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Achieving selective release of chemical anticancer agents and improving therapeutic efficacy has always been a hot spot in the field of cancer research, yet how to achieve this remains a great challenge. In this work, we constructed a novel chemical anticancer agent (named MCLOP) by introducing naphthalimide into the skeleton of methylene blue (MB). Under the stimulation by cellular hypochlorous acid (HClO) and visible light, selective release of active naphthalimide can be achieved within breast cancer cell lines, the release process of which can be tracked visually using near-infrared fluorescence of MB (685 nm). More importantly, we developed biotinylated curcumin (Cur-Bio) as a new chemosensitizer, which significantly enhanced the ability of MCLOP to induce autophagic cell death of breast cancer cells. This synergistic treatment strategy exhibited an excellent anti-proliferation effect on breast cancer cells in vitro , three-dimensional (3D) cell sphere model, and mouse tumor model in vivo. This work provides a new strategy for the treatment of breast cancer and also opens new opportunities for the efficient treatment of cancer with curcumin-based chemosensitizer. [Display omitted] • New anticancer agent MCLOP was developed based on naphthalimide and methylene blue. • Stimulation with HClO and visible light release active naphthalimide in MCF-7 cells. • The biotinylated curcumin (Cur-Bio) was constructed as a new chemosensitizer. • Cur-Bio enhances the ability of MCLOP to induce autophagic cell death of MCF-7 cells. • Treatment with MCLOP and Cur-Bio exhibits a synergistic anticancer effect in vivo. [ABSTRACT FROM AUTHOR]

[Display omitted] • UMIGH NPs, a targeted nanoplatform with multifunction and cascade effect, was introduced to treat colon cancer in mice. • UMIGH NPs could reduce the impact of HSPs at an upstream node through decreasing the adenosine triphosphate with glucose oxidase effectively. • UMIGH NPs realized the synergistic starvation therapy/low-temperature PTT with improved anti-tumor performance. Hypothermal photothermal therapy, as a non-invasive therapy method, is becoming ever more prevalent. However, due to cellular heat resistance from the generation of heat shock proteins (HSPs) and the monotonicity of therapeutic modality, the antitumor efficacy is severely restricted. Herein, a self-supplied O 2 multifunctional nanoplatform mediated by glucose oxidase (GOx) is developed, which may combine starvation therapy (ST) and hypothermal photothermal therapy (HPTT) for tumor therapy. The obtained nanoplatform, UM@ICG@GOX@HA (UMIGH), was assembled by the UIO-66 core, MnO 2 , indocyanine green (ICG) and hyaluronic acid (HA). GOx was introduced to decrease the ATP level thus alleviating the HSPs-mediated heat tolerance, while the loaded MnO 2 could decompose intratumoral H 2 O 2 into O 2 , which enhanced the effect of HPTT and ST. Due to the coated HA, UMIGH could target the high expressed CD44 in CT26 tumor cells. The active targeting and NPs-associated passive targeting promoted the uptake of nanoparticles. Furthermore, ICG encapsulated in UMIGH NPs could also accurately image tumors. This synergistic treatment strategy of HPTT and ST exhibited an excellent anti-proliferation effect on colon cancer cells in vitro and mouse xenograft model in vivo , which might bring an informatic strategy for future investigations. [ABSTRACT FROM AUTHOR]