1. Development of Classic Hodgkin Lymphoma after successful treatment of primary mediastinal large b-cell lymphoma: results from a well-defined database.
- Author
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Vassilakopoulos, Theodoros P., Piperidou, Alexia, Hadjiharissi, Evdoxia, Panteliadou, Alkistis-Kyra, Panitsas, Fotios, Vassilopoulos, Ioannis, Variamis, Eleni, Boutsis, Dimitrios, Michail, Michail, Papageorgiou, Sotirios, Tsourouflis, Gerassimos, Dimou, Maria, Karakatsanis, Stamatis, Kalpadakis, Christina, Stavroyianni, Niki, Katodritou, Eirini, Kotsopoulou, Maria, Kotsianidis, Ioannis, Verigou, Evgenia, and Hatzimichael, Eleftheria
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HODGKIN'S disease , *TREATMENT effectiveness , *LYMPHOMAS , *DIFFUSE large B-cell lymphomas - Abstract
To the editor Classic Hodgkin Lymphoma (cHL) and Primary Mediastinal Large B-Cell Lymphoma (PMLBCL)have been widely studied as separate entities but are poorly covered as metachronous pathologies in the literature. After a median follow-up of 45 months, we identified three cases, all of which had been reviewed at the time of cHL occurrence and both the diagnosis of PMLBCL and cHL had been confirmed by expert hematopathologists and there was no evidence of synchronous cHL or grey zone lymphoma. Assuming a background crude annual rate of 3/100.000 persons for cHL [9], 0.063 cases would have been expected on average over 2,093 person-years of observation of our PMLBCL cohort, measured from primary treatment initiation to the development of cHL, relapse/progression of PMLBCL or death from any cause without prior disease-related event. [Extracted from the article]
- Published
- 2021
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