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Recurrent aphthous ulcer (RAU) is one of the most common diseases of oral mucosa, which is generally believed to be related to immunity, though the etiology is still unclear. It is suspected that allergies are directly related to RAU. So we sought to explore the relationship between hypersensitivity and RAU. 40 RAU patients who were in ulceration period and 40 people who were in good health were selected from Jan 2016 to Feb 2017, matched in age and sex. The peripheral blood antigens of 40 RAU patients and 40 healthy people was tested, and serum specific IgE (sIgE) with 6 groups of antigens and total IgE (tIgE) analysis was performed to identify IgE-mediated allergic reaction possibly affecting RAU. We then investigated the food intolerance and IgG levels to discover the correlation between non-IgE mediated allergic reaction and RAU. The positive cases and rate of sIgE in RAU group was higher than that of control, but the difference was not statistically significant (P ＞0.05). Positive grade of animal fur scraps (EX1), house dust mixed (HX2) and the serum tIgE concentration of the RAU group were significantly higher than the control group (P ＜0.05).The number of food intolerance in RAU group was significantly higher than that in control group (P ＜0.05). Our findings suggested certain correlation between RAU and anaphylaxis. Daily contact allergens and food intolerance may be one of the causes of RAU. Moreover, this provides reference value for clinical diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Background: Childhood food allergy is a serious health problem. However, little is known about the frequency and manner in which it is currently diagnosed. Objective: To describe parent report of physician practices in the diagnosis of pediatric food allergy. Methods: Data from children with food allergy were identified for analysis from a representative survey administered in US households with children from June 2009 to February 2010. Analyses were performed at the level of the allergy. Demographic characteristics, symptom prevalence, and diagnostic methods were calculated as weighted proportions. Adjusted models were estimated to examine the association of reaction history and allergenic food with odds of physician diagnosis and testing. Results: Food allergies (n = 3,218) to 9 common allergens were reported among 2,355 children in a sample of 38,480. We found that 70.4% of reported food allergy was diagnosed by a physician. Among physician-diagnosed food allergy, 32.6% was not evaluated with diagnostic testing, 47.3% was assessed with a skin prick test, 39.9% with a serum specific IgE test, and 20.2% with an oral food challenge. Odds of physician diagnosis and testing were significantly higher for severe versus mild/moderate food allergy. Urticaria and angioedema were not reported as symptoms in 40.7% and 34.6% of severe food allergies, respectively. Conclusion: Thirty percent of parent-reported food allergies in this study were not diagnosed by a physician. One in 5 physician-diagnosed allergies was evaluated with oral food challenge. Understanding parent report of practices in food allergy provides insight into ways in which to streamline the diagnosis and management of care. [ABSTRACT FROM AUTHOR]

Abstract: Food allergy is a common medical problem in infants, children and teenagers. With a good history, appropriate allergy tests and some training, food allergy is relatively easy to diagnose. A correct diagnosis can allow the child to avoid the relevant allergens and reduce their risk of experiencing further allergic reactions. They and their families can also be taught how to recognize and manage any future reactions. This is important as allergenic foods can precipitate anaphylaxis, particularly in children with co-existing asthma. This article will provide a description of how to diagnose and manage infants, children and teenagers with possible food allergy. [Copyright &y& Elsevier]