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• Some patients with total knee arthroplasty are in a state of self-control fatigue, which negatively influences their rehabilitation behaviour. • Latent profile analysis was employed to define the subgroups of self-regulation fatigue. • Three heterogeneous self-regulation fatigue classes of patients with end-stage knee pathologies were identified with similar patterns in different intercepts. • Lower levels of hope, social support, self-efficacy and education were predictors of a high level of self-regulation fatigue. Patients with total knee arthroplasty encounter stressful events that consume their coping resources, resulting in self-control fatigue. Few studies have focused on this phenomenon. To identify subgroups of patients before total knee arthroplasty according to the heterogeneous patterns of self-regulation fatigue and to analyse the predictors of subtypes. A total of 210 patients awaiting total knee arthroplasty were enrolled. Data of demographic characteristics, clinical characteristics, psychological and social factors were collected. Latent profile analysis was employed to define the subgroups. Predictors of patterns were identified using multinomial logistic regression. Three latent classes were identified: the low, medium, and high self-regulation fatigue classes. For the high self-regulation fatigue class, lower levels of hope, social support, self-efficacy and education were major predictors. These predictors of patients with different levels of self-regulation fatigue provide evidence for the identification of vulnerable populations and lay a foundation for targeted interventions. [ABSTRACT FROM AUTHOR]