The SenseLab ontologies are designed for use on the Semantic Web that enables their integration into a growing collection of biomedical information resources. Conclusion: We demonstrate that our approach can yield significant potential benefits and that the Semantic Web is rapidly becoming mature enough to realize its anticipated promises. The ontologies are available online at http://neuroweb.med.yale.edu/senselab/. [Copyright &y& Elsevier]

• Confident itemsets are used to discretize the whole model into subspaces. • Concise instance-wise explanations approximate the behavior of the black-box. • Class-wise explanations approximate the black-box's behavior in different subspaces. • Confident itemsets explanations improve the fidelity by 9.3% over other methods. • Confident itemsets explanations improve the interpretability by 8.8% Black-box Artificial Intelligence (AI) methods, e.g. deep neural networks, have been widely utilized to build predictive models that can extract complex relationships in a dataset and make predictions for new unseen data records. However, it is difficult to trust decisions made by such methods since their inner working and decision logic is hidden from the user. Explainable Artificial Intelligence (XAI) refers to systems that try to explain how a black-box AI model produces its outcomes. Post-hoc XAI methods approximate the behavior of a black-box by extracting relationships between feature values and the predictions. Perturbation-based and decision set methods are among commonly used post-hoc XAI systems. The former explanators rely on random perturbations of data records to build local or global linear models that explain individual predictions or the whole model. The latter explanators use those feature values that appear more frequently to construct a set of decision rules that produces the same outcomes as the target black-box. However, these two classes of XAI methods have some limitations. Random perturbations do not take into account the distribution of feature values in different subspaces, leading to misleading approximations. Decision sets only pay attention to frequent feature values and miss many important correlations between features and class labels that appear less frequently but accurately represent decision boundaries of the model. In this paper, we address the above challenges by proposing an explanation method named Confident Itemsets Explanation (CIE). We introduce confident itemsets, a set of feature values that are highly correlated to a specific class label. CIE utilizes confident itemsets to discretize the whole decision space of a model to smaller subspaces. Extracting important correlations between the features and the outcomes of the classifier in different subspaces, CIE produces instance-wise and class-wise explanations that accurately approximate the behavior of the target black-box. Conducting a set of experiments on various black-box classifiers, and different tabular and textual data classification tasks, we show that our CIE method performs better than the previous perturbation-based and rule-based explanators in terms of the descriptive accuracy (an improvement of 9.3%) and interpretability (an improvement of 8.8%) of the explanations. Subjective evaluations demonstrate that the users find the explanations of CIE more understandable and interpretable than those of the other comparison methods. [ABSTRACT FROM AUTHOR]

Computational sleep scoring from multimodal neurophysiological time-series (polysomnography PSG) has achieved impressive clinical success. Models that use only a single electroencephalographic (EEG) channel from PSG have not yet received the same clinical recognition, since they lack Rapid Eye Movement (REM) scoring quality. The question whether this lack can be remedied at all remains an important one. We conjecture that predominant Long Short-Term Memory (LSTM) models do not adequately represent distant REM EEG segments (termed epochs), since LSTMs compress these to a fixed-size vector from separate past and future sequences. To this end, we introduce the EEG representation model ENGELBERT (electro En cephalo G raphic E poch L ocal B idirectional E ncoder R epresentations from T ransformer). It jointly attends to multiple EEG epochs from both past and future. Compared to typical token sequences in language, for which attention models have originally been conceived, overnight EEG sequences easily span more than 1000 30 s epochs. Local attention on overlapping windows reduces the critical quadratic computational complexity to linear, enabling versatile sub-one-hour to all-day scoring. ENGELBERT is at least one order of magnitude smaller than established LSTM models and is easy to train from scratch in a single phase. It surpassed state-of-the-art macro F1-scores in 3 single-EEG sleep scoring experiments. REM F1-scores were pushed to at least 86%. ENGELBERT virtually closed the gap to PSG-based methods from 4–5 percentage points (pp) to less than 1 pp F1-score. [ABSTRACT FROM AUTHOR]