1. The B Cell Inhibitory Fc Receptor Triggers Apoptosis by a Novel c-Abl Family Kinase-dependent Pathway.
- Author
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Shiang-Jong Tzeng, Bolland, Silvia, Inabe, Kazunori, Kurosaki, Tomohiro, and Pierce, Susan K.
- Subjects
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B cells , *ANTIGEN presenting cells , *PROTEIN-tyrosine kinases , *CELL receptors , *LYMPHOCYTES , *PHOSPHATASES , *APOPTOSIS - Abstract
The inhibitory Fc receptors function to regulate the antigen-driven activation and expansion of lymphocytes. In B cells, the FcγRIIB1 is a potent inhibitor of B cell antigen receptor (BCR) signaling when coligated to the BCR by engagement of antigen-containing immune complexes. Inhibition is mediated by the recruitment of the inositol phosphatase, SHIP, to the FcγRIIB1 phosphorylated tyrosine-based inhibitory motif (ITIM). Here we show that BCR-independent aggregation of the FcγRIIB1 transduces an ITIM- and SHIP-independent proapoptotic signal that is dependent on members of the c-Abl tyrosine kinase family. These results define a novel Abl family kinase-dependent FcγRIIB1 signaling pathway that functions independently of the BCR in controlling antigen-driven B cell responses. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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